Cervical cancer vaccine in early stages
October 10th, 2012
02:00 PM ET

Cervical cancer vaccine in early stages

The most common sexually transmitted disease is often silent and invisible: human papillomavirus (also called HPV). But in some people HPV leads to genital warts and cancers – notably, cervical cancer.

The vaccines Gardasil and Cervarix were designed as a prevention for young women who have not yet been exposed to HPV. Men up to age 26 are also eligible for Gardasil to protect against HPV. But there are a lot of people out there who still have HPV, and nothing protects against all 130 strains of the virus. At least half of all sexually active males and females have had HPV, according to the Centers for Disease Control and Prevention.

A Pennsylvania start-up company called Inovio Pharmaceuticals has developed an experimental vaccine for people who already have HPV and precancerous lesions that are associated with it. A new study demonstrating the vaccine's safety and potential effectiveness was published this week in the journal Science Translational Medicine.

The experimental vaccine does not use the live HPV virus; it is formulated in synthetic DNA and pure water. It uses the immune system of the treated women to fight off cancer, said Joseph Kim, president and CEO of Inovio Pharmaceuticals and study co-author.

Worldwide, cervical cancer is the second most common cancer after breast cancer, with about 493,000 new cases and 274,000 deaths annually, the study said. HPV causes about 5% of cancers globally.

Some women, because of their particular genetic makeup, can clear precancerous lesions on their own and would not need this vaccine. This happens in anywhere from 10% to 25% of women infected with HPV, Kim said.

No one knows why some women have this capability and others do not, but for those who lack it the Inovio vaccine is "giving our immune system a little boost," Kim said.

Eighteen women with high-grade precancerous cervical lesions participated in the phase 1 study.

Study authors say the vaccine is formulated to work against all cancers caused by HPV types 16 and 18, including cervical, anogenital (anal and genital), and head and neck cancers. The researchers did not observe any side effects.

In the next phase of this research 150 women worldwide are participating, but they are not included in these published results, Kim said.

The phase 1 results are very early in the experimentation of this vaccine. The study was not done as a randomized controlled trial, the gold standard for determining whether a drug works better than chance. Also, 18 people is a small number for examining the effects of a medication.

Given those drawbacks, it’s not appropriate to draw too many conclusions from this study, says Dr. Diane Harper, a prominent HPV researcher at the University of Missouri – Kansas City’s School of Medicine. Harper contributed to the studies on both HPV vaccines that are currently available, Cervarix and Gardasil, and is not involved with this research.

“Several therapeutic vaccines have shown great promise in phase 1 and then not panned out in phase 2,” she noted in an e-mail.

The vaccine consists of three injections in the arm over three months, Kim said. The vaccine trains T-cells in the body to go after cervical cells with potentially cancerous genes embedded in them.

Inovio is using this technology to develop vaccines for prostate cancer and HIV also, Kim said.

“We certainly have a technology that can change the medical field by being able to program and generate strong immune responses that are specific and effective,” he said.

Kim said the next phase results should be out at the end of 2013; then comes a larger phase 3 trial with about 500 patients, to be concluded around 2016 or 2017.

HPV is spread through genital contact, including oral sex, and partners can bounce the virus back and forth between them, making it harder to clear naturally. Kissing is not known to deliver this STD.

soundoff (257 Responses)
  1. fine dining Orlando

    Commenting on a blog is an art. Good comments create relations. You're doing great work. Keep it up.


    April 8, 2021 at 09:13 | Report abuse | Reply
  2. best italian restaurants in orlando

    Thank You for your information


    April 8, 2021 at 09:39 | Report abuse | Reply
  3. best restaurant Orlando

    best i have ever seen!Hello, always i used to check webpage posts here early in the daylight, for the reason that i love to gain knowledge of more and more.


    April 8, 2021 at 11:44 | Report abuse | Reply
  4. best restaurant Orlando

    thanks for sharing!


    April 8, 2021 at 12:19 | Report abuse | Reply
  5. Best Window Washing Service Near Me Auraria, Denver, CO

    This is a very interesting article. Please, share more like this!


    April 8, 2021 at 13:04 | Report abuse | Reply
  6. Window Washing Service Golden Triangle, Denver, CO

    I really like this post


    April 9, 2021 at 06:12 | Report abuse | Reply
  7. Window Washing Service Platt Park, Denver, CO

    Fairly high-quality explanation. continue the good work


    April 9, 2021 at 06:38 | Report abuse | Reply
  8. Window Cleaning Service University Hills, Denver, CO

    Thanks for wonderful information I used to be in search of this info for my mission.


    April 9, 2021 at 07:10 | Report abuse | Reply
  9. Window Cleaning Service Globeville

    best i have ever seen!Hello, always i used to check webpage posts here early in the daylight, for the reason that i love to gain knowledge of more and more.


    April 9, 2021 at 07:39 | Report abuse | Reply
  10. Best Window Washing Service Near Me Lower Highlands, Denver, CO

    such a great information for blogger i am a professional blogger thanks


    April 9, 2021 at 09:27 | Report abuse | Reply
  11. Best Window Cleaning Service Near Me Five Points, Denver, CO

    best i have ever seen!Hello, always i used to check webpage posts here early in the daylight, for the reason that i love to gain knowledge of more and more.


    April 9, 2021 at 10:09 | Report abuse | Reply
  12. Window Washing Service Villa Park, Denver, CO

    very nice! Ireally like your blog


    April 9, 2021 at 11:11 | Report abuse | Reply
  13. Window Washing Service Baker, Denver, CO

    A great read. I'll definitely be back.


    April 9, 2021 at 12:34 | Report abuse | Reply
  14. Window Washing Service Belcaro, Denver, CO



    April 9, 2021 at 13:05 | Report abuse | Reply
  15. Best Window Cleaning Service Near Me University Hills, Denver, CO

    thanks for sharing!


    April 9, 2021 at 13:38 | Report abuse | Reply
  16. Best Window Washing Service Near Me Belcaro, Denver, CO

    this is very informative and intersting for those who are interested in blogging field.


    April 10, 2021 at 02:38 | Report abuse | Reply
  17. Best Window Cleaning Service Near Me Platt Park, Denver, CO

    I really like this post


    April 10, 2021 at 04:48 | Report abuse | Reply
  18. Window Washing Service Barnum West, Denver, CO

    Thanks for wonderful information I used to be in search of this info for my mission.


    April 10, 2021 at 06:14 | Report abuse | Reply
  19. Window Washing Service Globeville

    such a great information for blogger i am a professional blogger thanks


    April 10, 2021 at 07:26 | Report abuse | Reply
  20. Best Window Cleaning Service Near Me South Park Hill, Denver, CO

    Wow this blog is very nice!


    April 10, 2021 at 07:54 | Report abuse | Reply
  21. Best Window Washing Service Near Me Golden Triangle, Denver, CO

    nice information for a new blogger. it is really helpful


    April 10, 2021 at 10:05 | Report abuse | Reply
  22. Window Cleaning Service East Colfax, Denver, CO

    This blog is great check it out


    April 11, 2021 at 05:39 | Report abuse | Reply
  23. erection injection medicine

    aprostadil https://alprostadildrugs.com/ injectable medication for erectile dysfunction

    April 12, 2021 at 01:24 | Report abuse | Reply
  24. organic viagra in canada

    pfizer viagra canada pharmistry https://canadaviagrastore.com/ buy viagra online from canada

    April 14, 2021 at 20:04 | Report abuse | Reply
  25. buy zithromax without prescription

    z pak 500 mg https://zithromaxes.com/ taking zithromax

    April 15, 2021 at 01:33 | Report abuse | Reply
  26. vardenafil sublingual generic

    vilitra 60mg vardenafil https://vegavardenafil.com/ why vardenafil dosage over 65

    April 17, 2021 at 07:55 | Report abuse | Reply
  27. cialis viagra combination canadian pharmacy

    buy generic cialis without prescription canadian pharmacy https://canadacialisstore.com/ cialis on line purches canadian pharmacy

    April 20, 2021 at 15:20 | Report abuse | Reply
  28. tadalafil 30 mg

    tadalafil 40 mg from india https://elitadalafill.com/ tadalafil pills

    April 24, 2021 at 09:18 | Report abuse | Reply
  29. Nick's Air Conditioning And Heating Orlando

    This blog is great check it out


    April 24, 2021 at 15:17 | Report abuse | Reply
  30. window cleaning denver

    Commenting on a blog is an art. Good comments create relations. You're doing great work. Keep it up.


    April 26, 2021 at 07:28 | Report abuse | Reply
  31. Fake GMB

    I've been absent for a while, but now I remember why I used to love this blog. Thank you, I'll try and check back more frequently. How frequently you update your web site?


    April 27, 2021 at 15:46 | Report abuse | Reply
  32. generic viagra cost walmart canada

    viagra cost canada https://canadaviagrastore.com/ viagra purchase from canada

    April 27, 2021 at 19:14 | Report abuse | Reply
  33. where to buy aralen

    cloraquinn https://chloroquineorigin.com/ chloroquine drug class

    April 28, 2021 at 02:33 | Report abuse | Reply
  34. sildenafil over the counter

    sildenafil coupon 100 mg https://eunicesildenafilcitrate.com/ sildenafil 100mg from india

    April 28, 2021 at 20:32 | Report abuse | Reply
  35. signature window washing denver CO

    thanks for sharing!


    April 29, 2021 at 16:03 | Report abuse | Reply
  36. signature window washing denver CO

    Impressive! Thanks for the post


    April 29, 2021 at 16:25 | Report abuse | Reply
  37. cialis, sale, canadian pharm.

    cialis on line purches canadian pharmacy https://canadacialisstore.com/ canadian pharmacy 5 mg daily cialis

    May 1, 2021 at 17:21 | Report abuse | Reply
  38. average perscription pills taken by 65 year old canadian?

    canadian weight loss pills https://canadapillstorex.com/ average perscription pills taken by 65 year old canadian?

    May 1, 2021 at 22:10 | Report abuse | Reply
  39. dapoxetine

    dapoxetine hydrochloride 60 priligy usa

    May 3, 2021 at 16:59 | Report abuse | Reply
  40. Airgun megastore

    Thanks for wonderful information I used to be in search of this info for my mission.


    May 5, 2021 at 15:47 | Report abuse | Reply
  41. Cupids Health


    Goodbyes are only for those who love with their eyes.

    Because for those who love with heart and soul

    there is no such thing as separation.

    Award Winning Health Alert Site.
    Be in the know before the rest.


    May 6, 2021 at 00:30 | Report abuse | Reply
  42. mersededind

    Dating utility – services as a one's duty to resolution acquaintances, friends, libidinous partners or a spouse as marriage. As a ukase, they are supported before a exclusively created coordination (epoch after ease a commercial a specific). Unpaid to their accessibility, dating services have fluctuate a stout prying in the collective fling of synchronous society.

    2021 a16ee25

    May 6, 2021 at 08:43 | Report abuse | Reply
  43. Bollywood

    hello!,I really like your writing vefy much! share we communicate more approximately your
    post on AOL? I need an expert in this area to resolve myy problem.

    Maybe that's you! Taking a look ahead to peer you.

    May 9, 2021 at 03:30 | Report abuse | Reply
  44. Petra Wassmann

    Have you ever heard of second life (sl for short). It is essentially a video game where you can do anything you want. Second life is literally my second life (pun intended lol). If you want to see more you can see these second life authors and blogs


    May 11, 2021 at 14:13 | Report abuse | Reply
  45. Cole Laravie

    This was great! I would like you to clean up all this spam though


    May 12, 2021 at 06:43 | Report abuse | Reply
1 2 3 4

Post a comment


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.