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January 31st, 2012
09:18 AM ET
New skin cancer drug approvedAdults with metastatic basal cell cancer now have a new drug to help them battle the disease. The Food and Drug Administration has approved Erivedge under the agency's priority review program. The program provides an expedited six-month review process for drugs that may result in major treatment advances. Erivedge is for patients with advanced basal cell carcinoma who are not candidates for radiation or surgery, or for those whose cancer has spread. BCC is the most common form of skin cancer in the country. It grows slowly and is generally curable.
The new drug inhibits a molecular pathway called the Hedgehog pathway, which is found in most basal cell cancers. "Our understanding of molecular pathways involved in cancer, such as the Hedgehog pathway, has enabled the development of targeted drugs for specific diseases," said Dr. Richard Pazdur, director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research. "This approach is becoming more common and will potentially allow cancer drugs to be developed more quickly. This is important for patients who will have access to more effective therapies with potentially fewer side effects." This is the first FDA-approved treatment for metastatic BCC. It comes in pill form - a capsule that's taken once a day. According to the drug's manufacturer, Genentech, an independent review of clinical studies found Erivedge shrank lesions in 43% of patients with locally advanced BCC and 30% in patients with metastatic BCC. "Today's approval provides a new treatment for people with advanced basal cell carcinoma who, until now, had no approved medicines to help shrink disfiguring or potentially life-threatening lesions," said Dr. Hal Barron, chief medical officer and head, Global Product Development for Genentech. Dr. Evan Lipson, and instructor of medical oncology at Johns Hopkins Kimmel Cancer Center has treated patients with the drug. "Like most of the pathway therapy drugs that we are using these days, these drugs are remarkably successful compared to the chemotherapy drugs that have been available to us up until now," Lipson said. "The downside is that the effects of the drug on the tumor are not as long lasting as we would like and research is underway to develop ways to create longer lasting responses." There are side effects , including muscle spasms, hair loss, weight loss, distorted sense of or loss of taste. Erivedge will come with a black box warning about the potential risk of death, and of severe birth defects to unborn babies. Pregnancy status must be verified before starting treatment. According to Genentech, the drug will be available within two weeks. soundoff (2,438 Responses)« Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 Next »
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Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.
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Мы предлагаем: вышка тура купить производитель
Особенности вышек тур
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Как известно, прямые инвестиции — наиболее гибкий вид финансирования развития бизнеса, доступный тогда, когда остальные источники не могут быть использованы. Сотрудничество фонда с компаниями может строиться различным путем: фонды могут выступать как отстраненными финансовыми инвесторами, так и участниками бизнеса, активно вмешиваясь в операционную деятельность. Private equity фонды, как правило, выходят из проектов в течение лет, получая в этот период доходность на уровне % годовых. По оценке экспертов, прямые инвестиции — сравнительно дорогой вид инвестиций, которые накладывают дополнительные обязательства на компанию. Например, фонды снижают риски, подписывая соглашения, противостоящие размыванию капитала, получают право на информацию, право первого выхода из проекта, вето на крупные транзакции.
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Кофе-каково оно на вкус?
Вы встаете, чтобы отправить ребенка в детский сад, в спешке выпиваете маленькую чашку черного кофе. Однако, иногда этот напиток Вам не нравится, и сейчас мы разберемся по чему.
Ученые решили провести исследование, и оказалось, что идеальное время для перерыва на утренний кофе, независимо от того, где вы находитесь, это одиннадцать часов утра. Профессор Чарльз Спенс из кафедры экспериментальной психологии Оксфордского университета подсчитал это по необычным уравнениям. В своих математических расчетах он принимал во внимание несколько факторов, таких как: общение, свет, музыку, аромат напитка. После кропотливых расчетов он обнаружил, что лучше всего пить кофе в 11 часов, в хорошо освещенном месте на открытом воздухе. Тогда, видимо, наш вкус более обострен. И для полного ощущения вкуса желательно слушать оперу.
Кофе так же лучше пить в компании близких и приятных Вам людей. Очевидно, от этого его вкус улучшится.
Так же оказалось, что, не смотря на содержание кофеина, зачастую считающегося вредным, этот напиток имеет и положительные стороны. Кофе содержит много полифенолов, которые защищают организм от свободных радикалов. Но помните, что кофе не рекомендуется при беременности и грудном вскармливании.
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