home
RSS
November 3rd, 2011
10:56 AM ET

Anti smoking drug may increase suicide risk, study says

The popular quit-smoking drug Chantix may increase the risk of suicide and suicidal thoughts in some patients, says a new report.

Researchers looked at more than 3,000  reports of "neuropsychiatric adverse events" - unexpected problems that result in risk or harm to the patientrelating to smoking cessation drugs, and found that more than 90% of the reports were associated with Chantix use.

"We compared people who took nicotine replacement therapy, Zyban and Chantix," said Dr. Curt Furberg, a study author, and professor of public health sciences at Wake Forrest Baptist Medical Center. "There was an increase in suicides even with nicotine replacement therapies, but Chantix was 8-10 times worse."

But the findings were in stark contrast to a report released just last week by the Food and Drug Administration, which claimed no difference in suicide risk between the three therapies. Furberg says the FDA's report was woefully underpowered.

[The FDA report] looked at hospitalized events," he said. "82% of all serious adverse events do not lead to hospitalization, so that means they missed 82% of all of the serious adverse events."

And though the FDA makes this very same point on its own report, the agency says the drug is safe when used appropriately.

"We continue to believe that when used as directed in the currently approved labeling, Chantix is a safe and effective treatment to help patients stop smoking," FDA spokeswoman Karen Riley said in an email to CNN.

Concerning reports about the drug's safety are nothing new. Since it was approved in 2006, Chantix has been banned by the Federal Aviation Administration for use in pilots, because of  concerns about possible blackouts. The U.S. military also has banned the drug for pilots, air-traffic controllers and missile teams; its use has been tightly controlled among truck drivers for similar reasons.

Since 2009, Chantix and Zyban have been required to carry "black box" warnings on their packaging, noting risks of depression and suicide.

Earlier this year, another report by Furberg and his associates found a 72% increased risk of serious cardiovascular events in Chantix users. Other previous studies have shown a link between the drug and an increase in violent and aggressive behavior.

Pfizer, the drug company that makes Chantix, said in a statement to CNN that any reports of suicidal behavior do not necessarily implicate the drug.

"It is important to remember that post-marketing reports do not establish a cause and effect relationship," wrote MacKay Jimeson, a drug company spokesman. He went on to cite the FDA's statement last week that “the agency continues to believe that the drug’s benefits outweigh the risks and current warnings in the Chantix label are appropriate.”

Furberg and his co-authors are calling on the FDA to change warning labels for Chantix, and say the drug may not be the best first-line defense against smoking.

"If you're going to use Chantix, it should be the last resort," Furberg said, "and even then you need to monitor a patient's mental status. That’s a reasonable policy, and we'd like the FDA to do that."

Furberg went onto say that people taking the drug now should talk with their doctor to determine whether Chantix is the best quit-smoking aid for their particular needs.

According to Pfizer's website, more than 7 million people in the United States have been prescribed Chantix since it was approved in 2006.


« Previous entry
soundoff (634 Responses)
  1. used trucks for sale near me

    Good blog post. I certainly love this site. Stick with it!

    https://www.shop-bell.com/out.php?id=kibocase&category=ladies&url=https://bestlocalnearme.com

    June 18, 2021 at 09:37 | Report abuse | Reply
  2. RV Repair Shop Near My Location

    http://www.georgewbushlibrary.smu.edu/exit.aspx?url=http://www.ocrv.art/rv-upgrades-near-me

    June 18, 2021 at 11:05 | Report abuse | Reply
  3. RV Repair Nearby

    http://200-155-82-24.bradesco.com.br/conteudo/pessoa-fisica/popExt.aspx?url=https://www.ocrvcenter.com/rv-repair-shop-canyon-country-california/

    June 18, 2021 at 11:38 | Report abuse | Reply
  4. RV Repair Shop Near Me

    Aw, this was an extremely nice post. Finding the time and actual effort to produce a good articleÖ but what can I sayÖ I put things off a whole lot and never seem to get nearly anything done.

    http://hudsonltd.com/?URL=http://ocrvcenter.com/rv-repair-shop-fountain-valley-california

    June 18, 2021 at 13:13 | Report abuse | Reply
  5. RV Repair Garden Grove

    http://mitsui-shopping-park.com/lalaport/iwata/redirect.html?url=http://www.ocrvcenter.com/rv-repair-shop-sierra-madre-california/

    June 18, 2021 at 14:01 | Report abuse | Reply
  6. RV Repair Santa Ana

    Great blog you have got here.. Itís difficult to find excellent writing like yours these days. I really appreciate individuals like you! Take care!!

    https://www.studivz.net/Link/Dereferer/?https://www.ocrvcenter.com/motorhome-interior-remodel-near-me/

    June 18, 2021 at 15:44 | Report abuse | Reply
  7. RV Repair Fountain Valley

    An outstanding share! I've just forwarded this onto a coworker who had been conducting a little research on this. And he in fact bought me dinner due to the fact that I found it for him... lol. So allow me to reword this.... Thanks for the meal!! But yeah, thanx for spending the time to discuss this subject here on your web site.

    http://response-o-matic.com/thank_you.php?u=https://clik.pw/0xCLj/

    June 18, 2021 at 16:35 | Report abuse | Reply
  8. RV Repairs Near Me

    https://ams.ceu.edu/optimal/optimal.php?url=https://pheecith.com/9Qdu/

    June 18, 2021 at 18:52 | Report abuse | Reply
  9. RV Repair Santa Ana

    That is a good tip especially to those new to the blogosphere. Short but very precise informationÖ Thank you for sharing this one. A must read article!

    https://www.yousite.com/__media__/js/netsoltrademark.php?d=https://ocrv.guru/rv-repair-shop-big-bear-lake-california/

    June 18, 2021 at 20:10 | Report abuse | Reply
  10. for rent near me

    http://lain.heavy.jp/lain/?wptouch_switch=desktop&redirect=http://bestservicenearme.com

    June 19, 2021 at 00:55 | Report abuse | Reply
  11. RV Repair Shop Near Me

    Oh my goodness! Awesome article dude! Thank you, However I am experiencing troubles with your RSS. I donít understand the reason why I am unable to join it. Is there anybody else getting the same RSS issues? Anyone that knows the solution can you kindly respond? Thanks!!

    https://historyhub.history.gov/external-link.jspa?url=https://ocrvcenter.com/rv-technician-near-me

    June 19, 2021 at 02:22 | Report abuse | Reply
  12. Sprinter Repair Costa Mesa

    http://www.pichak.net/verification/index.php?n=39&url=http://ocrvcenter.com/nationwide-rv-collision-repair-shop-near-me/

    June 19, 2021 at 04:13 | Report abuse | Reply
  13. tool rental near me

    Hi, I do believe this is a great site. I stumbledupon it 😉 I will revisit yet again since I saved as a favorite it. Money and freedom is the greatest way to change, may you be rich and continue to help others.

    https://www.ztjysp99.com/link.php?url=https://masternearme.com

    June 19, 2021 at 06:46 | Report abuse | Reply
  14. RV Repairs Nearby

    I enjoy reading a post that will make people think. Also, thank you for allowing for me to comment!

    http://client.paltalk.com/client/webapp/client/External.wmt?url=http://skiplink.org/UcoAOT

    June 19, 2021 at 08:20 | Report abuse | Reply
  15. RV Repair Shop Near My Location

    http://www.bad.org.uk/for-the-public/patient-information-leaflets/androgenetic-alopecia/?showmore=1&returnlink=https://ocrv.life/motorhome-window-repair-near-me/

    June 19, 2021 at 13:34 | Report abuse | Reply
  16. RV Repair Shop Near My Location

    bookmarked!!, I love your blog!

    http://directory.hawaiitribune-herald.com/__media__/js/netsoltrademark.php?d=https://ocrvart.com/rv-repair-shop-lakewood-california

    June 19, 2021 at 16:49 | Report abuse | Reply
  17. www.pharmaceptica.com

    hydroxochloriquine https://pharmaceptica.com/

    June 19, 2021 at 19:17 | Report abuse | Reply
  18. RV Repair Huntington Beach

    Greetings! Very useful advice in this particular post! It is the little changes which will make the biggest changes. Thanks a lot for sharing!

    https://neurostar.com/en/redirect.php?url=https://ocrvcenter.com/rv-repair-shop-cudahy-california

    June 19, 2021 at 21:01 | Report abuse | Reply
  19. RV Repair Nearby

    https://legacy.aom.org/verifymember.asp?nextpage=http://www.ocrvcenter.com/rv-repair-shop-imperial-beach-california

    June 19, 2021 at 22:29 | Report abuse | Reply
  20. RV Repair Near My Location

    http://www.treasury.gov/cgi-bin/redirect.cgi/?http://www.ocrv.guru/motorhome-mechanic-near-me

    June 20, 2021 at 00:26 | Report abuse | Reply
  21. SEO Marketing Consultants

    Your style is very unique compared to other folks I've read stuff from. Many thanks for posting when you have the opportunity, Guess I'll just book mark this page.

    https://www.fnb-trustmortgage.net/__media__/js/netsoltrademark.php?d=https://affordableranking.com/

    June 20, 2021 at 01:34 | Report abuse | Reply
  22. Internet Marketing Consultants

    http://uesoundadvice.net/__media__/js/netsoltrademark.php?d=https://affordableranking.com/

    June 20, 2021 at 07:11 | Report abuse | Reply
  23. Elroy Nemitz

    This site really has all the information and facts I needed concerning this subject and didnít know who to ask.

    http://marketplace.salisburypost.com/AdHunter/salisburypost/Home/EmailFriend?url=www.duiattorneyphoenixaz.com/

    June 20, 2021 at 12:03 | Report abuse | Reply
  24. Omer Huggett

    I couldnít resist commenting. Perfectly written!

    https://cse.google.com.cy/url?q=https://ocrvparts.com

    June 20, 2021 at 15:35 | Report abuse | Reply
  25. Paris Gallow

    I love it when folks get together and share views. Great blog, stick with it!

    http://www.mydoterra.com/Application/index.cfm?EnrollerID=458046&Theme=DefaultTheme&Returnurl=https://www.meticulousjess.com&LNG=en_dot&iact=1

    June 20, 2021 at 17:42 | Report abuse | Reply
  26. Hubert Vanasse

    https://maps.google.jo/url?q=https://ocrvmotorcoaches.com

    June 20, 2021 at 18:44 | Report abuse | Reply
  27. qt near me

    Oh my goodness! Incredible article dude! Many thanks, However I am experiencing problems with your RSS. I donít know why I can't join it. Is there anyone else having identical RSS issues? Anyone who knows the solution will you kindly respond? Thanks!!

    http://nrasporting.com/__media__/js/netsoltrademark.php?d=bulknearme.com

    June 20, 2021 at 22:53 | Report abuse | Reply
  28. RV Repair Shops Nearby

    Hi, I do think this is an excellent web site. I stumbledupon it 😉 I may return yet again since i have bookmarked it. Money and freedom is the best way to change, may you be rich and continue to help others.

    http://agiftforemma.org/__media__/js/netsoltrademark.php?d=ocrvcenter.com

    June 21, 2021 at 02:01 | Report abuse | Reply
  29. delivery near me

    http://novalogic.com/remote.asp?NLink=https://bjsnearme.com

    June 21, 2021 at 04:33 | Report abuse | Reply
  30. RV Repairs Near My Location

    Everything is very open with a really clear explanation of the challenges. It was definitely informative. Your site is extremely helpful. Thanks for sharing!

    http://www.newyork-lawyers.com/__media__/js/netsoltrademark.php?d=ocrvcenter.com

    June 21, 2021 at 05:10 | Report abuse | Reply
  31. culvers near me

    http://www.kidsbones.net/__media__/js/netsoltrademark.php?d=www.masternearme.com

    June 21, 2021 at 08:31 | Report abuse | Reply
  32. barbecue near me

    That is a very good tip especially to those fresh to the blogosphere. Simple but very accurate informationÖ Thanks for sharing this one. A must read post!

    https://community.rsa.com/external-link.jspa?url=http://reviewnearme.com/

    June 21, 2021 at 08:44 | Report abuse | Reply
  33. Nearby RV Repair

    http://www.celebsilove.com/cgi-bin/at3/out.cgi?id=437&tag=toptop&trade=https://ocrvcenter.com

    June 21, 2021 at 10:21 | Report abuse | Reply
  34. Camper Repair Near Me

    I blog often and I genuinely thank you for your content. This article has truly peaked my interest. I am going to book mark your site and keep checking for new details about once a week. I opted in for your RSS feed as well.

    https://www.merkinvestments.com/enter/?url=https://ocrvcenter.com/

    June 21, 2021 at 10:25 | Report abuse | Reply
  35. RV Repair Shops Nearby

    http://phionbalance.org/__media__/js/netsoltrademark.php?d=ocrvcenter.com

    June 21, 2021 at 11:31 | Report abuse | Reply
  36. Airport Van Repair

    http://wevc.com/__media__/js/netsoltrademark.php?d=fleetrepairshops.com

    June 21, 2021 at 14:21 | Report abuse | Reply
  37. RV Repair Shops Near Me

    Pretty! This has been an incredibly wonderful post. Thanks for providing these details.

    http://homekey.com/__media__/js/netsoltrademark.php?d=www.ocrvmotorsports.life

    June 21, 2021 at 17:43 | Report abuse | Reply
  38. Handicap Van Repair

    http://www.sageport.com/__media__/js/netsoltrademark.php?d=campervanrepairshop.com

    June 21, 2021 at 19:53 | Report abuse | Reply
  39. Nearby RV Repairs

    Greetings! Very helpful advice within this article! It's the little changes that will make the largest changes. Many thanks for sharing!

    http://letstalkbikes.com/__media__/js/netsoltrademark.php?d=ocrv.online

    June 21, 2021 at 20:47 | Report abuse | Reply
  40. www.pharmaceptica.com

    sildenafil buy over the counter https://pharmaceptica.com/

    June 21, 2021 at 23:17 | Report abuse | Reply
  41. RV Repair Parts Near Me

    http://www.fatbelly.com/__media__/js/netsoltrademark.php?d=ocrv.art

    June 21, 2021 at 23:54 | Report abuse | Reply
  42. Van Upholstery Shop

    I would like to thank you for the efforts you've put in writing this website. I'm hoping to see the same high-grade content from you in the future as well. In fact, your creative writing abilities has motivated me to get my own, personal blog now 😉

    http://www.businessdatainc.biz/__media__/js/netsoltrademark.php?d=sprintervanrepair.com

    June 21, 2021 at 23:57 | Report abuse | Reply
  43. RV Repair Orange County

    http://enhancedvoiceprocessing.com/__media__/js/netsoltrademark.php?d=ocrv.art/

    June 22, 2021 at 02:10 | Report abuse | Reply
  44. RV Repair Places Near Me

    There's definately a great deal to know about this issue. I really like all the points you've made.

    http://www.jecustom.com/index.php?pg=Ajax&cmd=Cell&cell=Links&act=Redirect&url=http://ocrv.fun/

    June 22, 2021 at 02:14 | Report abuse | Reply
  45. RV Repair Huntington Beach

    http://nyc.hiremedical.com/home/redirect/?site=https://ocrvandtrucks.com

    June 22, 2021 at 03:22 | Report abuse | Reply
  46. accountability membership

    http://bricasolutions.net/__media__/js/netsoltrademark.php?d=menmastermind.com

    June 22, 2021 at 04:16 | Report abuse | Reply
  47. Sprinter Van Recall Repair Near Me

    Aw, this was a very good post. Spending some time and actual effort to produce a really good articleÖ but what can I sayÖ I procrastinate a whole lot and never manage to get nearly anything done.

    http://joshuaink.com/__media__/js/netsoltrademark.php?d=commercialvanrepairshop.com/

    June 22, 2021 at 08:58 | Report abuse | Reply
  48. RV Repair Places Near Me

    http://www.oxfordeye.co.uk/redirect.aspx?url=http://ocrv.store

    June 22, 2021 at 11:50 | Report abuse | Reply
  49. RV Window Repair Near Me

    http://m.shopindenver.com/redirect.aspx?url=https://ocrvcenter.com

    June 22, 2021 at 15:33 | Report abuse | Reply
  50. throughline podcast

    Having read this I believed it was really informative. I appreciate you taking the time and energy to put this informative article together. I once again find myself spending a lot of time both reading and commenting. But so what, it was still worthwhile!

    https://gogvo.com/redir.php?url=https://backbonehunters.com/

    June 22, 2021 at 17:10 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13

Post a comment


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

« Previous entry
Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.