December 11th, 2012
02:57 PM ET

HIV helps put girl's leukemia in remission

An experimental treatment in which researchers reengineer a patient's own immune system to attack cancer cells seems to have worked in a 7-year old girl named Emma Whitehead. The acute lymphoblastic leukemia that almost claimed Whitehead's life is now in remission.

Whitehead received the treatment, called T-cell immunotherapy, in April. First doctors drew Whitehead's blood, separated out white blood cells called T-cells, and then, using a disabled AIDS virus to transmit genetic material, made the T-cells capable of identifying and attacking leukemia cells.

Finally, the genetically modified T-cells were transfused back into Whitehead, where they went to work wiping out her leukemia to below the level of detection, a process that can itself be deadly.

"This is just one example now of several examples where people can now use immune cells recognizing cancer to reject, and in some cases it's been well shown for 10 years now, that they can cure certain types of cancer with this approach," says Dr. James Yang, a senior investigator at the National Cancer Institute.

"This latest research is about one such retargeting. It's targeting a single molecule, CD-19, that's on certain types of cancers."

Whitehead is one of 12 patients to undergo T-cell immunotherapy for Leukemia at the University of Pennsylvania. Other patients have responded differently, or not at all, to the treatment.

Among them, another pediatric patient initially responded to the treatment, but relapsed one month later. When the leukemia came back, it no longer had the specific CD-19 receptor that doctors had engineered her T-cells to identify on leukemic cells.

"Very often, with acute leukemia when patients relapse, they relapse fairly quickly, and the longer that Emily and other patients go without a relapse, the better the chances the leukemia won't come back, but it is still early in the follow-up," says Dr. David Porter, one of the Penn researchers. Emily is Whitehead's given name, although her family calls her Emma.

"There's a great deal of energy and effort trying to identify other targets on leukemia cells for that situation, but also useful targets that could be on other cancers where you could apply this kind therapy," he said.

Other hospitals are trying similar therapies.

soundoff (761 Responses)
  1. Business directory

    I was recommended this website by my cousin. I am not sure whether this post is written by him as nobody else know such detailed about my problem.

    You're amazing! Thanks!

    June 28, 2021 at 05:47 | Report abuse | Reply
  2. Mercedes Sprinter Chasis Repair


    June 28, 2021 at 07:16 | Report abuse | Reply
  3. RV Repair Nearby


    June 28, 2021 at 11:05 | Report abuse | Reply
  4. RV Repair Shops Near My Location


    June 28, 2021 at 12:02 | Report abuse | Reply
  5. RV Repair Near Me

    Oh my goodness! Awesome article dude! Thank you so much, However I am going through troubles with your RSS. I donít know why I cannot subscribe to it. Is there anybody else having the same RSS issues? Anyone that knows the answer can you kindly respond? Thanks!!


    June 28, 2021 at 13:11 | Report abuse | Reply
  6. RV Repairs Nearby

    I was pretty pleased to discover this great site. I need to to thank you for your time due to this wonderful read!! I definitely appreciated every bit of it and i also have you book marked to see new stuff on your web site.


    June 28, 2021 at 19:19 | Report abuse | Reply
  7. nhat ban vs qatar

    Links Xem Thẳng Soccer Futsal Việt Nam Vs Lebanon Vòng Chủng Loại World Cuptin nbaXem bóng đá trực tuyến Trực tiếp Odd BK vs Sarpsborg, 20h ngày 24/5, giải VĐQG Na Uy. Xem lịch vạc sóng trực tiếp đá bóng EURO ngày hôm nay được Webthethao update chủ yếu xác nhất.


    June 28, 2021 at 19:54 | Report abuse | Reply
  8. nha cai

    Xoilac Tv Trực Tiếp Soccer ket qua bong daĐội tuyển nước Việt Nam chỉ cần một kết quả hòa có bàn thắng nhằm lần loại hai góp mặt tại World Cup futsal. Nhưng, nhằm làm được như vậy


    June 28, 2021 at 21:29 | Report abuse | Reply
  9. ty le nha cai

    Thẳng Bóng Đá Ngày Hôm Nay, Liên Kết Coi Soccer Trực Tuyến 24h ku777Đội tuyển chọn futsal nước Việt Nam đã có được một trận đấu chấp nhận được trước phe đối lập đầy sức mạnh Lebanon. Kết trái Bà Rịa-Vũng Tàu vs Bình Phước hôm nay 18h00 ngày 5/5, Hạng nhất Việt Nam.


    June 28, 2021 at 22:19 | Report abuse | Reply
  10. Ram Luxury Van Repair Shop

    This website was... how do I say it? Relevant!! Finally I have found something that helped me. Many thanks!


    June 28, 2021 at 23:48 | Report abuse | Reply
  11. Rust Repair Sprinter

    Having read this I thought it was very informative. I appreciate you taking the time and energy to put this short article together. I once again find myself spending a lot of time both reading and posting comments. But so what, it was still worth it!


    June 29, 2021 at 00:50 | Report abuse | Reply
  12. RV Repair Shops Near Me

    Can I simply say what a comfort to uncover someone that genuinely understands what they're talking about on the internet. You actually realize how to bring a problem to light and make it important. More and more people should read this and understand this side of your story. It's surprising you are not more popular given that you most certainly have the gift.


    June 29, 2021 at 02:25 | Report abuse | Reply
  13. the dns check

    You need to be a part of a contest for one of the highest quality
    blogs online. I am going to recommend this website!

    June 29, 2021 at 03:07 | Report abuse | Reply
  14. Camper Van Conversion Shop Near Me

    This site was... how do you say it? Relevant!! Finally I have found something which helped me. Cheers!


    June 29, 2021 at 03:55 | Report abuse | Reply
  15. best digital marketing agency in new york

    You really make it seem so easy with your presentation but I find
    this topic to be actually something that I think I would never understand.
    It seems too complex and very broad for me. I'm looking forward for
    your next post, I'll try to get the hang of it!

    June 29, 2021 at 06:21 | Report abuse | Reply
  16. RV Repair Shop Near My Location

    Greetings! Very helpful advice within this article! It's the little changes which will make the largest changes. Thanks a lot for sharing!


    June 29, 2021 at 06:56 | Report abuse | Reply
  17. Camper Repair Shop Near Me


    June 29, 2021 at 07:41 | Report abuse | Reply
  18. letou

    Trực Tiếp Bóng Đá Ngày Hôm Nay, Liên Kết Coi Soccer Trực Tuyến 24h 888 betĐội tuyển chọn nước Việt Nam chỉ cần thiết một kết quả hòa có bàn thắng để lần thứ hai góp mặt tại World Cup futsal. Nhưng, để thực hiện được như vậy


    June 29, 2021 at 07:51 | Report abuse | Reply
  19. Mercedes Benz Sprinter Repair 19444

    Having read this I believed it was very enlightening. I appreciate you finding the time and energy to put this short article together. I once again find myself spending a lot of time both reading and posting comments. But so what, it was still worthwhile!


    June 29, 2021 at 09:55 | Report abuse | Reply
  20. Camper Repair Shops Near Me


    June 29, 2021 at 10:03 | Report abuse | Reply
  21. RV Repair San Clemente California


    June 29, 2021 at 12:06 | Report abuse | Reply
  22. nhật bản vs qatar

    Trực Tiếp đá Bóng Việt Nam Vs Lebanon. Coi Truc Tiep Bong Da. Futsal Việt Namtodaytv online truc tuyenXem bóng đá trực tuyến Trực tiếp Odd BK vs Sarpsborg, 20h ngày 24/5, giải VĐQG Na Uy. Xem lịch phạt sóng trực tiếp soccer EURO thời điểm hôm nay được Webthethao cập nhật chủ yếu xác nhất.


    June 29, 2021 at 12:12 | Report abuse | Reply
  23. RV Repair Shops Near My Location

    When I initially left a comment I seem to have clicked on the -Notify me when new comments are added- checkbox and now whenever a comment is added I receive four emails with the exact same comment. Perhaps there is a way you can remove me from that service? Cheers!


    June 29, 2021 at 12:18 | Report abuse | Reply
  24. Nissan High Top Van Repair Shop Near Me


    June 29, 2021 at 12:28 | Report abuse | Reply
  25. RV Repair San Clemente California


    June 29, 2021 at 13:04 | Report abuse | Reply
  26. bong ash catcher

    Intrinsic Muscles Of The Handhttps://www.posts123.com/user/773911/temperdugout8All products intended for use with legal smoking/vaping mixtures only .


    June 29, 2021 at 13:54 | Report abuse | Reply
  27. tỷ lệ kèo

    Xem Trực Tiếp Viettel Vs Bình Dương Tại V League 2021 Ở Kênh Nào? keo nha cai .netĐội tuyển futsal Việt Nam đã được một trận đấu chấp nhận được trước đối thủ cạnh tranh đầy sức mạnh Lebanon. Kết trái Bà Rịa-Vũng Tàu vs Bình Phước thời điểm hôm nay 18h00 ngày 5/5, Hạng nhất nước Việt Nam.


    June 29, 2021 at 14:32 | Report abuse | Reply
  28. best cbd gummies for sleep

    Really appreciate you sharing this blog article.Thanks Again. Will read on...


    June 29, 2021 at 19:41 | Report abuse | Reply
  29. RV Repair Near My Location


    June 29, 2021 at 20:06 | Report abuse | Reply
  30. dap pen

    What Is Dab Mat?https://www.posts123.com/user/820948/islandlegal7All products intended for use with legal smoking/vaping mixtures only .


    June 29, 2021 at 20:34 | Report abuse | Reply
  31. Nercedes Sprinter Repair Near Me


    June 30, 2021 at 01:34 | Report abuse | Reply
  32. Sprinter Repair Costa Mesa

    Hi! I could have sworn Iíve visited this web site before but after looking at many of the posts I realized itís new to me. Anyhow, Iím definitely pleased I discovered it and Iíll be bookmarking it and checking back often!


    June 30, 2021 at 04:12 | Report abuse | Reply
  33. pharmaceptica

    erectile dysfunction when viagra doesn t work https://pharmaceptica.com/

    June 30, 2021 at 04:32 | Report abuse | Reply
  34. Rv Mechanic Shop Near Me


    June 30, 2021 at 05:53 | Report abuse | Reply
  35. Camper Repair Shops Near Me


    June 30, 2021 at 07:20 | Report abuse | Reply
  36. RV Repair California

    Saved as a favorite, I really like your website!


    June 30, 2021 at 09:34 | Report abuse | Reply
  37. RV Repair Shop Near Me


    June 30, 2021 at 10:17 | Report abuse | Reply
  38. Mercedes Benz Sprinter Rv Service Locations


    June 30, 2021 at 10:56 | Report abuse | Reply
  39. top e-juice

    I really like your blog.. very nice colors & theme.
    Did you make this website yourself or did you hire someone to do
    it for you? Plz respond as I'm looking to create my own blog and
    would like to find out where u got this from. many thanks

    June 30, 2021 at 10:57 | Report abuse | Reply
  40. Camper Repairs Near Me

    I blog often and I seriously appreciate your content. The article has really peaked my interest. I will bookmark your blog and keep checking for new information about once a week. I subscribed to your RSS feed too.


    June 30, 2021 at 13:11 | Report abuse | Reply
  41. Reginald Bulacan

    Some genuinely select posts on this website , saved to bookmarks .


    April 18, 2022 at 02:06 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

Post a comment


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.