Antiviral drugs help prevent HIV infection in IV drug users
June 12th, 2013
06:01 PM ET

Antiviral drugs help prevent HIV infection in IV drug users

Treating intravenous drug users with antiviral drugs may reduce their chances of HIV infection, according to a new study published Wednesday in the British medical journal The Lancet.

The Bangkok Tenofovir Study was done in Bangkok, Thailand, from 2005-2013. It was run by the Centers for Disease Control and Prevention in collaboration with the Thailand Ministry of Public Health.

Researchers recruited more than 24,000 people at 17 sites. Half took the pill tenofovir - an antiretroviral drug - daily, while the other half got a placebo. Participants were followed for about four years. Researchers found those taking the drug cut their chances of infection by 49% almost in half - approximately 49%.

This is not the first study to prove that PrEP - pre-exposure prophylaxis - is effective in reducing HIV transmission in high risk groups. Studies have already been done in heterosexuals as well as gay and bisexual men. But according to the CDC, this is the first study of its kind to prove effective in reducing rates among those who inject drugs.

“This study completes the picture of PrEP efficacy for all major HIV risk groups," said Dr. Michael Martin, chief of clinical research for the Thailand Ministry of Public Health-CDC collaboration. "We now know that pre-exposure prophylaxis can be a potentially vital option for HIV prevention in people at very high risk for infection, whether through sexual transmission or injecting drug use.”

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said, "The real important advance here is the proof of concept that in yet another high risk group - IV-drug users - pre-exposure prophylaxis can work if the individuals adhere to taking the drug."

The study found that the reduction rate for those who took their daily dose routinely was even higher - 74%.

“Adherence was a key factor determining efficacy in our trial among people who inject drugs,  as it has been in previous PrEP trials examining sexual transmission,” said Martin. “These results underscore the importance of helping people using pre-exposure prophylaxis achieve effective levels of adherence.”

It can often be difficult to directly attribute the antiviral drug's protective effect on people who get infected by injecting drugs, said Salim Karim, professor and director of the Centre for the AIDS Programme of Research in South Africa (CAPRISA) at the University of KwaZulu-Natal in Durban, South Africa. That's because, he says, some IV drug users engage in risky behavior such as prostitution to support their drug habit.

“Even though questions remain about the extent to which PrEP can be effective in preventing either of the routes of transmission in this group, the overall result is that daily tenofovir does reduce HIV transmission in injecting drug users," Karim said. "The introduction of PrEP for HIV prevention in injecting drug users should be considered as an additional component to accompany other proven prevention strategies like needle exchange programmes, methadone programmes, promotion of safer sex and injecting practices, condoms, and HIV counseling and testing.”

UNAIDS, the Joint United Nations Programme on HIV/AIDS, called the study results a complement to other PrEP trials released over the past few years.

“Piece by piece, scientific advances are paving the way to the end of the AIDS epidemic,” said Michel Sidibé, UNAIDS executive director. “The full potential of antiretroviral therapy in keeping people alive and well and in preventing new HIV infections is becoming apparent. The results of this study are important, and if used effectively in HIV programming, could have a significant impact in protecting people who inject drugs from becoming infected with HIV.”

So far, all evidence suggests PrEP is safe and effective for reducing the risk of HIV infection in high-risk populations, and there have been no concerns regarding its use daily, the CDC says.

soundoff (940 Responses)
  1. dapoxetine

    dapoxetine dapoxetine 100 mg

    May 22, 2021 at 13:49 | Report abuse | Reply
  2. dash store calabasas ca


    May 22, 2021 at 14:23 | Report abuse | Reply
  3. rv cabinets and furniture

    Very good post! We will be linking to this particularly great content on our site. Keep up the great writing.


    May 22, 2021 at 16:34 | Report abuse | Reply
  4. JebgEncox

    Lamictal discount pharmacy mexico onlinecanadianpharmacy

    May 22, 2021 at 16:51 | Report abuse | Reply
  5. cyclomune

    cyclomune eye drops 1% cyclomune

    May 22, 2021 at 18:10 | Report abuse | Reply
  6. Local Marketing Agencies Near Me

    Your style is unique in comparison to other folks I have read stuff from. Thanks for posting when you've got the opportunity, Guess I'll just bookmark this blog.


    May 22, 2021 at 19:12 | Report abuse | Reply
  7. RV Awning Riverside


    May 23, 2021 at 01:47 | Report abuse | Reply
  8. RV Fabrication Near Me

    After checking out a number of the blog articles on your web site, I truly like your technique of writing a blog. I saved it to my bookmark webpage list and will be checking back in the near future. Please visit my website too and let me know what you think.


    May 23, 2021 at 02:04 | Report abuse | Reply
  9. Google Marketing Consultant

    I quite like looking through an article that will make people think. Also, thank you for permitting me to comment!


    May 23, 2021 at 07:20 | Report abuse | Reply
  10. RebfZisse

    cialis on line sell https://rcialisgl.com/ – cialis legal online cialis ordering

    May 23, 2021 at 07:30 | Report abuse | Reply
  11. LbsoZisse

    cialis 5mg http://ucialisdas.com/ no prescription female cialis

    May 23, 2021 at 08:47 | Report abuse | Reply
  12. RV Shades Orange County

    This page definitely has all of the information and facts I needed concerning this subject and didn’t know who to ask.


    May 23, 2021 at 10:08 | Report abuse | Reply
  13. bucket truck band


    May 23, 2021 at 12:27 | Report abuse | Reply
  14. rv repair centers near me


    May 23, 2021 at 23:43 | Report abuse | Reply
  15. AnooEncox

    precio viagra argentina 2012 https://llviagra.com/ can you take viagra and extenze at the same time

    May 23, 2021 at 23:56 | Report abuse | Reply
  16. BbshMile

    compra viagra http://loxviagra.com/ – viagra over the counter walgreens street value of viagra

    May 24, 2021 at 00:36 | Report abuse | Reply
  17. RV Inspection Near Me

    Great article! We will be linking to this particularly great content on our site. Keep up the good writing.


    May 24, 2021 at 01:40 | Report abuse | Reply
  18. tausAffessy

    tadalafil cialis best price usa tadalafil cialis without a prescription https://tadagatadalafil.com/

    May 24, 2021 at 04:37 | Report abuse | Reply
  19. SEO Marketing Experts


    May 24, 2021 at 12:31 | Report abuse | Reply
  20. GtnbCrulk

    natural viagra https://jokviagra.com/ viagra video

    May 24, 2021 at 13:30 | Report abuse | Reply
  21. orange county rv dealers


    May 24, 2021 at 19:04 | Report abuse | Reply
  22. rv for sale in orange county


    May 24, 2021 at 22:14 | Report abuse | Reply
  23. horse trailer repair near me


    May 24, 2021 at 22:23 | Report abuse | Reply
  24. rv vinyl wraps

    This blog was... how do I say it? Relevant!! Finally I have found something which helped me. Cheers!


    May 24, 2021 at 22:39 | Report abuse | Reply
  25. Social Media Marketing Market


    May 25, 2021 at 03:12 | Report abuse | Reply
  26. Google Marketing Specialists

    I absolutely love your website.. Pleasant colors & theme. Did you build this amazing site yourself? Please reply back as I’m attempting to create my very own website and would love to find out where you got this from or exactly what the theme is named. Kudos!


    May 25, 2021 at 03:51 | Report abuse | Reply
  27. Google Marketing Business

    Great blog you have got here.. It’s hard to find excellent writing like yours these days. I seriously appreciate individuals like you! Take care!!


    May 25, 2021 at 04:44 | Report abuse | Reply
  28. Forklift Repair Shop


    May 25, 2021 at 05:03 | Report abuse | Reply
  29. Used Forklift Cylinders California


    May 25, 2021 at 07:23 | Report abuse | Reply
  30. Social Media Marketing Businesses

    This is a topic which is near to my heart... Take care! Exactly where are your contact details though?


    May 25, 2021 at 08:19 | Report abuse | Reply
  31. EncoxDev

    buy medication without an rx world best pharmacy online store reviews most reputable canadian pharmacy online

    May 25, 2021 at 08:50 | Report abuse | Reply
  32. EncoxGtv

    meds rx pharmacy sildenafil citrate online pharmacy Hydrea

    May 25, 2021 at 12:08 | Report abuse | Reply
  33. Social Media Marketing Service

    I really love your website.. Very nice colors & theme. Did you develop this website yourself? Please reply back as Iím planning to create my very own website and would like to know where you got this from or what the theme is named. Cheers!


    May 25, 2021 at 14:10 | Report abuse | Reply
  34. Tembepteriope

    buy cialis pills https://tadagatadalafil.com/ – buy cialis side effects of tadalafil tadalafil cialis https://apcalisetadalafil.com/

    May 25, 2021 at 14:21 | Report abuse | Reply
  35. Social Media Marketing Service


    May 25, 2021 at 14:25 | Report abuse | Reply
  36. Internet Marketing Experts

    After looking into a number of the blog posts on your web site, I seriously like your way of blogging. I saved it to my bookmark website list and will be checking back in the near future. Take a look at my website as well and let me know how you feel.


    May 25, 2021 at 15:27 | Report abuse | Reply
  37. Social Media Marketing Experts


    May 25, 2021 at 15:58 | Report abuse | Reply
  38. Digital Marketing Service

    Great site you have here.. It’s difficult to find quality writing like yours these days. I really appreciate people like you! Take care!!


    May 25, 2021 at 16:02 | Report abuse | Reply
  39. Internet Marketing Businesses


    May 25, 2021 at 18:21 | Report abuse | Reply
  40. Local Marketing Experts

    Saved as a favorite, I really like your web site!


    May 25, 2021 at 20:21 | Report abuse | Reply
  41. combigan

    brimonidine use buy brimonidine

    May 25, 2021 at 22:29 | Report abuse | Reply
  42. Social Media Marketing Agency


    May 25, 2021 at 22:31 | Report abuse | Reply
  43. Kerry Frantum


    May 26, 2021 at 00:35 | Report abuse | Reply
  44. MileSwa

    36 hour cialis online https://ckacialis.com/ – cialis 60mg cheap cialis pills uk

    May 26, 2021 at 00:48 | Report abuse | Reply
  45. RV Renovation Los Angeles

    There is certainly a lot to find out about this topic. I really like all the points you have made.


    May 26, 2021 at 01:08 | Report abuse | Reply
  46. dash store calabasas ca


    May 26, 2021 at 04:13 | Report abuse | Reply
  47. Zisseloh

    cialis online with prescription https://rcialisgl.com/ – cialis onset where can i get cialis

    May 26, 2021 at 05:02 | Report abuse | Reply
  48. horse trailer paint colors


    May 26, 2021 at 05:54 | Report abuse | Reply
  49. ZisseVed

    cialis professional 20 mg https://krocialis.com/ – how much is cialis how to get cialis prescription

    May 26, 2021 at 06:29 | Report abuse | Reply
  50. tausAffessy

    generic tadalafil from uk https://tadagatadalafil.com/ tadalafil blood pressure tadalafil online with out prescription lowest price cialis

    May 26, 2021 at 08:11 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19

Leave a Reply to HarryAbery


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.