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July 11th, 2012
05:45 PM ET
Studies highlight effectiveness of HIV prevention drugA drug widely used to treat HIV is also highly effective at preventing infection in HIV-free individuals - as long as those individuals take the drug every day as prescribed, newly released trial data shows. The drug, an antiretroviral pill known as Truvada, interferes with the replication of the most common HIV virus and can reduce the risk of new infection by 62% or more if taken consistently, according to the results of three studies published today on the website of the New England Journal of Medicine. In May, based on these and other studies, a Food and Drug Administration (FDA) advisory committee recommended that the agency approve Truvada for men who have sex with men, people whose romantic partner is HIV-positive, and other high-risk groups. If approved, Truvada would be the first drug indicated for the prevention of sexually transmitted HIV. "This offers a new way to keep an HIV-negative person HIV-free," says Dr. Jared Baeten, M.D., an associate professor of global health at the University of Washington School of Public Health, in Seattle, who led one of the studies. Health.com: What are the signs of HIV? Taken together, the studies underscore the importance of strictly following the daily drug regimen. In Baeten's study, which included 4,747 heterosexual African couples in which one partner was HIV-positive, the HIV-negative partners who took Truvada had a 75% lower risk of becoming infected compared with those taking placebo. In another study, however, Truvada was found to be no more effective than placebo among women in southeast Africa. Blood tests taken during the study revealed the likely reason: Less than 40% of uninfected women had taken a daily dose within the previous 48 hours. In the Baeten study, by contrast, a tally of leftover pills at the end of each month suggested that more than 90% of the participants had followed the regimen. "The difference between the studies does seem to be one of adherence," says Baeten, using the medical term for sticking to a treatment. "In our study, one motivator for high adherence is likely that all participants knew their partners had HIV, unlike in other studies, where HIV risk may have been more theoretical to some participants." The consistency required for Truvada to be effective has important implications for real-world use, especially given the drug's annual price tag, which can run as high as $14,000 per year in the United States, says Dr. Michael Kolber, M.D., director of the Comprehensive AIDS Program at the University of Miami Miller School of Medicine. "This is an expensive drug," says Kolber. "[Adherence] is a big deal, because if doctors order [Truvada] and people don't take it, it isn't useful, yet it's a big cost." Health.com: 10 questions to ask a new partner before having sex The potential side effects documented in the studies could discourage some people from taking the drug every day, says Dr. Michael Horberg, M.D., director of HIV/AIDS at Kaiser Permanente, a large nonprofit health care provider headquartered in Oakland, California. Although the most common side effects associated with Truvada - nausea, vomiting, and dizziness - were generally benign and short-lived, one of the trials found a decrease in bone density among people taking the drug, compared to placebo. And there are signs the drug also may impair liver and kidney function. The long-term side effects of Truvada - for instance, whether the decrease in bone density might lead to fractures - are still largely unknown, which raises questions about the advisability of prescribing this expensive drug to healthy people, HIV experts say. "There are probably patients who are motivated [and] eager who would probably benefit," Horberg says. "But as a general strategy, this may or may not be a successful one." Some researchers and health-care providers have expressed concern that the sense of security offered by the drug could lead people at high risk of HIV infection to grow complacent about condom use, routine HIV testing, and other precautions. Health.com: What to do if your sex partner refuses to wear a condom For his part, Baeten stresses that all the couples in his study received counseling, condoms, and access to other preventive services, in addition to Truvada. Similarly, in their review of the drug, FDA officials emphasized that Truvada, if approved, should be accompanied by a program aimed at educating doctors and their patients about the importance of adherence and maintaining existing safeguards. Truvada "would always be part of a more comprehensive prevention strategy," says Dr. Timothy Mastro, M.D., coauthor of a study published today and a researcher at FHI 360, a nonprofit research organization based in Durham, North Carolina. The FDA typically follows the recommendations of its advisory committees. The agency is expected to issue its decision on Truvada in mid-September, according to a statement released in June by the drug's manufacturer, Gilead Sciences. Copyright Health Magazine 2011
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