December 11th, 2012
02:57 PM ET

HIV helps put girl's leukemia in remission

An experimental treatment in which researchers reengineer a patient's own immune system to attack cancer cells seems to have worked in a 7-year old girl named Emma Whitehead. The acute lymphoblastic leukemia that almost claimed Whitehead's life is now in remission.

Whitehead received the treatment, called T-cell immunotherapy, in April. First doctors drew Whitehead's blood, separated out white blood cells called T-cells, and then, using a disabled AIDS virus to transmit genetic material, made the T-cells capable of identifying and attacking leukemia cells.

Finally, the genetically modified T-cells were transfused back into Whitehead, where they went to work wiping out her leukemia to below the level of detection, a process that can itself be deadly.

"This is just one example now of several examples where people can now use immune cells recognizing cancer to reject, and in some cases it's been well shown for 10 years now, that they can cure certain types of cancer with this approach," says Dr. James Yang, a senior investigator at the National Cancer Institute.

"This latest research is about one such retargeting. It's targeting a single molecule, CD-19, that's on certain types of cancers."

Whitehead is one of 12 patients to undergo T-cell immunotherapy for Leukemia at the University of Pennsylvania. Other patients have responded differently, or not at all, to the treatment.

Among them, another pediatric patient initially responded to the treatment, but relapsed one month later. When the leukemia came back, it no longer had the specific CD-19 receptor that doctors had engineered her T-cells to identify on leukemic cells.

"Very often, with acute leukemia when patients relapse, they relapse fairly quickly, and the longer that Emily and other patients go without a relapse, the better the chances the leukemia won't come back, but it is still early in the follow-up," says Dr. David Porter, one of the Penn researchers. Emily is Whitehead's given name, although her family calls her Emma.

"There's a great deal of energy and effort trying to identify other targets on leukemia cells for that situation, but also useful targets that could be on other cancers where you could apply this kind therapy," he said.

Other hospitals are trying similar therapies.

soundoff (761 Responses)
  1. Towanda Barck

    I blog often and I genuinely appreciate your information. The article has truly peaked my interest. I'm going to take a note of your blog and keep checking for new information about once a week. I subscribed to your RSS feed as well.


    June 2, 2021 at 23:53 | Report abuse | Reply
  2. Johnsie Dumay

    Have you ever heard of second life (sl for short). It is basically a game where you can do anything you want. sl is literally my second life (pun intended lol). If you want to see more you can see these second life authors and blogs


    June 3, 2021 at 00:14 | Report abuse | Reply
  3. RV Remodeling Riverside

    Hi there! This blog post couldn’t be written any better! Looking through this post reminds me of my previous roommate! He continually kept preaching about this. I most certainly will send this post to him. Pretty sure he'll have a very good read. Many thanks for sharing!


    June 3, 2021 at 05:43 | Report abuse | Reply
  4. Van Sliding Door Repair

    Hello there! This post couldn’t be written much better! Reading through this article reminds me of my previous roommate! He continually kept preaching about this. I am going to send this information to him. Fairly certain he'll have a great read. Thanks for sharing!


    June 3, 2021 at 06:27 | Report abuse | Reply
  5. Mercedes Winnebago Sprinter Repair


    June 3, 2021 at 09:21 | Report abuse | Reply
  6. Digital Marketing Companies

    Having read this I thought it was very informative. I appreciate you taking the time and energy to put this informative article together. I once again find myself spending way too much time both reading and posting comments. But so what, it was still worth it!


    June 3, 2021 at 11:11 | Report abuse | Reply
  7. Digital Marketing Consultants


    June 3, 2021 at 11:49 | Report abuse | Reply
  8. RV Batteries Los Angeles


    June 3, 2021 at 12:02 | Report abuse | Reply
  9. 2016 Sprinter Repair Shops

    This is the right webpage for anyone who would like to find out about this topic. You understand a whole lot its almost tough to argue with you (not that I personally will need to…HaHa). You definitely put a brand new spin on a topic that's been discussed for many years. Wonderful stuff, just great!


    June 3, 2021 at 14:44 | Report abuse | Reply
  10. 2006 Sprinter Transmission Repair


    June 3, 2021 at 14:46 | Report abuse | Reply
  11. camper van near me


    June 3, 2021 at 16:16 | Report abuse | Reply
  12. Sprinter Van Service Near Me


    June 3, 2021 at 16:19 | Report abuse | Reply
  13. rv restoration parts

    After looking over a handful of the blog posts on your blog, I truly appreciate your way of writing a blog. I bookmarked it to my bookmark website list and will be checking back soon. Please check out my website as well and tell me your opinion.


    June 3, 2021 at 16:23 | Report abuse | Reply
  14. truck shop in orange


    June 3, 2021 at 16:23 | Report abuse | Reply
  15. SEO Marketing Business

    May I simply say what a comfort to uncover an individual who truly understands what they're discussing over the internet. You certainly realize how to bring an issue to light and make it important. A lot more people must check this out and understand this side of your story. It's surprising you're not more popular since you most certainly have the gift.


    June 3, 2021 at 23:42 | Report abuse | Reply
  16. nearest rv repair

    Way cool! Some extremely valid points! I appreciate you writing this write-up and the rest of the site is also really good.


    June 4, 2021 at 00:01 | Report abuse | Reply
  17. Sprinter V6 Return Line Repair

    May I just say what a relief to discover someone that genuinely knows what they're discussing on the net. You actually realize how to bring a problem to light and make it important. More people really need to check this out and understand this side of your story. I was surprised that you aren't more popular since you definitely have the gift.


    June 4, 2021 at 01:38 | Report abuse | Reply
  18. Video Marketing Specialist

    Your style is unique compared to other folks I've read stuff from. Many thanks for posting when you've got the opportunity, Guess I'll just book mark this web site.


    June 4, 2021 at 01:40 | Report abuse | Reply
  19. rv roof repair near me


    June 4, 2021 at 01:43 | Report abuse | Reply
  20. Mercedes Sprinter 3.0 Intake Runner Repair

    After I initially commented I seem to have clicked on the -Notify me when new comments are added- checkbox and from now on every time a comment is added I get 4 emails with the exact same comment. There has to be a means you can remove me from that service? Cheers!


    June 4, 2021 at 01:44 | Report abuse | Reply
  21. lakes near me


    June 4, 2021 at 01:44 | Report abuse | Reply
  22. Zachery Godfray

    This was awesome! I would like you to clean up all this spam though


    June 4, 2021 at 08:51 | Report abuse | Reply
  23. woodland hills body shop


    June 4, 2021 at 09:25 | Report abuse | Reply
  24. big lots near me

    I really like looking through an article that will make men and women think. Also, thank you for allowing me to comment!


    June 4, 2021 at 12:54 | Report abuse | Reply
  25. Van Dent Repair


    June 4, 2021 at 13:13 | Report abuse | Reply
  26. Sprinter Repair Shop Near Me

    Very good write-up. I definitely love this site. Keep it up!


    June 4, 2021 at 14:20 | Report abuse | Reply
  27. rv generator repair near me

    Good write-up. I definitely appreciate this site. Keep writing!


    June 4, 2021 at 17:15 | Report abuse | Reply
  28. Digital Marketing Company Near Me


    June 5, 2021 at 00:15 | Report abuse | Reply
  29. toilet repair near me


    June 5, 2021 at 01:12 | Report abuse | Reply
  30. movies stores near me


    June 5, 2021 at 01:18 | Report abuse | Reply
  31. sushi near me


    June 5, 2021 at 01:22 | Report abuse | Reply
  32. Best Tucker Sprinter Repair


    June 5, 2021 at 01:32 | Report abuse | Reply
  33. Sprinter Window Regulator Repair


    June 5, 2021 at 02:29 | Report abuse | Reply
  34. Alease Jaross

    This was awesome! I would like you to clean up all this spam though


    June 5, 2021 at 03:26 | Report abuse | Reply
  35. Mercedes Sprinter Repair Panels


    June 5, 2021 at 18:53 | Report abuse | Reply
  36. dent devil san diego

    Excellent blog you have here.. Itís difficult to find high quality writing like yours nowadays. I seriously appreciate people like you! Take care!!


    June 5, 2021 at 19:37 | Report abuse | Reply
  37. denny's near me


    June 5, 2021 at 21:29 | Report abuse | Reply
  38. Mercedes Benz Sprinter Turbo Actuator Repair


    June 6, 2021 at 01:34 | Report abuse | Reply
  39. eryaman escort

    Great information. Lucky me I discovered your blog
    by chance (stumbleupon). I have saved as a favorite for later!

    June 6, 2021 at 02:12 | Report abuse | Reply
  40. rv vinyl wraps


    June 6, 2021 at 15:52 | Report abuse | Reply
  41. Transit Van Repair Panels


    June 6, 2021 at 23:56 | Report abuse | Reply
  42. RV Fiberglass Repair Near Me


    June 6, 2021 at 23:58 | Report abuse | Reply
  43. robux giveaway

    Hi there, after reading this awesome paragraph i am too
    glad to share my experience here with friends.

    June 7, 2021 at 00:59 | Report abuse | Reply
  44. Ollie Thain

    This was great! I would like you to clean up all this spam though


    June 7, 2021 at 13:30 | Report abuse | Reply
  45. checkers near me


    June 7, 2021 at 14:14 | Report abuse | Reply
  46. rv body repair shops near me


    June 7, 2021 at 22:00 | Report abuse | Reply
  47. geico near me

    I'm pretty pleased to uncover this page. I wanted to thank you for your time just for this wonderful read!! I definitely savored every little bit of it and I have you book marked to see new things on your web site.


    June 7, 2021 at 22:00 | Report abuse | Reply
  48. rv air conditioning repair near me

    I seriously love your website.. Excellent colors & theme. Did you make this amazing site yourself? Please reply back as Iím trying to create my own personal site and would love to learn where you got this from or what the theme is named. Kudos!


    June 7, 2021 at 22:01 | Report abuse | Reply
  49. RV Refrigerator Los Angeles


    June 7, 2021 at 22:01 | Report abuse | Reply
  50. repair shops near me

    Aw, this was a very good post. Taking a few minutes and actual effort to produce a superb articleÖ but what can I sayÖ I hesitate a lot and never seem to get nearly anything done.


    June 8, 2021 at 09:38 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

Leave a Reply to Mercedes Sprinter Chasis Repair


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.