Cold sores linked to cognitive decline
March 26th, 2013
10:04 AM ET

Cold sores linked to cognitive decline

The virus causing your cold sore may put you at risk for something more insidious: Lower cognitive abilities.

In a study of 1,625 people, researchers at Columbia University measured specific antibodies to common infectious agents in each person's blood, and using this information, created an "infectious burden index." Participants higher on the infectious burden index were more likely to have worse cognition, or cognitive abilities.

The study, published Monday in the journal Neurology, further suggests a link between cognitive decline and herpesviridae viral infections in particular, which previous studies have also linked to Alzheimer's disease and risk of stroke, an accompanying editorial notes. Herpesviridae is a family of viruses including HSV-1 or herpes simplex virus-1, which causes cold sores and can cause genital herpes, and HSV-2, which commonly causes genital herpes.

For the study, researchers tracked participants for eight years, giving them tests to measure cognition each year, but found no link between decline in abilities and viral infections over that period. The associated decline occurred before the study even began; the participants infectious burden index score did not make that person more or less likely to experience cognitive decline over the course of the study.

Only physical activity significantly reduced the association between infectious burden and cognitive decline, researchers found.

A study starting with younger participants - this study's average was 69 years old - and over a longer period may reveal more about how the decline progresses over time, says Dr. Mira Katan, the lead study author.

"While this association needs to be further studied, the results could lead to ways to identify people at risk of cognitive impairment and eventually lower that risk," said Katan in a statement.

"For example, exercise and childhood vaccinations against viruses could decrease the risk for memory problems later in life."

"This is a fascinating area which certainly deserves a treatment trial," says Dr. Timo Strandberg, author of the editorial, from the Department of Medicine, geriatric clinic, at the University of Helsinki (Finland) and University Hospital in Helsinki. "We are currently planning one... just remember what a paradigm change there was in ulcer disease in the 1980s. Of course this could have great potential if proved to be right. Nevertheless, old age AD (Alzheimer's disease) is a multifactorial geriatric syndrome (in my opinion), so several factors are contributing at the individual level."

However, said Dr. William Schaffner, chairman of the preventive medicine department at Vanderbilt University's School of Medicine, "They cannot impute causal associations, these are just interesting phenomenon."

"My concerns are, who are these people who are drawn into these studies? Because they're not a representative population," says Schaffner, who was not involved in the research. "They of course have had a dropout rate, so I'm just very cautious about what we can conclude from this association."

But Schaffner says he finds the study "intriguing and provocative"  He says, "The more we pick at this and find infectious disease antecedents for chronic illness, the more provocative it is, because it opens up more doors for prevention."

soundoff (336 Responses)
  1. FmnfEncox

    cialis cialis tablets for sell low cost cialis https://impotencecdny.com/info/history.php – online cialis canada ’

    February 2, 2021 at 01:08 | Report abuse | Reply
    • Tara

      The best herbal Cure for herpes......... Contact robinson.buckler [@]yahoo[.] com..]]]]]!!!🙂 🙂 🙂

      March 3, 2021 at 06:35 | Report abuse |
  2. JbbvEncox

    northwest pharmacy canadadrugs best canadian mail order pharmacies

    February 4, 2021 at 08:00 | Report abuse | Reply
  3. FqhhEncox

    Cialis Soft Tabs arthritis women's health

    February 4, 2021 at 09:37 | Report abuse | Reply
  4. AhkdEncox

    mexican pharmacies online best online international pharmacies canadianpharmacyusa24h

    February 4, 2021 at 12:43 | Report abuse | Reply
  5. KbcxMile

    board of pharmacy canada drugs medicine online order

    February 5, 2021 at 13:33 | Report abuse | Reply
  6. NncsZisse

    buy viagra online usa viagra canada buy viagra online express shipping

    February 6, 2021 at 11:52 | Report abuse | Reply
  7. xemkqxs.com

    I was recommended this blog by my cousin. I am not sure whether this post is written by him as no one else know such detailed about my difficulty. You are amazing! Thanks!|


    February 6, 2021 at 15:09 | Report abuse | Reply
  8. froleprotrem

    I enjoy looking through and I think this website got some truly useful stuff on it! .


    February 6, 2021 at 15:20 | Report abuse | Reply
  9. zortilo nrel

    I just couldn't depart your site prior to suggesting that I extremely enjoyed the standard information a person provide for your visitors? Is going to be back often in order to check up on new posts


    February 7, 2021 at 04:07 | Report abuse | Reply
  10. LbsxEncox

    general health viagra price drug prices comparison

    February 7, 2021 at 13:42 | Report abuse | Reply
  11. Kuikseelt

    buying viagra online legal viagra 50 vs 100mg coupons viagra

    February 7, 2021 at 19:02 | Report abuse | Reply
  12. Fókuszpályázat

    With havin so much content do you ever run into any issues of plagorism or copyright infringement? My blog has a lot of completely unique content I've either written myself or outsourced but it looks like a lot of it is popping it up all over the web without my agreement. Do you know any ways to help stop content from being ripped off? I'd genuinely appreciate it.


    February 9, 2021 at 03:19 | Report abuse | Reply
  13. Fókuszpályázat

    This site can be a walk-through for the entire information you wished about this and didn’t know who to ask. Glimpse right here, and also you’ll positively discover it.


    February 9, 2021 at 04:29 | Report abuse | Reply
  14. JbnbCrulk

    rx online panacea pharmacy international pharmacies that ship to the usa

    February 9, 2021 at 06:31 | Report abuse | Reply
  15. FvfcZisse

    pharmacie canadienne purchasing generic viagra using a paypal account buy viagra online w/questionnaire

    February 9, 2021 at 22:49 | Report abuse | Reply
  16. FqbbEncox

    cash loans greenville tx citibank cash loan singapore cash money payday advance saginaw mi

    February 11, 2021 at 07:10 | Report abuse | Reply
  17. JbbnEncox

    cialis 10 mg fiyatД± buy cialis online next day delivery cialis 5 mg somministrazione

    February 11, 2021 at 08:21 | Report abuse | Reply
  18. AhbzEncox

    cash advance 46360 guaranteed payday loans with no upfront fees advance america loan rates

    February 11, 2021 at 10:21 | Report abuse | Reply
  19. KvaxMile

    moneywise group home loans payday loan store merrillville in payday loans 46260

    February 12, 2021 at 11:59 | Report abuse | Reply
  20. NbnhZisse

    where to buy viagra in india order generic viagra from canada viagra price pharmacy

    February 14, 2021 at 00:48 | Report abuse | Reply
  21. LabxEncox

    rimedi naturali cialis cialis mas red bull rock hard song cialis commercial

    February 14, 2021 at 04:33 | Report abuse | Reply
  22. Kbbfseelt

    what\'s the difference in viagra viagra 36 hour buy ship viagra to canada

    February 14, 2021 at 05:43 | Report abuse | Reply
  23. JbnvCrulk

    wages payday advance loans cash advance online arizona payday loans not using teletrack

    February 16, 2021 at 19:20 | Report abuse | Reply
  24. FbsgZisse

    cialis, 20 mg, canadian http://llecialisjaw.com/ cialis soft tabs canada

    February 18, 2021 at 00:24 | Report abuse | Reply
  25. Tanzck

    your misery Treatment

    research studies do not predict individual responses to a specific depression treatment. put differently, want,wish treatment works for some (and / or most) People does not mean it is useful for you. It important to keep this in mind as you or a loved one undergoes treatment for depression, Because the first treatment or first set of treatments may not be efficient.

    sadness is a complex disorder. Most clinicians practicing today believe it's caused by a mix biological (just like genetics and bacterial), Social, And thought factors. A treatment approach that focuses exclusively on one of these factors is not likely to be as beneficial as a treatment approach that addresses both psychological and biological aspects (by way of, as an example, psychotherapy and medication). in point of fact, the mixture of psychotherapy and medication may provide the quickest, most powerful results.

    Depression treatment takes time. It normally takes up to 8 weeks to feel the effects of medication. But not everyone feels better after taking the first prescribed medication. You may have to try two or three different medications before finding the one which works for you. The same might be true for psychiatric therapy the first therapist might not be the one you end up working with. Most psychiatric therapy treatments for depression take 6 to 12 months, With weekly 50 minute lessons.

    hypnotherapy for DepressionToday, There's any amount of effective psychosocial treatments for depression. Some types of hypnosis have undergone more rigorous research than others. in addition, in total, The below care is helpful options. All are cash advance therapies, Lasting any place from 10 to 20 sessions.

    Cognitive behaviour therapy (CBT) Is famed and commonly used therapy for depression. Hundreds of experiments have been conducted that verify its safety and effectiveness. CBT focuses on changing negative or distorted thoughts and behaviors that perpetuate your depression. CBT typically doesn't target the past, But on changing your opinions, beliefs and feelings, And behaviors as of the moment. sociable therapy (IPT) Addresses an individual social associations, And how this will aid them. It's believed that good, Stable social support is imperative to a person overall well being. When partnerships falter, A person directly is experiencing the negativity and unhealthiness of that relationship. Therapy seeks to improve a person spousal relationship skills, with regard to: attaching effectively, Expressing emotions in the correct fashion, And being properly assertive in personal and licensed situations. You'll learn to notice if you're starting to get depressed, And to engage in activities that are aligned with your wants and values (Which is critical, Because sadness causes isolation, sleepiness, And lack of great interest). These activities might include anything from a bit of time with loved ones to taking a yoga class. BA is practical and helps you identify your goals, And get to them. People with depression might view problems as threats and believe they're not capable of solving them. The primary goal is to lower symptoms, And the secondary goal is to decrease your weeknesses to depression, And ones resilience. STPP is a family of coverings that's rooted in theories of psychoanalysis, Including drive therapy, Ego psychology, Object relations therapy, addition theory, And self therapy. Such therapy focuses on the interpersonal relationships among family members and seeks so communications are clear and without double (unknown) definitions. Also examined are the roles various spouse and children play in reinforcing your depression. companies provided include voicing your concerns with your therapist, And doing any daily or weekly assignments between therapy sessions. Therapy is an active cooperation between therapist and client.

    The most commonly prescribed medications for depression are mao inhibitors. Most antidepressants prescribed today are both safe and effective when taken as directed by your physician or psychiatrist. Are often prescribed by family doctors or general enthusiasts, You should nearly always seek out a psychiatrist for the best treatment of depression with medications.

    today, Selective this reuptake inhibitors (SSRIs) are likely to be prescribed for depression with Prozac (Fluoxetine), Paxil (Paroxetine), Zoloft (Sertraline), and as well,as well as the Luvox (Fluvoxamine) Being the mostly prescribed brand names. SSRIs work on helping the amount of serotonin in the brain. Researchers are not sure why a rise in serotonin helps relieve depression, But decades worth of studies suggest such medications nonetheless help to improve mood.

    SSRIs were once thought to have fewer side effects than other mao inhibitors, But research a long time ago decade suggests otherwise. While SSRIs are believed to be safe, Most people will experience side effects while taking them, include things like nausea, diarrhoea, dating a latina frustration, sleep loss, Or throbbing headache. for many, These initial aspect effects dissipate within 3 to 4 weeks.

    Many people taking an SSRI complain of sexual facet effects, Such as decreased virility (minimized libido), retarded orgasm, Or an inability to have an orgasm. some individuals also experience tremors with SSRIs. Serotonin syndrome is a rare but serious neurological condition for this use of SSRIs. It is seen as a high fevers, Seizures, And heart rhythm disorders.

    Long term side effects of taking SSRIs for over a year include sleep disturbance, sexual dysfunction, And fat.

    the massive scale, Multi clinic government research study called STARD found that individuals with depression who take medication often need to try different brands and be patient before they find one that works for them. The effects of medications will often be felt within 6 to 8 weeks of taking an antidepressant. But not everyone feels better with the first medication they try and needs to try several other medications to find the best one for them.

    Atypical antidepressants are often prescribed when a person hasn improved with a common SSRI. Such prescription medications include nefazodone (Serzone), Trazodone (Desyrel), along with bupropion (Wellbutrin).

    Your doctor also might prescribe an atypical antipsychotic to boost the potency of your antidepressant. The FDA has approved right here atypical antipsychotics for "Add on course of action, Aripiprazole (Abilify) over 2007; Quetiapine XR (Seroquel XR) also olanzapine fluoxetine (Symbyax) on the inside 2009; and / or brexpiprazole (Rexulti) as part of 2015.

    Other medications that are used to augment the potency of an antidepressant are the mood stabilizer lithium and thyroid hormones.

    Ketamine is the newest ringing in the ears severe forms of depression. inside March 2019, The FDA approved a endorsed nasal spray called esketamine (Spravato), A fast acting drug made from ketamine, To be used together with an antidepressant for treatment resistant depression. Spravato must be widely used at a certified doctor's office or clinic, Where patients have to be monitored for 2 hours after receiving a dose. This is because Spravato has the opportunity of abuse and misuse, And a risk of sedation and dissociation. the results of esketamine trials were mixed.

    sense intruders clinics who offer ketamine intravenously. An initial set of treatment sessions of ketamine infusion runs anywhere from around $4,000 $8,000, With regular booster treatments needed every month or two. This form of newer treatment is rarely covered by health insurance. While apparently effective many people who try it, Treatment appears to be life long; on top of that, Long term effects of chronic ketamine treatments weren't studied yet.

    Watch Our urged Video on Medications for Depression

    doctor. John Grohol is the creator, Editor in Chief CEO of Psych focused. doctor. Grohol sits on the column board of the journal Computers in Human Behavior and is a founding board member and treasurer of the Society for Participatory Medicine. He writes regularly and extensively on mental health problems, The intersection of technological innovation and psychology, And advocating for greater acceptance of the importance and value of mental health in current society. You can find out about Dr. bill Grohol here.

    February 19, 2021 at 20:38 | Report abuse | Reply
  26. generic tadalafil united states

    steel rx side effects order tadalafil tadalafil 10mg

    February 20, 2021 at 19:19 | Report abuse | Reply
  27. plaquenil brand name

    erectile clinic tulsa ok generic drug for plaquenil erectile pills that work

    February 24, 2021 at 13:22 | Report abuse | Reply
  28. KndnMile

    viagra alternatives over the counter how much is viagra per pill buy real viagra online

    February 27, 2021 at 23:15 | Report abuse | Reply
  29. NbmoZisse

    which one is better viagra cialis or laverta generic cialis tadalafil where can i buy cialis 20mg

    March 1, 2021 at 07:52 | Report abuse | Reply
  30. Doris Cottier

    I just added this website to my google reader, excellent stuff. Can not get enough!


    March 1, 2021 at 13:21 | Report abuse | Reply
  31. Carroll Vautour


    March 4, 2021 at 10:13 | Report abuse | Reply
  32. Latina Rivett

    There is perceptibly a bundle to identify about this. I assume you made various good points in features also.


    March 6, 2021 at 14:26 | Report abuse | Reply
  33. Bidner

    Was required to construct that you simply hardly any phrase to thanks a lot once more about the good ideas you’ve offered here.


    March 11, 2021 at 03:54 | Report abuse | Reply
  34. sagaming

    570662 50417Hmm, I never thought about it that way. I do see your point but I believe a lot of will disagree 930120

    March 12, 2021 at 18:25 | Report abuse | Reply
  35. zortilo nrel

    whoah this blog is magnificent i love reading your posts. Keep up the great work! You know, lots of people are looking around for this info, you could help them greatly.


    March 21, 2021 at 20:49 | Report abuse | Reply
  36. FbshEncox

    https://thesisacloud.com/ – thesis topics in education writing a graduate thesis write my thesis writing your thesis

    March 23, 2021 at 03:45 | Report abuse | Reply
  37. AbgcEncox

    https://thesiswritingtob.com/ – writing a thesis paper thesis research thesis editors thesis formatting

    March 23, 2021 at 05:49 | Report abuse | Reply
  38. JvqqEncox

    https://dissertationahelp.com/ – best dissertation service dissertation guidelines dissertation writing fellowship dissertation writing help uk

    March 23, 2021 at 06:12 | Report abuse | Reply
  39. LmoppEncox

    http://essaywriteris.com/ – buy an essay cheap best essay websites can someone write my essay for me pay someone to write my essay

    March 25, 2021 at 21:10 | Report abuse | Reply
  40. FbshEncox

    https://thesisacloud.com/ – best thesis writing service psychology thesis thesis coaching thesis binding service

    March 25, 2021 at 22:55 | Report abuse | Reply
  41. AbgcEncox

    https://thesiswritingtob.com/ – thesis printing best thesis writing thesis help phd thesis search

    March 26, 2021 at 00:40 | Report abuse | Reply
  42. BrfgMile

    https://ljcialishe.com/ – cialis 20mg price https://cialisvja.com/ – mixing viagra and cialis https://viagraonlinejc.com/ – order viagra from canada https://viagratx.com/ – lemonaid health viagra https://buycialisxz.com/ – cialis recommended dosage

    March 26, 2021 at 01:17 | Report abuse | Reply
  43. AbgcEncox

    https://thesiswritingtob.com/ – thesis editors thesis thesis writing services thesis writing services uk

    March 31, 2021 at 05:25 | Report abuse | Reply
  44. GrvCrulk

    https://kloviagrli.com/ – womens viagra https://vigedon.com/ – viagra lowers blood pressure https://llecialisjaw.com/ – sildenafil vs cialis https://jwcialislrt.com/ – where to buy cialis https://jecialisbn.com/ – cialis women

    March 31, 2021 at 14:30 | Report abuse | Reply
  45. FbshEncox

    [url=https://thesisacloud.com/]thesisacloud.com[/url] how to write thesis proposal thesisacloud.com how to write thesis

    April 7, 2021 at 20:34 | Report abuse | Reply
  46. AbgcEncox

    https://thesiswritingtob.com/ – thesiswritingtob.com writing a thesis paper thesiswritingtob.com phd degree

    April 7, 2021 at 22:40 | Report abuse | Reply
  47. RfvbZisse

    cialis super active plus http://cileve.com/ online pharmacy cialis cheap

    April 23, 2021 at 04:04 | Report abuse | Reply
  48. Johnyilu

    weblog posts merely by Morgan Hamilton closing results 1

    despite the presence of prematurely deficiencies by the most important benefit a card back then come across credit card shown up inside shadows of Sears personal economic Holdings as being a credit impetus to be reckoned while having.

    did you have a lot of fun as soon as you were from high school graduation? lots of people think it was the mention of those life, And ruined that it was a terrible adventure. with me, our own secondary school.

    automated coffee machines in truth bonus my routine way up

    everything they eat subject material December 8, 2006

    tea is one of many cold drinks in the ominous landscape and even milk products also herbal tea. just now, restoring a walk has been created a lot easier with introduced of the automated espresso maker. many people org.

    finding the right chess gameplay purchase

    all other content pages December 8, 2006

    If you charmingdate like to play mentally stimulating games and you aren't able to find anyone to get you will want to look for contest get a hold of sites on the internet. the main advantage of using a mentally stimulating games computer game purchase is that you can play on you.

    determining respite your way through low interest consolidation

    top finance articles December 8, 2006

    are you considering burdened a bill difficulties? You are truly fortunate without having any. but nevertheless, we all are virtually the fact well-off. that's banking companies existing low interest loan consolidat.

    Helpful advice on dating

    social information and facts blog posts and articles December 8, 2006

    all of us have to try social sooner or later in our way of life. unfortunately, numerous might probably struggle to locate the faith for it to cost the nighttime by using a wierder. suggestions about dating is what.

    determining The numerous ways to generate income

    article finance December 8, 2006

    having ways to generate money is important that alot of people be concerned with. Some people discover ways of this predicament very easily, whilst others spend decades attempting to discover numerous reactions. discover ways.

    April 23, 2021 at 05:27 | Report abuse | Reply
  49. JbsdEncox

    Vasotec Imitrex Himplasia

    April 23, 2021 at 05:55 | Report abuse | Reply
  50. FbsfEncox

    Prograf https://uspharmus.com/ discount drugs online pharmacy

    April 24, 2021 at 02:43 | Report abuse | Reply
1 2 3 4 5 6

Leave a Reply to AbgcEncox


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.