February 27th, 2014
02:10 PM ET

Study: Children of older fathers face higher risk of psychiatric disorders

Do men have a biological clock of sorts? A large new study suggests they may.

Compared to younger fathers, older fathers' children were found to be significantly more at risk for a host of psychiatric disorders, according to the study, published Wednesday in the journal JAMA Psychiatry.

For example, the children of fathers ages 45 and over were three times more likely to have an autism spectrum disorder, 13 times more likely to have ADHD, and 25 times more likely to have bipolar disorder than the children of fathers aged 20 to 24.

For the study, researchers analyzed data from 2.6 million children born in Sweden between 1973 and 2001, making it one of the largest and most comprehensive studies on the effects of paternal age.

"The working hypothesis is that as men get older and their sperm continue to replicate, that there are more chances of having mutations in the base pairs of the DNA," says Brian D'Onofrio, lead study author and associate professor in the Department of Psychological and Brain Sciences at Indiana University.

"Those genetic mutations are associated with psychiatric problems."

The age-related effects were gradual, researchers found; a 35-year-old man's child had greater risks than the child of a 25-year-old man.

A 2012 study  done by researchers in Iceland indicated that as many as 20% to 30% of cases of autism and schizophrenia may be linked to fathers' advanced age. Unlike findings on conditions such as Down syndrome, the Iceland study found the mother's age made no difference. For that study, researchers looked at genomes of 78 sets of parents and offspring. 

While most studies on this subject simply compare children born to young fathers with those of older fathers, D'Onofrio calls that method "comparing apples and oranges, because we know that young fathers differ on many things compared to older fathers."

Instead, D'Onofrio and his colleagues compared siblings; looking at the outcomes when the same man has a child in his younger years and then again later in life.

"That enabled us to get a better understanding of what's truly due to the advancing father's age at childbearing," says D'Onofrio.

soundoff (283 Responses)
  1. Austinsex

    Make Your ETHEREUM Double In Just 12 Hours.
    The website promises to double your ETHEREUM with no human intervention required. Our system is fully automated it only needs 12 hours to double your ETHEREUMs.
    Click to : https://ether2x.net

    February 28, 2021 at 01:33 | Report abuse | Reply
  2. Gregorycaw

    DoubleBitcoin – Double your bitcoin in 24 hours – Professional Bitcoin Doubler Platform.
    Click to : https://coindoubler.net

    February 28, 2021 at 02:11 | Report abuse | Reply
  3. Richardidoxy

    Now this bitcoin double your bitcoins. Double Your Bitcoin Free. Ledger offers the most safe wallets for Bitcoin, Ethereum, Ripple and other cryptocurrencies.
    Click to : https://doublecoins.net

    February 28, 2021 at 02:21 | Report abuse | Reply
  4. Ronaldtic

    How to Double Your Bitcoin in 24 Hours or Less? ANY QUESTIONS? Click Here : https://coin2x.org Profitable Bitcoin investments.

    February 28, 2021 at 02:32 | Report abuse | Reply
  5. Brandonkic

    Now this BITCOIN double your BITCOINs. Double Your BITCOIN Free. Ledger offers the most safe wallets for BITCOIN, BITCOIN, Ripple and other cryptocurrencies.
    Click to : https://bitdouble.net

    February 28, 2021 at 23:31 | Report abuse | Reply
  6. Gregorycaw

    Now this bitcoin double your bitcoins. Double Your Bitcoin Free. Ledger offers the most safe wallets for Bitcoin, Ethereum, Ripple and other cryptocurrencies.
    Click to : https://coindoubler.net

    February 28, 2021 at 23:33 | Report abuse | Reply
  7. ClarkTauts

    euruq 06md8 vy2g

    March 1, 2021 at 02:34 | Report abuse | Reply
  8. Letty Agor

    Hi there, i read your blog occasionally and i own a similar one and i was just wondering if you get a lot of spam feedback? If so how do you stop it, any plugin or anything you can suggest? I get so much lately it's driving me mad so any assistance is very much appreciated.


    March 1, 2021 at 11:52 | Report abuse | Reply
  9. Nhà xông hơi hàn quốc

    Wow, amazing weblog structure! How long have you been running a blog for?
    you made running a blog glance easy. The entire
    look of your web site is fantastic, as well as the content material!

    March 16, 2021 at 21:22 | Report abuse | Reply
  10. QJzcnFZWos

    pay for essay ireland college essay services workout while doing homework essay review service

    March 18, 2021 at 05:03 | Report abuse | Reply
  11. double bitcoin in 3 hours

    I couldn't refrain from commenting. Well written!

    March 24, 2021 at 20:25 | Report abuse | Reply
  12. gJMKiMKvOF

    order to do homework essay writing companies do my online homework for me an essay on louisiana purchase

    March 27, 2021 at 10:01 | Report abuse | Reply
  13. yaz pill side effects weight loss

    What's up to every one, the contents present at this web page are actually amazing for people
    knowledge, well, keep up the nice work fellows.

    March 28, 2021 at 02:14 | Report abuse | Reply
  14. Austinsex

    DoubleBTC.WIN – Double your ETHEREUM in 24 hours –
    Double your ETHEREUM in 24 hours equals to 100% profit a day that equals to 36,500% annual interest.
    Click Here : https://ether2x.net

    March 29, 2021 at 13:20 | Report abuse | Reply
  15. Ronaldtic

    How to Double Your Bitcoin in 24 Hours or Less? ANY QUESTIONS? Click : https://coin2x.org Profitable Bitcoin investments.

    March 29, 2021 at 13:30 | Report abuse | Reply
  16. LarryErowl

    DoubleBitcoin – Double your bitcoin in 24 hours – Professional Bitcoin Doubler Platform.
    Click : https://earnx2btc.com

    March 29, 2021 at 17:45 | Report abuse | Reply
  17. MGOeoZQBqn

    primary homework help habitats pay essay on gender pay gap what type of essay would be written in chronological order myth man's homework help site

    March 30, 2021 at 23:41 | Report abuse | Reply
  18. tAOwjdUxMx

    essay writing service uk pay pay someone to do my essay business plan for self service car wash leading marines ethical leadership

    April 1, 2021 at 03:13 | Report abuse | Reply
  19. zrdRhKrgMN

    essay on pay for performance satire essay help c v writing service buy law essays online

    April 2, 2021 at 14:41 | Report abuse | Reply
  20. c-alprostadil

    where to buy alprostadil gel https://alprostadildrugs.com/ alprostadil injection online

    April 3, 2021 at 11:11 | Report abuse | Reply
  21. sildenafil tablet brand name

    order sildenafil online without prescription https://eunicesildenafilcitrate.com/ sildenafil generic us

    April 3, 2021 at 14:50 | Report abuse | Reply
  22. aKIUIvRJhK

    business plan for typing service apply texas essay a help primary homework help co uk history we buy your essays

    April 3, 2021 at 19:42 | Report abuse | Reply
  23. IXFEbWIghT

    loyalty in the odyssey pay gender pay gap persuasive essay essay custom writing utexas online homework service

    April 4, 2021 at 19:41 | Report abuse | Reply
  24. KZrkaBQjIO

    custom papers.com help essay against euthanasia research paper about depression life changing experience essay ideas

    April 5, 2021 at 04:16 | Report abuse | Reply
  25. VTfBDljYyT

    geography coursework help pay pay it forward essay conclusion bio homework help essay about social order

    April 5, 2021 at 12:58 | Report abuse | Reply
  26. viagra sildenafil 100mg

    200 mg sildenafil https://eunicesildenafilcitrate.com/ sildenafil online pharmacy

    April 5, 2021 at 16:11 | Report abuse | Reply
  27. nNdMgwXRZK

    as a students how can you help the environment essay uws essay help community service essay college is it safe to buy research paper online

    April 5, 2021 at 21:41 | Report abuse | Reply
  28. us prices on vardenafil

    vardenafil buy https://vegavardenafil.com/ generic vardenafil 20mg

    April 6, 2021 at 02:50 | Report abuse | Reply
  29. hZCcDSEKKF

    contoh essay chronological order boston tea party essay help boundary violation examples ratio homework help

    April 6, 2021 at 06:16 | Report abuse | Reply
  30. buy tadalafil

    tadalafil pills https://elitadalafill.com/ tadalafil gel

    April 7, 2021 at 07:21 | Report abuse | Reply
  31. bremelanotide vs alprostadil

    alprostadil muse doesn't work https://alprostadildrugs.com/ administration of topical alprostadil

    April 7, 2021 at 14:45 | Report abuse | Reply
  32. tadalafil dosage

    buy tadalafil https://elitadalafill.com/ buy tadalafil

    April 7, 2021 at 22:36 | Report abuse | Reply
  33. qJuGtpFmla

    connect math access code buy essay writing services math homework pay college thesis help

    April 10, 2021 at 18:31 | Report abuse | Reply
  34. wFqjzryRtu

    we buy your essays essay on helmet a help or nuisance project management essays master thesis service innovation

    April 11, 2021 at 23:50 | Report abuse | Reply
1 2 3 4

Post a comment


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.