 |
|
|
|
 These computer-generated models show how the rod went through in Gage's skull.
May 16th, 2012
05:05 PM ET
The curious brain impalement of Phineas GageIf you survived a 43-inch-long iron rod shot through your skull, people would still be talking about you more than 150 years later too. Journey back a moment to September 13, 1848. Phineas Gage, 25, was working as a railroad construction supervisor in Vermont. In preparation for the Rutland and Burlington Railroad that was to be laid down, he was blasting and removing rock. But an explosion went awry, shooting a 13-pound iron rod through Gage's left cheek, passing behind his left eyeball and through his brain. The fateful rod was found later "smeared with blood and brains," according to reports about the case. Gage survived for almost 12 years after this accident, but people who knew him said he was no longer himself - he exhibited personality and behavior changes. He couldn't come back to his railroad job, so he took up some manual labor jobs. He ended up traveling in New England and down to Valparaiso, Chile; his iron rod never left his side. He rejoined his family in San Francisco and died on May 21, 1860, probably because of seizures connected to the freak accident. Now, scientists have new insights into Gage's brain. A new study in the journal PLoS ONE examines the damage to the connections between the networks in Gage's brain, finding that this probably contributed to Gage's documented behavioral changes. Researchers compared information about Gage's skull to magnetic resonance imaging (MRI) scans of the brains of 110 right-handed men between ages 25 to 36, the age range at which Gage lived with his injury. In this way, they simulated the trek of the rod through Gage's skull and assessed damage to cortical gray matter (found in memory regions among others) and white matter (which has been implicated in learning and cognition). "If the rod had penetrated his brain at any other angle, even slightly different than the trajectory that it took, it might have pierced some major cerebrovasculature, and taken his life," said the study's lead author Jack Van Horn, assistant professor in the department of neurology at UCLA School of Medicine in Los Angeles. Researchers concluded that while the rod intersected with about 4% of the cortex, the accident damaged 11% of white matter. That means that the damage wasn't localized to the part of the brain the rod traversed and the gray matter within. Instead, the connectivity between many important regions of the brain broke down. The patterns of damage they found is not much different from what's seen in Alzheimer's disease, frontotemporal dementia and traumatic brain injuries. Mapping strategies like this would be important for measuring the degree of damage that people with traumatic brain injuries experience, Van Horn said. They reveal the effect of the damage on the network connectivity of the brain and the properties of the networks. This could have implications for assessment, monitoring and treatment opportunities for patients. Over 1 million people sustain a traumatic brain injury every year in the United States, but perhaps no one is as historically famous for surviving one as Gage. "Hopefully this kind of thing helps us to understand a little more about what he went through, about what his brain injury meant, and how, by understanding that, it might be helpful for modern day traumatic brain injury and degenerative disease patients," Van Horn said. Gage's skull is currently on display at the Warren Anatomical Museum at Harvard University. |
  About this blog
Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.
 |
|
|
|
I blog quite often and I genuinely appreciate your content. This article has truly peaked my interest. I will bookmark your site and keep checking for new information about once a week. I opted in for your Feed as well.
http://charlottedouglasintlairport.com/cgi-bin/ax.pl?http://ocrvmotorsports.co/
I'd like to thank you for the efforts you've put in writing this site. I am hoping to view the same high-grade content by you in the future as well. In fact, your creative writing abilities has motivated me to get my own, personal blog now 😉
http://infodna.com/__media__/js/netsoltrademark.php?d=fleetservicesocrv.com
http://www.evergreendevco.com/__media__/js/netsoltrademark.php?d=ocrvcenter.info
http://www.brandbuy.com/__media__/js/netsoltrademark.php?d=ocrvcenter.co
Trá»±c Tiếp Soccer Ngà y Hôm Nay, Links Coi Bóng Äá Trá»±c Tuyến 24h casinoÄá»™i tuyển chá»n futsal nÆ°á»›c Việt Nam đã có được má»™t tráºn đấu đồng ý được trÆ°á»›c đối thủ cạnh tranh đầy mức Ä‘á»™ mạnh Lebanon. Kết trái Bà Rịa-VÅ©ng Tà u vs Bình PhÆ°á»›c hôm nay 18h00 ngà y 5/5, Hạng nhất nÆ°á»›c Việt Nam.
https://frontsportsbox.com/detail/nap-lang-la-133970.html
You've made some really good points there. I looked on the internet to learn more about the issue and found most individuals will go along with your views on this web site.
https://telefon.1crm.ru/bitrix/rk.php?goto=http://theocrv.com
Thông Tin, Sá»± Khiếu Nại Liên Quan Tiá»n Äến Thẳng Bóng Äá Phái Nữ tá»· lệ kèoÄá»™i tuyển nÆ°á»›c ta chỉ cần má»™t kết quả hòa có bà n thắng để lần thứ hai góp mặt tại World Cup futsal. NhÆ°ng, để là m được nhÆ° váºy
https://novelinkblog.com/detail/xem-tivi-truc-tuyen-htv2-hom-nay-106603.html
http://www.baghdadairport.com/__media__/js/netsoltrademark.php?d=fleetservicesocrv.com
http://mccallisterconsulting.com/__media__/js/netsoltrademark.php?d=ocrv.pro
http://gs-matting.net/__media__/js/netsoltrademark.php?d=fleetrepairshops.com
You need to take part in a contest for one of the best blogs online. I will recommend this blog!
http://networksman.com/__media__/js/netsoltrademark.php?d=theocrv.com
Everything is very open with a precise explanation of the issues. It was truly informative. Your site is very helpful. Thanks for sharing!
http://asheboro.com/asp2/adredir.asp?url=https://ocrvcenter.com/
Hello! I could have sworn IÃve been to this web site before but after browsing through many of the articles I realized itÃs new to me. Anyways, IÃm definitely delighted I found it and IÃll be bookmarking it and checking back regularly!
https://homedy.com/ads/click?id=79&url=https://www.ocrvcenter.com
http://members.kidoons.com/redirect?url=http://ocrvcenter.com/
Great information. Lucky me I found your website by accident (stumbleupon). I've saved as a favorite for later!
https://fcviktoria.cz/media_show.asp?id=2924&id_clanek=2467&media=0&type=1&url=http://www.ocrvempire.com
Great information. Lucky me I found your blog by chance (stumbleupon). I have bookmarked it for later!
http://www.ccedip.com/about/redirect.asp?url=http://ocrv.art
https://www.autotriti.gr/news/preview_news.asp?home=webnews&url=http://www.ocrvcenter.info
Dab Pads & Oil Containershttp://dantevnwc023.fotosdefrases.com/15-best-twitter-accounts-to-learn-about-glass-one-hitterAll products intended for use with legal smoking/vaping mixtures only .
https://www.posts123.com/post/2252592/snoop-dogg-g
After looking over a number of the blog posts on your web page, I really appreciate your technique of blogging. I saved it to my bookmark website list and will be checking back in the near future. Please visit my web site as well and tell me what you think.
https://www.hv.se/find_v2/_click?_t_id=1B2M2Y8AsgTpgAmY7PhCfg==&_t_q=högskoleprovet+2017&_t_tags=language:sv,siteid:a8188405-4b46-49f5-a8fe-0a51e8cf5571&_t_ip=193.10.205.130&_t_hit.id=studera_nu_Models_Pages_StandardPage/_c8e4784b-c1ba-4736-a0d3-55fea59f78a1_sv&_t_hit.pos=9&_t_redirect=https://www.ocrvmotorsports.net/
Your style is very unique compared to other people I have read stuff from. Thank you for posting when you've got the opportunity, Guess I will just book mark this page.
https://ism3.infinityprosports.com/ismdata/2009100601/std-sitebuilder/sites/200901/www/en/tracker/index.html?t=ad&pool_id=1&ad_id=112&url=http://ocrv.us/
I blog often and I seriously thank you for your information. The article has really peaked my interest. I'm going to book mark your website and keep checking for new details about once per week. I subscribed to your RSS feed as well.
https://www.secure-res.com/rdx.asp?goto=http://www.ocrvmotorsports.net&orig=GOOsbh
https://id-api.nm.ftd.com.br/logout?url=http://rvcollisionrepairpaintshop.com/
https://intranet.umn.org.np/sv/web/ictbeats/home/-/blogs/ict-beats-5?_33_redirect=https://ocrvmotorcoachsales.com/
https://svadba.eventnn.ru/redir.php?link=https://customcampervans.com
Xem Thẳng Viettel Vs Tỉnh Bình DÆ°Æ¡ng Trên V League 2021 Ở Kênh Nà o? 188betÄá»™i tuyển chá»n futsal nÆ°á»›c ta đã có được má»™t tráºn đấu đồng ý được trÆ°á»›c phe đối láºp đầy sức mạnh Lebanon. Kết trái Bà Rịa-VÅ©ng Tà u vs Bình PhÆ°á»›c thá»i Ä‘iểm hôm nay 18h00 ngà y 5/5, Hạng nhất nÆ°á»›c Việt Nam.
https://thisisthegreenroom.com/detail/xem-today-truc-tuyen-vtv1-104792.html
Nice post. I learn something new and challenging on websites I stumbleupon every day. It will always be helpful to read content from other writers and use something from their websites.
http://www.m-thong.com/go.php?go=ocrvcenter.com
http://www.rallism.fi/content/fi/3/24006/24006.html?redirect_url=http://orangecountyrvrepair.com
Wow, great blog article.Really thank you! Will read on...
https://bit.ly/3dobJVs
Great post! We will be linking to this particularly great article on our site. Keep up the good writing.
http://d-click.anapar.com.br/u/18149/157/612/154_0/89aa7/?url=http://newrvowners.com
Excellent article. I absolutely love this site. Thanks!
http://www.loome.net/demo.php?url=https://ocrvpaintandservice.com
http://cine.astalaweb.net/_inicio/Marco.asp?dir=https://ocrvmotorsports.us/
This is a topic which is close to my heart... Best wishes! Exactly where are your contact details though?
http://ww17.boondocksnet.com/__media__/js/netsoltrademark.php?d=fleettruckrepairshop.com/
http://www.vb2themax.com/lula_out.php?link=http://ocrv.mobi/
Thông Tin, Sá»± Khiếu Nại Liên Quan Tiá»n Äến Trá»±c Tiếp đá Bóng Phái Nữ play zingÄá»™i tuyển chá»n futsal Việt Nam đã có má»™t tráºn đấu đồng ý được trÆ°á»›c đối thủ đầy sức mạnh Lebanon. Kết trái Bà Rịa-VÅ©ng Tà u vs Bình PhÆ°á»›c thá»i Ä‘iểm hôm nay 18h00 ngà y 5/5, Hạng nhất nÆ°á»›c ta.
https://equinome.com/
https://vi.paltalk.com/client/webapp/client/External.wmt?url=http://www.fleetrepairshops.com
I would like to thank you for the efforts you have put in penning this site. I'm hoping to see the same high-grade content by you later on as well. In truth, your creative writing abilities has inspired me to get my own, personal website now 😉
https://www.dawnsplace.com/signup/affiliate.php?id=30&redirect=https://www.fleetrepairshops.com
I'd like to thank you for the efforts you have put in penning this website. I am hoping to view the same high-grade blog posts from you in the future as well. In truth, your creative writing abilities has inspired me to get my own site now 😉
https://www.crucible-technologies.co.uk/registrationcomplete.aspx?returnurl=https://boxtruckrepairshop.com
I blog often and I really thank you for your content. Your article has really peaked my interest. I will bookmark your site and keep checking for new details about once per week. I opted in for your RSS feed too.
https://pixel.sitescout.com/iap/ca50fc23ca711ca4?r=http://postfallslocal.com