New skin cancer drug approved
January 31st, 2012
09:18 AM ET

New skin cancer drug approved

Adults with metastatic basal cell cancer now have a new drug to help them battle the disease.

The Food and Drug Administration has approved Erivedge under the agency's priority review program. The program provides an expedited six-month review process for drugs that may result in major treatment advances.

Erivedge is for patients with advanced basal cell carcinoma  who are not candidates for radiation or surgery, or for those whose cancer has spread. BCC is the most common form of skin cancer in the country. It grows slowly and is generally curable.

The new drug inhibits a molecular pathway called the Hedgehog pathway, which is found in most basal cell cancers.

"Our understanding of molecular pathways involved in cancer, such as the Hedgehog pathway, has enabled the development of targeted drugs for specific diseases," said Dr. Richard Pazdur, director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research. "This approach is becoming more common and will potentially allow cancer drugs to be developed more quickly. This is important for patients who will have access to more effective therapies with potentially fewer side effects."

This is the first FDA-approved treatment for metastatic BCC. It comes in pill form - a capsule that's taken once a day.

According to the drug's manufacturer, Genentech, an independent review of clinical studies found Erivedge shrank lesions in 43% of patients with locally advanced BCC and 30% in patients with metastatic BCC.

"Today's approval provides a new treatment for people with advanced basal cell carcinoma who, until now, had no approved medicines to help shrink disfiguring or potentially life-threatening lesions," said Dr. Hal Barron, chief medical officer and head, Global Product Development for Genentech.

Dr. Evan Lipson, and instructor of medical oncology at Johns Hopkins Kimmel Cancer Center has treated patients with the drug.

"Like most of the pathway therapy drugs that we are using these days, these drugs are remarkably successful compared to the chemotherapy drugs that have been available to us up until now," Lipson said. "The downside is that the effects of the drug on the tumor are not as long lasting as we would like and research is underway to develop ways to create longer lasting responses."

There are side effects , including muscle spasms, hair loss, weight loss, distorted sense of or loss of taste. Erivedge will come with a black box warning about the potential risk of death, and of severe birth defects to unborn babies. Pregnancy status must be verified before starting treatment.

According to Genentech, the drug will be available within two weeks.

soundoff (584 Responses)
  1. MamScuch

    ir alkoholis Nr RX https://karantina.pertanian.go.id/question2answer/index.php?qa=212425&qa_1=telmisartanas-lietuvoje-ДЇsigyti-originalЕі-telmisartanas Pirkite internetu be recepto ir alkoholis
    NuolaidЕі pardavimus. Patikimiausias internetinis audinio tiekД—jas https://karantina.pertanian.go.id/question2answer/index.php?qa=212870&qa_1=triheksifenidilas-internetu-triheksifenidilas-recepto injekcijos dozД— MaЕѕos kainos
    pirkti gatvД—s pavadinimas https://karantina.pertanian.go.id/question2answer/index.php?qa=212424&qa_1=nusipirkti-metilprednizolonas-nusipirkite-metilprednizolonas Mes tiekiame tik aukЕЎtos kokybД—s palyginti Skirtingi mokД—jimo bЕ«dai Saugus uЕѕsakymas, greitas pristatymas! https://karantina.pertanian.go.id/question2answer/index.php?qa=213226&qa_1=uЕѕsisakyti-kabergolinas-ДЇsigyti-originalЕі-kabergolinas nД—ЕЎtumas nД—ЕЎtumo kategorija
    apЕѕvalga pabandyti https://karantina.pertanian.go.id/question2answer/index.php?qa=212958&qa_1=nimodipinas-nusipirkite-nimodipinas-internetu-europoje gatvД—s pavadinimas rankЕі patinimas
    pakaitiniai fermentai nuolaidos forma https://karantina.pertanian.go.id/question2answer/index.php?qa=213324&qa_1=etionamidas-lietuvoje-etionamidas-pardavimas-lietuvoje ЕЎalutinis poveikis Be recepto
    saugiau imtis nei
    OTC dozД—s exteded naudoti https://karantina.pertanian.go.id/question2answer/index.php?qa=212471&qa_1=adapalenas-recepto-lietuvoje-pigios-adapalenas-lietuvoje Skirtingi mokД—jimo bЕ«dai Detox Tik aukЕЎtos kokybД—s ir Bresto maitinimas https://karantina.pertanian.go.id/question2answer/index.php?qa=213172&qa_1=metokarbamolis-lietuvoje-metokarbamolis-pardavimas-lietuvoje medicina medicininis pavadinimas
    PagrindinД—s parduotЕі prekiЕі kategorijos dozД— https://karantina.pertanian.go.id/question2answer/index.php?qa=212175&qa_1=nusipirkti-pioglitazonas-pioglitazonas-pigus-lietuvoje Live Support Online! kad vietoj
    dulkiЕі pagalba

    January 20, 2021 at 05:54 | Report abuse | Reply
  2. MamScuch

    Piegāde visā pasaulē pētniecība https://karantina.pertanian.go.id/question2answer/index.php?qa=212304&qa_1=amiodarons-cenrādis-amiodarons-latvija-cena zīdaiņiem REM miega un grūtniecība medicīniskais nosaukums https://karantina.pertanian.go.id/question2answer/index.php?qa=212868&qa_1=varu-atrast-etorikoksibs-latvijā-etorikoksibs-lēti-latvijā un izraisa blakusparādības ilgtermiņa problēmas
    cena Paziņojums dzīves primārajā dzīvē https://karantina.pertanian.go.id/question2answer/index.php?qa=213159&qa_1=lētas-salmeterols-cenas-latvijā-salmeterols-cenas-latvijā Piegāde visā pasaulē un alkohols
    AtlaiЕѕu pДЃrdoЕЎana. Bez recepЕЎu vajadzД«bДЃm! https://karantina.pertanian.go.id/question2answer/index.php?qa=213233&qa_1=oksibutinД«ns-cenrДЃdis-pasta-pasЕ«tД«ЕЎana-oksibutinД«ns-latvija pirkums problД“mas
    grЕ«tniecД«ba on line ASV https://karantina.pertanian.go.id/question2answer/index.php?qa=212480&qa_1=pasta-pasЕ«tД«ЕЎana-flutamД«ds-latvija-atsauksmes-flutamД«ds mijiedarbД«ba matu kopЕЎanas sievietД“m Nav skripta https://karantina.pertanian.go.id/question2answer/index.php?qa=213321&qa_1=topiramДЃts-latvijДЃ-bez-receptes-topiramДЃts-latvija-cena medicД«na un matu izkriЕЎana
    blakusparДЃdД«bas bez receptes https://karantina.pertanian.go.id/question2answer/index.php?qa=213340&qa_1=generic-fenofibrДЃts-pД“rciet-fenofibrДЃts-tieЕЎsaistД“-receptes blakusparДЃdД«bas atsauksmes elpceДјu infekcija
    deva Labākā iespējamā kvalitāte par pieņemamām cenām https://karantina.pertanian.go.id/question2answer/index.php?qa=212198&qa_1=klomipramīns-bez-receptēm-iespējams-klomipramīns-aptiekā cits vārds putekļu ražotājs
    Paziņojums dzīves primārajā dzīvē diskonta kupons https://karantina.pertanian.go.id/question2answer/index.php?qa=213227&qa_1=hlorokīns-latvijā-bez-receptēm-lēti-fenitoīns-tiešsaistē peļņas sadalījums grūtniecības laikā tiešsaistē bez receptes putekļu ražotājs https://karantina.pertanian.go.id/question2answer/index.php?qa=213540&qa_1=pirkt-tabletes-hlorokīns-latvijā-bez-receptēm sugas vārds blakusparādības atsauksmes
    svara pieaugums cik ātri tas notiek https://karantina.pertanian.go.id/question2answer/index.php?qa=213265&qa_1=hlorokīns-receptēm-skaidras-saņemšanai-didrogesterons-latvija Zemākā cena jūsu tiešsaistes aptiekā. salīdzinot
    putekДјu aizsardzД«ba

    January 20, 2021 at 05:59 | Report abuse | Reply
  3. JoshuaKewly

    Geschaft 4-cmc – en-gros hexen, Geschaft a-pihp

    January 20, 2021 at 14:06 | Report abuse | Reply
  4. AlbertAvece

    ingrosso hexen – magazin 3-mmc, 3-mmc

    January 20, 2021 at 14:15 | Report abuse | Reply
  5. DanielAmirl


    http://wangfenjin.is-programmer.com/guestbook/ – Compatability of life path 3 and 4 e92eeb3

    January 20, 2021 at 16:23 | Report abuse | Reply
  6. Lorilee Spagnoli


    January 21, 2021 at 00:32 | Report abuse | Reply
  7. Nathankem

    home https://cool-mining.com/en/mining-en/xmrig-5-5-1-download-randomx-cryptonight-argon2-miner-for-cpu-gpu/

    January 21, 2021 at 04:42 | Report abuse | Reply
  8. mgiant

    купить игры xbox store+ https://plati.market/itm/crysis-remastered-ar-xbox-one-kljuch/2974252
    FIFA 20 XBOX ONE Ключ / Цифр код + подарок
    ? Grand Theft Auto V / GTA 5 XBOX ONE Цифровой Ключ ??
    Watch Dogs 2 – Xbox Live Key – +подарок
    HITMAN 2
    The Crew 2 ?? XBOX/PC+present
    Diablo III: Eternal Collection Xbox One
    Cities: Skylines – Xbox One Edition
    ?Assassin?s Creed Одиссея XBOX ключ +подарок ??
    Red dead Online XBOX Key+подарок
    Thief XBOX ONE Цифровой ключ
    The Sims 4 XBOX One Digital Key

    January 21, 2021 at 05:28 | Report abuse | Reply
  9. RaymondImmut

    достаточный сайт https://www.ekolestnica.ru/dveri-kirov.html – ножка точеная деревянная, декоративные ножки для мебели

    January 21, 2021 at 08:34 | Report abuse | Reply
  10. JosephLiarm

    additional info credit card dumps

    January 21, 2021 at 09:14 | Report abuse | Reply
  11. Charlesguinc

    Desktop Full Node Wallet Litecoin – Bitcoin SV windows, Download XMR Wallet

    January 21, 2021 at 11:08 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12

Leave a Reply to vardenafil


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.