 |
|
|
|
September 21st, 2011
12:01 PM ET
New ALS gene mutation discoveredResearchers have identified a genetic abnormality which they believe to be the most common cause of two devastating neurological diseases and could provide future clues to treatment. Two new studies, published online in the journal Neuron, found that amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig's disease and frontotemporal dementia or FTD that run in families are caused in many cases by a mutation on a single gene on chromosome number 9. This mutation causes a short DNA sequence to repeat over and over, much more frequently than in healthy people. The ALS Association, which funded both studies, calls the identification of this genetic mutation "a major milestone in ALS research." According to the data, in healthy individuals the DNA sequence repeats 2 to 23 times. In 23% of familial ALS patients and 12% of familial FTD patients the sequence repeated 700-1,600 times. ALS and FTD are both fatal neurological diseases of the brain. In ALS, nerve cells in the brain and spinal cord begin to degenerate and patients lose the ability to move their bodies and breathe. Almost 6,000 American are diagnosed with the crippling disease each year. FTD causes the degeneration of parts of the brain that control language, emotion, behavioral control and the ability to make decisions (the temporal and frontal lobes). About 20-40% of people with FTD have a family history of the disease. One study looked at patients in Finland which has a high population of ALS patients, according to lead study author Dr. Bryan Traynor from the National Institute on Aging (NIA). "With this finding we've gone from understanding a quarter of familial ALS to two-thirds of familial ALS," Traynor said. "In terms of thinking of the future, what this provides us with is a target to go after. What this allows us to do is to design cell models and animal models of disease we can use to start to screen drugs, and therapeutic agents to see if they are effective in turning off this particular genetic mutation." Traynor says there are 4 genes known to account for 25% of all familial ALS cases. The chromosome 9 gene accounts for an additional 40%. In the second study, researchers at the Mayo Clinic in Jacksonville, Florida also found the same repeat DNA sequence. "This finding has the potential to lead to significant insights into how both of these neurodegenerative diseases develop," Senior Investigator Dr. Rosa Rademakers, neuroscientist at the Mayo Clinic said. "And may give us much needed leads into new ways to treat our patients." The ALS Association's Chief Scientist Lucie Bruijn calls the new data tremendously exciting. "These findings will significantly impact the field as we begin to understand more about the consequences of these changes to the disease process, aid or understanding of FTD and ALS, potentially provide a diagnostic tool, and enable the development of new therapeutic approaches." Still, Traynor says he wants to keep expectations within bounds and be careful not to raise false hopes. That's because typically it's 10 years from gene discovery to clinical trial. He says that's a long time when ALS patients usually live 2-3 years after the onset of symptoms. "It's a step forward, Traynor said. "Now we know which room in which house on which street in which city and that knowledge facilitates ultimately working up a treatment that will slow down this fatal disease.". soundoff (1,143 Responses)« Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Next »Leave a Reply to embroidery near me
Next entry »How did your childhood affect your sexuality?
« Previous entryWhat's the difference in diabetes?
|
  About this blog
Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.
 |
|
|
|
That is a very good tip particularly to those fresh to the blogosphere. Short but very precise infoÖ Many thanks for sharing this one. A must read article!
http://anma1daysky3.bravesites.com/entries/general/massage-therapy-along-with-watsu
http://www.rockclimbing.net/__media__/js/netsoltrademark.php?d=bestlocalnearme.com
The next time I read a blog, I hope that it doesn't disappoint me just as much as this particular one. After all, Yes, it was my choice to read, however I truly believed you would probably have something helpful to talk about. All I hear is a bunch of complaining about something you could fix if you were not too busy searching for attention.
http://braking-sunstar.com/__media__/js/netsoltrademark.php?d=www.reviewnearme.com
https://barbados.org/al/?event=ad.logClickampadvert=DC6FF007FAD78E23C54A673E3258DDC0EE638CB31CFE6FB9D0F4E0C53EF6B1276EC9DDCA3D10A7EA5E5F52955053E7F2A0C5D4D51F5050E21EC0B7F8CDCDA1EB3BBEEEDAB3EBDC25114C276741BA028E&webAddress=https://quotenearme.com
http://www.769372677.eu/__media__/js/netsoltrademark.php?d=bjsnearme.com
I absolutely love your website.. Great colors & theme. Did you build this amazing site yourself? Please reply back as Iím attempting to create my own blog and would love to learn where you got this from or just what the theme is named. Many thanks!
https://forums.bestbuy.com/t5/user/viewprofilepage/user-id/1348124
http://www.marcomanfredini.it/radio/visualizzacollezione.php?paginanews=5&contenuto=13&quale=40&origine=http://bestservicenearme.com
Hello there! This article could not be written much better! Looking at this post reminds me of my previous roommate! He constantly kept preaching about this. I most certainly will send this article to him. Pretty sure he's going to have a great read. Thank you for sharing!
http://vmx.italiandecor.com/__media__/js/netsoltrademark.php?d=www.bulknearme.com
Having read this I believed it was really informative. I appreciate you spending some time and effort to put this short article together. I once again find myself spending a lot of time both reading and posting comments. But so what, it was still worth it!
https://www.bungersurf.com/Redirect.aspx?destination=http://bestshopnearme.com/
https://www.besanthill.org/redirect.php?url=https://bjsnearme.com
Spot on with this write-up, I truly believe this website needs much more attention. Iíll probably be back again to read through more, thanks for the info!
http://telce.com/__media__/js/netsoltrademark.php?d=nearmyspot.com
This website was... how do I say it? Relevant!! Finally I have found something which helped me. Many thanks!
https://sfi-edu.com/members/anma1fingerwhite9/activity/255442/
bookmarked!!, I love your site!
http://ssomgmt.ascd.org/profile/createsso/createsso.aspx?returnurl=http://anma5zanemvgx036.raidersfanteamshop.com/5-lessons-about-jeonjuchuljangmasaji-you-can-learn-from-superheroes
http://biology.africamuseum.be/BiocaseProvider_2.4.2/www/utilities/queryforms/qf_manual.cgi?url=https://www.reviewnearme.com
Everything is very open with a clear explanation of the issues. It was definitely informative. Your site is extremely helpful. Thanks for sharing!
https://0rz.tw/create?url=https3A2F2Fedukite.org2Fmembers2Fsoundweapon752Factivity2F11715412F
I was able to find good information from your blog articles.
http://ccharities.org/__media__/js/netsoltrademark.php?d=bestservicenearme.com
I want to to thank you for this wonderful read!! I absolutely enjoyed every bit of it. I have got you book marked to check out new stuff you postÖ
https://www.openlearning.com/u/weeksun17/blog/FibromyalgiaAndBackCareHowToEasePainWithAMassage
I couldnít resist commenting. Perfectly written!
http://book.ly/redirect.php?action=buysearch&schoolid=-1§ionid=-1&isbn=9780136042594&vendor=biblio&price=39.64&url=http://bonus-books.com
I needed to thank you for this fantastic read!! I definitely loved every little bit of it. I have got you book-marked to check out new things you postÖ
http://onlinecasinoguide.com/__media__/js/netsoltrademark.php?d=masternearme.com
You've made some decent points there. I checked on the net for more information about the issue and found most people will go along with your views on this site.
https://luxuszugreisen.info/redirect/?url=https://bonus-books.com
Excellent article. I am dealing with some of these issues as well..
http://www.islulu.com/link.php?url=https://www.reviewnearme.com/
http://matherfield.org/__media__/js/netsoltrademark.php?d=www.bjsnearme.com
http://www.bankononb.com/redirect.php?http://bjsnearme.com/
http://globalindustrial.de/__media__/js/netsoltrademark.php?d=bonus-books.com/
http://datastory.com/__media__/js/netsoltrademark.php?d=bestshopnearme.com
I was able to find good advice from your blog posts.
http://www.pichak.net/verification/index.php?n=39&url=www.spokanevalleymarketing.com
http://www.ams.ceu.edu/optimal/optimal.php?url=www.prnroofing.com
Pretty! This has been an extremely wonderful article. Thank you for supplying these details.
https://edukite.org/members/fallshade0/activity/1141985/
Hi, I do think this is an excellent website. I stumbledupon it 😉 I will return once again since i have book-marked it. Money and freedom is the best way to change, may you be rich and continue to help other people.
http://bad.org.uk/for-the-public/patient-information-leaflets/androgenetic-alopecia/?showmore=1&returnlink=http://www.newrvowners.com/
I used to be able to find good information from your blog articles.
https://www.brivium.com/proxy.php?link=http://www.ocrvmotorsports.org/
https://fr.paltalk.com/client/webapp/client/External.wmt?url=http://postfallsholistic.com/
Having read this I believed it was very informative. I appreciate you taking the time and effort to put this short article together. I once again find myself personally spending way too much time both reading and leaving comments. But so what, it was still worth it!
http://www.7ba.info/out.php?url=https://www.ocrvluxurycoaches.com
https://www.info-dvd.ru/support/ezine/confirm-html.html?smartemail=sam-christian@bikecraze.com/
https://www.htcdev.com/?URL=http://ocrvpaintandservice.com
This is the perfect web site for everyone who hopes to find out about this topic. You realize a whole lot its almost tough to argue with you (not that I personally will need toÖHaHa). You definitely put a new spin on a topic that has been discussed for a long time. Excellent stuff, just great!
https://www.ww17.2test.com/__media__/js/netsoltrademark.php?d=www.assistedlivingseniorcarepalmdesert.com
I have to thank you for the efforts you've put in writing this blog. I really hope to see the same high-grade content from you later on as well. In truth, your creative writing abilities has motivated me to get my very own site now 😉
http://www.how2power.com/pdf_view.php?url=http://affordableranking.com
Great blog you've got here.. Itís hard to find excellent writing like yours these days. I really appreciate individuals like you! Take care!!
https://www.spreaker.com/user/14454961
Your style is unique compared to other folks I've read stuff from. I appreciate you for posting when you have the opportunity, Guess I'll just bookmark this web site.
https://www.girisimhaber.com/redirect.aspx?url=ependantprotection.com/
http://fms.treas.gov/fmsweb/disclaimer.jsp?ciURL=www.webdesignpostfalls.com
Good day! I could have sworn Iíve been to this blog before but after looking at many of the articles I realized itís new to me. Nonetheless, Iím certainly happy I came across it and Iíll be bookmarking it and checking back frequently!
https://blogfreely.net/noisetailor9/the-function-of-reflexology
Can I simply just say what a relief to uncover someone who really knows what they're discussing online. You actually understand how to bring an issue to light and make it important. More and more people must look at this and understand this side of the story. I was surprised that you are not more popular since you most certainly possess the gift.
http://sfwater.org/redirect.aspx?url=http://www.reviewnearme.com/
You have made some decent points there. I looked on the internet for more information about the issue and found most individuals will go along with your views on this site.
http://q2a.sydt.com.tw/index.php?qa=user&qa_1=headwater14
Great site you have got here.. Itís difficult to find excellent writing like yours these days. I truly appreciate individuals like you! Take care!!
http://www.kab3.com/home.php?mod=space&uid=693672
Can I just say what a comfort to discover somebody that actually understands what they're discussing on the net. You definitely realize how to bring a problem to light and make it important. More and more people have to check this out and understand this side of the story. It's surprising you're not more popular given that you certainly possess the gift.
https://telegra.ph/Swedish-Massage-and-Ayurvedic-Massage-04-28
https://www.paeria.cat/ang/ajuntament/noticies.asp?Detall=True&IdNoticia=21087&Dia=-1&Mes=-1&Any=2014&IdDepartament=-1&Consulta=False&PaginaAnterior=www.fleetrepairshops.com
Saved as a favorite, I really like your site!
https://hubpages.com/@farmersalad69
This is a topic that's near to my heart... Thank you! Where are your contact details though?
https://spinalhub.win/wiki/Why_You_Should_Report_Incorrect_Content_In_Google_And_Other_Video_Sharing_Websites
Hi there! This article couldnít be written much better! Looking through this post reminds me of my previous roommate! He always kept preaching about this. I will send this article to him. Pretty sure he will have a very good read. I appreciate you for sharing!
http://xn--3-8sblf7a0afi.xn--p1ai/index.php?option=com_k2&view=itemlist&task=user&id=1084178
Nice post. I learn something new and challenging on websites I stumbleupon everyday. It will always be interesting to read through articles from other writers and practice a little something from other sites.
https://www.ww17.instagurum.com/__media__/js/netsoltrademark.php?d=ocrvcenter.com/airport-bus-collision-repair-shop-near-me/
The next time I read a blog, I hope that it doesn't disappoint me as much as this one. After all, Yes, it was my choice to read through, but I genuinely believed you'd have something helpful to talk about. All I hear is a bunch of complaining about something that you can fix if you weren't too busy searching for attention.
http://cs.odu.edu/~mln/teaching/cs518-f08/?method=display&redirect=http://keo888.com/tile/profile.php?id=13507