December 11th, 2012
02:57 PM ET

HIV helps put girl's leukemia in remission

An experimental treatment in which researchers reengineer a patient's own immune system to attack cancer cells seems to have worked in a 7-year old girl named Emma Whitehead. The acute lymphoblastic leukemia that almost claimed Whitehead's life is now in remission.

Whitehead received the treatment, called T-cell immunotherapy, in April. First doctors drew Whitehead's blood, separated out white blood cells called T-cells, and then, using a disabled AIDS virus to transmit genetic material, made the T-cells capable of identifying and attacking leukemia cells.

Finally, the genetically modified T-cells were transfused back into Whitehead, where they went to work wiping out her leukemia to below the level of detection, a process that can itself be deadly.

"This is just one example now of several examples where people can now use immune cells recognizing cancer to reject, and in some cases it's been well shown for 10 years now, that they can cure certain types of cancer with this approach," says Dr. James Yang, a senior investigator at the National Cancer Institute.

"This latest research is about one such retargeting. It's targeting a single molecule, CD-19, that's on certain types of cancers."

Whitehead is one of 12 patients to undergo T-cell immunotherapy for Leukemia at the University of Pennsylvania. Other patients have responded differently, or not at all, to the treatment.

Among them, another pediatric patient initially responded to the treatment, but relapsed one month later. When the leukemia came back, it no longer had the specific CD-19 receptor that doctors had engineered her T-cells to identify on leukemic cells.

"Very often, with acute leukemia when patients relapse, they relapse fairly quickly, and the longer that Emily and other patients go without a relapse, the better the chances the leukemia won't come back, but it is still early in the follow-up," says Dr. David Porter, one of the Penn researchers. Emily is Whitehead's given name, although her family calls her Emma.

"There's a great deal of energy and effort trying to identify other targets on leukemia cells for that situation, but also useful targets that could be on other cancers where you could apply this kind therapy," he said.

Other hospitals are trying similar therapies.

soundoff (761 Responses)
  1. Content Marketing Near Me


    May 11, 2021 at 15:58 | Report abuse | Reply
  2. Social Media Marketing Agency Around Me

    This is the perfect web site for anyone who hopes to understand this topic. You understand a whole lot its almost hard to argue with you (not that I actually will need to…HaHa). You definitely put a brand new spin on a topic that has been written about for a long time. Wonderful stuff, just wonderful!


    May 11, 2021 at 18:37 | Report abuse | Reply
  3. Content Marketing Market


    May 11, 2021 at 18:38 | Report abuse | Reply
  4. RV Wraps Near Me


    May 11, 2021 at 19:44 | Report abuse | Reply
  5. orange county truck service


    May 11, 2021 at 20:19 | Report abuse | Reply
  6. camper repair shops near me


    May 11, 2021 at 22:55 | Report abuse | Reply
  7. Chevy Van Repair

    An interesting discussion is worth comment. I do believe that you ought to publish more on this subject matter, it might not be a taboo subject but usually people do not speak about these topics. To the next! Best wishes!!


    May 11, 2021 at 23:56 | Report abuse | Reply
  8. motorhome repair shops

    Hi there! I could have sworn I’ve visited this website before but after browsing through many of the posts I realized it’s new to me. Regardless, I’m certainly pleased I discovered it and I’ll be bookmarking it and checking back frequently!


    May 12, 2021 at 02:18 | Report abuse | Reply
  9. rv shower wall repair


    May 12, 2021 at 03:06 | Report abuse | Reply
  10. Sidney Semenec

    This was awesome! I would like you to clean up all this spam though


    May 12, 2021 at 05:00 | Report abuse | Reply
  11. RV Bedroom Los Angeles

    Very good post. I am dealing with many of these issues as well..


    May 12, 2021 at 09:19 | Report abuse | Reply
  12. RV Supplies Los Angeles

    An interesting discussion is worth comment. I believe that you should publish more on this topic, it might not be a taboo subject but generally folks don't talk about these subjects. To the next! Cheers!!


    May 12, 2021 at 09:34 | Report abuse | Reply
  13. Diesel Sprinter Engine Repair Service


    May 12, 2021 at 15:03 | Report abuse | Reply
  14. travel trailers for sale in orange county ca


    May 12, 2021 at 15:48 | Report abuse | Reply
  15. mcd shades repair


    May 12, 2021 at 17:06 | Report abuse | Reply
  16. custom rv painting


    May 12, 2021 at 17:34 | Report abuse | Reply
  17. RV Storage Riverside


    May 12, 2021 at 17:39 | Report abuse | Reply
  18. RV Dent Repair Los Angeles


    May 12, 2021 at 20:18 | Report abuse | Reply
  19. trailer repair near me now

    There's certainly a great deal to find out about this issue. I really like all the points you made.


    May 12, 2021 at 20:20 | Report abuse | Reply
  20. nearby rv repair


    May 12, 2021 at 20:30 | Report abuse | Reply
  21. Mercedes Sprinter Van Abs Repair


    May 12, 2021 at 21:34 | Report abuse | Reply
  22. rv floor repair cost

    Great post. I am experiencing some of these issues as well..


    May 13, 2021 at 00:48 | Report abuse | Reply
  23. Sprinter Van Rooftop A/C Leak Repair


    May 13, 2021 at 01:00 | Report abuse | Reply
  24. rv inspection service near me

    Hi, I do believe this is an excellent web site. I stumbledupon it 😉 I will return once again since I book-marked it. Money and freedom is the greatest way to change, may you be rich and continue to guide other people.


    May 13, 2021 at 02:14 | Report abuse | Reply
  25. RV Plumbing Riverside


    May 13, 2021 at 02:19 | Report abuse | Reply
  26. RV AC Near Me


    May 13, 2021 at 05:13 | Report abuse | Reply
  27. rv collision repair

    I’m impressed, I have to admit. Rarely do I come across a blog that’s both equally educative and engaging, and let me tell you, you have hit the nail on the head. The issue is something which too few folks are speaking intelligently about. Now i'm very happy I found this during my search for something concerning this.


    May 13, 2021 at 05:55 | Report abuse | Reply
  28. car upholstery repair orange county


    May 13, 2021 at 12:21 | Report abuse | Reply
  29. videos stores near me

    When I initially left a comment I seem to have clicked the -Notify me when new comments are added- checkbox and from now on every time a comment is added I recieve four emails with the same comment. Is there an easy method you are able to remove me from that service? Appreciate it!


    May 13, 2021 at 14:13 | Report abuse | Reply
  30. orange county tv repair


    May 13, 2021 at 16:47 | Report abuse | Reply
  31. RV Upholstery Orange County


    May 13, 2021 at 17:57 | Report abuse | Reply
  32. trailer repair near me now

    Everything is very open with a really clear clarification of the challenges. It was truly informative. Your website is extremely helpful. Thanks for sharing!


    May 13, 2021 at 21:01 | Report abuse | Reply
  33. orange county rv dealers

    Very good article. I am dealing with a few of these issues as well..


    May 13, 2021 at 22:11 | Report abuse | Reply
  34. RV Remodeling Riverside


    May 14, 2021 at 01:30 | Report abuse | Reply
  35. wall paint shops near me

    Aw, this was an exceptionally good post. Spending some time and actual effort to produce a superb article… but what can I say… I hesitate a whole lot and never seem to get anything done.


    May 14, 2021 at 02:10 | Report abuse | Reply
  36. 2016 Sprinter Repair Shops

    An intriguing discussion is worth comment. There's no doubt that that you need to publish more about this subject matter, it may not be a taboo matter but generally people do not speak about these subjects. To the next! Best wishes!!


    May 14, 2021 at 08:32 | Report abuse | Reply
  37. trailer services near me

    This site certainly has all the information and facts I wanted concerning this subject and didn’t know who to ask.


    May 14, 2021 at 08:49 | Report abuse | Reply
  38. Art Van Repair


    May 14, 2021 at 09:06 | Report abuse | Reply
  39. Dodge Sprinter Repair Near Me


    May 14, 2021 at 11:26 | Report abuse | Reply
  40. school bus repair near me


    May 14, 2021 at 12:40 | Report abuse | Reply
  41. Vision Center

    That is a good tip especially to those new to the blogosphere. Simple but very precise info… Thank you for sharing this one. A must read article!


    May 14, 2021 at 15:28 | Report abuse | Reply
  42. Maserati Orlando


    May 14, 2021 at 15:57 | Report abuse | Reply
  43. near by home for sale


    May 14, 2021 at 16:29 | Report abuse | Reply
  44. rv remodeling companies


    May 14, 2021 at 18:05 | Report abuse | Reply
  45. rv repair los angeles

    I enjoy reading an article that will make people think. Also, thank you for allowing for me to comment!


    May 14, 2021 at 20:19 | Report abuse | Reply
  46. three bedroom houses for sale near me


    May 14, 2021 at 20:49 | Report abuse | Reply
  47. rv parts close to me


    May 14, 2021 at 21:19 | Report abuse | Reply
  48. Pediatric Eye Exam


    May 14, 2021 at 23:07 | Report abuse | Reply
  49. house for sale wallace id


    May 14, 2021 at 23:16 | Report abuse | Reply
  50. fiberglass repair near me

    I really love your site.. Excellent colors & theme. Did you create this amazing site yourself? Please reply back as I’m looking to create my own website and would like to find out where you got this from or exactly what the theme is called. Appreciate it!


    May 15, 2021 at 01:49 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

Leave a Reply to rv shower wall repair


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.