 |
|
|
|
September 21st, 2011
12:01 PM ET
New ALS gene mutation discoveredResearchers have identified a genetic abnormality which they believe to be the most common cause of two devastating neurological diseases and could provide future clues to treatment. Two new studies, published online in the journal Neuron, found that amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig's disease and frontotemporal dementia or FTD that run in families are caused in many cases by a mutation on a single gene on chromosome number 9. This mutation causes a short DNA sequence to repeat over and over, much more frequently than in healthy people. The ALS Association, which funded both studies, calls the identification of this genetic mutation "a major milestone in ALS research." According to the data, in healthy individuals the DNA sequence repeats 2 to 23 times. In 23% of familial ALS patients and 12% of familial FTD patients the sequence repeated 700-1,600 times. ALS and FTD are both fatal neurological diseases of the brain. In ALS, nerve cells in the brain and spinal cord begin to degenerate and patients lose the ability to move their bodies and breathe. Almost 6,000 American are diagnosed with the crippling disease each year. FTD causes the degeneration of parts of the brain that control language, emotion, behavioral control and the ability to make decisions (the temporal and frontal lobes). About 20-40% of people with FTD have a family history of the disease. One study looked at patients in Finland which has a high population of ALS patients, according to lead study author Dr. Bryan Traynor from the National Institute on Aging (NIA). "With this finding we've gone from understanding a quarter of familial ALS to two-thirds of familial ALS," Traynor said. "In terms of thinking of the future, what this provides us with is a target to go after. What this allows us to do is to design cell models and animal models of disease we can use to start to screen drugs, and therapeutic agents to see if they are effective in turning off this particular genetic mutation." Traynor says there are 4 genes known to account for 25% of all familial ALS cases. The chromosome 9 gene accounts for an additional 40%. In the second study, researchers at the Mayo Clinic in Jacksonville, Florida also found the same repeat DNA sequence. "This finding has the potential to lead to significant insights into how both of these neurodegenerative diseases develop," Senior Investigator Dr. Rosa Rademakers, neuroscientist at the Mayo Clinic said. "And may give us much needed leads into new ways to treat our patients." The ALS Association's Chief Scientist Lucie Bruijn calls the new data tremendously exciting. "These findings will significantly impact the field as we begin to understand more about the consequences of these changes to the disease process, aid or understanding of FTD and ALS, potentially provide a diagnostic tool, and enable the development of new therapeutic approaches." Still, Traynor says he wants to keep expectations within bounds and be careful not to raise false hopes. That's because typically it's 10 years from gene discovery to clinical trial. He says that's a long time when ALS patients usually live 2-3 years after the onset of symptoms. "It's a step forward, Traynor said. "Now we know which room in which house on which street in which city and that knowledge facilitates ultimately working up a treatment that will slow down this fatal disease.". soundoff (1,143 Responses)« Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Next »Leave a Reply to tire shops near me
Next entry »How did your childhood affect your sexuality?
« Previous entryWhat's the difference in diabetes?
|
  About this blog
Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.
 |
|
|
|
each time i used to read smaller content that
as well clear their motive, and that is also happening with this
post which I am reading now.
http://sergiok70m8.blogdigy.com/significance-of-appointed-day-helpful-date-in-restructuring-15065771
Greetings! Very helpful advice within this article! It's the little changes that will make the greatest changes. Thanks for sharing!
https://bitly.com/a/warning?hash=3nUs1YL&url=https://devind83g8.idblogz.com/4853416/fascination-about-corporate-coaching
Hello there! This post could not be written any better! Looking at this article reminds me of my previous roommate! He continually kept preaching about this. I am going to forward this post to him. Fairly certain he's going to have a great read. Thanks for sharing!
https://www.bing.com/news/apiclick.aspx?ref=FexRss&aid=&url=https://cesart52k1.howeweb.com/4764515/how-much-you-need-to-expect-you-ll-pay-for-a-good-dodge-sprinter-repair-near-me
Hi there! This post could not be written any better! Looking through this post reminds me of my previous roommate! He always kept talking about this. I most certainly will forward this post to him. Fairly certain he will have a great read. Thanks for sharing!
https://www.tkdk.gov.tr/Home/Dil?Dil=en&ReturnUrl=http://whatisdisplayadvertising.com/
You are so cool! I do not believe I've truly read through anything like this before. So wonderful to discover someone with some genuine thoughts on this subject matter. Seriously.. thanks for starting this up. This site is something that is needed on the web, someone with a bit of originality!
https://jasperj70n8.blogsumer.com/4158189/the-smart-trick-of-security-companies-that-nobody-is-discussing
https://www.bing.com/news/apiclick.aspx?ref=FexRss&aid=&url=https://kylern81q9.59bloggers.com/4552580/considerations-to-know-about-mechanic
Aw, this was a very nice post. Taking the time and actual effort to generate a really good articleÖ but what can I sayÖ I procrastinate a lot and don't seem to get anything done.
https://tieba.baidu.com/mo/q/checkurl?url=https://judahtkxk4.amoblog.com/getting-my-land-for-sale-cheney-wa-to-work-22153722
I couldnít resist commenting. Well written!
https://www.domainsherpa.com/share.php?site=http://www.diybathroomdecorideas.blogspot.com/2020/08/small-rv-bathroom-remodel.html/
There's certainly a lot to learn about this issue. I like all the points you made.
http://myleso92s0.blog-mall.com/5337849/time-for-kitchen-transforming-five-signs-that-provide-you-with-it-is-time-to-remodel
http://eduardou26k8.is-blog.com/5739806/helping-the-others-realize-the-advantages-of-security-companies
Pretty! This was an extremely wonderful article. Thank you for supplying this information.
http://promo.pertinger.com/?URL=http://www.dot.mn/archives/943/comment-page-56/
Good web site you have got here.. Itís difficult to find high quality writing like yours these days. I honestly appreciate individuals like you! Take care!!
Hi! I could have sworn Iíve visited this blog before but after browsing through many of the posts I realized itís new to me. Anyways, Iím certainly happy I found it and Iíll be book-marking it and checking back regularly!
http://www.casaberabbtrani.it/index.php?option=com_k2&view=itemlist&task=user&id=1626645
Saved as a favorite, I like your web site!
https://www.instapaper.com/p/clicknurse79
Way cool! Some extremely valid points! I appreciate you writing this write-up and also the rest of the website is extremely good.
https://anotepad.com/notes/bq7ddafr
Itís difficult to find educated people on this topic, but you sound like you know what youíre talking about! Thanks
https://www.openlearning.com/u/airspot36/blog/WhyYouShouldTrySwedishMassageTherapy
I wanted to thank you for this very good read!! I certainly loved every little bit of it. I have got you bookmarked to check out new stuff you postÖ
https://edwinh69l7.prublogger.com/4383320/significance-of-appointed-day-helpful-date-in-restructuring
I'm very happy to find this web site. I want to to thank you for your time due to this wonderful read!! I definitely loved every little bit of it and i also have you saved to fav to check out new stuff in your web site.
http://www.dorsten.de/Externer_Link.asp?ziel=www.interiordesignpicts.blogspot.com/2020/08/small-rv-bathroom-remodel.html
Having read this I believed it was very enlightening. I appreciate you taking the time and effort to put this short article together. I once again find myself spending way too much time both reading and posting comments. But so what, it was still worthwhile!
http://images.google.be/url?q=http://holdenh18a7.blognody.com/4086937/the-ultimate-guide-to-commercial-truck-repair
http://help.dedecms.com/plus/player/index.php?url=https://johnathanh28c8.blog5star.com/4888944/getting-my-repair-shop-to-work
Hello there! This blog post could not be written much better! Reading through this article reminds me of my previous roommate! He constantly kept talking about this. I most certainly will forward this information to him. Pretty sure he's going to have a very good read. Thanks for sharing!
This is a topic that's close to my heart... Best wishes! Where are your contact details though?
https://lukass52i0.gynoblog.com/4098442/rv-body-shop-for-dummies
Hi, I do believe this is an excellent web site. I stumbledupon it 😉 I may revisit yet again since i have book marked it. Money and freedom is the best way to change, may you be rich and continue to help other people.
http://bezvoprosa.ru/index.php?qa=user&qa_1=roadracing5
https://www.google.bt/url?q=http://neanarchist.net/event/how-choose-best-luxury-rv-collision-shop-company/
Hi! I just wish to offer you a huge thumbs up for your great info you have got here on this post. I am coming back to your website for more soon.
https://www.treasury.gov/cgi-bin/redirect.cgi/?https://www.franciscoh69m8.oblogation.com/4058048/rv-repair-companies-options
I really like it when individuals get together and share opinions. Great blog, continue the good work!
https://game-cotuong.com/forum/profile.php?section=personality&id=1055998
I blog frequently and I truly appreciate your content. This great article has really peaked my interest. I am going to take a note of your website and keep checking for new details about once a week. I opted in for your Feed too.
http://franciscoq52l2.blogzet.com/an-unbiased-view-of-your-van-repair-shop-orange-county-15306625
Very good information. Lucky me I ran across your website by accident (stumbleupon). I have saved it for later!
https://www.captainco.net/forums/user/e1ygbvh726/
food
Next time I read a blog, I hope that it doesn't disappoint me just as much as this one. I mean, Yes, it was my choice to read, nonetheless I genuinely believed you would have something helpful to talk about. All I hear is a bunch of complaining about something you can fix if you were not too busy seeking attention.
http://www.guru-pon.jp/search/rank.cgi?mode=link&id=107&url=https://www.ocrv.org/
Very good article. I'm experiencing some of these issues as well..
https://profitquery.com/share/?url=http://rvcollisionrepairpaintshop.com
http://www.medreview.com/__media__/js/netsoltrademark.php?d=boxtruckrepairshop.com
Good site you have got here.. Itís difficult to find excellent writing like yours these days. I truly appreciate individuals like you! Take care!!
http://mb.wendise.com/tools/thumbs.php?tds=3&trs=1&pid=videos&tid=bpgfr&pad=4px&cat=0&ts=156×117&tb=0px&tbc=FFFFFF&fs=12px&ff=Verdana&su=td&sl=ttm&tg=n&url=https://fleetvehiclerepairshop.com/
http://m.taijiyu.net/chongzhi.aspx?return=http://campervanrepairshop.com
http://www.cellaccessories.com/__media__/js/netsoltrademark.php?d=ocrvpaintandservice.com/
This blog was... how do I say it? Relevant!! Finally I've found something which helped me. Kudos!
https://squareblogs.net/crowsleep52/blackjack-a-good-card-game
Hi! I simply would like to offer you a huge thumbs up for your excellent information you have right here on this post. I will be coming back to your website for more soon.
http://p1-uranai.com/rank.cgi?mode=link&id=538&url=ocrvparts.com/
https://www.ajcampos.org/web/intranet/actualitat-a-campos/-/asset_publisher/M6mI/content/informacio-d-interes-de-la-revisio-de-gas-buta-facilitada-per-la-policia-local?redirect=http://www.ocrv.pro/
This blog was... how do I say it? Relevant!! Finally I have found something which helped me. Thanks!
https://creativecommons.org/choose/results-one?field_attribute_to_url=https://fleetautorepairshop.com/
http://vocce-gourmet.com/modules/wordpress0/wp-ktai.php?view=redir&url=https://fleetrepairshops.com/
Everything is very open with a clear description of the challenges. It was truly informative. Your website is extremely helpful. Thanks for sharing!
http://academyartuniversityfaculty.biz/__media__/js/netsoltrademark.php?d=campervanrepairshop.com
This would be the proper blog for anybody who wishes to learn about this topic. You know so much its almost challenging to argue along (not too I just would want…HaHa). You definitely put a whole new spin for a topic thats been revealed for several years. Wonderful stuff, just wonderful!
http://whoy.beginnersstop.com/story/a-lot-of-people-diet-to-lose-weight-these-days-a-lot-of-people-diet-to-lose/
Hello there! I could have sworn Iíve visited this site before but after browsing through some of the articles I realized itís new to me. Nonetheless, Iím definitely happy I found it and Iíll be book-marking it and checking back regularly!
http://deani69l7.tribunablog.com/5-easy-facts-about-digital-marketing-course-described-15026143
https://tieba.baidu.com/mo/q/checkurl?url=https://gunnera36e5.designertoblog.com/31019910/the-5-second-trick-for-internet-marketing-consultant
That is a good tip especially to those fresh to the blogosphere. Short but very accurate informationÖ Appreciate your sharing this one. A must read post!
https://telegra.ph/Worldwide-Aquatic-Bodywork-Benefits-of-Warming-Up–Relaxing-Down-04-25-3
Having read this I thought it was rather informative. I appreciate you finding the time and energy to put this short article together. I once again find myself personally spending a lot of time both reading and commenting. But so what, it was still worthwhile!
http://igrice-igre.biz/profile/1743011/adultthomas5.htm
http://nelliecravens.com/__media__/js/netsoltrademark.php?d=hootnholler.net/