Antiviral drugs help prevent HIV infection in IV drug users
June 12th, 2013
06:01 PM ET

Antiviral drugs help prevent HIV infection in IV drug users

Treating intravenous drug users with antiviral drugs may reduce their chances of HIV infection, according to a new study published Wednesday in the British medical journal The Lancet.

The Bangkok Tenofovir Study was done in Bangkok, Thailand, from 2005-2013. It was run by the Centers for Disease Control and Prevention in collaboration with the Thailand Ministry of Public Health.

Researchers recruited more than 24,000 people at 17 sites. Half took the pill tenofovir - an antiretroviral drug - daily, while the other half got a placebo. Participants were followed for about four years. Researchers found those taking the drug cut their chances of infection by 49% almost in half - approximately 49%.

This is not the first study to prove that PrEP - pre-exposure prophylaxis - is effective in reducing HIV transmission in high risk groups. Studies have already been done in heterosexuals as well as gay and bisexual men. But according to the CDC, this is the first study of its kind to prove effective in reducing rates among those who inject drugs.

“This study completes the picture of PrEP efficacy for all major HIV risk groups," said Dr. Michael Martin, chief of clinical research for the Thailand Ministry of Public Health-CDC collaboration. "We now know that pre-exposure prophylaxis can be a potentially vital option for HIV prevention in people at very high risk for infection, whether through sexual transmission or injecting drug use.”

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said, "The real important advance here is the proof of concept that in yet another high risk group - IV-drug users - pre-exposure prophylaxis can work if the individuals adhere to taking the drug."

The study found that the reduction rate for those who took their daily dose routinely was even higher - 74%.

“Adherence was a key factor determining efficacy in our trial among people who inject drugs,  as it has been in previous PrEP trials examining sexual transmission,” said Martin. “These results underscore the importance of helping people using pre-exposure prophylaxis achieve effective levels of adherence.”

It can often be difficult to directly attribute the antiviral drug's protective effect on people who get infected by injecting drugs, said Salim Karim, professor and director of the Centre for the AIDS Programme of Research in South Africa (CAPRISA) at the University of KwaZulu-Natal in Durban, South Africa. That's because, he says, some IV drug users engage in risky behavior such as prostitution to support their drug habit.

“Even though questions remain about the extent to which PrEP can be effective in preventing either of the routes of transmission in this group, the overall result is that daily tenofovir does reduce HIV transmission in injecting drug users," Karim said. "The introduction of PrEP for HIV prevention in injecting drug users should be considered as an additional component to accompany other proven prevention strategies like needle exchange programmes, methadone programmes, promotion of safer sex and injecting practices, condoms, and HIV counseling and testing.”

UNAIDS, the Joint United Nations Programme on HIV/AIDS, called the study results a complement to other PrEP trials released over the past few years.

“Piece by piece, scientific advances are paving the way to the end of the AIDS epidemic,” said Michel Sidibé, UNAIDS executive director. “The full potential of antiretroviral therapy in keeping people alive and well and in preventing new HIV infections is becoming apparent. The results of this study are important, and if used effectively in HIV programming, could have a significant impact in protecting people who inject drugs from becoming infected with HIV.”

So far, all evidence suggests PrEP is safe and effective for reducing the risk of HIV infection in high-risk populations, and there have been no concerns regarding its use daily, the CDC says.

soundoff (940 Responses)
  1. LbsoZisse

    cheap cialis with dapoxetine http://ucialisdas.com/ – cialis generic canada pharmacy cialis black 800 mg pill house

    May 13, 2021 at 16:51 | Report abuse | Reply
  2. maintenance shops near me

    Everything is very open with a clear description of the challenges. It was truly informative. Your site is extremely helpful. Many thanks for sharing!


    May 13, 2021 at 17:35 | Report abuse | Reply
  3. mission hills collision center


    May 13, 2021 at 19:29 | Report abuse | Reply
  4. kenworth shop near me


    May 13, 2021 at 20:38 | Report abuse | Reply
  5. AnooEncox

    viagra effetti collaterali pressione http://llviagra.com/ gia thuoc viagra viet nam

    May 13, 2021 at 23:40 | Report abuse | Reply
  6. national interstate rv insurance reviews

    I could not refrain from commenting. Very well written!


    May 14, 2021 at 00:55 | Report abuse | Reply
  7. box truck door repair near me

    I love it when individuals come together and share ideas. Great site, stick with it!


    May 14, 2021 at 04:35 | Report abuse | Reply
  8. RebfZisse

    36 hour cialis price http://rcialisgl.com/ where to buy cialis in singapore

    May 14, 2021 at 14:14 | Report abuse | Reply
  9. homes for sale near me now


    May 14, 2021 at 15:15 | Report abuse | Reply
  10. FmrfEncox

    fastest delivery of cialis http://cialisee.com/ cialis online canada paypal

    May 14, 2021 at 15:35 | Report abuse | Reply
  11. Kids Eye Doctor Near Me

    You're so interesting! I don't think I've read through a single thing like that before. So great to discover somebody with a few genuine thoughts on this topic. Really.. many thanks for starting this up. This website is one thing that's needed on the web, someone with a little originality!


    May 15, 2021 at 00:32 | Report abuse | Reply
  12. commercial truck painting near me

    I was more than happy to find this great site. I need to to thank you for ones time just for this wonderful read!! I definitely loved every little bit of it and i also have you bookmarked to look at new things on your blog.


    May 15, 2021 at 06:37 | Report abuse | Reply
  13. sofa upholstery repair near me

    Pretty! This was an incredibly wonderful article. Many thanks for providing these details.


    May 15, 2021 at 06:47 | Report abuse | Reply
  14. Arizona Eye Care


    May 15, 2021 at 07:54 | Report abuse | Reply
  15. Arizonas Vision


    May 15, 2021 at 08:30 | Report abuse | Reply
  16. 2019 Maserati Granturismo

    Pretty! This has been an incredibly wonderful post. Many thanks for providing this info.


    May 15, 2021 at 10:10 | Report abuse | Reply
  17. LebnEncox

    try our ed pack Zenegra thecanadianpharmacy

    May 15, 2021 at 13:22 | Report abuse | Reply
  18. BbshMile

    benefits of viagra for men http://loxviagra.com/ viagra para mujeres

    May 15, 2021 at 15:40 | Report abuse | Reply
  19. Seo Marketing Orange County


    May 15, 2021 at 17:14 | Report abuse | Reply
  20. AnooEncox

    viagra creator's house http://llviagra.com/ viagra store in karachi

    May 15, 2021 at 18:19 | Report abuse | Reply
  21. Digital Marketing Jobs


    May 15, 2021 at 19:54 | Report abuse | Reply
  22. JebgEncox

    canada pharmacies without script canadian drugs online pharmacies pain meds online without doctor prescription

    May 15, 2021 at 21:37 | Report abuse | Reply
  23. Content Marketing Association

    Your style is unique in comparison to other people I have read stuff from. Thank you for posting when you have the opportunity, Guess I'll just book mark this blog.


    May 15, 2021 at 23:51 | Report abuse | Reply
  24. aika online private server


    May 16, 2021 at 00:44 | Report abuse | Reply
  25. Social Media Marketing Event

    Aw, this was an extremely good post. Finding the time and actual effort to create a really good article… but what can I say… I hesitate a whole lot and don't manage to get anything done.


    May 16, 2021 at 05:16 | Report abuse | Reply
  26. Internet Marketing Consultant

    I was extremely pleased to uncover this website. I wanted to thank you for your time due to this wonderful read!! I definitely appreciated every part of it and i also have you saved to fav to check out new stuff in your blog.


    May 16, 2021 at 06:06 | Report abuse | Reply
  27. GtnbCrulk

    what drugs should not be taken with viagra? http://jokviagra.com/ normal dose of viagra

    May 16, 2021 at 09:27 | Report abuse | Reply
  28. orange cz


    May 16, 2021 at 10:42 | Report abuse | Reply
  29. repair rv floor


    May 16, 2021 at 11:01 | Report abuse | Reply
  30. aika online gameplay

    Very good article! We are linking to this great post on our site. Keep up the good writing.


    May 16, 2021 at 12:16 | Report abuse | Reply
  31. rv roof leak detection

    That is a really good tip particularly to those fresh to the blogosphere. Short but very accurate information… Appreciate your sharing this one. A must read article!


    May 16, 2021 at 12:50 | Report abuse | Reply
  32. Rust Repair Sprinter

    Great post. I am facing some of these issues as well..


    May 16, 2021 at 15:40 | Report abuse | Reply
  33. Vanlife Repair Costs For Mercedes Sprinter


    May 16, 2021 at 21:11 | Report abuse | Reply
  34. Sprinter Repair Los Angeles


    May 17, 2021 at 01:31 | Report abuse | Reply
  35. Mercedes Sprinter Repair Near Mee

    I blog frequently and I really thank you for your content. This article has truly peaked my interest. I will bookmark your website and keep checking for new information about once per week. I subscribed to your Feed as well.


    May 17, 2021 at 04:21 | Report abuse | Reply
  36. Sprinter Van Brake Repair Near Me


    May 17, 2021 at 04:31 | Report abuse | Reply
  37. Sprinter Turbocharger Repair

    Hello, I believe your blog could be having browser compatibility issues. Whenever I look at your website in Safari, it looks fine however, if opening in IE, it's got some overlapping issues. I just wanted to give you a quick heads up! Apart from that, great website!


    May 17, 2021 at 04:35 | Report abuse | Reply
  38. GtnbCrulk

    viagra cvs http://jokviagra.com/ what does viagra cost

    May 17, 2021 at 05:04 | Report abuse | Reply
  39. RebfZisse

    cialis black box warning http://rcialisgl.com/ buy generic cialis 5mg

    May 17, 2021 at 06:38 | Report abuse | Reply
  40. LbsoZisse

    cialis canadian http://ucialisdas.com/ – cialis purchase canada cialisВ® online

    May 17, 2021 at 08:02 | Report abuse | Reply
  41. 2010 Sprinter Seat Belt Buckle Repair


    May 17, 2021 at 09:11 | Report abuse | Reply
  42. LebnEncox

    Lexapro canadian pharmacies compare Rumalaya

    May 17, 2021 at 10:59 | Report abuse | Reply
  43. JebgEncox

    Cilostazol best drugstore liquid eyeliner Lamivudin (Cipla Ltd)

    May 17, 2021 at 13:53 | Report abuse | Reply
  44. rv repair in riverside ca


    May 17, 2021 at 15:47 | Report abuse | Reply
  45. Maserati Supercars

    Can I simply just say what a comfort to discover someone who actually knows what they're discussing on the internet. You certainly know how to bring an issue to light and make it important. More and more people really need to read this and understand this side of the story. It's surprising you aren't more popular since you definitely have the gift.


    May 17, 2021 at 21:15 | Report abuse | Reply
  46. semi truck paint shops near me

    I was able to find good advice from your content.


    May 18, 2021 at 01:46 | Report abuse | Reply
  47. rv slide out water damage repair

    Greetings! Very useful advice in this particular post! It's the little changes which will make the most significant changes. Thanks a lot for sharing!


    May 18, 2021 at 07:46 | Report abuse | Reply
  48. rv interior upgrades

    Very nice write-up. I absolutely love this website. Keep writing!


    May 18, 2021 at 08:25 | Report abuse | Reply
  49. FmrfEncox

    genaric cialis https://cialisee.com/ – cialis purchase online cialis buy paypal

    May 18, 2021 at 11:01 | Report abuse | Reply
  50. aftermarket installation shops near me


    May 18, 2021 at 11:14 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19

Leave a Reply to Used Forklift Cylinders California


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.