home
RSS
November 3rd, 2011
10:56 AM ET

Anti smoking drug may increase suicide risk, study says

The popular quit-smoking drug Chantix may increase the risk of suicide and suicidal thoughts in some patients, says a new report.

Researchers looked at more than 3,000  reports of "neuropsychiatric adverse events" - unexpected problems that result in risk or harm to the patientrelating to smoking cessation drugs, and found that more than 90% of the reports were associated with Chantix use.

"We compared people who took nicotine replacement therapy, Zyban and Chantix," said Dr. Curt Furberg, a study author, and professor of public health sciences at Wake Forrest Baptist Medical Center. "There was an increase in suicides even with nicotine replacement therapies, but Chantix was 8-10 times worse."

But the findings were in stark contrast to a report released just last week by the Food and Drug Administration, which claimed no difference in suicide risk between the three therapies. Furberg says the FDA's report was woefully underpowered.

[The FDA report] looked at hospitalized events," he said. "82% of all serious adverse events do not lead to hospitalization, so that means they missed 82% of all of the serious adverse events."

And though the FDA makes this very same point on its own report, the agency says the drug is safe when used appropriately.

"We continue to believe that when used as directed in the currently approved labeling, Chantix is a safe and effective treatment to help patients stop smoking," FDA spokeswoman Karen Riley said in an email to CNN.

Concerning reports about the drug's safety are nothing new. Since it was approved in 2006, Chantix has been banned by the Federal Aviation Administration for use in pilots, because of  concerns about possible blackouts. The U.S. military also has banned the drug for pilots, air-traffic controllers and missile teams; its use has been tightly controlled among truck drivers for similar reasons.

Since 2009, Chantix and Zyban have been required to carry "black box" warnings on their packaging, noting risks of depression and suicide.

Earlier this year, another report by Furberg and his associates found a 72% increased risk of serious cardiovascular events in Chantix users. Other previous studies have shown a link between the drug and an increase in violent and aggressive behavior.

Pfizer, the drug company that makes Chantix, said in a statement to CNN that any reports of suicidal behavior do not necessarily implicate the drug.

"It is important to remember that post-marketing reports do not establish a cause and effect relationship," wrote MacKay Jimeson, a drug company spokesman. He went on to cite the FDA's statement last week that “the agency continues to believe that the drug’s benefits outweigh the risks and current warnings in the Chantix label are appropriate.”

Furberg and his co-authors are calling on the FDA to change warning labels for Chantix, and say the drug may not be the best first-line defense against smoking.

"If you're going to use Chantix, it should be the last resort," Furberg said, "and even then you need to monitor a patient's mental status. That’s a reasonable policy, and we'd like the FDA to do that."

Furberg went onto say that people taking the drug now should talk with their doctor to determine whether Chantix is the best quit-smoking aid for their particular needs.

According to Pfizer's website, more than 7 million people in the United States have been prescribed Chantix since it was approved in 2006.


« Previous entry
soundoff (634 Responses)
  1. Sprinter Turbocharger Repair

    https://www.dawnsplace.com/signup/affiliate.php?id=30&redirect=http://ocrvcenter.org

    June 29, 2021 at 06:04 | Report abuse | Reply
  2. RV Repair Around Me

    https://www.pet-fufu.com/cgi-bin/pet/rank.cgi?mode=link&id=6054&url=https://rvcollisionrepairpaintshop.com/

    June 29, 2021 at 07:08 | Report abuse | Reply
  3. RV Repair California

    Having read this I believed it was very informative. I appreciate you taking the time and effort to put this informative article together. I once again find myself personally spending a lot of time both reading and leaving comments. But so what, it was still worth it!

    https://emex.ru/error?url=https://carsonrvexperience.com/

    June 29, 2021 at 08:19 | Report abuse | Reply
  4. Sprinter Repair Orange County

    http://www.doctor-navi.com/cgi/hospital-search-engine2/rank.cgi?mode=link&id=14979&url=https://ocrv.life/

    June 29, 2021 at 08:24 | Report abuse | Reply
  5. Sprinter Repair Costa Mesa

    I'm extremely pleased to discover this web site. I wanted to thank you for your time for this particularly fantastic read!! I definitely enjoyed every little bit of it and I have you bookmarked to look at new information on your website.

    http://www.italianculture.net/redir.php?url=https://www.ocrvmotorsports.us/

    June 29, 2021 at 08:44 | Report abuse | Reply
  6. Ford High Top Van Repair

    An intriguing discussion is worth comment. I do believe that you should write more about this subject matter, it may not be a taboo matter but usually people don't speak about these subjects. To the next! Kind regards!!

    https://wfc2.wiredforchange.com/dia/track.jsp?v=2&c=hdorrh+HcDlQ+zUEnZU5qlfKZ1Cl53X6&url=http://ocrv.info

    June 29, 2021 at 09:24 | Report abuse | Reply
  7. Sprinter Repair Near Me

    I could not resist commenting. Well written!

    https://portalaz.com.br/client_login_check?redirectUrl=https://www.ocrvmotorsports.biz

    June 29, 2021 at 09:44 | Report abuse | Reply
  8. RV Repair Places Near Me

    https://www.nbmain.com/NetBooking.Reservations.Server.Servlets.Availability.SiteAvailabilityMainR?innkey=mcdaniel&bg=&formname=rdetail&s=BookMark&backpage=https://ocrvmotorsports.us&ikback=&pcode=&ik=0&months=3&month=May&day=1&year=2022

    June 29, 2021 at 14:28 | Report abuse | Reply
  9. Sprinter Repair Near Me

    Having read this I believed it was really informative. I appreciate you spending some time and energy to put this article together. I once again find myself spending a significant amount of time both reading and commenting. But so what, it was still worthwhile!

    http://www.im/__media__/js/netsoltrademark.php?d=ocrvparts.com/

    June 29, 2021 at 19:22 | Report abuse | Reply
  10. Travel Van Repair Shop

    http://sns.rightpsy.com/sns/u/link.php?url=https://fleetrepairshops.com

    June 29, 2021 at 20:37 | Report abuse | Reply
  11. Ford Transit Conversion Shop Near Me

    https://firmen.liste24.at/frontend/scripts/branch_companyurlcounter.php?companyUrl=h://customcampervans.com&companyId=9560

    June 30, 2021 at 00:31 | Report abuse | Reply
  12. RV Repairs Near My Location

    bookmarked!!, I love your blog!

    http://marketplace.salisburypost.com/AdHunter/salisburypost/Home/EmailFriend?url=https://ocrvart.com/

    June 30, 2021 at 02:24 | Report abuse | Reply
  13. Sprinter Van Wrap

    I'm more than happy to discover this web site. I wanted to thank you for ones time just for this fantastic read!! I definitely enjoyed every part of it and I have you book marked to see new things in your web site.

    https://vi.paltalk.com/client/webapp/client/External.wmt?url=https://sprintervanrepair.com

    June 30, 2021 at 02:30 | Report abuse | Reply
  14. RV Repair Around Me

    https://toolstud.io/network/redirect.php?url=http://ocrv.org

    June 30, 2021 at 03:22 | Report abuse | Reply
  15. RV Repair Around Me

    http://templateshares.net/redirector.php?url=https://ocrv.info/

    June 30, 2021 at 04:26 | Report abuse | Reply
  16. RV Repair Fountain Valley

    http://luizineje.entregadordecampanhas.net/registra_clique.php?id=TH|teste|22319|1&url=https://www.ocrv.me

    June 30, 2021 at 04:37 | Report abuse | Reply
  17. 2004 Mercedes Sprinter Engine Block Repair

    Excellent article. I will be going through a few of these issues as well..

    http://banatanama.ir/banatanama.ir/viewpage.aspx?url=http://fleetvehiclerepairshop.com

    June 30, 2021 at 06:57 | Report abuse | Reply
  18. Technician Shop

    Spot on with this write-up, I really think this web site needs far more attention. Iíll probably be back again to read through more, thanks for the info!

    http://www.nexto.pl/rf/pg?pid=576&url=http://fleetservicerepairshop.com/

    June 30, 2021 at 07:44 | Report abuse | Reply
  19. Van Dent Repair

    An outstanding share! I've just forwarded this onto a friend who had been conducting a little research on this. And he actually ordered me dinner because I found it for him... lol. So let me reword this.... Thank YOU for the meal!! But yeah, thanx for spending time to talk about this subject here on your web page.

    http://www.noexcuselist.com/li/?url=https://www.ocrvfleetservices.com

    June 30, 2021 at 08:07 | Report abuse | Reply
  20. RV Repair Seal Beach

    Pretty! This has been a really wonderful article. Thank you for supplying this info.

    https://afm-invest.com/index.cfm?Display=resources.cfm&Exit=https://ocrvexperts.com/

    June 30, 2021 at 08:20 | Report abuse | Reply
  21. RV Repair Shops Near Me Now

    This blog was... how do you say it? Relevant!! Finally I have found something which helped me. Appreciate it!

    https://error404.atomseo.com/away?to=https://newrvowners.com/

    June 30, 2021 at 11:07 | Report abuse | Reply
  22. Sprinter Repair Near Me

    http://www.oxfordeye.co.uk/redirect.aspx?url=http://ocrv.info

    June 30, 2021 at 11:10 | Report abuse | Reply
  23. Sprinter Repair Shop Near Me

    Hi there! This post could not be written much better! Going through this post reminds me of my previous roommate! He constantly kept preaching about this. I most certainly will forward this information to him. Pretty sure he's going to have a good read. Thank you for sharing!

    http://d-click.cesa.org.br/u/4762/1839/1078/11584_0/5d8f0/?url=https://ocrvshop.com/

    June 30, 2021 at 11:16 | Report abuse | Reply
  24. RV Repairs Nearby

    You need to be a part of a contest for one of the greatest websites on the internet. I most certainly will highly recommend this site!

    http://flogiston.ru/stat/click.php?http://www.ocrv.tv/

    June 30, 2021 at 11:40 | Report abuse | Reply
  25. Nissan Luxury Van Repair Shop Near Me

    http://www.theamericanmuslim.org/tam.php?URL=http://www.fleetvehiclerepairshop.com

    June 30, 2021 at 12:06 | Report abuse | Reply
  26. Advertising Company

    http://www.kanazawa-navi.com/navi/rank.cgi?mode=link&id=700&url=http://spokanevalleymarketing.com

    June 30, 2021 at 13:56 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13

Post a comment


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

« Previous entry
Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.