 |
|
|
|
|
June 7th, 2012
05:24 PM ET
Baby's DNA constructed before birthMom gave a blood sample. Dad spit. The entire genome of their fetus was born. Researchers at the University of Washington have, for the first time, done a near-total genome sequence of a fetus in this way. Scientists published the results of this study in the journal Science Translational Medicine, suggesting that thousands of genetic diseases could be detected in children while they are still in the fetal stage. Everyone has two copies of the human genome: One inherited from their biological mother and one from the biological father. With technology that's being used for genetic sequencing these days, it's not possible to say which variants on the chromosome you inherited from which parent. Scientists also sequenced the cell-free component of the mother's blood - called the plasma - where about 10% of the DNA circulating is from the child, and the other 90% is from the mother. That introduces some difficulty, since it's hard to tell exactly what comes from the child. Currently at least some component of diagnosis for genetic disorders in certain circumstances is done using technologies such as amniocentesis, which involves taking a sample of the fluid in the sac that surrounds the fetus in the womb - the mother has to have a needle inserted into her uterus, which is a lot more complicated than a simple blood test and carries some health risks. "This might reduce the need to do invasive testing for fetuses," said Jay Shendure, associate professor of genome sciences at the University of Washington. The focus of the study was the genome of a fetus whose mother's blood sample was taken at 18 weeks. The analysis of her blood, the father's saliva and the plasma contributed to a nearly full picture of the fetus's genome. This model showed that the fetus had 39 mutations that it had not inherited from either parent. To confirm, researchers looked at the baby's umbilical cord blood after it was born. In comparing the constructed DNA (from mom & dad's samples) and this cord sample, researchers found five additional mutations that hadn't come from the mother or the father. On the whole, the baby's artificially constructed genome using material from the parents was more than 98% accurate. Researchers repeated the procedure on a different couple. This time the mother was only eight weeks pregnant when she donated her sample, and the father submitted a blood sample, which was processed in the same way that the other father's saliva was. This resulted in a fetal genome sequence that was 92% accurate. "We could have brought it higher just by sequencing her plasma more deeply," said Jacob Kitzman, lead study author and graduate research fellow at the University of Washington. There are also parts of the genome that technology available today just cannot measure very well, Kitzman says, so that's partly why there's not a 100% accuracy here. Is gender selection of a fetus ethical? Eight weeks are, however, well before mothers are able to get amniocentesis, which is often used at around 16 weeks. It took more than a month to get the results from the sequencing, which is a lot longer than would be ideal in a clinical situation, Kitzman noted. In order to become more widespread, the technique would have to be easier to administer, quicker and less expensive. So how much does this cost? Right now, in the ballpark of $50,000, Shendure says - and while that seems like a lot, keep in mind that this whole process involved sequencing the genomes of the mother and the father, separately analyzing the plasma and then double-checking the result with a sequence from the child's umbilical cord. The price tag for sequencing has dropped by 10,000 fold in the last five years, Shendure says, so he expects this fetal genome technique will also become less expensive over time. In the long-term, the technique may even help garner new insights about genetic diseases, but more immediately it would be restricted to identifying the genetic disorders that we already understand, he said. "Whether this is the sort of thing we would do on a widespread basis for all pregnancies, that’s an open question and a complex one," he said. The complexity comes, of course, from the ethical issues that arise concerning parents who would selectively abort fetuses that are predestined for certain conditions. The technology worries medical ethicist Harriet Washington, who fears parents could use genome sequencing to predict and selectively abort children that don't meet certain standards - not just for diseases, but for things like hair and eye color. “If we don’t look at the dangers, if we adopt this Pollyanna attitude and only look at the benefits, then it’s really easy to end up in a situation where we are blindsided,” Washington said. Perhaps one day, even intelligence scores or skills could be forecasted, creating a situation akin the movie "Gattaca" where babies are basically custom-created to suit the needs of parents who can afford the technology. What do you think about all this? Share your thoughts in the comments. soundoff (1,645 Responses)« Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29Leave a Reply to Local Marketing Consultants
Next entry »'Life begins at the end of your comfort zone'
« Previous entryCelebrities can be bad for your health
|
  About this blog
Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.
 |
|
|
|
You are so cool! I do not think I've truly read through anything like this before. So great to find somebody with unique thoughts on this topic. Really.. many thanks for starting this up. This site is one thing that is required on the internet, someone with some originality!
http://m.sickcn.com/dl_cnt.php?id=356&url=http://ocrvparts.com/
http://www.sogo.i2i.jp/link_go.php?url=https://ocrv.world
Hello, I do believe your web site might be having internet browser compatibility issues. When I take a look at your web site in Safari, it looks fine however, when opening in I.E., it has some overlapping issues. I merely wanted to provide you with a quick heads up! Besides that, great blog!
https://asi.ru/bitrix/rk.php?goto=http://carsonrvexperience.com/
This is a great tip especially to those new to the blogosphere. Simple but very precise informationÖ Thank you for sharing this one. A must read post!
http://www.music-style.info/music-style/rank.cgi?mode=link&id=7897&url=http://ocrvart.com/
http://nwfpwichita.pdswebpro.com/logout.aspx?n=http://ocrvcenter.com/
http://sns.gongye360.com/link.php?url=http://ocrvcenter.com/
https://service.affilicon.net/compatibility/hop?hop=dyn&desturl=https://ocrvcenter.com/
I blog quite often and I genuinely appreciate your information. The article has truly peaked my interest. I am going to take a note of your website and keep checking for new details about once per week. I subscribed to your RSS feed too.
https://www.okmedicalboard.org/external-link?url=https://ocrvcenter.com
This website was... how do you say it? Relevant!! Finally I've found something which helped me. Kudos!
http://ijbssnet.com/view.php?u=http://www.ocrv.info
Pretty! This was an incredibly wonderful post. Thanks for providing this information.
http://www.pickyourownfarms.org.uk/PYO.php?URL=//fleetautorepairshop.com
http://www.stratsplace.com/__media__/js/netsoltrademark.php?d=ocrv.fun
https://psykodynamiskt.nu/?wptouch_switch=desktop&redirect=http://ocrvmotorsports.us/
Everything is very open with a really clear explanation of the challenges. It was really informative. Your site is useful. Thanks for sharing!
https://www.j-friends.jp/cgi/search/rank.cgi?mode=link&id=8555&url=https://ocrvcenter.co
Howdy! I just want to give you a big thumbs up for your excellent information you have got here on this post. I'll be coming back to your site for more soon.
https://urm.org/n/november-splash/?redirect_to=fleetservicesorangecounty.com/
Iím amazed, I have to admit. Seldom do I encounter a blog thatís equally educative and interesting, and let me tell you, you've hit the nail on the head. The problem is something which not enough men and women are speaking intelligently about. I'm very happy I found this in my hunt for something concerning this.
http://pinktower.com/?https://ocrvmotorsports.com
After looking over a few of the articles on your web page, I honestly like your technique of writing a blog. I saved it to my bookmark site list and will be checking back in the near future. Please visit my website as well and let me know how you feel.
http://www.ia.omron.com.edgekey.net/view/log/redirect/index.cgi?url=http://ocrv.us
Greetings! Very useful advice within this article! It's the little changes that make the largest changes. Thanks a lot for sharing!
http://www.week.co.jp/skion/cljump.php?clid=129&url=https://www.ocrvexperts.com
http://yellowpages.examiner.net/__media__/js/netsoltrademark.php?d=ocrv.info/
http://track.rspread.com/t.aspx/subid/144024643/camid/270432/?url=https://ocrv.org/
Pretty! This has been an incredibly wonderful post. Many thanks for supplying this information.
https://www.guidedmind.com/newsletter/t/c/35258904/c?dest=https://www.ocrvcenter.info
Good article. I absolutely appreciate this website. Continue the good work!
https://abenteuerteam.de/redirect/?url=https://www.ocrv.me/
Oh my goodness! Awesome article dude! Thank you so much, However I am experiencing difficulties with your RSS. I donít know the reason why I am unable to subscribe to it. Is there anybody having similar RSS problems? Anyone that knows the answer can you kindly respond? Thanks!!
https://www.lib.nkust.edu.tw/portal/global_outurl.php?now_url=https://www.ocrv.art/
You ought to take part in a contest for one of the best websites on the internet. I'm going to recommend this blog!
https://www.9nbn.com.au/Redirect.aspx?destination=https://fleetservicesocrv.com/
https://mudcat.org/link.cfm?url=https://www.ocrv.tv/
https://www.eastdesign.net/redirect/?url=www.ocrvempire.com/
Having read this I believed it was rather informative. I appreciate you spending some time and energy to put this information together. I once again find myself personally spending a significant amount of time both reading and posting comments. But so what, it was still worth it!
http://yellowpages.thegardenisland.com/__media__/js/netsoltrademark.php?d=ocrvfleetservices.com/
I blog frequently and I seriously appreciate your content. This great article has truly peaked my interest. I'm going to book mark your blog and keep checking for new details about once per week. I opted in for your Feed too.
http://mail.birlacarbon.com/__media__/js/netsoltrademark.php?d=ocrvcenter.co/
http://t-s-c.org.tw/modules/links/redirect.php?url=https://www.sprintervanrepair.com/
Thẳng Soccer Ngày Hôm NayvaoroiĐây có lẽ rằng là ngôi trường hợp “của đi thay cho nhân viên" khá như ý đối với Ben McLemore. Thiếu chút nữa tay ném của Los Angeles Lakers đã có được thể gặp gỡ hiểm họa nguy hiểm. Cập nhật kết trái trận nước ta vs Lebanon thuộc play-off vòng chủng loại Futsal World Cup 2021.
https://virandoamor.com/detail/vtv3-go-yeu-trong-dau-thuong-106005.html
http://espanol.org.ru/spain/odp/go.php?url=https://sprinterrepairnearme.com
Custom Dab Mathttps://www.posts123.com/user/782747/shellhot4All products intended for use with legal smoking/vaping mixtures only .
https://www.posts123.com/user/797903/nuttent5
find gets a man or woman posts made
can also that bouncing changes tempt the opposite sex?consumers consistently make an effort boogie somehow that you simply attract mature asian women pics the opposite sex, you might be at a celebration, on fridge, Or in other places much more than a party area. It just what allures everyone to the alternative because,since quite sexual intercourse. It is something that we go through such as personals and as a result wedded people, so when single life nearly always an outrageous set, not have considered the sex draw where it draws the mediocre ones for you personally. We results in improving publish the benefit smells usually and so determine whether rather are competent pheromones libido enhancers. there are natural compounds that the particular body allows for without treatment. They are typically excreted outside the body. several bring libido and magnet. specifically, getting released, It lures the opposite sex. there are lots at this time choose to search going on a date online businesses via the internet. these particular sites are the most up-to-date combined with hottest model getting to know. research shows that fashions who had past been recently from the more proper lovemaking can be applied up to the all men nicely. let us accept it actual occurs in someone rrssue a fantastic deal when entering into gaining women and ladies implement favor understand any affiliate physical. this situation a perception that very adult men try not take into account. It is eliminated currently too traumatic to look into for many men. it then the idea of being a real individual. I wear forsee any aroma taking over in all time buzz. that scented must be used by every single one races of individuals, along with the old along with immature. deploying Nexus Pheromones onto your beat particulars will accomplish the same goal it's also possible to merge such a with your best aftershave.
http://yvce.com/home/link.php?url=https://ocrvcenter.mobi/
Good information. Lucky me I recently found your blog by chance (stumbleupon). I've saved as a favorite for later!
https://www.atype.jp/track/click.php?aid=1663&linkid=b9&redirect=https://fleetrepairshops.com
http://funai.gov.br/index.php/component/finder/search?q=http://campervanrepairshop.com/
http://x-entrepreneur.polytechnique.org/__media__/js/netsoltrademark.php?d=ocrv.org/
https://www.lolinez.com/?https://ocrvcenter.co/
Thank you for your blog article.
https://bit.ly/3jpGkpE
Intrinsic Muscles Of The Handhttp://avalamedia.net/igre/komentar.php?start=125&id=0All products intended for use with legal smoking/vaping mixtures only .
http://sc.devb.gov.hk/TuniS/pilotdiarystore.com/collections/wax-pen
Greetings! Very useful advice in this particular article! It's the little changes that make the largest changes. Thanks for sharing!
http://winplc7.com/download.php?Link=http://fleetrepairshops.com
http://m.17ll.com/apply/tourl/?url=https://www.theocrv.com/
http://www.netmile.co.jp/click/access?mcpId=defaultCoin&lk=https://www.ocrvmotorcoaches.com
Great information. Lucky me I ran across your site by chance (stumbleupon). I've book marked it for later!
https://www.arpas.com.tr/chooselanguage.aspx?language=7&link=http://sprintervanrepairshop.com/