home
RSS
Confused about estrogen therapy?
July 19th, 2013
02:30 PM ET

Confused about estrogen therapy?

Hormone replacement therapy has been a controversial issue for a lot of women over the last decade. Many have rejected any type of hormone therapy since a large, federally funded study found hormone replacement therapy could increase a woman’s risks for heart disease and strokes.

Now, a new study out of Yale School of Medicine suggests anywhere from 18,000 to 91,000 women in their 50s who had hysterectomies may have died prematurely in the last decade because they did not take estrogen-only hormone replacement therapy.

A bit of background

Before 2002, it was standard practice for gynecologists to recommend estrogen therapy to women with hysterectomies. More than 90% of those patients used it to treat symptoms such as hot flashes and to prevent osteoporosis and other diseases related to menopausal hormone deficiency. But according to the Yale study, only about 10% of these women use estrogen therapy today.

The data analyzed for this study comes from the large Women’s Health Initiative trial. That study was designed to confirm the hypotheses that hormone replacement therapy not only provides relief for menopause symptoms, but also helps protect women from heart disease, osteoporosis and dementia. The WHI first looked at the benefit of taking two hormones - estrogen and progestin, and then examined the benefits of taking estrogen alone.

The first part of the study was stopped in 2002, when early results suggested the combined estrogen-progestin therapy was actually increasing the risk of heart disease, stroke, breast cancer and dementia. Researchers saw a sharp decline in overall hormone use afterward as women heeded their doctors' warnings and stopped taking all post-menopausal hormones, whether they had had a hysterectomy or not.

In 2005 and 2012, the U.S. Preventive Services Task Force recommended against using the combined therapy or estrogen alone to prevent chronic conditions in postmenopausal women, which may have deterred more women from asking their doctors about these therapies - or stopped doctors from offering it in the first place.

The study

In this new study, published Thursday in the American Journal of Public Health, researchers looked at data from the second portion of the WHI trial, which looked at estrogen-only therapy.

According to the Yale researchers, the increased risks discovered in the first part of the WHI study only applied to women who had not had a hysterectomy and were taking pills that combined estrogen and progestin. They say the dangers did not apply to women without a uterus who used estrogen-only therapy - but few understood the difference.

"Sadly, the media, women, and health care providers did not appreciate the difference between the two kinds of hormone therapy," said Dr. Philip Sarrel, lead author of the study and emeritus professor in the departments of obstetrics, gynecology & reproductive sciences and psychiatry, at Yale. "As a result, the use of all forms of FDA-approved menopausal hormone therapy declined precipitously."

The study noted that results from the second part of the WHI study were very different.

A series of papers published by the WHI between 2004 and 2012 showed that estrogen-only therapy had mostly positive health outcomes; they said women who received estrogen, compared to those who received a placebo, had fewer deaths each year for 10 years and were less likely to develop breast cancer and heart disease.

Each year, the death rate among those not taking estrogen was 13 more per 10,000 women. Most of those deaths were due to heart disease. This doesn't need to happen, the study authors say.

The takeaway

"Women need to know that estrogen replacement is an important part of therapy, especially for women who are in their 50s and have had a hysterectomy and their ovaries removed," says Dr. Holly Thacker, director of the Cleveland Clinic Center for Specialized Women’s Health.

She says it’s time for women who have had hysterectomies to "stop being fearful of estrogen.” She points to other recent studies that show starting estrogen therapy shortly after menopause is key to reaping the benefits of the drugs.

Because each woman's health issues are different, experts recommend that women talk to their physicians about estrogen and other hormone replacement therapy before they make a decision on whether to take it.

"Estrogen avoidance has resulted in a real cost in women's lives every year for the last 10 years — and the deaths continue," said Sarrel. "We hope this article will stir an overdue debate and raise consciousness about the health benefits of estrogen-only therapy for women in their 50s with no uterus."


soundoff (504 Responses)
  1. RV Repair Around Me

    Excellent post! We will be linking to this particularly great content on our site. Keep up the great writing.

    http://www.afm-invest.com/index.cfm?Display=resources.cfm&Exit=http://ocrvcenter.com/rv-furniture-repair-near-me/

    June 15, 2021 at 16:06 | Report abuse | Reply
  2. Sprinter Repair Orange County

    https://dailygood.org/more.php?op=get&url=https://ocrvcenter.com/tractor-truck-collision-repair-shop-near-me

    June 15, 2021 at 22:39 | Report abuse | Reply
  3. RV Repair Shops Near Me

    https://ww31.instergram.com/__media__/js/netsoltrademark.php?d=http://www.ocrvcenter.com/haul-truck-collision-repair-shop-near-me/

    June 16, 2021 at 04:45 | Report abuse | Reply
  4. RV Repair Shops Near Me Now

    http://eridan.websrvcs.com/System/Login.asp?id=48747&Referer=http://www.ocrvcenter.com/contact

    June 16, 2021 at 09:17 | Report abuse | Reply
  5. RV Repairs Nearby

    http://ymg-ssz.jp/cms/modules/wordpress0/wp-ktai.php?view=redir&url=ocrvcenter.com/camper-collision-repair-shop-near-me/

    June 16, 2021 at 11:08 | Report abuse | Reply
  6. satta king

    Hi there would you mind letting me know which webhost you're using?

    I've loaded your blog in 3 different web browsers
    and I must say this blog loads a lot quicker then most. Can you suggest a good hosting provider
    at a honest price? Thanks, I appreciate it!

    June 16, 2021 at 18:30 | Report abuse | Reply
  7. outlets near me

    http://www.quarterhorsebuilding.com/__media__/js/netsoltrademark.php?d=www.ocrvcenter.com

    June 16, 2021 at 19:52 | Report abuse | Reply
  8. salon near me

    https://yellowpages.sfexaminer.com/__media__/js/netsoltrademark.php?d=http://ocrvcenter.com

    June 16, 2021 at 20:27 | Report abuse | Reply
  9. RV Repair Huntington Beach

    https://cross-a.net/go_out.php?url=http://ocrvcenter.com/motorhome-body-repair-near-me/

    June 16, 2021 at 22:15 | Report abuse | Reply
  10. Sprinter Repair Costa Mesa

    Hi, I do believe this is an excellent blog. I stumbledupon it 😉 I may return once again since i have bookmarked it. Money and freedom is the best way to change, may you be rich and continue to help others.

    http://www.cassinausa.com/__media__/js/netsoltrademark.php?d=ocrvcenter.com/rv-furniture-near-me/

    June 17, 2021 at 04:08 | Report abuse | Reply
  11. Sprinter Repair Shops Near Me

    Spot on with this write-up, I honestly think this amazing site needs a great deal more attention. Iíll probably be returning to read through more, thanks for the info!

    http://greatmindsinstem.org/Redirect.aspx?destination=ocrvcenter.com/toy-hauler-repair-near-me

    June 17, 2021 at 04:42 | Report abuse | Reply
  12. Sprinter Repair Orange County

    Very nice blog post. I absolutely love this website. Thanks!

    http://www.aesham.com/__media__/js/netsoltrademark.php?d=www.ocrvcenter.com/foremost-rv-collision-repair-shop-near-me

    June 17, 2021 at 06:07 | Report abuse | Reply
  13. Camper Repair Shop Near Me

    Pretty! This has been an incredibly wonderful article. Thank you for providing this info.

    https://www.how2power.com/pdf_view.php?url=www.ocrvcenter.com/bus-collision-repair-shop-near-me/

    June 17, 2021 at 08:19 | Report abuse | Reply
  14. Sprinter Repair Shop Near Me

    https://b.grabo.bg/special/dealbox-492×73/?rnd=2019121711&affid=19825&deal=199235&cityid=1&city=Sofia&click_url=www.ocrvcenter.com/rv-ac-repair-near-me/

    June 17, 2021 at 10:36 | Report abuse | Reply
  15. RV Repair Shops Near My Location

    http://www.oraung02.iamgold.com/__media__/js/netsoltrademark.php?d=http://www.ocrvcenter.com/rv-cabinet-repair-near-me/

    June 17, 2021 at 12:37 | Report abuse | Reply
  16. kmart near me

    http://www.novalogic.com/remote.asp?NLink=http://www.masternearme.com

    June 17, 2021 at 15:48 | Report abuse | Reply
  17. brewery near me

    A motivating discussion is definitely worth comment. I believe that you need to write more on this topic, it might not be a taboo matter but typically people do not speak about such topics. To the next! Kind regards!!

    http://usahotelsguide.com/__media__/js/netsoltrademark.php?d=masternearme.com/

    June 17, 2021 at 18:09 | Report abuse | Reply
  18. covid rapid test near me

    Iím amazed, I must say. Seldom do I come across a blog thatís equally educative and interesting, and let me tell you, you have hit the nail on the head. The issue is an issue that too few men and women are speaking intelligently about. I am very happy I found this in my search for something regarding this.

    http://sys.labaq.com/cli/go.php?s=lbac&p=1410jt&t=02&url=https://www.bestservicenearme.com/

    June 17, 2021 at 18:56 | Report abuse | Reply
  19. dry ice near me

    http://www.shainerin.com/__media__/js/netsoltrademark.php?d=masternearme.com/

    June 17, 2021 at 23:13 | Report abuse | Reply
  20. chinese restaurants near me

    Good web site you have here.. Itís hard to find quality writing like yours nowadays. I seriously appreciate people like you! Take care!!

    http://www.electiondata.net/__media__/js/netsoltrademark.php?d=bestshopnearme.com

    June 17, 2021 at 23:28 | Report abuse | Reply
  21. flea market near me

    http://www.greenlightmyselfproductions.com/__media__/js/netsoltrademark.php?d=bestshopnearme.com/

    June 18, 2021 at 00:11 | Report abuse | Reply
  22. apartments near me

    Hi! I could have sworn Iíve visited this blog before but after going through many of the posts I realized itís new to me. Anyhow, Iím certainly delighted I discovered it and Iíll be bookmarking it and checking back regularly!

    http://woi-tv.com/__media__/js/netsoltrademark.php?d=bestlocalnearme.com/

    June 18, 2021 at 03:12 | Report abuse | Reply
  23. sallys near me

    Very good article. I will be facing many of these issues as well..

    http://www.sgraff.net/__media__/js/netsoltrademark.php?d=bjsnearme.com

    June 18, 2021 at 03:27 | Report abuse | Reply
  24. resturants near me

    http://www.littlekidsbigsteps.net/__media__/js/netsoltrademark.php?d=quotenearme.com/

    June 18, 2021 at 07:01 | Report abuse | Reply
  25. white kitchen remodel

    http://gregoryr26i8.blogrenanda.com/6337233/not-known-details-about-generator-repair

    June 18, 2021 at 13:20 | Report abuse | Reply
  26. RV Repair Near My Location

    Excellent blog you have here.. Itís hard to find high quality writing like yours nowadays. I seriously appreciate individuals like you! Take care!!

    http://www.secure.duoservers.com/?lang=en&s_id=123179&rdomain=www.ocrv.fun/rv-supplies-near-me&action=order&popup=1

    June 18, 2021 at 13:42 | Report abuse | Reply
  27. RV Repair Near Me

    http://autocar.co.nz/Redirect.aspx?destination=https://ocrvcenter.com/rv-repair-shop-malibu-california

    June 18, 2021 at 14:05 | Report abuse | Reply
  28. RV Repair California

    I could not resist commenting. Perfectly written!

    http://ww17.acconsthost.com/__media__/js/netsoltrademark.php?d=http://ocrvcenter.com/motorhome-frame-repair-near-me

    June 18, 2021 at 14:17 | Report abuse | Reply
  29. Nearest RV Repair

    This site was... how do you say it? Relevant!! Finally I have found something which helped me. Many thanks!

    http://yellowpages.uticaod.com/__media__/js/netsoltrademark.php?d=http://www.ocrvcenter.com/rv-frame-repair-near-me/

    June 18, 2021 at 15:00 | Report abuse | Reply
  30. Camper Repairs Near Me

    https://www.faseb.org/pdfviewer?loadthis=https://www.ocrvcenter.com/rv-repair-shop-malibu-california/

    June 18, 2021 at 20:20 | Report abuse | Reply
  31. kayaking near me

    You are so cool! I don't think I've truly read a single thing like that before. So nice to find somebody with a few unique thoughts on this issue. Really.. thanks for starting this up. This website is one thing that is required on the web, someone with a little originality!

    https://guozhenlai.com/link.php?url=https://masternearme.com/

    June 18, 2021 at 22:50 | Report abuse | Reply
  32. RV Repair California

    https://yellowpages.sfexaminer.com/__media__/js/netsoltrademark.php?d=https://www.ocrvcenter.com/motorhome-headlight-repair-near-me/

    June 18, 2021 at 23:17 | Report abuse | Reply
  33. RV Repair Fountain Valley

    http://local.katc.com/__media__/js/netsoltrademark.php?d=https://www.ocrvcenter.com/rv-repair-shop-diamond-bar-california

    June 19, 2021 at 02:06 | Report abuse | Reply
  34. RV Repair Mission Viejo

    Hi, I do think this is an excellent site. I stumbledupon it 😉 I am going to return once again since I book-marked it. Money and freedom is the best way to change, may you be rich and continue to guide other people.

    http://physics-animations.com/__media__/js/netsoltrademark.php?d=sfgov.org

    June 19, 2021 at 02:12 | Report abuse | Reply
  35. Camper Repair Shops Near Me

    Excellent post! We will be linking to this great content on our site. Keep up the great writing.

    http://stg.cablegate.tv/pc/recommend_detail.php?catvid=964GG6Vi&si=8&bindex=1531659&networkid=65534&serviceid=232&tsid=65029&supplierid=pe&url=ocrvcenter.com/rv-repair-shop-lemon-grove-california/

    June 19, 2021 at 05:57 | Report abuse | Reply
  36. RV Repair Near Me

    http://anonymz.com/?http://ocrvcenter.com/rv-repair-shop-universal-city-california

    June 19, 2021 at 13:15 | Report abuse | Reply
  37. RV Repairs Near My Location

    http://sfwater.org/redirect.aspx?url=https://ocrvcenter.co/rv-repair-shop-banning-california

    June 19, 2021 at 13:22 | Report abuse | Reply
  38. Nearby RV Repair

    Aw, this was a very good post. Finding the time and actual effort to generate a superb articleÖ but what can I sayÖ I hesitate a lot and never manage to get anything done.

    https://www.pt-br.paltalk.com/client/webapp/client/External.wmt?url=ocrv.vip/tour-bus-collision-repair-paint-shop-near-me-orange-county/

    June 19, 2021 at 14:27 | Report abuse | Reply
  39. RV Repair California

    http://www.bitly.com/a/warning?hash=3nUs1YL&url=http://ocrvcenter.com/rv-repair-shop-la-mesa-california/

    June 19, 2021 at 18:31 | Report abuse | Reply
  40. RV Repair Shop Near My Location

    https://www.fhwa.dot.gov/reauthorization/reauexit.cfm?link=https://cutwin.com/QiaJWOM/

    June 19, 2021 at 21:16 | Report abuse | Reply
  41. RV Repair Near Me

    https://www.haltern-am-see.de/Inhalte/Startseite/Tourismus/Sport_Freizeit/Vereine/index.asp?db=17&form=RedirectAction&redirecturl=www.ocrvcenter.com/rv-repair-shop-imperial-beach-california&druckansicht=ja

    June 19, 2021 at 23:38 | Report abuse | Reply
  42. Video Marketing Services

    Hi there! I could have sworn Iíve been to your blog before but after going through some of the posts I realized itís new to me. Anyhow, Iím certainly pleased I found it and Iíll be bookmarking it and checking back often!

    http://www.goodeal.com/__media__/js/netsoltrademark.php?d=www.https://www.affordableranking.com/

    June 20, 2021 at 06:42 | Report abuse | Reply
  43. Google Marketing Consultant

    https://www.acceletronics.de/__media__/js/netsoltrademark.php?d=http://www.affordableranking.com/

    June 20, 2021 at 06:56 | Report abuse | Reply
  44. Social Media Marketing Businesses

    http://payhealth.com/__media__/js/netsoltrademark.php?d=http://affordableranking.com/

    June 20, 2021 at 07:02 | Report abuse | Reply
  45. Rudolph Odle

    Nice post. I learn something new and challenging on blogs I stumbleupon on a daily basis. It's always helpful to read through content from other authors and practice something from their web sites.

    https://europe.google.com/url?sa=j&url=https://ocrvmotorsports.info

    June 20, 2021 at 12:58 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10

Post a comment


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.