home
RSS
New skin cancer drug approved
January 31st, 2012
09:18 AM ET

New skin cancer drug approved

Adults with metastatic basal cell cancer now have a new drug to help them battle the disease.

The Food and Drug Administration has approved Erivedge under the agency's priority review program. The program provides an expedited six-month review process for drugs that may result in major treatment advances.

Erivedge is for patients with advanced basal cell carcinoma  who are not candidates for radiation or surgery, or for those whose cancer has spread. BCC is the most common form of skin cancer in the country. It grows slowly and is generally curable.

The new drug inhibits a molecular pathway called the Hedgehog pathway, which is found in most basal cell cancers.

"Our understanding of molecular pathways involved in cancer, such as the Hedgehog pathway, has enabled the development of targeted drugs for specific diseases," said Dr. Richard Pazdur, director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research. "This approach is becoming more common and will potentially allow cancer drugs to be developed more quickly. This is important for patients who will have access to more effective therapies with potentially fewer side effects."

This is the first FDA-approved treatment for metastatic BCC. It comes in pill form - a capsule that's taken once a day.

According to the drug's manufacturer, Genentech, an independent review of clinical studies found Erivedge shrank lesions in 43% of patients with locally advanced BCC and 30% in patients with metastatic BCC.

"Today's approval provides a new treatment for people with advanced basal cell carcinoma who, until now, had no approved medicines to help shrink disfiguring or potentially life-threatening lesions," said Dr. Hal Barron, chief medical officer and head, Global Product Development for Genentech.

Dr. Evan Lipson, and instructor of medical oncology at Johns Hopkins Kimmel Cancer Center has treated patients with the drug.

"Like most of the pathway therapy drugs that we are using these days, these drugs are remarkably successful compared to the chemotherapy drugs that have been available to us up until now," Lipson said. "The downside is that the effects of the drug on the tumor are not as long lasting as we would like and research is underway to develop ways to create longer lasting responses."

There are side effects , including muscle spasms, hair loss, weight loss, distorted sense of or loss of taste. Erivedge will come with a black box warning about the potential risk of death, and of severe birth defects to unborn babies. Pregnancy status must be verified before starting treatment.

According to Genentech, the drug will be available within two weeks.


soundoff (1,203 Responses)
  1. generic tadalafil

    tadalafil 30 mg https://elitadalafill.com/ tadalafil gel

    April 11, 2021 at 23:46 | Report abuse | Reply
  2. Arthurcal

    Купить лицензионные игры +на xbox стать ГАЙМЕРОМ + https://plati.market/itm/bioshock-the-collection-us-xbox-live/2964469
    xbox купить игру лицензию+ https://plati.market/itm/assassin-s-creed-origins-us-xbox-present/2891230
    какую игру xbox купить+ https://plati.market/itm/mafia-iii-definitive-edition-xbox-cd-key/3009258
    ? Grand Theft Auto V / GTA 5 XBOX ONE Цифровой Ключ ??
    Watch Dogs 2 – Xbox Live Key – +подарок
    Resident Evil 3 Xbox One Key
    HITMAN 2
    METRO: LAST LIGHT REDUX +подарок
    The Crew 2 ?? XBOX/PC+present
    Diablo III: Eternal Collection Xbox One
    АККАУНТЫ xbox one RED dead red 2 Call OF duty Cold WARS Rezident Evil 1,2 Assasins creed Vhalhalla
    Wolfenstein II: The New Colossus
    Bioshock – The Collection US XBOX LIVE
    Thief XBOX ONE Цифровой ключ
    DARK SOULS™ III Xbox
    MORTAL KOMBAT 11 XBOX ONE X/S
    STAR WARS Jedi: Fallen Order Key
    GOOGLE PLAY US 15$
    iTUNES GIFT CARD – $10 (USA) ?? +подарок
    Sniper Elite 3 ULTIMATE EDITION Xbox
    The Witcher 3: Wild Hunt Game of the Year XBOX Key
    Random STEAM KEY по 55 р.
    Avast! internet security/ Premium Security

    April 12, 2021 at 00:51 | Report abuse | Reply
  3. Buick

    Таможенный агент "Азия-Трейдинг"

    April 12, 2021 at 00:52 | Report abuse | Reply
  4. sildenafil online purchase in india

    sildenafil price singapore https://eunicesildenafilcitrate.com/ sildenafil soft gel capsule

    April 12, 2021 at 01:02 | Report abuse | Reply
  5. OZaimRupum

    Взял займ потому что ozaim.ru
    Займем и возьмем взаймы в чем разница? Самое время нам познакомиться. А скажите-ка мне, что такое благородный самурай? Можете объяснить по-японски?
    Деньги не бывают лишними тем более если берешь займ.
    Где быстрее это сделать? конечно на сайте ozaim.ru
    Я в эти игры давно играю. И займ за 5 минут очень удобно .

    April 12, 2021 at 01:25 | Report abuse | Reply
  6. skyreveryCrigh

    Bombardier Global 8000 Private Jet – more information on our website skyrevery.com
    Private jet rental at SkyRevery allows you to use such valuable resource as time most efficiently.
    You are the one who decides where and when your private jet will fly. It is possible to organize and perform a flight between any two civil airports worldwide round the clock. In airports, private jet passengers use special VIP terminals where airport formalities are minimized, and all handling is really fast – you come just 30 minutes before the estimated time of the departure of the rented private jet.
    When you need private jet charter now, we can organise your flight with departure in 3 hours from confirmation.

    April 12, 2021 at 02:09 | Report abuse | Reply
  7. Антонина

    Здравствуйте! Хотела бы переговорить по поводу ремонта квартиры. Просьба перезвонить.
    Антонина Николаевна +79261277717

    April 12, 2021 at 07:00 | Report abuse | Reply
  8. Pax Era Pods

    809146 317296I gotta favorite this web site it seems invaluable really valuable 931797

    April 12, 2021 at 07:01 | Report abuse | Reply
  9. Антонина

    Здравствуйте! Хотела бы переговорить по поводу строительства дома. Просьба перезвонить.
    Антонина Николаевна +79261277717

    April 12, 2021 at 08:02 | Report abuse | Reply
  10. best canadian mail order pharmacies for diet pills

    canadian weight loss pills https://canadapillstorex.com/ canadian pharmacies ed pills

    April 12, 2021 at 08:27 | Report abuse | Reply
  11. lok

    Добрый день!
    Жизненно серьезный и важный вопрос!?
    Уважаемые и дорогие мужчины, помогите!
    Кто понимает и разбирается в строительстве фундамента для бани, дома, дачи, гаража есть такие?
    Было бы отлично и здорово, если бы вы имели опыт и занимались строительством фундаментов, есть такие?Было бы здорово и отлично, если бы вы имели опыт и занимались строительством фундаментов, есть такие?
    В интернете много пишут и говорят о строительстве фундамента за 50% или за полцены.
    Мне интересно это правда или уловка?
    Нашла в интернете сайт Школы частных прорабов Prorab2.ru, они утверждают, что можно строить качественные и дешевые фундаменты для гаража, дома, дачи, бани и т.д.
    Это правда или нет, действительно можно строить фундаменты за полцены или за 1/2, не нарушая технологического процесса и соблюдая все строительные нормы?
    Взгляд на вещи у меня конечно женский, а не мужской, мне что-то мало в это верится, в общем, я колеблюсь и сомневаюсь.
    Сайт у них конечно хороший и пояснительный, с множеством подробных и разъясняющих статей с схематическими рисунками и таблицами, например:
    Высота ленточного фундамента для двухэтажного дома
    После прочтения нескольких статей и ознакомления с сайтом начинаешь верить в реальность и правдоподобность этого утверждения.
    Действительно начинаешь верить в строительство качественных и дешевых фундаментов под дом, дачу, баню, гараж и т.д. за 1/2 или полцены.
    Еще есть важный и хороший момент, на сайте есть раздел посвященный психологии в строительстве и ремонте, в нем рассказывается обо всех строительных и ремонтных процессах, как бы изнутри.
    Есть моменты и тонкости, о которых вообще ни кто не рассказывает и не пишет, например:
    Критерии обеспечивающие экономические выгоды для заказчика
    Специалисты, профессионалы и практики в строительстве фундаментов, можно ли строить качественные и дешевые фундаменты за полцены или за 50% от цены фундамента, или нельзя?
    Вот адрес Школы частных прорабов Prorab2.ru, осуществляющей и обучающей строительство фундаментов за полцены или за 50% от цены фундамента https://prorab2.ru/ .
    До встречи!

    April 12, 2021 at 09:45 | Report abuse | Reply
  12. zithromax prescription

    azithromycin generic name https://zithromaxes.com/ zithromax 500 mg

    April 12, 2021 at 10:18 | Report abuse | Reply
  13. zythromax

    do you need a prescription for zithromax https://zithromaxes.com/ azithromycin drug class

    April 12, 2021 at 11:40 | Report abuse | Reply
  14. buy cheap zithromax online

    zithromax tab https://zithromaxes.com/ zithromax epocrates

    April 12, 2021 at 11:56 | Report abuse | Reply
  15. zithromax buying

    zithromax azithromycine https://zithromaxes.com/ z pak strength

    April 12, 2021 at 16:20 | Report abuse | Reply
  16. Mobile-Rooca

    Can you get money on online casinos?
    Yes, playing online casino games are legal on Australian players. ... When online gambling for physical money, it is necessary to induce a entrust into your casino account. The finery online casinos advance their players a encyclopedic option of reputable banking options to store and withdraw their legal tender
    Try this website
    here are the findings

    April 12, 2021 at 21:32 | Report abuse | Reply
  17. buy zithromax z-pak

    what is zithromax 500mg used for https://zithromaxes.com/ zithromax oral

    April 12, 2021 at 23:05 | Report abuse | Reply
  18. Horace Hazlett

    There is obviously a lot to realize about this. I assume you made various good points in features also.

    https://extraproxies.com/how-to-protect-wordpress-from-hacking/

    April 12, 2021 at 23:22 | Report abuse | Reply
  19. Spotifyreeme

    lofi hip hop and chill

    tiktok spotify diy

    max korzh album download

    ramil' russian singer

    dream team house 2020

    April 12, 2021 at 23:31 | Report abuse | Reply
  20. canadian pharmacy for cialis

    cialis through canadian pharmacies https://canadacialisstore.com/ canadian pharmacy cialis no prescription

    April 12, 2021 at 23:40 | Report abuse | Reply
  21. generic vardenafil 20mg

    is vardenafil in the va formulary https://vegavardenafil.com/ vardenafil hcl 20mg tab

    April 12, 2021 at 23:51 | Report abuse | Reply
  22. recommended doseage of alprostadil suppository

    buy muse alprostadil urethral suppository https://alprostadildrugs.com/ how to adminiter transurethral alprostadil muse video

    April 13, 2021 at 02:58 | Report abuse | Reply
  23. canadian pills online

    canadian diet pills https://canadapillstorex.com/ canadian diet pills

    April 13, 2021 at 02:59 | Report abuse | Reply
  24. what is tadalafil

    buy tadalafil https://elitadalafill.com/ tadalafil generic

    April 13, 2021 at 04:47 | Report abuse | Reply
  25. PMFernando

    https://mostbet1.azurewebsites.net/

    April 13, 2021 at 05:20 | Report abuse | Reply
  26. SSHABRom

    лендинг торты

    April 13, 2021 at 09:21 | Report abuse | Reply
  27. Russel Vanorsdale

    you've gotten an excellent blog here! would you prefer to make some invite posts on my weblog?

    https://extraproxies.com/why-is-it-ok-to-pay-botw-directory-but-not-others/

    April 13, 2021 at 11:07 | Report abuse | Reply
  28. Mariydiale

    Bienvenue tout le monde. Presque tout le monde profite des avantages du streaming gratuit en français partout en France. C'est pourquoi on vous propose plusieurs sites de streaming! Le site streamizseries de choix concernant les parcs. C'est un très bon site de streaming. Il n'y a pas d'interface de fond blanc et c'est sympas. Effectivement, vous pensez que sur l'une des affiches, Voir les series sur wikiserie en streaming vf et vostfr gratuit en complet. Vous pouvez trouver des films classés par catégories et par années. Les films les plus populaires en streaming complet gratuit. Il est également important de noter qu'il n'y a presque pas de pub sur le site de streaming.

    C'est rare pour un site de streaming. Si vous nous envoyez pour vous divertir, vous donnez ce que nous faisons sur le site film en streaming est une référence au genre. En fait, elle est en ligne depuis des années. Une partie des trois est pourquoi il est connu. Vous pouvez choisir des films et des dessins animés rares et très appréciés, vous trouverez de nombreuses mangas sur le site. Il est très simple d'utilisation. Si vous êtes à la cour, beaucoup d'amour disponible ne vous suffit pas. Si vous n'êtes pas membre du site de streaming, vous acceptez que cinemay vous accompagne.

    En fait, vous apportez certains de vos series que vous voyez habituellement. Qu'il s'agisse d'un blockbuster ou des dernières nouvelles saisons, ce n'est pas la même chose que le choix. Tout est disponible. Et aussi de nombreuses series en streaming vf gratuit qualite hd en ligne français.

    April 13, 2021 at 14:01 | Report abuse | Reply
  29. HenryBrire

    My name is Kate I’m new here and I would like you to support me with likes and comments)) I don’t meet in real life but you can order a custom video and realize your fantasies.
    золото

    пизда

    хуй

    оральныйсекс

    April 13, 2021 at 14:55 | Report abuse | Reply
  30. buy zithromax online uk

    azithromycin drug class https://zithromaxes.com/ zithromax 250 mg dosage

    April 13, 2021 at 15:06 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24

Leave a Reply to gelQuota


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.