Study: Fat hormone increases risk of dementia in women
January 2nd, 2012
04:00 PM ET

Study: Fat hormone increases risk of dementia in women

Some risk factors for dementia like getting old and having a family history cannot be prevented, but a new study shows that hormones produced in excess weight around the middle may be another risk factor, particularly for women. 

A report in Monday’s Archives of Neurology has found that an increased presence of the hormone adiponectin can increase the risk for loss of brain function and Alzheimer's disease.

According to the World Alzheimer’s Report, currently, 36 million people are affected by dementia worldwide, and that number is expected to double in the next 20 years. Alzheimer’s disease is the most common form of dementia, impacting 80% of the elderly. The Alzheimer’s Association says two-thirds of those with Alzheimer’s are women, and today, of the 5.4 million Americans with Alzheimer’s, 96% are over the age of 65.

Adiponectin is a hormone produced by fat cells that helps regulate the body’s response to insulin and metabolism. Higher levels of adiponectin have been shown to help lower the risk for Type 2 Diabetes.  But, the authors found that older women who had developed dementia also had higher levels of the hormone.

Dr. Ernst Schaefer, director of the Tufts University Lipid Metabolism Laboratory, one of the study’s authors was surprised by the findings. “ We expected adiponectin to protect against dementia, and it turned out to be just the opposite.”

The authors of the study tracked 841 men and women who were part of the original generation of patients enrolled in the famed Framingham Heart Study.  That study began tracking over 5,000 patients in 1948, to get a better sense of what factors led to cardiovascular disease.  While the Framingham Heart Study initially had similar numbers of men and women enrolled, by the time the patients were tracked for the dementia study, beginning in the late 1980s, most of the surviving patients left were women.

Of the 541 women that were tracked for dementia over the following 13 years, 159 developed some form of dementia, including 125 cases of Alzheimer’s disease.  The study authors found that increased levels of adiponectin increased the likelihood of dementia development by 60%, and of Alzheimer’s by 90%.

In addition to adiponectin, the study also tracked homocysteine and glucose levels.

Schaefer suggested that the dementia study might indicate a connection between nutrition and dementia.  Adiponectin levels were found to be inversely correlated to body mass index, or BMI.  Older women with higher BMIs were found to have lower levels of adiponectin, and  lower rates of dementia. 

While Schaefer mentioned that these factors probably also hold true for men, he said that unfortunately, the numbers weren’t there to support it because of the low number of men still participating in the study.

He said for women over 60, “it may be that being very thin may not be a good thing.” But carrying to much weight can lead to other diseases like diabetes and heart disease. As people age, Schaefer says nutrition should be of big concern. “We need to make sure that people are involved in eating three square meals and getting the nutrients they need. It may be vital to their mental health.

The study was supported in part by the National Institute of Health, the US Department of Agriculture, and the Framingham Heat Study.

soundoff (298 Responses)
  1. BbshMile

    real life experiences viagra http://loxviagra.com/ – mexican viagra brands viagra replacement

    May 16, 2021 at 21:17 | Report abuse | Reply
  2. AnooEncox

    best online pharmacy to buy viagra https://llviagra.com/ up il viagra di fitoterapia

    May 17, 2021 at 04:15 | Report abuse | Reply
  3. LbsoZisse

    can you buy cialis without a prescription http://ucialisdas.com/ viagra vs cialis

    May 17, 2021 at 15:27 | Report abuse | Reply
  4. AnooEncox

    samantha toma viagra http://llviagra.com/ will viagra work if cialis doesnt

    May 18, 2021 at 00:57 | Report abuse | Reply
  5. FmrfEncox

    cheapest cialis in australia https://cialisee.com/ – cheapest cialis review cialis black 800mg

    May 18, 2021 at 02:12 | Report abuse | Reply
  6. LebnEncox

    canadadrugs compare prescription prices Flomax

    May 18, 2021 at 03:31 | Report abuse | Reply
  7. LebnEncox

    eye drop https://xlnpharmacy.com/ pharmacy canadian superstore

    May 19, 2021 at 00:12 | Report abuse | Reply
  8. LbsoZisse

    cialis pills for sale http://ucialisdas.com/ cialis black

    May 19, 2021 at 11:26 | Report abuse | Reply
  9. JebgEncox

    trusted online pharmacy reviews Zebeta canadian drugs online pharmacy

    May 20, 2021 at 07:57 | Report abuse | Reply
  10. RebfZisse

    cialis cheaper https://rcialisgl.com/ purchase cialis

    May 20, 2021 at 14:01 | Report abuse | Reply
  11. JebgEncox

    pharmacy home delivery online pharmacy pharmacy website india

    May 21, 2021 at 02:11 | Report abuse | Reply
  12. AnooEncox

    how do you get viagra to work http://llviagra.com/ order viagra canada pharmacy

    May 21, 2021 at 05:39 | Report abuse | Reply
  13. GtnbCrulk

    do i need a prescription for viagra https://jokviagra.com/ does viagra really work

    May 21, 2021 at 20:18 | Report abuse | Reply
  14. AnooEncox

    vatican position on viagra https://llviagra.com/ otra pastilla que no sea viagra

    May 22, 2021 at 01:16 | Report abuse | Reply
  15. FmrfEncox

    20mg cialis http://cialisee.com/ buy cialis no prescription uk

    May 22, 2021 at 02:23 | Report abuse | Reply
  16. RebfZisse

    20mg cialis generic http://rcialisgl.com/ – generic cialis for sale buy 10 mg cialis

    May 22, 2021 at 16:20 | Report abuse | Reply
  17. BbshMile

    what does viagra do for women http://loxviagra.com/ viagra ingredients

    May 22, 2021 at 19:56 | Report abuse | Reply
  18. GtnbCrulk

    marley generics viagra https://jokviagra.com/ pills like viagra over the counter

    May 23, 2021 at 04:10 | Report abuse | Reply
  19. LebnEncox

    king pharmacy Trimox pharmacy online no prescription

    May 23, 2021 at 09:38 | Report abuse | Reply
  20. LbsoZisse

    cialis dapoxetine 24 tab http://ucialisdas.com/ generic cialis tadalafil

    May 23, 2021 at 14:44 | Report abuse | Reply
  21. LebnEncox

    canada drug http://xlnpharmacy.com/ drugstore

    May 24, 2021 at 15:28 | Report abuse | Reply
  22. LbsoZisse

    cialis usa online http://ucialisdas.com/ best online to buy cialis

    May 24, 2021 at 16:27 | Report abuse | Reply
  23. BbshMile

    is there a generic viagra https://loxviagra.com/ – canadian viagra sales best time to take viagra 100mg

    May 25, 2021 at 03:12 | Report abuse | Reply
  24. EncoxAni

    india pharmacy mail order https://pharmacyken.com/ – pharmacy global rx review buy drugs from canada legal

    May 25, 2021 at 09:51 | Report abuse | Reply
  25. Zisseloh

    is generic cialis available now? https://rcialisgl.com/ – prescription free cialis generic cialis or tadalafil

    May 25, 2021 at 11:55 | Report abuse | Reply
  26. EncoxDev

    canada drugs pharmacy checker prescription drugs ad canada pharmacy coupon code

    May 26, 2021 at 04:37 | Report abuse | Reply
  27. EncoxAni

    Celexa https://pharmacyken.com/ – online pharmacy usa online pharmacy program

    May 26, 2021 at 05:31 | Report abuse | Reply
  28. EncoxHtf

    30 day free trial of cialis https://cialishav.com/ – buy cialis online overnight shipping cialis definition

    May 26, 2021 at 06:47 | Report abuse | Reply
  29. ZisseVed

    is cialis a prescription drug https://krocialis.com/ – where to buy cialis without prescription how much does cialis 20 mg cost

    May 26, 2021 at 14:07 | Report abuse | Reply
  30. EncoxDev

    prescription drugs from canada online abc pharmacy store locator canadian pharmacy viagra generic

    May 27, 2021 at 09:54 | Report abuse | Reply
  31. ZisseVed

    cialis prescription canada https://krocialis.com/ – how to use cialis 5mg cialis without prescriptions

    May 27, 2021 at 20:35 | Report abuse | Reply
  32. CrulkAsd

    cialis 5mg 10mg no prescription https://cialisjla.com/ – cialis® order online cialis with dapoxetine

    May 27, 2021 at 22:52 | Report abuse | Reply
  33. EncoxGtv

    giant food store pharmacy hours buy growth hormone online pharmacy canadian pharmacy vyvanse

    May 28, 2021 at 15:53 | Report abuse | Reply
  34. MileSwa

    where to get cialis cheap https://ckacialis.com/ – buy cialis overnight delivery cialis dapoxetine

    May 28, 2021 at 19:01 | Report abuse | Reply
  35. CrulkAsd

    discount cialis 20mg https://cialisjla.com/ – generic cialis cialis dose

    May 29, 2021 at 03:06 | Report abuse | Reply
  36. EncoxHtf

    buy generic cialis canada https://cialishav.com/ – cialis indigestion remedy buy cialis without

    May 29, 2021 at 05:14 | Report abuse | Reply
  37. EncoxGtv

    pill pharmacy river pharmacy canada reviews rx solutions pharmacy help desk

    May 29, 2021 at 12:35 | Report abuse | Reply
  38. Zisseloh

    taking cialis https://rcialisgl.com/ – compounded cialis cialis vs.viagra reviews

    May 29, 2021 at 22:53 | Report abuse | Reply
  39. MileSwa

    buy dapoxetine with cialis https://ckacialis.com/ – black cialis from singapore buy cialis c5

    May 30, 2021 at 22:17 | Report abuse | Reply
  40. EncoxAni

    canada pharmacy viagra antibacterial canadian pharmacy online store

    May 31, 2021 at 06:39 | Report abuse | Reply
  41. Zisseloh

    generic cialis fedex non prescription cialis is there a generic cialis available?

    May 31, 2021 at 07:50 | Report abuse | Reply
  42. EncoxDev

    pharmacy online australia cvs pharmacy store location Glucotrol

    May 31, 2021 at 20:25 | Report abuse | Reply
  43. EncoxAni

    Cipro legal online pharmacy coupon code legal online pharmacies in the us

    June 1, 2021 at 02:38 | Report abuse | Reply
  44. ZisseVed

    does cialis shrink the prostate viagra with cialis cialis side effects women

    June 1, 2021 at 02:42 | Report abuse | Reply
  45. EncoxHtf

    cialis coupons cialis 20mg vs viagra 100mg cialis and viagra

    June 1, 2021 at 03:57 | Report abuse | Reply
  46. EncoxDev

    Viagra Plus best online pharmacy no prescription store locator lloyds pharmacy

    June 1, 2021 at 17:27 | Report abuse | Reply
  47. ZisseVed

    generic cialis name cialis self life viagra cialis canada

    June 2, 2021 at 00:39 | Report abuse | Reply
  48. EncoxGtv

    list of approved canadian pharmacies azithromycin canadian pharmacy singapore pharmacy online store

    June 2, 2021 at 13:47 | Report abuse | Reply
  49. CrulkAsd

    cialis trial pack cialis cialis available in walgreens over counter??

    June 2, 2021 at 22:41 | Report abuse | Reply
  50. MileSwa

    best cialis online cialis 100 mg usa cialis los angeles

    June 3, 2021 at 12:47 | Report abuse | Reply
1 2 3 4 5 6

Post a comment


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.