June 12th, 2013
06:01 PM ET
Antiviral drugs help prevent HIV infection in IV drug users
Treating intravenous drug users with antiviral drugs may reduce their chances of HIV infection, according to a new study published Wednesday in the British medical journal The Lancet.
The Bangkok Tenofovir Study was done in Bangkok, Thailand, from 2005-2013. It was run by the Centers for Disease Control and Prevention in collaboration with the Thailand Ministry of Public Health.
Researchers recruited more than 24,000 people at 17 sites. Half took the pill tenofovir - an antiretroviral drug - daily, while the other half got a placebo. Participants were followed for about four years. Researchers found those taking the drug cut their chances of infection by 49% almost in half - approximately 49%.
This is not the first study to prove that PrEP - pre-exposure prophylaxis - is effective in reducing HIV transmission in high risk groups. Studies have already been done in heterosexuals as well as gay and bisexual men. But according to the CDC, this is the first study of its kind to prove effective in reducing rates among those who inject drugs.
“This study completes the picture of PrEP efficacy for all major HIV risk groups," said Dr. Michael Martin, chief of clinical research for the Thailand Ministry of Public Health-CDC collaboration. "We now know that pre-exposure prophylaxis can be a potentially vital option for HIV prevention in people at very high risk for infection, whether through sexual transmission or injecting drug use.”
Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said, "The real important advance here is the proof of concept that in yet another high risk group - IV-drug users - pre-exposure prophylaxis can work if the individuals adhere to taking the drug."
The study found that the reduction rate for those who took their daily dose routinely was even higher - 74%.
“Adherence was a key factor determining efficacy in our trial among people who inject drugs, as it has been in previous PrEP trials examining sexual transmission,” said Martin. “These results underscore the importance of helping people using pre-exposure prophylaxis achieve effective levels of adherence.”
It can often be difficult to directly attribute the antiviral drug's protective effect on people who get infected by injecting drugs, said Salim Karim, professor and director of the Centre for the AIDS Programme of Research in South Africa (CAPRISA) at the University of KwaZulu-Natal in Durban, South Africa. That's because, he says, some IV drug users engage in risky behavior such as prostitution to support their drug habit.
“Even though questions remain about the extent to which PrEP can be effective in preventing either of the routes of transmission in this group, the overall result is that daily tenofovir does reduce HIV transmission in injecting drug users," Karim said. "The introduction of PrEP for HIV prevention in injecting drug users should be considered as an additional component to accompany other proven prevention strategies like needle exchange programmes, methadone programmes, promotion of safer sex and injecting practices, condoms, and HIV counseling and testing.”
UNAIDS, the Joint United Nations Programme on HIV/AIDS, called the study results a complement to other PrEP trials released over the past few years.
“Piece by piece, scientific advances are paving the way to the end of the AIDS epidemic,” said Michel Sidibé, UNAIDS executive director. “The full potential of antiretroviral therapy in keeping people alive and well and in preventing new HIV infections is becoming apparent. The results of this study are important, and if used effectively in HIV programming, could have a significant impact in protecting people who inject drugs from becoming infected with HIV.”
So far, all evidence suggests PrEP is safe and effective for reducing the risk of HIV infection in high-risk populations, and there have been no concerns regarding its use daily, the CDC says.
About this blog
Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.
https://kloviagrli.com/ – generic viagra names https://vigedon.com/ – roman viagra review https://llecialisjaw.com/ – cialis free sample https://jwcialislrt.com/ – canadian cialis https://jecialisbn.com/ – cialis shelf life
https://thesiswritingtob.com/ – best thesis writing help with thesis statement best thesis thesis consultant
https://ljcialishe.com/ – what is the difference between viagra and cialis https://cialisvja.com/ – п»їcialis https://viagraonlinejc.com/ – marley generics viagra https://viagratx.com/ – viagra generic date https://buycialisxz.com/ – 5mg cialis
https://thesiswritingtob.com/ – thesiswritingtob.com thesis consulting thesiswritingtob.com proposal for thesis
azithromycin pills https://zithromaxes.com/ zithromax strength
alprostadil pellets https://alprostadildrugs.com/ alprostadil urethral suppository otc
canadian customs pills vitamins https://canadapillstorex.com/ canadian diet pills
order levitra online http://uslevitraanna.com/ viagra versus cialis versus levitra
prescription pricing canada pharmacies online Top Avana
viagra and nitrates https://gensitecil.com/ – viagra without presc viagra condoms
best price for cialis 20 mg https://cileve.com/ overnight delivery cialis
buy cialis online in usa http://asciled.com/ buying cialis online
cialis viagra combination canadian pharmacy https://canadacialisstore.com/ canadian pharmacy cialis without prescription
buy prescription drugs without doctor https://uspharmus.com/ – diabetes canadian drug store
Spot on with this write-up, I honestly believe this web site needs far more attention. I’ll probably be returning to read through more, thanks for the information!
I need to to thank you for this excellent read!! I absolutely enjoyed every bit of it. I have got you bookmarked to look at new things you post…
Oh my goodness! Impressive article dude! Many thanks, However I am going through issues with your RSS. I don’t understand why I cannot join it. Is there anyone else having identical RSS issues? Anyone that knows the answer can you kindly respond? Thanks!!
sildenafil usa https://eunicesildenafilcitrate.com/ sildenafil generic without prescription
cialisgeneric http://asciled.com/ cialis for free
An outstanding share! I've just forwarded this onto a co-worker who had been doing a little research on this. And he actually bought me breakfast because I discovered it for him... lol. So let me reword this.... Thanks for the meal!! But yeah, thanks for spending time to talk about this issue here on your internet site.
Spot on with this write-up, I actually feel this website needs far more attention. I’ll probably be returning to see more, thanks for the advice!
erectile dysfunction causes https://canadaerectiledysfunctionpills.com/ erectile stamina in older men
cialis 20 mg usa http://cileve.com/ cialis 200 mg what is it
free sample levitra http://uslevitraanna.com/ levitra generic online
cheap prescription drugs online https://onlinecanda21.com/ Uroxatral
walmart pharmacy viagra http://uspharmus.com/ – Cardizem ER cialis generic pharmacy online
Cordarone http://canadianeve21.com/ approved canadian pharmacies online
This site truly has all of the information and facts I needed about this subject and didn’t know who to ask.
mom son viagra https://gensitecil.com/ sublingual viagra
buy generic cialis with paypal http://cileve.com/ cialis for cheap
cialis tadalafil patent https://boxtadafil.com/ is tadalafil available in the united states
cialis overnight shipping http://asciled.com/ cialis professional vs cialis super active
cost of levitra vs viagra https://uslevitraanna.com/ levitra clinical data
cheap pharmacy online https://onlinecanda21.com/ Detrol
how long does tadalafil last https://boxtadafil.com/ tadalafil metabolism
priligy generic dapoxetine
online pet pharmacy https://uspharmus.com/ best online canadian pharcharmy
cialis canadian https://canadacialisstore.com/ buy generic cialis without prescription canadian pharmacy
dapoxetine cialis american express https://asciled.com/ splitting cialis
ordering viagra from canada https://canadaviagrastore.com/ generic viagra canada free shipping
used to treat malaria chloro https://chloroquineorigin.com/ who makes chloroquine phosphate
does viagra make you last longer in bed https://gensitecil.com/ best places to buy viagra
viagra professional Zudena pharma
Furosemide http://pharmacylo.com/ best online pharmacy reddit
otc viagra alternative https://loxviagra.com/ max dose of viagra
when does cialis patent expire https://rcialisgl.com/ cialis pills online
cialis 50mg price http://ucialisdas.com/ cheap online cialis
avana avanafil stendra