home
RSS
A single dose of HPV vaccine may be enough
November 4th, 2013
10:27 AM ET

A single dose of HPV vaccine may be enough

Just one dose of the HPV vaccine Cervarix appears to provide enough of an immune response to protect women from two strains of human papillomavirus (HPV) and ultimately cervical cancer, according to a new study published Monday.

HPV is the most common sexually transmitted infection (STI), according to the U.S. Centers for Disease Control and Prevention (CDC). The infection, transmitted through genital contact, is the primary cause of cervical cancer, which affects about 10,300 women in the United States each year.  It causes about 275,000 deaths annually worldwide and is a leading cause of cancer deaths among women in low-income countries, according to the World Health Organization.

“Cervical cancer is a major cause of public health concern, especially in less developed countries where about 85% of cervical cancer occurs,” says study author Mahboobeh Safaeian. “The reason for that is mainly because of lack of screening infrastructure offered.”

Safaeian and her team followed a group of women in Costa Rica who were participating in the National Cancer Institute-funded phase III clinical trial testing the efficacy of Cervarix.  About 20% of these women did not complete the three-dose vaccine regimen. Safaeian compared the groups of women who had received one, two and three doses of the vaccine, as well as women who had antibodies from having been naturally infected.

The researchers found that women vaccinated with a single dose of Cervarix, as opposed to the current CDC recommendation of three, had antibodies against HPV that remained stable in their blood after four years. The findings suggest that the common recommendation for three doses may not be necessary to ensure long-lasting antibodies that prevent HPV.  Safaeian, a researcher for the National Cancer Institute's Division of Cancer Epidemiology & Genetics, Infections and Immunoepidemiology, says this could have significant implications for women across the world by simplifying the logistics and costs of vaccinations.

“This vaccine is about $130 a dose ... It’s just not feasible in a lot of undeveloped countries,” Safaeian explains.

Even in the United States, where vaccinations are easily accessible and covered under health insurance and federal programs for children, many women are not getting all three doses.  In 2012, only about half of girls between ages 13 and 17 started the HPV vaccination regimen and only about a third had received all three doses, according to the CDC.

Dr. Kevin Ault, a physician and professor at the Emory University Department of Gynecology and Obstetrics, emphasizes that it is always easier to get people into the office for a one-time vaccination. In countries outside the United States, one stop may be the only option.

“Certainly if you’re in South Asia or Africa, where you have a high burden of cancer and screening is expensive, a single dose vaccine would really be a game changer,” says Ault, who worked on the clinical trials that led to the approval of the first HPV vaccine Gardasil, which protects against four strains of HPV.

However, while this new study reveals promising results for one and two doses of Cervarix, Ault does not see this changing the standards in the United States anytime soon.  He said he believes further research will be conducted in the following years, for Cervarix and also for Gardasil, the more common of the two HPV vaccines in America. Gardasil has not yet been tested for the efficacy of less than three doses.  Until then, Ault plans to stick to the CDC recommendation of the three-dose vaccine for his patients.

Safaeian also stresses that this research is still at the beginning stages.  She notes that long-term protection is one of the outstanding questions.
“The data we have thus far only goes up to four years,” Safaeian emphasized.  “Ideally, you would want protection to last 10 to 15 years.  So, we still are not there yet – the studies have not gone that far.”

Some countries, such as Chile, have already implemented a two-dose vaccination plan, but Safaeian said that it’s still too early to tell whether it is sufficient for long-term protection.

Safaeian continues to move forward with her research, following the same participants to see whether the antibody stability extends beyond the four years.  She said that while it’s not over yet, her team has “provided some intriguing research that could help discussions of what should be the next step for evaluating number of doses.”

The new study was published Monday in Cancer Prevention Research, a journal of the American Association for Cancer Research.

Post by: ,
Filed under: Cancer • HPV • Living Well • Sex

soundoff (491 Responses)
  1. Dodge Sprinter Service

    https://record.affiliatelounge.com/_WS-jvV39_rv4IdwksK4s0mNd7ZgqdRLk/7/?deeplink=https://commercialrepairshop.com/delivery-van-repair-shop-near-me

    May 13, 2021 at 13:33 | Report abuse | Reply
  2. dent devil san diego

    I must thank you for the efforts you've put in writing this site. I am hoping to view the same high-grade blog posts from you later on as well. In fact, your creative writing abilities has inspired me to get my own website now 😉

    https://5100.itmo.ru/go.php?url=https://ocrvcenter.mobi/rv-interior-remodel-near-me

    May 13, 2021 at 15:15 | Report abuse | Reply
  3. RV Bedroom Orange County

    http://www.nfpsucks.biz/__media__/js/netsoltrademark.php?d=youtube.com/channel/UCGb9aC76nAmfzNsCru2KBHA/videos

    May 13, 2021 at 19:36 | Report abuse | Reply
  4. american leak detection orange county

    I would like to thank you for the efforts you've put in writing this website. I'm hoping to check out the same high-grade content from you in the future as well. In truth, your creative writing abilities has inspired me to get my own, personal site now 😉

    https://mp.weixinbridge.com/mp/wapredirect?url=https://youtube.com/watch?v=53nOFlnEu_0

    May 13, 2021 at 20:35 | Report abuse | Reply
  5. RV Generator California

    Greetings! Very helpful advice within this article! It is the little changes which will make the greatest changes. Thanks a lot for sharing!

    https://otsukaamerica.biz/__media__/js/netsoltrademark.php?d=instagram.com/ocrvcenter

    May 14, 2021 at 03:09 | Report abuse | Reply
  6. rv shades repair

    http://old.nepalimmigration.gov.np/site/languages/languageA/3?url=https://ocrvart.com/farmers-rv-collision-repair-shop-near-me

    May 14, 2021 at 05:51 | Report abuse | Reply
  7. RV Supplies Los Angeles

    Everything is very open with a really clear explanation of the issues. It was definitely informative. Your site is extremely helpful. Many thanks for sharing!

    http://coolbuddy.com/newlinks/framelink.asp?add=http://yelp.com/biz/ocrv-center-yorba-linda

    May 14, 2021 at 07:15 | Report abuse | Reply
  8. Mercedes Sprinter Brake Caliper Repair Kit

    After I initially commented I appear to have clicked on the -Notify me when new comments are added- checkbox and from now on whenever a comment is added I recieve 4 emails with the same comment. There has to be a way you can remove me from that service? Thanks a lot!

    https://track.aftermarket.pl/track.php?ref=&url=https://commercialvanrepairshop.com/delivery-truck-repair-shop-near-me

    May 14, 2021 at 07:22 | Report abuse | Reply
  9. travel trailer slide out repair

    https://adengine.old.rt.ru/go.jsp?to=https://ocrvcenter.biz/rv-repair-shop-mission-viejo-california

    May 14, 2021 at 07:44 | Report abuse | Reply
  10. RV Blinds Near Me

    Everyone loves it when folks get together and share views. Great site, stick with it!

    http://calgoo.com/__media__/js/netsoltrademark.php?d=g.page/OCRVFleetServices

    May 14, 2021 at 12:58 | Report abuse | Reply
  11. how to repair rv blinds

    This is a topic which is near to my heart... Take care! Where are your contact details though?

    https://ovatu.com/e/c?url=http://youtube.com/watch?v=n5KM4Itkalg

    May 14, 2021 at 12:58 | Report abuse | Reply
  12. RV Parts Riverside

    http://teachingnx.com/__media__/js/netsoltrademark.php?d=youtube.com/channel/UCGb9aC76nAmfzNsCru2KBHA/videos

    May 14, 2021 at 13:40 | Report abuse | Reply
  13. RV Blinds Riverside

    Great post! We will be linking to this particularly great article on our website. Keep up the good writing.

    http://www.metropolitanct.com/__media__/js/netsoltrademark.php?d=www.yelp.com/biz/ocrv-center-anaheim-2

    May 14, 2021 at 14:28 | Report abuse | Reply
  14. Maserati 2 Door

    http://www.landofvolunteers.com/go.php?http://www.club-maserati.com/

    May 14, 2021 at 17:02 | Report abuse | Reply
  15. nearby homes for sale

    This is a topic that's close to my heart... Best wishes! Where are your contact details though?

    http://tamiroom.com/bbs/cafe.php?mode=node&id=936&page=1&home=https://www.meganleary.com

    May 14, 2021 at 20:37 | Report abuse | Reply
  16. Eye Exam

    http://allfilm.net/go?https://arizonasvision.com/

    May 15, 2021 at 04:03 | Report abuse | Reply
  17. fiberglass dent repair

    An outstanding share! I have just forwarded this onto a friend who was conducting a little research on this. And he actually ordered me lunch simply because I discovered it for him... lol. So allow me to reword this.... Thank YOU for the meal!! But yeah, thanx for spending the time to discuss this matter here on your web page.

    https://www.morhipo.com/shared/partnercookie?k=gort&url=http://ocrv.mobi/

    May 15, 2021 at 04:06 | Report abuse | Reply
  18. houses for sale athol idaho

    I really like looking through an article that will make men and women think. Also, thanks for permitting me to comment!

    http://metro.cz/_servix/recombee/collector.aspx?recommendation=000000000020-0000-0000-000000000000&page=A200123_121653_veda_pka&url=https://meganleary.com/

    May 15, 2021 at 05:31 | Report abuse | Reply
  19. real estate for sale near my area

    You ought to take part in a contest for one of the best websites on the web. I am going to recommend this web site!

    http://www.xyzprinting.com/prc?e=11p541&redir=http://meganleary.com

    May 15, 2021 at 05:55 | Report abuse | Reply
  20. rv appliance repair near me

    http://zdorov.online/goto.php?l=https://ocrv.store/

    May 15, 2021 at 06:23 | Report abuse | Reply
  21. nearby realtor

    https://space.sosot.net/link.php?url=https://meganleary.com/

    May 15, 2021 at 08:16 | Report abuse | Reply
  22. houses for sale sandpoint idaho

    Having read this I believed it was very informative. I appreciate you spending some time and effort to put this content together. I once again find myself spending way too much time both reading and posting comments. But so what, it was still worthwhile!

    http://flash.wakunavi.net/rank.cgi?mode=link&id=333&url=https://meganleary.com

    May 15, 2021 at 09:20 | Report abuse | Reply
  23. Eyeglasses Near Me

    When I initially commented I seem to have clicked on the -Notify me when new comments are added- checkbox and now whenever a comment is added I receive 4 emails with the exact same comment. Is there an easy method you are able to remove me from that service? Thanks!

    http://pubmiddleware.mims.com/resource/external?externalUrl=http://arizonasvision.com

    May 15, 2021 at 14:52 | Report abuse | Reply
  24. 2021 Maserati Granturismo

    https://www.triathlon.org/?URL=https://club-maserati.com

    May 15, 2021 at 16:19 | Report abuse | Reply
  25. houses for sale spokane river

    https://datum.tv/ra.asp?url=https://meganleary.com/

    May 15, 2021 at 16:38 | Report abuse | Reply
  26. Content Marketing Orange County

    Good post. I learn something new and challenging on websites I stumbleupon everyday. It will always be interesting to read through content from other authors and use something from other websites.

    https://sso.esolutionsgroup.ca/default.aspx?SSO_redirect=https://bestservicenearme.com

    May 15, 2021 at 20:43 | Report abuse | Reply
  27. Digital Marketing Agency Orange County

    https://swipeclock.com/sc/cookie.asp?sitealias=79419397&redirect=https://www.affordableranking.com/

    May 16, 2021 at 00:03 | Report abuse | Reply
  28. WilliamPeesy

    In any box, the standards of propitious news-casting haven't been ready of through this significant network index. Google indeed thinks instances relative to the style and sum total of articles, uncommonly as a component of its XML. Vast news-casting is tied in with being straightforward and as consistent headed as could be expected.

    Benefit of what reason do you meditate on the Google XML sitemap creeps, lists, and distributes general area site content from CNN, BBC, Techcrunch, The Impediment In someone's bailiwick Magazine and others in its slate items?

    my blog

    $e33987j

    May 16, 2021 at 00:10 | Report abuse | Reply
  29. Content Marketing Videos

    Oh my goodness! Incredible article dude! Thank you so much, However I am encountering problems with your RSS. I don’t know the reason why I cannot subscribe to it. Is there anyone else having the same RSS issues? Anyone who knows the solution will you kindly respond? Thanks!!

    http://www.2mbx.ru/bitrix/rk.php?id=22&event1=banner&event2=click&event3=1+/+%5B22%5D+%5BLEFT_BOTTOM%5D+&goto=https://affordableranking.com

    May 16, 2021 at 00:15 | Report abuse | Reply
  30. Local Marketing Agency

    Hi, I do think this is an excellent blog. I stumbledupon it 😉 I am going to return once again since I saved as a favorite it. Money and freedom is the greatest way to change, may you be rich and continue to guide others.

    http://mygpoint.com/__media__/js/netsoltrademark.php?d=http://affordableranking.com

    May 16, 2021 at 00:47 | Report abuse | Reply
  31. Social Media Marketing Business

    Nice post. I learn something totally new and challenging on websites I stumbleupon everyday. It will always be helpful to read through articles from other writers and use something from their web sites.

    http://marry8.cc/RFPTW/global_outurl.php?now_url=http3A2F2Faffordableranking.com

    May 16, 2021 at 01:38 | Report abuse | Reply
  32. Content Marketing Specialist

    Hi, I do believe your website could be having browser compatibility issues. When I take a look at your website in Safari, it looks fine however, if opening in Internet Explorer, it's got some overlapping issues. I simply wanted to give you a quick heads up! Apart from that, fantastic site!

    https://www.illongconstruction.com/__media__/js/netsoltrademark.php?d=affordableranking.com

    May 16, 2021 at 02:45 | Report abuse | Reply
  33. Seo Marketing Firm

    I'm very happy to discover this page. I wanted to thank you for your time due to this fantastic read!! I definitely loved every part of it and i also have you saved as a favorite to look at new stuff in your website.

    http://cjcity.ru/2/?http://affordableranking.com

    May 16, 2021 at 03:00 | Report abuse | Reply
  34. private schools near me

    http://www.demo.cloudhostedresources.com/?id=7cde069d28fee9161e9475b01c2cf8cf&fullscreen=1&task=get&url=http://www.sandyfeetsprayer.com

    May 16, 2021 at 09:18 | Report abuse | Reply
  35. semi truck paint shops near me

    After exploring a handful of the blog posts on your site, I honestly like your way of writing a blog. I bookmarked it to my bookmark webpage list and will be checking back soon. Please visit my website as well and tell me what you think.

    http://music-style.info/music-style/rank.cgi?mode=link&id=7897&url=louishuhlp.p2blogs.com/3147682/a-secret-weapon-for-rv-service-near-me

    May 16, 2021 at 09:57 | Report abuse | Reply
  36. Dodge Sprinter Step Repair

    https://www.medknow.com/crt.asp?prn=20&aid=IJCCM_2015_19_4_220_154556&rt=P&u=https://tns.world/urdu/?p=8760

    May 16, 2021 at 10:53 | Report abuse | Reply
  37. trailer repair shops near me

    https://kzsoft.to/rank.cgi?mode=link&id=1187&url=https://geniustools.ir/hello-world/

    May 16, 2021 at 11:05 | Report abuse | Reply
  38. shower repair near me

    /

    May 16, 2021 at 11:41 | Report abuse | Reply
  39. local rv repair shops

    Greetings! Very helpful advice in this particular article! It's the little changes that make the largest changes. Thanks a lot for sharing!

    /

    May 16, 2021 at 12:02 | Report abuse | Reply
  40. Van Repair Near Me

    http://redir.speedbit.com/redir.asp?id=8030&urldirect=http://fleetautorepairshop.com/truck-mechanic-shop-near-me

    May 16, 2021 at 14:01 | Report abuse | Reply
  41. Shauna Luckow

    I don't know about you guys but I am obsessed with airplanes. I have a friend in highschool that loved airplanes, so here are some airplane related stuff I don't know about you guys but I love airplanes. I had a friend in highschool that loved airplanes, so here are some airplane related stuff https://www.airlinereporter.com/2010/10/whats-the-difference-between-airline-merger-and-buy-out/

    http://myemail.constantcontact.com/Be-a-Part-of-Giving-Tuesday-by-Supporting-the-Future-of-Flight-Foundation-.html?soid=1111846961938&aid=zrXG1JFUdEw

    May 16, 2021 at 15:20 | Report abuse | Reply
  42. How Much Is A 2016 Maserati

    https://lhero.org/?lh_multisite_sso-do_sso=1&site-id=59&final_url=http://www.maseratiforum.net/

    May 16, 2021 at 18:23 | Report abuse | Reply
  43. Maserati Big Boobs

    You've made some decent points there. I checked on the web to learn more about the issue and found most individuals will go along with your views on this site.

    https://www.silence-seal.com/__media__/js/netsoltrademark.php?d=club-maserati.com

    May 16, 2021 at 20:20 | Report abuse | Reply
  44. Sprinter Broken Flex Pipe Repair

    http://cornerofberkshireandfairfax.ca/forum/index.php?thememode=full;redirect=http://sprintervanrepairshop.com/box-truck-alignment-shop-near-me/

    May 16, 2021 at 21:33 | Report abuse | Reply
  45. 2014 Maserati Quattroporte S Q4

    https://cat.hlserve.com/b/YnoRM5FyM0i4YGAADwgABA?fid=180&hl_qs=GShnU9Zf2XGf81cd1692B9jFQMUxECt9URf2F93IFYTDFuEJFJrpDYVk4SyPwBk7Qn550JrjeMnpOCNGHbHmBgmZTHyXT2FbJh2BExG4bkiegf3wfbZDdr2T3wiDpwcqJFjtgu9Gso5kfnK2vNFjYGmvgpfUIGpEK2BK4FOgU2B3gDeo3QXracasu2F06fgX0sAWXqHHYM1S12BSJkwz2FOp2HuclLJoNEhION0znMzxlTHShsS9nHVAJGaIDfZfmxzUrP822BDdkCFOdxMp2vQtCKRFP1Dqyfh9QTuDYh5KnGQxVEeL2BzKzA2urV8ow5GBfjqdJGABtqaqQPDNt4OQQh8y6FjtA3D3D&ev=2&action=click&impressionpid=fc2da23d-b89a-4c4c-a86f-967857cff39b&rn=764549665&abe=0&dest=maseratis.net

    May 16, 2021 at 23:18 | Report abuse | Reply
  46. Sprinter Rust Repair Panels

    Great information. Lucky me I discovered your website by chance (stumbleupon). I've book marked it for later!

    https://shop.merchtable.com/users/authorize?return_url=http://fleetservicesorangecounty.com/gmc-luxury-van-repair-shop-near-me/

    May 17, 2021 at 02:35 | Report abuse | Reply
  47. Maserati For Sale Chicago

    I could not resist commenting. Well written!

    https://www.ruben-hernandez.com/PhotoLibrary/main.php?g2_view=core.UserAdmin&g2_subView=core.UserLogin&g2_return=https://www.maseratis.net

    May 17, 2021 at 04:13 | Report abuse | Reply
  48. Maserati For Sell Near Me

    https://www.bquest.org/Links/Redirect.aspx?ID=164&url=http://maseratis.net/

    May 17, 2021 at 05:45 | Report abuse | Reply
  49. Deangelo Shirley

    Have you ever heard of second life (sl for short). It is basically a game where you can do anything you want. SL is literally my second life (pun intended lol). If you want to see more you can see these second life websites and blogs

    http://thisteachinglife.blogspot.com/2004/01/some-moore-about-me.html

    May 17, 2021 at 06:01 | Report abuse | Reply
  50. Release Clip Repair On Mercedes Sprinter Seat

    http://www.humanbrainmapping.org/i4a/etrack/track.cfm?rType=2&campaignID=3572&contactID=4524&origURL=www.fleetvehiclerepairshop.com/body-damage-shop-near-me/

    May 17, 2021 at 06:25 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10

Post a comment


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.