Antiviral drugs help prevent HIV infection in IV drug users
June 12th, 2013
06:01 PM ET

Antiviral drugs help prevent HIV infection in IV drug users

Treating intravenous drug users with antiviral drugs may reduce their chances of HIV infection, according to a new study published Wednesday in the British medical journal The Lancet.

The Bangkok Tenofovir Study was done in Bangkok, Thailand, from 2005-2013. It was run by the Centers for Disease Control and Prevention in collaboration with the Thailand Ministry of Public Health.

Researchers recruited more than 24,000 people at 17 sites. Half took the pill tenofovir - an antiretroviral drug - daily, while the other half got a placebo. Participants were followed for about four years. Researchers found those taking the drug cut their chances of infection by 49% almost in half - approximately 49%.

This is not the first study to prove that PrEP - pre-exposure prophylaxis - is effective in reducing HIV transmission in high risk groups. Studies have already been done in heterosexuals as well as gay and bisexual men. But according to the CDC, this is the first study of its kind to prove effective in reducing rates among those who inject drugs.

“This study completes the picture of PrEP efficacy for all major HIV risk groups," said Dr. Michael Martin, chief of clinical research for the Thailand Ministry of Public Health-CDC collaboration. "We now know that pre-exposure prophylaxis can be a potentially vital option for HIV prevention in people at very high risk for infection, whether through sexual transmission or injecting drug use.”

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said, "The real important advance here is the proof of concept that in yet another high risk group - IV-drug users - pre-exposure prophylaxis can work if the individuals adhere to taking the drug."

The study found that the reduction rate for those who took their daily dose routinely was even higher - 74%.

“Adherence was a key factor determining efficacy in our trial among people who inject drugs,  as it has been in previous PrEP trials examining sexual transmission,” said Martin. “These results underscore the importance of helping people using pre-exposure prophylaxis achieve effective levels of adherence.”

It can often be difficult to directly attribute the antiviral drug's protective effect on people who get infected by injecting drugs, said Salim Karim, professor and director of the Centre for the AIDS Programme of Research in South Africa (CAPRISA) at the University of KwaZulu-Natal in Durban, South Africa. That's because, he says, some IV drug users engage in risky behavior such as prostitution to support their drug habit.

“Even though questions remain about the extent to which PrEP can be effective in preventing either of the routes of transmission in this group, the overall result is that daily tenofovir does reduce HIV transmission in injecting drug users," Karim said. "The introduction of PrEP for HIV prevention in injecting drug users should be considered as an additional component to accompany other proven prevention strategies like needle exchange programmes, methadone programmes, promotion of safer sex and injecting practices, condoms, and HIV counseling and testing.”

UNAIDS, the Joint United Nations Programme on HIV/AIDS, called the study results a complement to other PrEP trials released over the past few years.

“Piece by piece, scientific advances are paving the way to the end of the AIDS epidemic,” said Michel Sidibé, UNAIDS executive director. “The full potential of antiretroviral therapy in keeping people alive and well and in preventing new HIV infections is becoming apparent. The results of this study are important, and if used effectively in HIV programming, could have a significant impact in protecting people who inject drugs from becoming infected with HIV.”

So far, all evidence suggests PrEP is safe and effective for reducing the risk of HIV infection in high-risk populations, and there have been no concerns regarding its use daily, the CDC says.

soundoff (940 Responses)
  1. ZisseVed

    cost of daily cialis kupi online cialis long term effects of cialis

    May 31, 2021 at 21:31 | Report abuse | Reply
  2. MileSwa

    generic levitra and cialis in australia cialis or viagra ? cialis paypal bezahlen

    May 31, 2021 at 22:25 | Report abuse | Reply
  3. Upholstery Shop


    June 1, 2021 at 00:46 | Report abuse | Reply
  4. Mercedes Luxury Van Repair Shop Near Me

    There is definately a lot to find out about this subject. I love all the points you've made.


    June 1, 2021 at 00:50 | Report abuse | Reply
  5. Leisure Travel Van Repair Shop Near Me

    Hello there! I simply wish to give you a huge thumbs up for the excellent information you have got right here on this post. I'll be returning to your website for more soon.


    June 1, 2021 at 11:23 | Report abuse | Reply
  6. EncoxHtf

    cialis in vegas cialis 5 mg price cialis 36 hours

    June 1, 2021 at 14:40 | Report abuse | Reply
  7. Troy Honyumptewa


    June 1, 2021 at 15:03 | Report abuse | Reply
  8. fabrication near me

    I could not resist commenting. Well written!


    June 1, 2021 at 16:08 | Report abuse | Reply
  9. Karl Barcelona


    June 1, 2021 at 20:29 | Report abuse | Reply
  10. Rayna Brisson


    June 1, 2021 at 22:51 | Report abuse | Reply
  11. windshield repair orange county ca

    Everything is very open with a very clear description of the challenges. It was truly informative. Your website is useful. Many thanks for sharing!


    June 2, 2021 at 02:12 | Report abuse | Reply
  12. rv solar installation near me

    Great information. Lucky me I recently found your site by accident (stumbleupon). I have bookmarked it for later!


    June 2, 2021 at 02:16 | Report abuse | Reply
  13. ZisseVed

    cialis price walgreens cialis shelf life find cheapest cialis pills

    June 2, 2021 at 11:49 | Report abuse | Reply
  14. paint shops near me

    Good day! I simply want to offer you a big thumbs up for the excellent information you've got right here on this post. I will be coming back to your website for more soon.


    June 2, 2021 at 16:10 | Report abuse | Reply
  15. horse trailer paint colors

    Can I just say what a comfort to uncover a person that really understands what they are discussing over the internet. You actually know how to bring an issue to light and make it important. A lot more people should look at this and understand this side of the story. I can't believe you aren't more popular given that you certainly possess the gift.


    June 2, 2021 at 17:16 | Report abuse | Reply
  16. Cargo Van Repair Shop Near Me

    I'd like to thank you for the efforts you've put in writing this website. I really hope to see the same high-grade content by you later on as well. In truth, your creative writing abilities has inspired me to get my very own website now 😉


    June 2, 2021 at 18:20 | Report abuse | Reply
  17. semi truck ac repair near me

    Can I simply say what a relief to uncover an individual who actually understands what they're talking about online. You definitely understand how to bring an issue to light and make it important. A lot more people really need to look at this and understand this side of your story. It's surprising you aren't more popular given that you definitely possess the gift.


    June 2, 2021 at 18:48 | Report abuse | Reply
  18. oc wheel repair


    June 3, 2021 at 04:13 | Report abuse | Reply
  19. EncoxAni

    price pro pharmacy canada rx smith pharmacy cheap prescription drugs canada

    June 3, 2021 at 04:36 | Report abuse | Reply
  20. Sprinter Tcu Repair


    June 3, 2021 at 08:29 | Report abuse | Reply
  21. Mercedes Sprinter Chasis Repair


    June 3, 2021 at 08:32 | Report abuse | Reply
  22. rv repair services near me


    June 3, 2021 at 08:37 | Report abuse | Reply
  23. Content Marketing Business


    June 3, 2021 at 11:05 | Report abuse | Reply
  24. kenworth shop near me

    An impressive share! I have just forwarded this onto a coworker who has been conducting a little research on this. And he actually bought me lunch due to the fact that I stumbled upon it for him... lol. So let me reword this.... Thank YOU for the meal!! But yeah, thanx for spending the time to discuss this issue here on your site.


    June 3, 2021 at 14:11 | Report abuse | Reply
  25. EncoxDev

    online prescription drugs rx one pharmacy llc online pharmacy no prescription required

    June 3, 2021 at 18:31 | Report abuse | Reply
  26. EncoxHtf

    cialis 30 day cialis in mexico cialis in canada pharmacy

    June 3, 2021 at 18:49 | Report abuse | Reply
  27. rv solar installation los angeles


    June 3, 2021 at 18:59 | Report abuse | Reply
  28. trailer painting near me

    I blog often and I really thank you for your content. This great article has really peaked my interest. I will bookmark your site and keep checking for new information about once per week. I opted in for your RSS feed too.


    June 3, 2021 at 19:39 | Report abuse | Reply
  29. rv slide out water damage repair

    Iím impressed, I have to admit. Seldom do I encounter a blog thatís both educative and amusing, and without a doubt, you've hit the nail on the head. The issue is something which too few people are speaking intelligently about. Now i'm very happy I stumbled across this in my hunt for something regarding this.


    June 3, 2021 at 19:55 | Report abuse | Reply
  30. rv shades repair


    June 3, 2021 at 20:17 | Report abuse | Reply
  31. Nearest Mercedes Service Center


    June 3, 2021 at 20:24 | Report abuse | Reply
  32. EncoxGtv

    walgreens pharmacy store number Silagra doctor prescription

    June 4, 2021 at 03:04 | Report abuse | Reply
  33. repair rv door


    June 4, 2021 at 04:19 | Report abuse | Reply
  34. Zisseloh

    generic cialis canada get cialis online online pharmacy for cialis

    June 4, 2021 at 04:38 | Report abuse | Reply
  35. Start Error Mercedes Sprinter Repair

    Aw, this was a really good post. Spending some time and actual effort to make a great articleÖ but what can I sayÖ I procrastinate a whole lot and don't seem to get nearly anything done.


    June 4, 2021 at 05:21 | Report abuse | Reply
  36. firewood near me

    Iím impressed, I must say. Seldom do I come across a blog thatís both equally educative and amusing, and without a doubt, you've hit the nail on the head. The problem is something not enough men and women are speaking intelligently about. I am very happy that I stumbled across this during my hunt for something regarding this.


    June 4, 2021 at 05:22 | Report abuse | Reply
  37. Mercedes Sprinter Refrigerater Repair

    Itís nearly impossible to find educated people about this topic, but you seem like you know what youíre talking about! Thanks


    June 4, 2021 at 05:27 | Report abuse | Reply
  38. Mercedes Sprinter Service Centers


    June 4, 2021 at 07:32 | Report abuse | Reply
  39. travel trailer remodeling companies


    June 4, 2021 at 12:11 | Report abuse | Reply
  40. EncoxAni

    indianpharmacy com rx care pharmacy abilify canada pharmacy

    June 4, 2021 at 16:18 | Report abuse | Reply
  41. macys near me

    Very good article. I am dealing with some of these issues as well..


    June 4, 2021 at 17:05 | Report abuse | Reply
  42. Sprinter Van Body Repair


    June 4, 2021 at 17:31 | Report abuse | Reply
  43. MileSwa

    generic cialis for sale cheap cialis online overnight shipping cialis online no prescription

    June 4, 2021 at 17:51 | Report abuse | Reply
  44. upholstery orange county


    June 4, 2021 at 20:01 | Report abuse | Reply
  45. CrulkAsd

    levitra vs cialis vs viagra canadian cialis reviews buy cialis online overnight delivery

    June 5, 2021 at 03:09 | Report abuse | Reply
  46. Rv Mercedes Sprinter Service Center Near Me

    Good blog post. I absolutely appreciate this site. Keep writing!


    June 5, 2021 at 07:10 | Report abuse | Reply
  47. trailer repair orange county

    I must thank you for the efforts you've put in penning this site. I really hope to check out the same high-grade blog posts by you in the future as well. In fact, your creative writing abilities has inspired me to get my very own blog now 😉


    June 5, 2021 at 07:26 | Report abuse | Reply
  48. physical therapy near me


    June 5, 2021 at 07:48 | Report abuse | Reply
  49. Digital Marketing Service


    June 5, 2021 at 07:54 | Report abuse | Reply
  50. Chun Vanvickle

    This was awesome! I would like you to clean up all this spam though


    June 5, 2021 at 09:00 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19

Leave a Reply to Camper Repair Shops Near Me


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.