home
RSS
Finding clues to Alzheimer’s in DNA
July 2nd, 2012
05:13 PM ET

Finding clues to Alzheimer’s in DNA

In what's being described as the largest, most complete genetic mapping project for a single disease, scientists Monday announced a plan to obtain the genetic make-up of more than 800 individuals enrolled in an Alzheimer’s research study.

The research will determine all 6 billion letters in each individual’s DNA. The new data – vast and shared worldwide with eligible researchers – may explain how genes cause changes in the body that lead people to develop Alzheimer’s disease.

“It’s probably dozens or scores of genes that are contributing to whether you get it and how severe it is in you,” said Dr. Robert Green, a physician-scientist at Harvard Medical School who is tasked with coordinating the genetic sequencing. “The genome is a complicated place. It’s not just about identifying a gene that puts you at risk. It’s about identifying other genes that modify those genes. It’s about identifying genes that protect you.”

The $2 million genetic sequencing project is being conducted by the Alzheimer's Disease Neuroimaging Initiative in partnership with the Alzheimer’s Association and the Brin Wojcicki Foundation.

The sequencing will be completed in three months.

It will take much longer to know whether the study participant’s decoded genomes yield any breakthrough strategies to treat the more than 5 million Americans who have Alzheimer’s disease.

“I would expect it to point us to new areas we might want to investigate for therapies,” said William Thies, chief medical and scientific officer at the Alzheimer’s Association. “I expect that it may point us to new areas that will allow us to predict who’s at high risk for Alzheimer’s disease and who could be treated early before they have any signs of dementia.”


soundoff (98 Responses)
  1. darlene

    its about time. Thank you in advance for all the hard work going into this study. I watched my grandmother linger for many years with this awful disease and it scares my to think i too might get this. So thank you.

    July 3, 2012 at 08:42 | Report abuse | Reply
  2. caseykurlander

    Hi everyone. I lived with my grandma, who has dementia and Alzheimer's for over a year. All I can say is that I have many, many stories about the ups and downs. You can check them out here:

    http://caseykurlander.wordpress.com/category/grandma/

    Thanks!
    Casey

    July 3, 2012 at 13:26 | Report abuse | Reply
  3. rachel brockmeyer

    I have my cna and working with alzheimer patients, its a very sad thing to watch someone slowly leave life and reality. I just hope in the future a cure can be made.

    July 3, 2012 at 18:19 | Report abuse | Reply
  4. Deborah Alfano

    What will the government do with our DNA once we are all on the government controlled health care program? It would be just like the government to say it is best if we are all tested so they can prepare to care for us? Do we really trust the government to take care of us? Really, is our DNA ours or does the government now have or will it have the power to force us to have DNA testing? Or will it just do the testing and not tell us? I will pay the fine before I will join any government controlled health care program.

    July 3, 2012 at 19:43 | Report abuse | Reply
    • Laura

      At least I can vote govt officials in and out. In contrast, I have no vote when it comes to the blood-sucking mega-corps that have no accountability.

      July 3, 2012 at 23:02 | Report abuse |
    • I call BS

      What the eff are you two smoking? No one is talking about forcing you to undergo any tests on your DNA. Really, dears, stop listening to those voices in your heads or on the radio.

      July 3, 2012 at 23:09 | Report abuse |
  5. Rosa Michelle

    I didn't know much about this disease, but I have recently opened my eyes, and started discovering about it..

    July 4, 2012 at 04:32 | Report abuse | Reply
  6. Kelly Schaefer

    I hope researchers can discover a test that can be given to detect Alzheimer's in unborn babies, then treat it agressively.

    Caregiver Resources

    July 13, 2012 at 18:45 | Report abuse | Reply
  7. Necole Pinales

    In my medical intuitive practice, I have often been consulted by family and friends of those whose parents or loved ones have been diagnosed with Alzheimer’s disease. The origin of this disease is unknown, however much attention is being placed upon the growth of Amyloid plaques in the brain.Amyloid plaques are waxy and translucent protein-polysaccharide complexes that are deposited in organs or tissues during certain diseases. These deposits cause the degeneration of the organ or tissue involved. Amyloid plaques are associated with a number of conditions including Alzheimer’s disease, Hodgkin’s disease and Osteomyelitis.-

    Look at the freshest content on our personal internet page
    <http://www.foodsupplementdigest.com/low-vitamin-d-symptoms/

    February 10, 2013 at 02:40 | Report abuse | Reply
  8. Julio Condi

    Alzheimer's disease is a progressive disease that destroys memory and other important mental functions. It's the most common cause of dementia — a group of brain disorders that results in the loss of intellectual and social skills. These changes are severe enough to interfere with day-to-day life. ..*-`

    Please do check into our online site
    <http://caramoan.ph/

    June 7, 2013 at 07:49 | Report abuse | Reply
  9. shelley

    contact:_________________((Robinson.buckler)) @yahoo. com,,... ........ his result is 100% guarantee. ..............He restored my broken relationship just in 48 hours…………Get Your Ex Boyfriend/Girlfriend Back! He cured me from herpes virus through herbal means...certainly the best online and...{{https://robinbuckler. com}}}}}}}}.......

    November 11, 2020 at 07:51 | Report abuse | Reply
  10. zortilonrel

    You are a very smart person!

    http://www.zortilonrel.com/

    December 18, 2020 at 11:00 | Report abuse | Reply
  11. http://www.fokuszpalyazat.hu/rolunk

    It's appropriate time to make a few plans for the longer term and it is time to be happy. I've read this post and if I may I want to recommend you some fascinating issues or advice. Perhaps you could write subsequent articles referring to this article. I desire to learn more issues approximately it!

    http://www.fokuszpalyazat.hu/rolunk

    February 9, 2021 at 03:13 | Report abuse | Reply
  12. vreyro linomit

    I'm extremely impressed with your writing skills and also with the layout on your weblog. Is this a paid theme or did you modify it yourself? Either way keep up the nice quality writing, it is rare to see a great blog like this one nowadays..

    http://www.vreyrolinomit.com/

    February 26, 2021 at 11:14 | Report abuse | Reply
  13. vách ngăn vệ sinh

    Hi my friend! I want to say that this article is amazing,
    great written and come with almost all important
    infos. I'd like to look extra posts like this .

    March 2, 2021 at 06:44 | Report abuse | Reply
  14. mbee.com.vn

    Hi! I could have sworn I've been to this blog before but after browsing through some of the post I
    realized it's new to me. Anyhow, I'm definitely delighted I found it and I'll
    be book-marking and checking back frequently!

    March 2, 2021 at 07:03 | Report abuse | Reply
  15. mbee.com.vn

    This web site certainly has all of the information I
    needed about this subject and didn't know who to ask.

    March 2, 2021 at 13:22 | Report abuse | Reply
  16. https://mbee.com.vn/dia-chi-ban-vach-ngan-ve-sinh-compact-tai-ho-chi-minh-hcm

    I know this if off topic but I'm looking into starting my own weblog and was
    curious what all is needed to get set up? I'm assuming having a blog
    like yours would cost a pretty penny? I'm not very web smart so
    I'm not 100% sure. Any suggestions or advice would be greatly appreciated.
    Many thanks

    March 2, 2021 at 14:07 | Report abuse | Reply
  17. vách ngăn vệ sinh

    Good day! Do you know if they make any plugins to protect against hackers?
    I'm kinda paranoid about losing everything I've worked hard on. Any tips?

    March 2, 2021 at 20:54 | Report abuse | Reply
  18. vách ngăn vệ sinh

    Everything is very open with a really clear explanation of the challenges.
    It was definitely informative. Your site is very helpful.
    Thanks for sharing!

    March 3, 2021 at 08:43 | Report abuse | Reply
  19. vách ngăn vệ sinh

    I pay a quick visit daily some web sites and websites to read content, except
    this webpage provides quality based writing.

    March 3, 2021 at 09:38 | Report abuse | Reply
  20. vách ngăn vệ sinh

    Hello, i think that i saw you visited my site
    thus i came to “return the favor”.I'm trying to find things to enhance
    my website!I suppose its ok to use a few of your ideas!!

    March 3, 2021 at 09:39 | Report abuse | Reply
  21. mbee.com.vn

    We absolutely love your blog and find the majority of your post's to be exactly what I'm looking
    for. can you offer guest writers to write content available for you?
    I wouldn't mind publishing a post or elaborating on a few of the
    subjects you write about here. Again, awesome web
    log!

    March 3, 2021 at 10:50 | Report abuse | Reply
  22. mbee.com.vn

    I’m not that much of a online reader to be honest but your sites really nice, keep it
    up! I'll go ahead and bookmark your site to come
    back later. All the best

    March 3, 2021 at 11:49 | Report abuse | Reply
  23. vách ngăn vệ sinh

    I loved as much as you will receive carried out right here.
    The sketch is attractive, your authored material stylish.

    nonetheless, you command get bought an edginess over that you wish be delivering the following.
    unwell unquestionably come further formerly again as exactly the same nearly
    very often inside case you shield this hike.

    March 3, 2021 at 14:49 | Report abuse | Reply
  24. https://mbee.com.vn/dia-chi-ban-vach-ngan-ve-sinh-compact-tai-ho-chi-minh-hcm

    Hi, always i used to check webpage posts here early in the dawn, as i enjoy to find out more and more.

    March 3, 2021 at 15:16 | Report abuse | Reply
  25. vách ngăn vệ sinh

    I like the valuable information you provide
    in your articles. I'll bookmark your blog and check again here regularly.

    I am quite sure I will learn many new stuff right here!
    Best of luck for the next!

    March 3, 2021 at 19:04 | Report abuse | Reply
  26. Angela

    Excellent weblog right here! Additionally your web site lots up very
    fast! What host are you the use of? Can I get your affiliate link in your host?

    I wish my site loaded up as quickly as yours lol

    March 3, 2021 at 22:52 | Report abuse | Reply
  27. vách ngăn vệ sinh

    I like it whenever people come together and share thoughts.
    Great blog, continue the good work!

    March 4, 2021 at 08:58 | Report abuse | Reply
  28. vách ngăn vệ sinh

    Pretty! This was a really wonderful article. Many thanks for supplying this information.

    March 5, 2021 at 15:19 | Report abuse | Reply
  29. vách ngăn vệ sinh

    Fantastic blog! Do you have any hints for aspiring writers?
    I'm hoping to start my own website soon but I'm a little lost
    on everything. Would you advise starting with a free platform like
    Wordpress or go for a paid option? There are so many options out
    there that I'm completely confused .. Any ideas? Cheers!

    March 7, 2021 at 18:55 | Report abuse | Reply
  30. vách ngăn vệ sinh

    Pretty part of content. I just stumbled upon your weblog and in accession capital to assert that I acquire actually
    enjoyed account your weblog posts. Any way I'll be subscribing for your augment or even I
    achievement you get admission to constantly quickly.

    March 8, 2021 at 08:13 | Report abuse | Reply
  31. vách ngăn vệ sinh

    I am really loving the theme/design of your website.

    Do you ever run into any browser compatibility problems?
    A small number of my blog audience have complained about
    my site not operating correctly in Explorer but looks great in Firefox.
    Do you have any suggestions to help fix this problem?

    March 8, 2021 at 09:50 | Report abuse | Reply
  32. https://mbee.com.vn/dia-chi-ban-vach-ngan-ve-sinh-compact-tai-ho-chi-minh-hcm/

    Thanks a lot for sharing this with all folks you
    really recognise what you are speaking approximately!
    Bookmarked. Please additionally consult with my web site
    =). We could have a hyperlink trade contract between us

    March 8, 2021 at 11:16 | Report abuse | Reply
  33. vách ngăn vệ sinh

    Very nice post. I just stumbled upon your weblog and wanted to
    say that I've truly enjoyed browsing your blog posts.
    After all I will be subscribing to your rss feed and I hope you write again soon!

    March 8, 2021 at 11:49 | Report abuse | Reply
  34. https://mbee.com.vn/dia-chi-ban-vach-ngan-ve-sinh-compact-tai-ho-chi-minh-hcm/

    Howdy would you mind letting me know which webhost you're working with?
    I've loaded your blog in 3 different browsers and I must say this
    blog loads a lot faster then most. Can you recommend a good internet hosting provider at a fair price?
    Thank you, I appreciate it!

    March 8, 2021 at 12:01 | Report abuse | Reply
  35. Jenifer

    For most up-to-date information you have to visit the web and on web I
    found this site as a best site for most up-to-date updates.

    March 8, 2021 at 13:42 | Report abuse | Reply
  36. https://mbee.com.vn/dia-chi-ban-vach-ngan-ve-sinh-compact-tai-ho-chi-minh-hcm/

    Awesome! Its truly amazing piece of writing, I have got much clear idea about from this paragraph.

    March 8, 2021 at 13:50 | Report abuse | Reply
  37. vách ngăn vệ sinh

    I just like the helpful information you supply on your articles.
    I will bookmark your blog and check again right here frequently.
    I am rather certain I'll be informed a lot of new stuff right here!
    Good luck for the following!

    March 8, 2021 at 14:59 | Report abuse | Reply
  38. vách ngăn vệ sinh

    Hi, i think that i saw you visited my site thus i came to “return the favor”.I'm attempting to find things to enhance
    my web site!I suppose its ok to use some of your ideas!!

    March 8, 2021 at 21:53 | Report abuse | Reply
  39. vách ngăn vệ sinh

    Hello There. I discovered your weblog using msn. That is an extremely
    smartly written article. I'll make sure to bookmark it and return to read more of your
    useful information. Thank you for the post. I'll definitely comeback.

    March 8, 2021 at 22:40 | Report abuse | Reply
  40. vách ngăn vệ sinh

    I'm amazed, I have to admit. Rarely do I encounter a blog that's both equally educative and amusing,
    and let me tell you, you've hit the nail on the head.
    The issue is something that not enough men and women are speaking intelligently about.
    I am very happy I came across this during my hunt for something relating to this.

    March 9, 2021 at 06:30 | Report abuse | Reply
  41. vách ngăn vệ sinh

    I like the valuable information you provide
    in your articles. I'll bookmark your weblog and check again here frequently.
    I'm quite certain I will learn many new stuff right here! Good luck for the next!

    March 9, 2021 at 17:28 | Report abuse | Reply
  42. vách ngăn vệ sinh

    When someone writes an post he/she retains the plan of a
    user in his/her brain that how a user can be aware of
    it. Thus that's why this article is amazing. Thanks!

    March 9, 2021 at 22:04 | Report abuse | Reply
  43. vách ngăn vệ sinh

    This text is invaluable. When can I find out more?

    March 10, 2021 at 18:28 | Report abuse | Reply
  44. vách ngăn vệ sinh

    You can certainly see your enthusiasm within the work you write.
    The world hopes for more passionate writers such as you who aren't afraid
    to say how they believe. Always follow your heart.

    March 11, 2021 at 04:57 | Report abuse | Reply
  45. vách ngăn vệ sinh

    I constantly spent my half an hour to read this blog's
    articles every day along with a mug of coffee.

    March 11, 2021 at 06:53 | Report abuse | Reply
  46. vách ngăn vệ sinh

    Hi i am kavin, its my first time to commenting anywhere, when i read this paragraph i
    thought i could also make comment due to this good
    piece of writing.

    March 11, 2021 at 10:14 | Report abuse | Reply
  47. mbee.com.vn

    Great blog here! Also your site loads up very fast!
    What web host are you using? Can I get your affiliate link to your host?
    I wish my website loaded up as fast as yours lol

    March 12, 2021 at 12:41 | Report abuse | Reply
  48. vách ngăn vệ sinh

    Howdy, i read your blog from time to time and i own a similar one and i was just wondering if you get a lot of spam remarks?
    If so how do you stop it, any plugin or anything you can recommend?
    I get so much lately it's driving me mad so any assistance is very much appreciated.

    March 12, 2021 at 19:23 | Report abuse | Reply
  49. vách ngăn vệ sinh

    These are really enormous ideas in regarding blogging.
    You have touched some good things here. Any way keep up wrinting.

    March 13, 2021 at 00:56 | Report abuse | Reply
  50. vách ngăn vệ sinh

    Wow that was unusual. I just wrote an really long comment but after I clicked submit
    my comment didn't show up. Grrrr... well I'm not
    writing all that over again. Anyway, just wanted to say excellent blog!

    March 15, 2021 at 04:42 | Report abuse | Reply
1 2

Post a comment


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.