 |
|
|
|
September 21st, 2011
12:01 PM ET
New ALS gene mutation discoveredResearchers have identified a genetic abnormality which they believe to be the most common cause of two devastating neurological diseases and could provide future clues to treatment. Two new studies, published online in the journal Neuron, found that amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig's disease and frontotemporal dementia or FTD that run in families are caused in many cases by a mutation on a single gene on chromosome number 9. This mutation causes a short DNA sequence to repeat over and over, much more frequently than in healthy people. The ALS Association, which funded both studies, calls the identification of this genetic mutation "a major milestone in ALS research." According to the data, in healthy individuals the DNA sequence repeats 2 to 23 times. In 23% of familial ALS patients and 12% of familial FTD patients the sequence repeated 700-1,600 times. ALS and FTD are both fatal neurological diseases of the brain. In ALS, nerve cells in the brain and spinal cord begin to degenerate and patients lose the ability to move their bodies and breathe. Almost 6,000 American are diagnosed with the crippling disease each year. FTD causes the degeneration of parts of the brain that control language, emotion, behavioral control and the ability to make decisions (the temporal and frontal lobes). About 20-40% of people with FTD have a family history of the disease. One study looked at patients in Finland which has a high population of ALS patients, according to lead study author Dr. Bryan Traynor from the National Institute on Aging (NIA). "With this finding we've gone from understanding a quarter of familial ALS to two-thirds of familial ALS," Traynor said. "In terms of thinking of the future, what this provides us with is a target to go after. What this allows us to do is to design cell models and animal models of disease we can use to start to screen drugs, and therapeutic agents to see if they are effective in turning off this particular genetic mutation." Traynor says there are 4 genes known to account for 25% of all familial ALS cases. The chromosome 9 gene accounts for an additional 40%. In the second study, researchers at the Mayo Clinic in Jacksonville, Florida also found the same repeat DNA sequence. "This finding has the potential to lead to significant insights into how both of these neurodegenerative diseases develop," Senior Investigator Dr. Rosa Rademakers, neuroscientist at the Mayo Clinic said. "And may give us much needed leads into new ways to treat our patients." The ALS Association's Chief Scientist Lucie Bruijn calls the new data tremendously exciting. "These findings will significantly impact the field as we begin to understand more about the consequences of these changes to the disease process, aid or understanding of FTD and ALS, potentially provide a diagnostic tool, and enable the development of new therapeutic approaches." Still, Traynor says he wants to keep expectations within bounds and be careful not to raise false hopes. That's because typically it's 10 years from gene discovery to clinical trial. He says that's a long time when ALS patients usually live 2-3 years after the onset of symptoms. "It's a step forward, Traynor said. "Now we know which room in which house on which street in which city and that knowledge facilitates ultimately working up a treatment that will slow down this fatal disease.". soundoff (1,143 Responses)« Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Next »Leave a Reply to grocery stores near me
Next entry »How did your childhood affect your sexuality?
« Previous entryWhat's the difference in diabetes?
|
  About this blog
Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.
 |
|
|
|
https://neurostar.com/en/redirect.php?url=https://ocrvcenter.com/rv-repair-shop-highland-california
https://www.treasury.gov/cgi-bin/redirect.cgi/?http://ocrvcenter.com/farmers-rv-collision-repair-shop-near-me/
https://cbts2.thischurch.org/mod/admin/view-image.php?i=/share/mod_news_images/2767.jpg&ru=ocrvcenter.com/commercial-vehicle-collision-repair-shop-near-me
It's a shame you don't have a donate button! I'd certainly donate to this superb blog! I suppose for now i'll settle for bookmarking and adding your RSS feed to my Google account. I look forward to brand new updates and will talk about this blog with my Facebook group. Talk soon!|
https://postheaven.net/museumease2/property-decor-accessories-you-require-to-purchase
http://www.afm-invest.com/index.cfm?Display=resources.cfm&Exit=https://ocrvcenter.com/motorhome-couch-repair-near-me/
Can I just say what a relief to find somebody who really knows what they are discussing on the web. You definitely know how to bring an issue to light and make it important. More people have to check this out and understand this side of the story. I was surprised you aren't more popular since you definitely possess the gift.
https://otohits.net/home/redirectto?url=http://ocrvcenter.com/rv-repair-shop-la-habra-california
https://lifestream.tv/players/mocd.php?c=secebenezer&access=1&url=http://www.ocrvcenter.com/refrigerator-truck-collision-repair-shop-near-me/
This blog was... how do I say it? Relevant!! Finally I have found something which helped me. Cheers!
http://www.leadclub.net/classifieds/user/profile/473704
http://www.nanos.jp/jmp?url=www.ocrvcenter.com/conventional-trailer-collision-repair-shop-near-me
https://bellinghoven-online.de/index.php?url=ocrvcenter.com/rv-repair-shop-seal-beach-california/
https://www.kms.fr/Eprv/Spe/GoPartenaires/?Url=http://www.ocrvcenter.com/rv-repair-shop-temple-city-california/
This is a really good tip particularly to those fresh to the blogosphere. Short but very precise infoÖ Thank you for sharing this one. A must read article!
https://forums.bestbuy.com/t5/user/viewprofilepage/user-id/1268707
http://qnrwz.com/__media__/js/netsoltrademark.php?d=http://ocrvcenter.com/rv-repair-shop-sierra-madre-california/
I have to thank you for the efforts you have put in writing this website. I really hope to check out the same high-grade content from you in the future as well. In fact, your creative writing abilities has motivated me to get my very own site now 😉
https://pbase.com/topics/casino4alleygas79/a_casino_programs_for_single
http://edesk.jp/atp/Redirect.do?url=https://www.ocrvcenter.com/rv-plumbing-repair-near-me/
Aw, this was an exceptionally good post. Finding the time and actual effort to generate a good articleÖ but what can I sayÖ I put things off a whole lot and don't seem to get anything done.
https://pediascape.science/wiki/Different_Kinds_of_Gambling_Items_That_Can_Be_Found_at_a_Casino
Very nice write-up. I definitely appreciate this website. Keep it up!
https://yellowpages.therolladailynews.com/__media__/js/netsoltrademark.php?d=www.ocrvcenter.com/rv-repair-shop-panorama-city-california
http://www.bellinghoven-online.de/index.php?url=https://www.ocrvcenter.com/camper-repair-near-me
Having read this I thought it was really enlightening. I appreciate you spending some time and effort to put this informative article together. I once again find myself personally spending a lot of time both reading and commenting. But so what, it was still worth it!
https://blogfreely.net/actorbrake9/traditional-thai-massage-techniques-and-their-advantages
This website was... how do I say it? Relevant!! Finally I've found something that helped me. Thanks a lot!
https://e-tsuyama.com/cgi-bin/jump.cgi?jumpto=https://ocrvcenter.com/rv-frame-repair-near-me
After exploring a number of the blog articles on your site, I seriously like your way of blogging. I book marked it to my bookmark site list and will be checking back soon. Please visit my web site too and let me know what you think.
https://game-offline.com/forum/profile.php?section=personality&id=776530
There's definately a lot to learn about this topic. I like all the points you made.
http://www.2ip.ru/lookup/?ip=ocrvcenter.com/rv-repair-shop-canoga-park-california/
Oh my goodness! Incredible article dude! Thanks, However I am experiencing troubles with your RSS. I donít understand why I am unable to join it. Is there anyone else having the same RSS problems? Anybody who knows the solution can you kindly respond? Thanks!!
https://zenwriting.net/bitllama98/advantages-of-structural-integration-of-this
http://historyhub.history.gov/external-link.jspa?url=http://ingenieurleistungenreiter.com/index.php?option=com_phocaguestbook&view=phocaguestbook&id=1&Itemid=4&t=2340&limitstart=86060
It is perfect time to make a few plans for the future and it is time to be happy. I've read this put up and if I may just I desire to counsel you few attention-grabbing issues or tips. Perhaps you could write subsequent articles relating to this article. I desire to read more issues approximately it!
https://philadelphiaweekly.com/10-best-cbd-lubes-to-buy-in-2021/
Aw, this was a really good post. Spending some time and actual effort to generate a really good articleÖ but what can I sayÖ I hesitate a lot and don't manage to get anything done.
http://www.fireprotection.org.nz/Redirect.aspx?destination=http://www.ocrvcenter.com/industrial-bus-collision-repair-shop-near-me/
https://www.chemical.cc/__media__/js/netsoltrademark.php?d=ocrvcenter.com/
Having read this I thought it was rather informative. I appreciate you taking the time and effort to put this content together. I once again find myself personally spending a significant amount of time both reading and posting comments. But so what, it was still worth it!
https://www.empowher.com/users/chesscycle69
I seriously love your blog.. Excellent colors & theme. Did you develop this site yourself? Please reply back as Iím attempting to create my very own blog and want to learn where you got this from or what the theme is called. Appreciate it!
https://dribbble.com/crossport43
https://blogpaint.com/__media__/js/netsoltrademark.php?d=http://www.ocrvcenter.com/
Excellent post! We will be linking to this great post on our site. Keep up the great writing.
https://soundswiss81.werite.net/post/2021/04/23/Benefits-Of-Reflexology
https://www.mercuryinsurancebrokers.biz/__media__/js/netsoltrademark.php?d=http://ocrvcenter.com/
https://www.e-pests.com/__media__/js/netsoltrademark.php?d=www.ocrvcenter.com/
Spot on with this write-up, I absolutely believe this site needs a lot more attention. Iíll probably be back again to see more, thanks for the advice!
https://bitly.com/a/warning?hash=3nUs1YL&url=https://www.ocrvcenter.com
Hello there, I think your site might be having browser compatibility problems. Whenever I look at your site in Safari, it looks fine however, when opening in I.E., it has some overlapping issues. I just wanted to provide you with a quick heads up! Apart from that, fantastic website!
http://greaterearth.com/__media__/js/netsoltrademark.php?d=ocrvcenter.com
Pretty! This has been a really wonderful post. Many thanks for supplying this info.
http://forum.bokser.org/user-559312.html
This is a topic that's near to my heart... Many thanks! Where are your contact details though?
http://yqwbbs.com/home.php?mod=space&uid=302199
Hi, I do think this is an excellent blog. I stumbledupon it 😉 I will come back yet again since I saved as a favorite it. Money and freedom is the best way to change, may you be rich and continue to guide other people.
https://devot-ee.com/?URL=ocrvcenter.com/rv-repair-shop-tarzana-california/
Having read this I believed it was really informative. I appreciate you taking the time and effort to put this short article together. I once again find myself personally spending a lot of time both reading and commenting. But so what, it was still worth it!
https://squareblogs.net/casino2beautywish77/why-you-need-to-play-the-fan-tan-and-sevens-card-game-at-your-favorite-casino
Oh my goodness! Incredible article dude! Thanks, However I am going through problems with your RSS. I donít know the reason why I am unable to join it. Is there anyone else having similar RSS problems? Anybody who knows the solution will you kindly respond? Thanx!!
https://pastebin.pl/view/622179ee
http://htcdev.com/?URL=www.ocrvcenter.com/rv-repair-shop-diamond-bar-california
https://www.ams.ceu.edu/optimal/optimal.php?url=https://ocrvcenter.com/rv-repair-shop-buena-park-california&refresh=1
https://kultur-bad-vilbel.de/goto/?u=ocrvcenter.com/motorhome-remodel-near-me/
Spot on with this write-up, I honestly believe this web site needs much more attention. Iíll probably be back again to see more, thanks for the advice!
http://consumerhealthcareinformation.net/__media__/js/netsoltrademark.php?d=http://ocrvcenter.com
Oh my goodness! Awesome article dude! Thank you, However I am going through problems with your RSS. I donít understand why I am unable to join it. Is there anyone else having similar RSS issues? Anyone who knows the solution will you kindly respond? Thanx!!
https://blabshack.com/members/gambling3rodwall83/activity/141637/
https://offers.sidex.ru/stat_ym_new.php?redir=http://ocrvcenter.com/rv-repair-shop-rialto-california&hash=1577762
Way cool! Some extremely valid points! I appreciate you writing this write-up and the rest of the site is also very good.
http://www.drupalconsult.com/demo/qa/index.php?qa=user&qa_1=magicattack85
Great information. Lucky me I recently found your website by chance (stumbleupon). I've book-marked it for later!
https://www.georgewbushlibrary.smu.edu/exit.aspx?url=http://www.ocrvcenter.com/rv-repair-shop-banning-california
http://forum.everleap.com/proxy.php?link=http://www.ocrvcenter.com/motorhome-toilet-repair-near-me
The very next time I read a blog, I hope that it doesn't fail me just as much as this particular one. After all, I know it was my choice to read, but I really believed you'd have something useful to say. All I hear is a bunch of whining about something that you could possibly fix if you were not too busy searching for attention.
https://gambling6israelamount09.tumblr.com/post/650001000888991744/the-problems-with-gambling-part-two