home
RSS
February 27th, 2014
02:10 PM ET

Study: Children of older fathers face higher risk of psychiatric disorders

Do men have a biological clock of sorts? A large new study suggests they may.

Compared to younger fathers, older fathers' children were found to be significantly more at risk for a host of psychiatric disorders, according to the study, published Wednesday in the journal JAMA Psychiatry.

For example, the children of fathers ages 45 and over were three times more likely to have an autism spectrum disorder, 13 times more likely to have ADHD, and 25 times more likely to have bipolar disorder than the children of fathers aged 20 to 24.

For the study, researchers analyzed data from 2.6 million children born in Sweden between 1973 and 2001, making it one of the largest and most comprehensive studies on the effects of paternal age.

"The working hypothesis is that as men get older and their sperm continue to replicate, that there are more chances of having mutations in the base pairs of the DNA," says Brian D'Onofrio, lead study author and associate professor in the Department of Psychological and Brain Sciences at Indiana University.

"Those genetic mutations are associated with psychiatric problems."

The age-related effects were gradual, researchers found; a 35-year-old man's child had greater risks than the child of a 25-year-old man.

A 2012 study  done by researchers in Iceland indicated that as many as 20% to 30% of cases of autism and schizophrenia may be linked to fathers' advanced age. Unlike findings on conditions such as Down syndrome, the Iceland study found the mother's age made no difference. For that study, researchers looked at genomes of 78 sets of parents and offspring. 

While most studies on this subject simply compare children born to young fathers with those of older fathers, D'Onofrio calls that method "comparing apples and oranges, because we know that young fathers differ on many things compared to older fathers."

Instead, D'Onofrio and his colleagues compared siblings; looking at the outcomes when the same man has a child in his younger years and then again later in life.

"That enabled us to get a better understanding of what's truly due to the advancing father's age at childbearing," says D'Onofrio.


soundoff (376 Responses)
  1. Royal Katzner

    Have you ever heard of second life (sl for short). It is basically a online game where you can do anything you want. Second life is literally my second life (pun intended lol). If you would like to see more you can see these second life authors and blogs

    http://everydayliteracies.blogspot.com/2008/11/camstudio.html

    May 29, 2021 at 04:07 | Report abuse | Reply
  2. Cecil Seibold

    Have you ever heard of second life (sl for short). It is basically a online game where you can do anything you want. Second life is literally my second life (pun intended lol). If you would like to see more you can see these Second Life articles and blogs

    http://myvedana.blogspot.com/2013/07/itinerant-academic.html?m=0

    May 30, 2021 at 04:53 | Report abuse | Reply
  3. Kaleigh Reinsch

    Have you ever heard of second life (sl for short). It is basically a online game where you can do anything you want. SL is literally my second life (pun intended lol). If you would like to see more you can see these Second Life articles and blogs

    http://manainkblog.typepad.com/witty_knitter/2007/07/feeling-extra-w.html

    May 31, 2021 at 03:32 | Report abuse | Reply
  4. Conrad Amble

    This was awesome! I would like you to clean up all this spam though

    https://www.linkedin.com/in/yusufhanafy

    June 1, 2021 at 00:00 | Report abuse | Reply
  5. Camille Nealen

    Have you ever heard of second life (sl for short). It is essentially a video game where you can do anything you want. Second life is literally my second life (pun intended lol). If you want to see more you can see these sl articles and blogs

    http://everydayliteracies.blogspot.com/2013/08/new-book-in-our-series.html?showComment=1377942558871

    June 2, 2021 at 22:20 | Report abuse | Reply
  6. cialis online

    tadalafil liquid buy cialis tadalafil alcohol

    June 4, 2021 at 03:14 | Report abuse | Reply
  7. tadalafil liquid

    tadalafil warnings tadalafil brands generic tadalafil from uk

    June 4, 2021 at 03:19 | Report abuse | Reply
  8. buy cialis online

    tadalafil contraindications cialis pills what is tadalafil

    June 4, 2021 at 15:48 | Report abuse | Reply
  9. lowest price cialis

    taldalafil cialis cost sx brands coupons

    June 4, 2021 at 16:15 | Report abuse | Reply
  10. tadalafil peptide

    canada generic tadalafil is tadalafil and cialis the same thing cialis tadalafil

    June 4, 2021 at 18:23 | Report abuse | Reply
  11. chloroquine

    where to get chloroquine hydroxychloroquine online chloroquine without prescription

    June 4, 2021 at 22:43 | Report abuse | Reply
  12. chloroquine sulfate

    hydroxychloroq chloroquine price in india what is hydroxychloroquine for

    June 5, 2021 at 11:06 | Report abuse | Reply
  13. cialis 20mg

    tadalafil daily online cialis generic purchase peptides tadalafil

    June 5, 2021 at 18:45 | Report abuse | Reply
  14. buy hydroxychloroquine

    chloroquine side effect plaquinol premature babies wikipedia

    June 5, 2021 at 19:30 | Report abuse | Reply
  15. Lindsy Ahmadi

    This was awesome! I would like you to clean up all this spam though

    https://www.linkedin.com/in/yusufhanafy

    June 6, 2021 at 07:32 | Report abuse | Reply
  16. hydroxychloroquine

    hydochloroquine hydroxychloroquin hydroxychloroquine drugs

    June 6, 2021 at 15:52 | Report abuse | Reply
  17. Skye Cashin

    This was great! I would like you to clean up all this spam though

    https://www.linkedin.com/in/yusufhanafy

    June 7, 2021 at 14:14 | Report abuse | Reply
  18. buy aralen

    what is hcq medicine chloroquine tablets what is hydroxychloroquine used to treat

    June 7, 2021 at 20:48 | Report abuse | Reply
  19. clonidin

    hydroxychloroquinone aralen where to buy hydro chloroquine

    June 8, 2021 at 03:08 | Report abuse | Reply
  20. custom bracelets bulk

    Real excellent visual appeal on this web site,
    I'd rate it 10.

    June 9, 2021 at 11:31 | Report abuse | Reply
  21. vaoroi.tv

    Trực Tiếp đá Bóng Việt Nam Vs Lebanon. Coi Truc Tiep Bong Da. Futsal Việt Nam7mTrên băng ghế đào tạo, Lebanon đã bửa nhiệm Ramiro Lopez cách đây 3 tuần. Nhà cầm cố quân người Tây Ban Nha chủ yếu đuối làm việc tại Ý và từng có thời gian thực hiện việc trên Kuwait.|Và NHM bóng đá Việt Nam đang được đợi Minh Trí cùng đồng đội hóa giải đối thủ để tạo lợi thế đến trận lượt về sau đây hai ngày. Chelsea đã nên trải qua 8 phút bù giờ khó thở đảm bảo thành công.

    https://murraystivoli.com/detail/htv7-hom-nay-101458.html

    June 9, 2021 at 20:54 | Report abuse | Reply
  22. Man Beberwyk

    This was awesome! I would like you to clean up all this spam though

    https://www.linkedin.com/in/yusufhanafy

    June 10, 2021 at 08:08 | Report abuse | Reply
  23. xem vtv6 fpt play

    Kết Quả Futsal Việt Nam Vs Lebanonlich copa america 2019Theo thể thức thi đấu, đội thắng ở cặp đấu này sẽ giành tấm vé đến Lithuania trong ngày hội bóng đá lớn nhất thế giới đến futsal. Tuyển futsal Việt Nam bước vào trận play-off lượt đi tranh vé dự play-off World Cup 2021 với sự tự tin. Tuy vậy, HLV Phạm Minh Giang bày tỏ, toàn đội ko ngán Lebanon song sẽ tìm cách để khắc chế sức mạnh của đối thủ bởi bên trên băng ghế huấn luyện là nhà cầm quân Ramiro Lopez, người từng dẫn dắt futsal Tây Ban Nha.|Dựa vào lịch tranh tài, bạn hoàn toàn có thể sắp xếp công việc

    https://virandoamor.com/detail/dai-vtv6-hd-54439.html

    June 11, 2021 at 05:53 | Report abuse | Reply
  24. kq ngoai hang

    Thẳng đá Bóng Thời Điểm Hôm Nay, Liên Kết Xem Trực Tuyến Video Trường Hợplive90Trên băng ghế đào tạo, Lebanon đã bửa nhiệm Ramiro Lopez cơ hội đây 3 tuần. Nhà nắm quân nhân viên Tây Ban Nha chủ yếu ớt làm việc tại Ý và từng có thời hạn thực hiện việc trên Kuwait.|Và NHM bóng đá Việt Nam đang được đợi Minh Trí cùng đồng đội hóa giải đối thủ để tạo lợi thế mang đến trận lượt về sau đây hai ngày. Chelsea đã cần trải qua 8 phút bù giờ không thở được đảm bảo chiến thắng.

    https://chiefscreolecafe.com/detail/xem-truc-tiep-vtv3hd-44430.html

    June 11, 2021 at 14:51 | Report abuse | Reply
  25. video ban thang world cup 2018

    Tỷ Số đá Bóng Trực Tuyến Ngày Hôm Nayvtv 1 onlineTheo thể thức thi đấu, đội thắng ở cặp đấu này sẽ giành tấm vé đến Lithuania trong ngày hội bóng đá lớn nhất thế giới cho futsal. Tuyển futsal Việt Nam bước vào trận play-off lượt đi tranh vé dự play-off World Cup 2021 với sự tự tin. Tuy vậy, HLV Phạm Minh Giang bày tỏ, toàn đội ko ngán Lebanon song sẽ tìm cách để khắc chế sức mạnh của đối thủ bởi trên băng ghế huấn luyện là nhà cầm quân Ramiro Lopez, người từng dẫn dắt futsal Tây Ban Nha.|Dựa vào lịch thi đấu, quý khách hoàn toàn có thể chuẩn bị xếp làm việc

    https://equinome.com/detail/xem-vtv3-93984.html

    June 11, 2021 at 16:27 | Report abuse | Reply
  26. xem vtv1 trực tuyến nhanh nhất

    Thẳng Bóng Đá Việt Nam Vs Lebanon. Xem Truc Tiep Bong Da. Futsal Việt Namxem trực tuyến vtv1Trên băng ghế đào tạo, Lebanon đã bửa nhiệm Ramiro Lopez cách đây 3 tuần. Nhà cầm cố quân nhân viên Tây Ban Nha công ty yếu làm việc tại Ý và từng có thời hạn thực hiện việc tại Kuwait.|Và NHM bóng đá Việt Nam đang được đợi Minh Trí cùng đồng đội hóa giải đối thủ để tạo lợi thế đến trận lượt về sau đây hai ngày. Chelsea đã phải trải qua 8 phút bù giờ khó thở bảo đảm an toàn thành công.

    https://bongdatv.vn/detail/kqbd-tbn-b-13287.html

    June 11, 2021 at 21:41 | Report abuse | Reply
  27. Russell Wierschem

    Have you ever heard of second life (sl for short). It is basically a game where you can do anything you want. Second life is literally my second life (pun intended lol). If you would like to see more you can see these Second Life authors and blogs

    http://myvedana.blogspot.com/2006/09/bad-luck.html?m=0

    June 12, 2021 at 16:11 | Report abuse | Reply
1 2 3 4 5 6

Leave a Reply to RnlCJAVIgA


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.