Vitamin B12 deficiency linked to memory problems
September 26th, 2011
04:49 PM ET

Vitamin B12 deficiency linked to memory problems

There's been a lot of buzz about vitamin B12 in recent years, and here's another reason to pay attention to it:

A new study finds that a deficiency in vitamin B12 is associated with memory and thinking problems, as well as brain shrinkage. The research is published in the journal Neurology.

Researchers did not prove that low vitamin B12 levels cause these cognitive abnormalities, but they did find a strong association with markers of deficiency, said study co-author Dr. Martha Morris of the Rush University Medical Center in Chicago.

The theory is that adequate levels of vitamin B12 is necessary for the brain's myelin sheath, an insulating layer around nerves. When the sheath gets damaged, impulses between transmitted along nerve cells slow down.

Vitamin B12 is found in meats, fish, shellfish and dairy products, and some cereals are fortified with it. People over 65 in particular may need B12 supplements because older patients' bodies have a harder time absorbing this vitamin.

Researchers looked at 121 participants in the Chicago Health and Aging Project. They looked at both serum levels of vitamin B12 and markers of vitamin B12 deficiency.

The study found that methylmalonate, a marker of vitamin B12 deficiency, is associated with a reduction of brain volume and so may contribute to cognitive problems. Homocysteine, an amino acid associated with low B12 levels as well as folate, was linked to thinking problems through a different mechanism involving abnormal white matter signals (as seen on certain kinds of MRIs).

There aren't a lot of data on using these markers clinically for the purposes of testing the health of older patients, said Dr. James Lah, neurologist at the Emory University School of Medicine in Atlanta, Georgia, who was not involved in the study. The study points to them as potentially helpful, but more research needs to be done, he said.

The study did not find an association between the serum B12 levels of participants and the likelihood of brain problems. Morris said that makes sense because while low levels negatively affect the brain, high levels above normal aren't necessarily better than adequate levels.

"There’s a level we should all have, and if you fall below that, it could cause problems," she said.

Quantifying that level is up for debate, but the National Institutes of Health offers  guidelines for recommended vitamin B12 intake at various ages.

Morris and colleagues did not look at this phenomenon in Alzheimer's patients, but a small 2010 study in Neurology found that people who tended to eat vitamin B12-rich foods are less likely to develop Alzheimer's than those who did not. Vitamin B12 deficiency has not been shown to be directly involved in the pathology of Alzheimer's in the brain, but it may aggravate the brain in other ways that could lead to Alzheimer's. "We can't discount its involvement," Lah said.

soundoff (629 Responses)
  1. Memory Vitamins

    thanks for posting such informative post. . The best way to get the right vitamin is to take only those which are specifically manufactured to promote cognitive functioning and brain functions. Some of the important vitamins required for good memory include vitamin B6, vitamin B1 and B-Complex vitamins.


    November 24, 2011 at 05:41 | Report abuse | Reply
    • Sandie Webb

      I have had memory problems since I was a young teen, as I have gotten o!der they have become much worse. I recently seen a new physician, and they did blood work and my Vitamin B 12 was under 200. It seems that my system is not absorbing vit d at all. Is there a way that I could do injections, and would this help?

      February 26, 2016 at 14:53 | Report abuse |
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  4. nicola

    im a 44 yr old woman who has been struggling for yrs with many problems ranging from memory loss inability to cope with stress numbness in hands an d feet random pains everywhere which i couldnt explain eg sore mouth tender joints etc for the last 6yrs iv been to the doctors more times than ive ever been in my whole life and gradually got worse and worse, anxiety fear depression etc, doctors sent me to alsorts of differant places from ruematoid osteo athritus clinics chronic pain clinics and basically i felt like i wasnt believed or that they had exhausted all there meical nolage? ha after 6yrs and just a simple full blood screening i was found to have a severe b12 deficiency..........after reading up on it cos no doctor iv met knows nothing about it and they freely admit this to my face ha i now realise the extent of this silent but devastaing disease, im having shots every 2mnths which makes me feel alittle brighter but physically no change so for any one whos finding no answers ask yr doctor to give you a full blood screen just to cover all bases......and better luck than me.

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    • Charlotte

      Not sure if this helps or if you are interested but for those struggling with B12 deficiency, I recently heard about a new alternative to the injections. Has anyone heard of it, it's called Eligen B12? Apparently it is the first and only true alternative to the intramuscular injection. I recently read that it works even if you don't have intrinsic factor (so even if you don't have normal gut absorption). I think it came out a month or two ago

      May 8, 2015 at 10:47 | Report abuse |
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    Vitamin B12 was discovered from its relationship to the disease pernicious anemia, which is an autoimmune disease in which parietal cells of the stomach responsible for secreting intrinsic factor are destroyed. Intrinsic factor is crucial for the normal absorption of B12, so a lack of intrinsic factor, as seen in pernicious anemia, causes a vitamin B12 deficiency. Many other subtler kinds of vitamin B12 deficiency and their biochemical effects have since been elucidated.'-.."

    Till next time

    July 9, 2013 at 05:08 | Report abuse | Reply
    • Charlotte

      For those struggling with B12 deficiency, I recently heard about a new oral prescription alternative to the injections called Eligen B12. I recently read that it works even if you don't have intrinsic factor (so even if you don't have normal gut absorption). Apparently it came out a month or two ago

      May 8, 2015 at 10:49 | Report abuse |
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      Charlotte, I have taken Eligen B12 since it came out. I am currently dosing it once daily and my B12 level on my last test was 1990–when I started my levels were around 400. I had been taking a sublingual 1000mcg but my doctor informed me that my levels were not improving because I was passing most of the product due to absorption issues.

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