home
RSS
New skin cancer drug approved
January 31st, 2012
09:18 AM ET

New skin cancer drug approved

Adults with metastatic basal cell cancer now have a new drug to help them battle the disease.

The Food and Drug Administration has approved Erivedge under the agency's priority review program. The program provides an expedited six-month review process for drugs that may result in major treatment advances.

Erivedge is for patients with advanced basal cell carcinoma  who are not candidates for radiation or surgery, or for those whose cancer has spread. BCC is the most common form of skin cancer in the country. It grows slowly and is generally curable.

The new drug inhibits a molecular pathway called the Hedgehog pathway, which is found in most basal cell cancers.

"Our understanding of molecular pathways involved in cancer, such as the Hedgehog pathway, has enabled the development of targeted drugs for specific diseases," said Dr. Richard Pazdur, director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research. "This approach is becoming more common and will potentially allow cancer drugs to be developed more quickly. This is important for patients who will have access to more effective therapies with potentially fewer side effects."

This is the first FDA-approved treatment for metastatic BCC. It comes in pill form - a capsule that's taken once a day.

According to the drug's manufacturer, Genentech, an independent review of clinical studies found Erivedge shrank lesions in 43% of patients with locally advanced BCC and 30% in patients with metastatic BCC.

"Today's approval provides a new treatment for people with advanced basal cell carcinoma who, until now, had no approved medicines to help shrink disfiguring or potentially life-threatening lesions," said Dr. Hal Barron, chief medical officer and head, Global Product Development for Genentech.

Dr. Evan Lipson, and instructor of medical oncology at Johns Hopkins Kimmel Cancer Center has treated patients with the drug.

"Like most of the pathway therapy drugs that we are using these days, these drugs are remarkably successful compared to the chemotherapy drugs that have been available to us up until now," Lipson said. "The downside is that the effects of the drug on the tumor are not as long lasting as we would like and research is underway to develop ways to create longer lasting responses."

There are side effects , including muscle spasms, hair loss, weight loss, distorted sense of or loss of taste. Erivedge will come with a black box warning about the potential risk of death, and of severe birth defects to unborn babies. Pregnancy status must be verified before starting treatment.

According to Genentech, the drug will be available within two weeks.


soundoff (105 Responses)
  1. Anthonypap

    вполне себе годнота
    _________________
    игровые автоматы играть бесплатно без регистрации братва

    November 27, 2020 at 10:16 | Report abuse | Reply
  2. topinfCrota

    Что произошло
    Джет Ли

    November 27, 2020 at 18:52 | Report abuse | Reply
  3. Tommychota

    леон промокод – бетсити бонус, leon промокод

    November 27, 2020 at 19:45 | Report abuse | Reply
  4. Julianna nob

    New skin cancer drug approved – The Chart – CNN.com Blogs
    Best Place To Buy Clozaril in AUSTRALIA Buy Online Clozaril in CANADA without rx ; Buy Discount Clozaril in AUSTRALIA
    http://b7club.ru/viewtopic.php?f=3&t=506309
    Clozaril in UK/GB no script needed
    Clozaril free worldwide shipping
    New skin cancer drug approved – The Chart – CNN.com Blogs

    GO TO PHARMACY ENTER HERE! https://bit.ly/us-uk-canada-meds

    New skin cancer drug approved – The Chart – CNN.com Blogs

    How To Purchase Clozaril in USA Cheap Generic http://www.schermaforli.it/2020/06/12/ripresa-attivita/#comment-124454 ; Clozaril in USA no script next day delivery ; http://pandarion-wow.com/forum/viewtopic.php?f=9&t=257198&p=479452#p479452 ; Buy Online Cheapest Clozaril in CANADA no prescription https://therealtimmyt.com/forum/viewtopic.php?f=7&t=354 ; Buy Cheap Clozaril in CANADA internet drugs overnight http://www.crusaders-cagliari.it/forum/welcome-mat/293946-cheapest-price-to-order-cialis-light-pack-90-no-prescription-required-cialis-light-pack-90-no-dr-approval.html#296275 ; Clozaril in CANADA next day no prescription Thousands of people feel blue every fall, but many of them struggle and win! – http://forums.inwing.com/index.php/topic,600901.msg806808.html#msg806808 | Improving our pharmacy is to what all our team members dedicate their time and enthusiasm! – http://techniqueauto.ch/forum/welcome-mat/727292-ordering-at-lowest-price-naprosyn-pay-with-mastercard-visa-ach-echeck-naprosyn-next-day-no-prescription#727260 |This medication will make a great surprise both for you and for your tired penis. Try out the magic! – http://kiev.ukrbb.net/viewtopic.php?f=2&t=117248 |What do you know about the painkiller you take daily? Does it really have advantages only? – http://lecrise.org/forums/topic/buy-at-low-cost-minocycline-shipped-with-no-prescription/page/15/#post-135865 |What is your lifetime goal? Is it restoring your potency! Oh, man it’s easy as A-B-C! – https://tunapop.io/post/5fbe58078ffac104d920d656 |Most therapists don’t know yet about the innovative bladder infection treatment! Get the info! – http://nocnekino.pl/showthread.php?tid=16007 |Forget about insomnia and keep well! It’s easy with our new antidepressant! – http://highhopeshuntclub.com/viewtopic.php?f=1&t=1161414 |If you have difficulty keeping an erection more than 25% , it is considered a problem. – https://pixarplanet.com/forums/viewtopic.php?f=10&t=257370 |Is your asthma preventing you from exercising? It doesn’t have to! Keep on moving! – https://pixarplanet.com/forums/viewtopic.php?f=10&t=259153 |What are your ways to struggle seasonal depression if you have some? – http://forums.inwing.com/index.php/topic,581886.msg837836.html#msg837836 |If good mood leaves you together with summer warmth and sun, you need help! – http://www.nsu-club.com/forum/viewtopic.php?f=6&t=1581645 |You doctor’s ultimate goal is to provide you with best asthma treatment and avoid risk! – http://qa.rmutto.ac.th/phpBB3/viewtopic.php?f=7&t=170050&p=1587320#p1587320 |Every man wants to have normal sexual activity, but life’s plans often differ greatly. Learn more! – http://qa.rmutto.ac.th/phpBB3/viewtopic.php?f=7&t=170050&p=1588657#p1588657 |Don’t forget how interesting your life had been before that depression ruined it totally. – http://www.ambervibe.com/forum/viewtopic.php?f=37&t=386728 |Obesity is often caused by desire to look more attractive, particularly in skinny teenage girls. – http://www.vmalumni.com/forums/topic/cheapest-hair-loss-cream-with-no-rx-hair-loss-cream-fast-shipping-no-prescription/ |You are more likely to have problems with cholesterol if members of your family have it. – http://vaishak-udacity.appspot.com/blog/1435314014

    November 27, 2020 at 20:10 | Report abuse | Reply
  5. StevenPhant

    Pegas – Банковский пробив,ФНС и не только!Также все виды ЭЦП без селфи и визитов! Открытие ООО,ИП под Ваши нужды.
    Также предоставляем сопровождение в нескольких Банках.
    Контакты:
    Telegram: @PegasRUS https://t.me/PegasRUS

    Пробив Bmб / Bmб24, сопровождение на ВЭД, банковские пробивы локо банка купить, пробить банковскую карту по номеру, Пробив Сбepбaнk, [url=https://darkmoney.tw/probiv-informacii-122/pegas-bankovskii-probiv-fns-i-ne-tol-ko-243021/]пробив фнс[/url], банковские пробивы локо банка купить, Пробив CoвKoмБaнk, Пробив УбPИP, лом НДС, пробив фнс

    November 27, 2020 at 23:30 | Report abuse | Reply
  6. SeoMeganRow

    [b]Имя SEO может красоваться определен следующим образом:[/b]

    [url=https://vk.com/prodvizhenie_saytov_msk]seo оптимизация продвижение сайтов[/url] в общем понимании — это комплексный дело работы над сайтом ради увеличения количества ответов, связанных со страницами Вашего сайта, в поисковой выдаче сообразно ключевым словам и привлечение по ним посетителей;
    SEO в профессиональном понимании – это оптимизация коллекции документов (страниц сайта) чтобы увеличения посещений сайта пользователями из поисковых систем и/или поднятия позиций по запросам для посадочной страницы;
    SEO – это канал привлечения целевой аудитории из поисковых систем;
    SEO – это способ возбуждение для формирование выдачи сообразно определенным поисковым запросам.
    Современные поисковые системы — это миллионы пользователей, сложные алгоритмы и огромные объемы данных. Когда посетитель что-то ищет в поиске, формируется страница c ответами. Она состоит из разных элементов. Чаще только это:
    мы в социальных сетях : https://ok.ru/prodvizhenie.saitov , https://www.facebook.com/prodvizheniesaytov , https://twitter.com/big_seo_ru , https://www.instagram.com/big_seo/
    контекстная объявление – блок с платной рекламой в поисковой выдаче, размещенный в нескольких зонах;
    органическая выдача – блок с естественными ответами на запросы пользователей. Обычно состоит из 10 страниц различных сайтов. Разделение происходит на основе факторов ранжирования. Для улучшения позиций сайта проводится поисковая оптимизация (SEO).

    November 27, 2020 at 23:34 | Report abuse | Reply
  7. Duanehig

    [url=https://bonus-betting.ru/bukmekery/winline/winline-promokod/]winline бонус[/url] – 1xslots промокод, лайнбет

    November 28, 2020 at 00:08 | Report abuse | Reply
  8. Louisporma

    [url=https://betslive.ru/bonus-bk/ligastavok/ligastavok-promokod/]лига ставок промокод[/url] – промокод винлайн, leon промокод

    November 28, 2020 at 01:26 | Report abuse | Reply
  9. ThCaday

    Restoration of baths in Khimki [url=https://megaremont.pro/kazan-restavratsiya-vann]https://megaremont.pro/kazan-restavratsiya-vann[/url]

    November 28, 2020 at 10:07 | Report abuse | Reply
  10. RobertFar

    В нашем магазине сможете приобрести мягонькую меблировка по
    доступной стоимости. Вналичии всякий раз большущий выбор
    плавной мебели. Приобрести диванчикдиван дешево вы сможете
    по адресу Острогоржская 69А . Наши диваны доступны каждому!
    [url=https://prodivan136.ru/]купить диван[/url]
    [url=https://prodivan136.ru/katalog/]купить диван дешево[/url]
    [url=https://prodivan136.ru/katalog/akkordeony/]диваны Воронеж[/url]
    [url=https://prodivan136.ru/o-nas/]купить диван дешево[/url]

    November 28, 2020 at 10:46 | Report abuse | Reply
  11. Jessiejak

    click here for more
    movers in Mississauga

    November 28, 2020 at 12:13 | Report abuse | Reply
  12. vardenafil

    symptoms of gastrointestinal asthma causes symptoms prevention and treatment
    levitra https://levitrahill.com/# vardenafil
    levitra

    November 28, 2020 at 12:23 | Report abuse | Reply
  13. ivmcjaqau

    Интересный пост
    _________________
    tempobet uzantД±

    November 28, 2020 at 12:45 | Report abuse | Reply
  14. DonmaK

    Новый год уже близко.
    В интернет магазине Товаромания.РФ снижены цены.
    Бесплатная доставка.
    Самый выгодные предложения на Аксессуары для кукол только сейчас.

    November 28, 2020 at 14:15 | Report abuse | Reply
  15. Billyway

    Fed up with your humble life?
    We will show you how to earn more! http://freeforryou.blogspot.com

    November 28, 2020 at 21:24 | Report abuse | Reply
  16. StanleySique

    Деньги на любые цели, оформление онлайн, только фото паспорта.

    Умный подбор на сайте https://credonline.ru

    Даже с плохой кредитной историей, если вам везде отказывают в займе, то наш алгоритм бодберет для вас варианты с одобрением.

    До 50000 рублей за 5 минут на карту.

    Ищите в телеграм @credonline_bot или заходите на сайт https://credonline.ru

    November 29, 2020 at 02:36 | Report abuse | Reply
  17. Curtissassy

    Hi,

    I am contacting you today because i have Jackpotbetonline.com site for advertising.

    Please check the website where you place link or article post.

    Jackpotbetonline.com are evryday updated & have good Domain Autority (DA=62) & Good Domain Rating (DR=72).

    The Following advertising Options are available:

    Text Link Space
    Article post (Max of 3 links per article)
    Advertising Banner Space (460×60 or 250×250)
    Best " Online casino Slots " Review

    Regards,

    November 29, 2020 at 04:00 | Report abuse | Reply
  18. Arthurded

    health care waste https://courrierdesameriques.com/forums/topic/acheter-lorazepam-en-ligne-sans-ordonnance health care oklahoma

    November 29, 2020 at 07:23 | Report abuse | Reply
  19. JohnnyInsut

    Довольно интересно
    _________________
    nesine android uygulamasД± indir

    November 29, 2020 at 09:58 | Report abuse | Reply
  20. JosephLoack

    CBD Oil, It's About the Quality of Your Life

    cbd oil for migraines
    cbd dabs
    cbd hemp oil for pain

    Discomfort. Stress. Fatigue. They’re just parts of our everyday lives that we must adjust our routines around. Well, not anymore! Thanks to CBD, many are reclaiming their quality of life. In fact, Joy Smith, founder of Joy Organics, is one of those people. Now, Joy wants others to live their best lives with CBD too.

    To celebrate two years in business, we’re offering a special deal to our customers. When you buy one product, you'll receive another one for free!

    Place an order anytime this week, and you’ll also be automatically be entered to win up to $600 worth of CBD products!

    Join the celebration and don’t miss this limited-time offer!

    November 29, 2020 at 15:57 | Report abuse | Reply
  21. BobbyRap

    справный ресурс https://coleso.md/265_45_r21_anvelope/ – 225 45 r19 зима, 225 60r17, 215 65 r15 лето

    November 29, 2020 at 21:52 | Report abuse | Reply
  22. Valeruyas

    Bitcoin Explodes Profits!
    Find out how he became a millionaire in 6 months >> http://moneyactivess.blogspot.gr

    November 30, 2020 at 02:34 | Report abuse | Reply
  23. RaymondPaype

    https://berezovec.ru/roject/
    https://berezovec.ru/ompany/
    https://berezovec.ru/poteka/
    https://berezovec.ru/ortgage-calculator/
    https://berezovec.ru/aternity-capital/
    https://berezovec.ru/nstallment/
    https://berezovec.ru/ubsidy/
    https://berezovec.ru/ews/
    https://berezovec.ru/uarantee/
    https://berezovec.ru/roperty/
    https://berezovec.ru/ooperation/
    https://berezovec.ru/ommerce/
    https://berezovec.ru/ontact/
    https://berezovec.ru/lient/login

    November 30, 2020 at 09:27 | Report abuse | Reply
  24. KaseySpuck

    https://berezovec.ru/awject/
    https://berezovec.ru/awpany/
    https://berezovec.ru/awteka/
    https://berezovec.ru/awtgage-calculator/
    https://berezovec.ru/awernity-capital/
    https://berezovec.ru/awtallment/
    https://berezovec.ru/awsidy/
    https://berezovec.ru/aws/
    https://berezovec.ru/awrantee/
    https://berezovec.ru/awperty/
    https://berezovec.ru/awperation/
    https://berezovec.ru/awmerce/
    https://berezovec.ru/awtact/
    https://berezovec.ru/awent/login

    November 30, 2020 at 14:18 | Report abuse | Reply
  25. GeorgeEximi

    https://berezovec.ru/ject/
    https://berezovec.ru/pany/
    https://berezovec.ru/teka/
    https://berezovec.ru/tgage-calculator/
    https://berezovec.ru/ernity-capital/
    https://berezovec.ru/tallment/
    https://berezovec.ru/sidy/
    https://berezovec.ru/s/
    https://berezovec.ru/rantee/
    https://berezovec.ru/perty/
    https://berezovec.ru/peration/
    https://berezovec.ru/merce/
    https://berezovec.ru/tact/
    https://berezovec.ru/ent/login

    November 30, 2020 at 15:13 | Report abuse | Reply
  26. exiting

    Viagra Online Sale Canada Arratteval buy cialis professional NodyDete Viagra Et Angor

    November 30, 2020 at 17:33 | Report abuse | Reply
  27. Nmvjefbjedddskhfugfhisjdiubgufihwsdjwsu ifhsidjiswfhdueihfiehifeji ifheidfheidhfiehfiejofejgi jfoedjfoejdgiehdfocjfdenghirho https://mail.ru/?bvncdbjdfjdfh=rhfidbvgjf

    Nmvjefbjedddskhfugfhisjdiubgufihwsdjwsu ifhsidjiswfhdueihfiehifeji ifheidfheidhfiehfiejofejgi jfoedjfoejdgiehdfocjfdenghirho https://mail.ru/?bvncdbjdfjdfh=rhfidbvgjf

    November 30, 2020 at 20:15 | Report abuse | Reply
  28. Tanaeq

    examine of ages of Chinese Olympians expanded

    overseas gymnastics officials are examining whether Yang Yun and Dong Fangxiao, including, Were who are old enough to compete.

    Most Read Sports StoriesWashington's sports officials are vanishing at an alarming rate. what do i mean for Chris Carson?Ex Carolina Hurricanes owner says he'd have fired coach had current NHL Seattle GM Ron Francis told him of player abuse allegations

    We had a look at all the articles that came before, During and following a Games, there have been always rumors about the ages of China athletes in Sydney, Andre Gueisbuhler, Secretary general of the overseas Gymnastics Federation, Told The correlated Press on Wednesday.

    Did not have another option, he was quoted saying. you want to remain credible, Then we should instead look into things. Other Chinese teams are being looked at, Gueisbuhler asserted.

    This instant, We take concerns about 2000 and 2008, he was quoted saying.

    The examine is ongoing, A month following the Beijing Games ended, and there's no timetable for when it will be finished.

    Bobcats broaden offer sheet to Rockets Landry: The charlotte now Bobcats moved to bolster their thin frontcourt, Signing Houston Rockets tied-down free agent forward Carl Landry to a three year, $9 million offer list.

    The Rockets have a week to decide calling match the offer or lose Landry to Charlotte.

    our 6 foot 9, 248 single Landry averaged 8.1 shows chinese women and 4.9 boards in 42 games for the Rockets as a rookie last season. Houston extended him a determining offer, But the two sides weren't able to reach a deal.

    Landry played while attending school at Purdue. He was drafted by Seattle in the second round yr after, Then sent to the Rockets in a deal towards draft picks and cash.

    Canadiens Carle carried off the ice on stretcher: Montreal defenseman Mathieu Carle was carried off the ice on a stretcher after being hit by Detroit Tomas Kopecky during an event game. Carle lost and regained intelligence on the ice after the hit. He was taken to Detroit medical.

    Sharks sign Murray to off shoot: Defenseman Doug Murray agreed to a four year contract extendable with the San Jose Sharks.

    brazilian stars selected in women draft: brazilian stars Marta, Daniela and Cristiane were selected in the first round of the Women Professional Soccer crucial draft.

    Santa Anita opens racing on its new floor: father christmas Anita in Arcadia, Calif, Opened racing at its Oak Tree meeting on a new synthetic surface that is being closely scrutinized before next month Breeders Cup.

    Having an effective month of racing going into the sport richest two days could help attract reigning Horse of the Year Curlin to challenge Big Brown in the $5 million Breeders Cup Classic.

    Owner Jess Jackson said this week he is unsure about trying Curlin on a synthetic surface at last, And that the track malady would play into his decision.

    November 30, 2020 at 22:06 | Report abuse | Reply
  29. topten.aia

    Hi there, just came across your posts, really appreciate your works!
    Would like to share some useful free website, hope you like it.
    https://fabpdf.com/
    https://myconverters.com
    https://topten.review/
    https://vidusoft.com
    https://vanceai.com/image-enhancer/

    November 30, 2020 at 23:16 | Report abuse | Reply
  30. JamesFloug

    САмое эффективное для продаж – Pinterest. Dbltj – Сотни Продаж на Etsy, amazon, ebay, shopify за 2 месяца при ср.цене чека 300 usd https://youtu.be/GNOZtXGGM-I

    December 1, 2020 at 09:46 | Report abuse | Reply
  31. KennethCig

    Спасибо за пост
    _________________
    kasyno online bet at home

    December 1, 2020 at 13:50 | Report abuse | Reply
  32. Yipfiz

    promptly the whole story needed for essential injure wellbeing

    warm conditions are definitely at this website, indicates much of our days happen to be filled up with outdoors gems that can on occasion induce trivial slices, scuff marks and as a consequence burns. So it is important to choose a first-aid heal which include Betadine antiseptic creamy to protect by themselves and as a result keep the fun selecting months on the way.

    pass up the very first-aid section when much pharmacy and there are various tons of techniques. additionally, countless superbly written articles then dvds for the internet touting i would say the "major" natural treatments would add puzzled concerning whom rehab to buy. as for minor injury cure, period of time really needs to be simple. we are going to reviews others first-aid particulars as well as Betadine can protect stomach and your family.

    consider pains in time. Both types as well as,while our skin's surface by nature hold bacterias, many of which might result in illness.1,2,3 issues can radically hold-up wound healing,4 also coming out of wounds to get better only on their is a game your close relatives should be as it might quit your already familiar with possibly damaging germs. to match nutrient rich dealing with, earn Betadine you are choose germ killing to kill many types of bacterias whenever you are the treatment of secondary nicks, scores as well as can burn.

    simply, There's no need to hang about until you go back home to be treating all those trivial wounds. Betadine is now available as a basic to make use of remedy to make fitting treatment program fitness center shopping with an adult.

    our click on emergency first aid kit main points

    Replenishing our first aid sets definitely isn't towards the top of our to handle listings, but first aid lotions enjoy run out into the future. it's time to take a glance your own first aid kit and additionally restock companies absolutely need merchandise.

    (essentially, latamdate.com produce this site also raise this shopping list along in the direction of online pharmacy.)

    topical antiseptic, resembling Betadine antiseptic CreamAdhesive and also gauze bages

    prompt ice cubes kits

    aspirin or ibuprofenMedical tape

    additionally it is beneficial to include did you know the emergency get in numbers in your first aid kit in the event you need to reach your family's medical exam retailers.

    when contemplating storing all your family members preserved, set up prudent consisting of Betadine (Povidone iodine), A topical ointment germ killing, As very first type of barricade to assist in preventing trojans before the many get going.

    Betadine variety should be creditworthy near nursing homes for over 50 time.

    safe relating to a minimal amount of acute wounds as well as,while immediate tissue to help nutrient rich re-conditioning.

    really doesn't associated with alcoholic drinks or simply hydrogen peroxide and a No agony assures.

    The golden light brown tone tells you that antiseptic was initially installed and provides you a secure feeling uncover that executing.

    realize when your parents or grandma and grandpa normally used a container connected with iodine to cure your slices and scores? though it may be effective, this treatment appeared to be usually when combined alcoholic beverage, Which produces itching and also extend the time of hurt recovery.

    Betadine's povidone iodine strategy don't hold drinking or peroxide, which commonly poke after implemented. Betadine carries a it doesn't trick swear.

    December 1, 2020 at 13:59 | Report abuse | Reply
1 2

Leave a Reply to Smock


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.