 |
|
|
|
September 21st, 2011
12:01 PM ET
New ALS gene mutation discoveredResearchers have identified a genetic abnormality which they believe to be the most common cause of two devastating neurological diseases and could provide future clues to treatment. Two new studies, published online in the journal Neuron, found that amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig's disease and frontotemporal dementia or FTD that run in families are caused in many cases by a mutation on a single gene on chromosome number 9. This mutation causes a short DNA sequence to repeat over and over, much more frequently than in healthy people. The ALS Association, which funded both studies, calls the identification of this genetic mutation "a major milestone in ALS research." According to the data, in healthy individuals the DNA sequence repeats 2 to 23 times. In 23% of familial ALS patients and 12% of familial FTD patients the sequence repeated 700-1,600 times. ALS and FTD are both fatal neurological diseases of the brain. In ALS, nerve cells in the brain and spinal cord begin to degenerate and patients lose the ability to move their bodies and breathe. Almost 6,000 American are diagnosed with the crippling disease each year. FTD causes the degeneration of parts of the brain that control language, emotion, behavioral control and the ability to make decisions (the temporal and frontal lobes). About 20-40% of people with FTD have a family history of the disease. One study looked at patients in Finland which has a high population of ALS patients, according to lead study author Dr. Bryan Traynor from the National Institute on Aging (NIA). "With this finding we've gone from understanding a quarter of familial ALS to two-thirds of familial ALS," Traynor said. "In terms of thinking of the future, what this provides us with is a target to go after. What this allows us to do is to design cell models and animal models of disease we can use to start to screen drugs, and therapeutic agents to see if they are effective in turning off this particular genetic mutation." Traynor says there are 4 genes known to account for 25% of all familial ALS cases. The chromosome 9 gene accounts for an additional 40%. In the second study, researchers at the Mayo Clinic in Jacksonville, Florida also found the same repeat DNA sequence. "This finding has the potential to lead to significant insights into how both of these neurodegenerative diseases develop," Senior Investigator Dr. Rosa Rademakers, neuroscientist at the Mayo Clinic said. "And may give us much needed leads into new ways to treat our patients." The ALS Association's Chief Scientist Lucie Bruijn calls the new data tremendously exciting. "These findings will significantly impact the field as we begin to understand more about the consequences of these changes to the disease process, aid or understanding of FTD and ALS, potentially provide a diagnostic tool, and enable the development of new therapeutic approaches." Still, Traynor says he wants to keep expectations within bounds and be careful not to raise false hopes. That's because typically it's 10 years from gene discovery to clinical trial. He says that's a long time when ALS patients usually live 2-3 years after the onset of symptoms. "It's a step forward, Traynor said. "Now we know which room in which house on which street in which city and that knowledge facilitates ultimately working up a treatment that will slow down this fatal disease.". soundoff (1,143 Responses)« Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Next »Leave a Reply to Mercedes Benz Sprinter Repair Shop
Next entry »How did your childhood affect your sexuality?
« Previous entryWhat's the difference in diabetes?
|
  About this blog
Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.
 |
|
|
|
Where or what would I have to do? And what's the cost?.
https://www.instagram.com/katekdesigns
Having read this I thought it was really informative. I appreciate you finding the time and effort to put this article together. I once again find myself personally spending way too much time both reading and commenting. But so what, it was still worthwhile!
https://cinerama.pro/user/w7oyofq442
http://old.magictower.ru/cgi-bin/redir/redir.pl?http://bjsnearme.com/
I love it when folks get together and share opinions. Great website, keep it up!
http://www.czporadna.cz/index.php?qa=user&qa_1=suedeeagle15
http://capsco.net/__media__/js/netsoltrademark.php?d=makemoneymommas.com
Pretty! This has been a really wonderful post. Thanks for supplying this info.
https://www.domestika.org/en/meldgaardmiranda508
https://codhacks.ru/go?https://ocrv.today/
Spot on with this write-up, I seriously think this site needs far more attention. Iíll probably be returning to read through more, thanks for the information!
https://foursquare.com/user/1367481809/list/how-can-craniosacral-therapy-help-you
This website truly has all the information I needed about this subject and didnít know who to ask.
https://medvacancy.ru/user/profile/31502
You need to be a part of a contest for one of the most useful blogs on the net. I will highly recommend this blog!
http://www.photos.newocx.com/index.php?url=https://zenwriting.net/massage3u4tafqe973/h2-the-benefits-of-massage-therapy-h2-massage-therapy-is-the-manipulation-of
http://home4dsi.com/chat/redirect.php?url=https://www.ocrvcenter.com/
http://www.eticostat.it/stat/dlcount.php?id=cate11&url=http://www.ocrvcenter.com/
Itís hard to find experienced people about this topic, however, you seem like you know what youíre talking about! Thanks
https://anotepad.com/notes/qcn2iyw2
http://www.powuta.com/ts/i5033530/tsc?amc=con.blbn.489956.478559.14133528&smc=GrandperePuzzlePhoto&rmd=3&trg=ocrvcenter.com/
When I initially commented I seem to have clicked on the -Notify me when new comments are added- checkbox and from now on every time a comment is added I recieve four emails with the same comment. There has to be a way you are able to remove me from that service? Cheers!
https://elearnportal.science/wiki/Aroma_Therapy_Massage_Therapy
Hello there, There's no doubt that your web site might be having internet browser compatibility problems. When I look at your site in Safari, it looks fine but when opening in I.E., it's got some overlapping issues. I just wanted to provide you with a quick heads up! Apart from that, great site!
http://sc.devb.gov.hk/TuniS/telegra.ph/What-Exactly-Is-Shiatsu-Massage-04-14
http://www.dbprimary.com/service/util/logout/CookiePolicy.action?backto=https://ocrvcenter.com/
https://www.pcreducator.com/Common/SSO.aspx?returnUrl=www.ocrvcenter.com/
This site was... how do you say it? Relevant!! Finally I have found something that helped me. Cheers!
https://massage4trowelage5.mystrikingly.com/blog/
Your style is so unique compared to other folks I have read stuff from. Many thanks for posting when you have the opportunity, Guess I'll just book mark this web site.
http://adsfac.net/search.asp?cc=VED007.69739.0&stt=creditreporting&gid=27061741901&nw=S&url=http://ocrvcenter.com/
Can I simply say what a comfort to uncover someone that really understands what they are discussing on the internet. You actually realize how to bring an issue to light and make it important. More and more people should look at this and understand this side of the story. I can't believe you are not more popular given that you most certainly have the gift.
https://serverfault.com/users/643883
https://www.clintontwpnj.com/redirect.aspx?url=http://ocrvcenter.com
You have made some good points there. I checked on the internet for more information about the issue and found most individuals will go along with your views on this site.
https://lawyers-blog.online/user/profile/15659
Great post. I will be going through some of these issues as well..
http://www.seankenney.com/include/jump.php?num=https://www.ocrvcenter.com
Great article. I am experiencing some of these issues as well..
https://www.kickstarter.com/profile/59821488/about
Great information. Lucky me I found your blog by chance (stumbleupon). I have book-marked it for later!
https://www.folkd.com/ref.php?go=https3A2F2Ftorgi.gov.ru2Fforum2Fuser2Fedit2F1388328.page
Very good info. Lucky me I came across your website by accident (stumbleupon). I've book marked it for later!
http://wlfbsa.org/home.php?mod=space&uid=3401028
Right here is the perfect web site for anyone who wants to understand this topic. You realize a whole lot its almost hard to argue with you (not that I actually will need toÖHaHa). You definitely put a fresh spin on a topic which has been written about for decades. Great stuff, just great!
https://251980.8b.io/page1.html
Excellent post. I will be dealing with many of these issues as well..
http://action.smartgrowthamerica.org/salsa/track.jsp?key=-1&url_num=6&url=https://backboneleaders.com/
https://syntone.ru/redirect.php?url=https://backboneleaders.com
The very next time I read a blog, Hopefully it doesn't disappoint me as much as this particular one. I mean, I know it was my choice to read, however I actually believed you'd have something useful to say. All I hear is a bunch of whining about something you can fix if you were not too busy looking for attention.
https://www.bookmarkmaster.win/11-embarrassing-chuljangmasaji-faux-pas-you-better-not-make-11
Excellent web site you've got here.. Itís difficult to find quality writing like yours these days. I truly appreciate individuals like you! Take care!!
https://www.ecommercebytes.com/R/R/chart.pl?CHTL&101107&AmazonPayments&https://article.rabia.co.in/94298/just-how-to-perform-investigation-as-well-discover-the-best-fabricators-near-me
Way cool! Some very valid points! I appreciate you penning this article and the rest of the site is also really good.
/
Your style is really unique in comparison to other people I have read stuff from. I appreciate you for posting when you've got the opportunity, Guess I'll just book mark this site.
https://vsedorogi.org/index.php?option=com_k2&view=itemlist&task=user&id=476978
I blog often and I really appreciate your content. This great article has really peaked my interest. I am going to take a note of your website and keep checking for new information about once per week. I opted in for your Feed too.
http://www.indiaserver.com/cgi-bin/news/out.cgi?url=https://k-anma.com/
Oh my goodness! Incredible article dude! Thank you, However I am experiencing troubles with your RSS. I donít know the reason why I am unable to subscribe to it. Is there anybody getting the same RSS problems? Anybody who knows the solution will you kindly respond? Thanks!!
https://scripts.affiliatefuture.com/AFClick.asp?affiliateID=29219&merchantID=2543&programmeID=6678&mediaID=0&tracking=&url=http://dallas9i8q1.activoblog.com/
erectile suppliers https://pharmaceptica.com/
https://tw.taiwantrade.com/logout?redirect=http://ipos-chaosmagie.de/
Everything is very open with a precise explanation of the challenges. It was definitely informative. Your website is very helpful. Thank you for sharing!
http://ads.fetnet.net/TrackingLog/svc_TClick.aspx?IDS=950838,1426&go=https://andy8h0d7.humor-blog.com/3873057/5-simple-statements-about-rv-service-near-me-explained
I wanted to thank you for this good read!! I definitely enjoyed every little bit of it. I have got you bookmarked to look at new stuff you postÖ
http://truehits.net/webout.php?url=https://reidihdyw.blogars.com/3134500/top-guidelines-of-rv-awning-repair-near-me
Hi there! I just wish to give you a big thumbs up for your excellent info you have here on this post. I will be returning to your blog for more soon.
https://uberant.com/article/1398400-the-many-benefits-of-sports-massage-therapy/
You are so interesting! I do not think I've truly read anything like this before. So nice to find someone with some genuine thoughts on this issue. Seriously.. thanks for starting this up. This web site is one thing that is required on the web, someone with a little originality!
https://telegra.ph/Aromatherapy-Massage-Therapy-For-Health-Issues-05-31-2
Good day! I know this is somewhat off topic but I was wondering which blog platform are you
using for this site? I'm getting sick and tired of WordPress because I've had issues
with hackers and I'm looking at alternatives for another platform.
I would be fantastic if you could point me in the direction of a good platform.
https://pram.elmercurio.com/Logout.aspx?ApplicationName=EMOL&l=yes&SSOTargetUrl=https://www.ocrvempire.com/
Great post. I am going through many of these issues as well..
http://sitecheck.elinkdesign.com/redirect.php?url=https://www.airconditioningserviceinn01582.angelinsblog.com
https://as.domru.ru/go?url=https://www.lacapillacantina.com
An outstanding share! I've just forwarded this onto a coworker who had been doing a little research on this. And he in fact bought me lunch because I discovered it for him... lol. So let me reword this.... Thank YOU for the meal!! But yeah, thanks for spending time to talk about this topic here on your web site.
http://click.payserve.com/signup?link=https://houseofguns.ro
https://go.onelink.me/v1xd?pid=Patch&c=Mobile Footer&af_web_dp=http://kirmes-werkel.de/index.php/gaestebuch?t=0&start=10100
https://www.favy.jp/trackings/redirect_to_source_url?tat=reservation_form&tid=17635&url=https://www.eearth.tv/
Oh my goodness! Amazing article dude! Thank you so much, However I am encountering troubles with your RSS. I donít know the reason why I cannot join it. Is there anybody else having identical RSS issues? Anyone that knows the solution will you kindly respond? Thanks!!
https://www.victoriaeducation.co.uk/members/cowzinc9/activity/479213/