 |
|
|
|
September 21st, 2011
12:01 PM ET
New ALS gene mutation discoveredResearchers have identified a genetic abnormality which they believe to be the most common cause of two devastating neurological diseases and could provide future clues to treatment. Two new studies, published online in the journal Neuron, found that amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig's disease and frontotemporal dementia or FTD that run in families are caused in many cases by a mutation on a single gene on chromosome number 9. This mutation causes a short DNA sequence to repeat over and over, much more frequently than in healthy people. The ALS Association, which funded both studies, calls the identification of this genetic mutation "a major milestone in ALS research." According to the data, in healthy individuals the DNA sequence repeats 2 to 23 times. In 23% of familial ALS patients and 12% of familial FTD patients the sequence repeated 700-1,600 times. ALS and FTD are both fatal neurological diseases of the brain. In ALS, nerve cells in the brain and spinal cord begin to degenerate and patients lose the ability to move their bodies and breathe. Almost 6,000 American are diagnosed with the crippling disease each year. FTD causes the degeneration of parts of the brain that control language, emotion, behavioral control and the ability to make decisions (the temporal and frontal lobes). About 20-40% of people with FTD have a family history of the disease. One study looked at patients in Finland which has a high population of ALS patients, according to lead study author Dr. Bryan Traynor from the National Institute on Aging (NIA). "With this finding we've gone from understanding a quarter of familial ALS to two-thirds of familial ALS," Traynor said. "In terms of thinking of the future, what this provides us with is a target to go after. What this allows us to do is to design cell models and animal models of disease we can use to start to screen drugs, and therapeutic agents to see if they are effective in turning off this particular genetic mutation." Traynor says there are 4 genes known to account for 25% of all familial ALS cases. The chromosome 9 gene accounts for an additional 40%. In the second study, researchers at the Mayo Clinic in Jacksonville, Florida also found the same repeat DNA sequence. "This finding has the potential to lead to significant insights into how both of these neurodegenerative diseases develop," Senior Investigator Dr. Rosa Rademakers, neuroscientist at the Mayo Clinic said. "And may give us much needed leads into new ways to treat our patients." The ALS Association's Chief Scientist Lucie Bruijn calls the new data tremendously exciting. "These findings will significantly impact the field as we begin to understand more about the consequences of these changes to the disease process, aid or understanding of FTD and ALS, potentially provide a diagnostic tool, and enable the development of new therapeutic approaches." Still, Traynor says he wants to keep expectations within bounds and be careful not to raise false hopes. That's because typically it's 10 years from gene discovery to clinical trial. He says that's a long time when ALS patients usually live 2-3 years after the onset of symptoms. "It's a step forward, Traynor said. "Now we know which room in which house on which street in which city and that knowledge facilitates ultimately working up a treatment that will slow down this fatal disease.". soundoff (1,143 Responses)« Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Next »Leave a Reply to 먹튀검증커뮤니티
Next entry »How did your childhood affect your sexuality?
« Previous entryWhat's the difference in diabetes?
|
  About this blog
Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.
 |
|
|
|
I used to be able to find good advice from your content.
https://audiodat.ru/forum/index.php?action=profile;area=forumprofile;u=175292
Oh my goodness! Awesome article dude! Many thanks, However I am encountering difficulties with your RSS. I donít know why I can't subscribe to it. Is there anybody else having identical RSS issues? Anybody who knows the solution can you kindly respond? Thanks!!
https://postheaven.net/massage6pingsweets4/burmese-therapeutic-massage-spa-have-you-been-having-a-true-burmese
Clifton Steel's is a Hadfield Grade Manganese Steel made to harden with influence. Merely The Best Manganese Wear Plate
https://www.instructables.com/member/a1uflcq097/
Can I just say what a comfort to find an individual who truly understands what they are talking about on the internet. You actually understand how to bring a problem to light and make it important. A lot more people ought to read this and understand this side of your story. I was surprised that you're not more popular because you certainly possess the gift.
https://ticketbox.vn/lang/en?redirectUrl=http://fleetservicerepairshop.com/sprinter-van-upgrades-shop-near-me
I absolutely love your site.. Great colors & theme. Did you create this website yourself? Please reply back as Iím planning to create my own personal website and would love to learn where you got this from or just what the theme is named. Appreciate it!
http://liquorradio71.jigsy.com/entries/general/Advantages-of-Sports-Massage–What-Can-I-Do-When-Ive-Been-Injured-
http://ewebcounter.com/__media__/js/netsoltrademark.php?d=sprintervanrepairshop.com/rv-wrap-shop-near-me
Nice post. I learn something new and challenging on websites I stumbleupon on a daily basis. It's always exciting to read articles from other writers and use a little something from their web sites.
https://anotepad.com/notes/gwgrdxwt
http://hammer.if.tv/cgi/search/rank.cgi?mode=link&id=2613&url=ocrvpaintandservice.com
http://feeds.feedburner.com/techstat/GHSw
http://feeds.feedburner.com/techstat/GHSw
I have learn several good stuff here. Definitely price
bookmarking for revisiting. I surprise how a lot
effort you place to make this kind of fantastic informative site.
Feel free to visit my web page ... 사설바둑이
Wonderful article! We are linking to this great article on our website. Keep up the good writing.
https://debtenergy42.tumblr.com/post/649707094977724416/massage-therapy-explained
I like reading through a post that can make people think. Also, thanks for permitting me to comment!
https://myspace.com/switchepoch6
Howdy! I just wish to offer you a huge thumbs up for the great info you have got right here on this post. I'll be coming back to your blog for more soon.
http://www.response-o-matic.com/thank_you.php?u=https://sprintervanrepair.com/&t=near+me
https://glowing.com/external/link?next_url=http://boxtruckrepairshop.com/ford-luxury-van-repair-shop-near-me
http://www.treasury.gov/cgi-bin/redirect.cgi/?http://www.commercialvanrepairshop.com/sprinter-van-conversion-shop-near-me/
Clifton Steel's is a Hadfield Grade Manganese Steel created to set with influence. Merely The Best Manganese Wear Plate
https://ameblo.jp/castingsuggestsbov/entry-12675664479.html
Right here is the perfect website for anyone who wants to find out about this topic. You realize a whole lot its almost tough to argue with you (not that I really will need to…HaHa). You definitely put a fresh spin on a topic that has been written about for decades. Wonderful stuff, just wonderful!
http://nilaima.com/link.php?url=http://sprinterrepairnearme.com/
Great article. I will be dealing with some of these issues as well..
http://donolx.ru/user/profile/33977
Good article! We will be linking to this great content on our website. Keep up the good writing.
https://www.ultimate-guitar.com/u/susansmoke52
Pretty! This was a really wonderful post. Thanks for supplying this information.
http://tstz.com/link.php?url=https://vizitka.az/2018/07/27/define-academic-performance-20/
Nice post. I learn something new and challenging on websites I stumbleupon on a daily basis. It will always be interesting to read content from other authors and use something from other web sites.
http://1000love.net/lovelove/link.php?url=http://kirmes-werkel.de/index.php/gaestebuch?start=8640
http://kebrt.webz.cz/download.php?url=https://monicheis.com/el-hueco-de-donde-venimos/
Howdy! I simply want to offer you a huge thumbs up for your great information you've got right here on this post. I am returning to your blog for more soon.
https://birchenergy18.tumblr.com/post/649706753264631808/massage-treatment-getting-started
Hi there, I do believe your website could be having web browser compatibility issues. When I look at your website in Safari, it looks fine however, if opening in IE, it's got some overlapping issues. I merely wanted to provide you with a quick heads up! Aside from that, great website!
https://www.fms.treas.gov/fmsweb/disclaimer.jsp?ciURL=https://www.blog.sunmence.com.ng/police-explains-trending-photo-of-elisha-abbo-with-igp-mohammed-adamu/
Your Online Metal Marketplace In Texas With Lowest Prices, Guaranteed. Hundreds Of Steel Items Available, Custom or Stock. Call Our Experts, Shop Steel Now
https://writeablog.net/p2bvpch356/made-by-ordinary-carbon-structural-steel-reduced-alloy-architectural-steel
Having read this I believed it was extremely enlightening. I appreciate you spending some time and effort to put this informative article together. I once again find myself personally spending way too much time both reading and posting comments. But so what, it was still worth it!
https://telegra.ph/Is-Thai-Massage-Therapy-Difficult-to-Gauge-Asian-Massage-Therapy-04-25
https://rspcb.safety.fhwa.dot.gov/pageRedirect.aspx?RedirectedURL=https://archers27o0.daneblogger.com/4045195/painting-shop-can-be-fun-for-anyone
Howdy, There's no doubt that your blog could possibly be having web browser compatibility problems. When I look at your web site in Safari, it looks fine however, if opening in Internet Explorer, it has some overlapping issues. I simply wanted to provide you with a quick heads up! Aside from that, wonderful website!
https://diigo.com/0kdzpj
Hello! I could have sworn Iíve been to this website before but after looking at some of the articles I realized itís new to me. Anyways, Iím definitely happy I discovered it and Iíll be bookmarking it and checking back regularly!
http://pubglife.ru/user/gaugespear7/
http://dol.deliver.ifeng.com/c?z=ifeng&la=0&si=2&cg=1&c=1&ci=2&or=7549&l=28704&bg=28703&b=37275&u=https://johnnyt15f6.arwebo.com/24094040/roofing-and-siding-near-me-no-further-a-mystery
Very nice blog post. I absolutely love this site. Keep it up!
/
http://dlibrary.mediu.edu.my/cgi-bin/koha/tracklinks.pl?uri=https://bestshopnearme.com/
Learn about plating on steel, its benefits as well as potential applications. Get In Touch With Hard Chrome Specialists for plating remedies for steel in PA, MD as well as past.
https://uberant.com/article/1478980-the-covering-category-of-hot-dip-galvanizing-steel/
http://asagaassociates.com/__media__/js/netsoltrademark.php?d=www.commercialrepairshop.com/
tadalafil bph mechanism tadalafil from india reviews tadalafil sublingual
http://mypracticepartner.com/__media__/js/netsoltrademark.php?d=sprinterrepairnearme.com
Very good information. Lucky me I found your blog by accident (stumbleupon). I've bookmarked it for later!
https://postheaven.net/tiestove7/soft-tissue-massage-treatment-requires-relaxation-for-your-residence
http://www3.bigcosmic.com/board/s/board.cgi?id=tetsujin&mode=damy&moveurl=https://ocrv.tv
I truly love your site.. Pleasant colors & theme. Did you make this website yourself? Please reply back as Iím attempting to create my own personal site and would like to learn where you got this from or what the theme is called. Thank you!
http://apps.stablerack.com/flashbillboard/redirect.asp?url=http://massage3ossidyvbty.huicopper.com/24-hours-to-improving-chuljangmasaji
https://maps.google.com.mm/url?q=https://youtube.com/watch?v=P3A8tAQwZRA
I need to to thank you for this good read!! I certainly enjoyed every little bit of it. I have you book marked to check out new things you postÖ
http://massage4brimurdczv.jigsy.com/entries/general/meet-the-steve-jobs-of-the-ECB69CEC9EA5EC9588EBA788-industry
Saved as a favorite, I love your web site!
https://migrantcinema.net.gridhosted.co.uk/?URL=www.youtube.com/watch?v=0eb9oP6XDs0/
https://happylife.com/__media__/js/netsoltrademark.php?d=www.youtube.com/watch?v=14-Dd6tpG_k/
http://whois.zunmi.com/?d=youtube.com/watch?v=jHarhMSw7eY/
https://nutritiondata.self.com/facts/recipe/1304991/2?mbid=HDFD&trackback=https://youtube.com/watch?v=pP9ZQx-_atI/
https://cross-a.net/go_out.php?url=https://youtube.com/watch?v=j5CE6R4KLz4
Find out about plating on steel, its benefits and also prospective applications. Contact Hard Chrome Specialists for layering options for steel in PA, MD as well as beyond.
https://www.weddingbee.com/members/a6yqrve583/
I'd like to thank you for the efforts you've put in writing this site. I'm hoping to see the same high-grade content by you in the future as well. In truth, your creative writing abilities has inspired me to get my very own blog now 😉
https://massage5drillwax4.bravejournal.net/post/2021/04/25/Burmese-Massage-Spa-Are-You-Getting-A-True-Burmese-Massage
I was able to find good information from your blog articles.
http://ichikawa.genki365.net/gnki02/common/redirect.php?url=http://www.ocrvcenter.com/
Greetings! Very useful advice within this post! It is the little changes that will make the most significant changes. Thanks a lot for sharing!
http://www.fitnfurry.biz/__media__/js/netsoltrademark.php?d=postfallsmarketing.com