FDA recommends lowering Celexa's maximum daily dose
August 25th, 2011
12:51 PM ET

FDA recommends lowering Celexa's maximum daily dose

The Food and Drug Administration is recommending that patients taking the anti-depressant Celexa (citalopram hydrobromide) take no more than 40mg a day. The FDA says anything more can cause abnormal heart rhythms, and studies show there is no therapeutic benefit with doses higher than 40mg. The recommendation includes generic versions of the drug.

Celexa, is made by Forest Laboratories Inc., and is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs). Serotonin is a neurotransmitter–it helps relay messages from one part of the brain to another. Researchers believe serotonin imbalances can influence your mood and lead to depression. SSRIs like Celexa increase the amount of serotonin in the brain, which can help improve mood.

Although the drug is available in 10mg, 20mg and 40mg pills, 60mg doses can be used to treat certain patients with depression.

"Most patients are treated with lower doses of Celexa," Sandy Walsh, FDA spokesperson said. "But we issued the safety communication today [Wednesday] to make sure doctors and patients have the most up to date information possible to make treatment decisions."

The FDA says at-risk patients include "those with underlying heart conditions and those who tend to have low levels of potassium and magnesium in their blood."

The  safety announcement warns doctors not to prescribe the drug for patients with congenital long QT syndrome (LQTS)–a condition of the heart's electrical system that can lead to cardiac arrest or sudden death. LQTS is rare–only about 1 in 5,000 Americans have the condition.

Patients, the agency says, should not stop taking Celexa or change their dose without first talking to their doctor.  Stopping suddenly can cause side effects. Any patient who has shortness of breath, irregular heartbeat or dizziness while taking the medication should see their doctor.

soundoff (2,302 Responses)
  1. 먹튀검증커뮤니티

    You made some decent points there. I looked on the net for additional information about the issue and found most individuals will go along with your views on this website.


    June 30, 2021 at 09:57 | Report abuse | Reply
  2. 먹튀

    I love it when folks get together and share opinions. Great website, continue the good work!


    June 30, 2021 at 10:21 | Report abuse | Reply
  3. Transport Van Repair


    June 30, 2021 at 10:24 | Report abuse | Reply
  4. 경주출장

    Very good article. I'm experiencing some of these issues as well..


    June 30, 2021 at 10:27 | Report abuse | Reply
  5. 먹튀검증커뮤니티

    There is certainly a lot to know about this topic. I like all of the points you've made.


    June 30, 2021 at 11:06 | Report abuse | Reply
  6. RV Repair Orange County California

    Great site you have got here.. Itís difficult to find excellent writing like yours nowadays. I truly appreciate people like you! Take care!!


    June 30, 2021 at 11:07 | Report abuse | Reply
  7. 먹튀사이트

    There's definately a lot to know about this topic. I love all of the points you made.


    June 30, 2021 at 11:26 | Report abuse | Reply
  8. 구미출장안마

    Having read this I believed it was extremely informative. I appreciate you finding the time and energy to put this short article together. I once again find myself spending way too much time both reading and leaving comments. But so what, it was still worth it!


    June 30, 2021 at 11:33 | Report abuse | Reply
  9. 먹튀검증사이트

    Having read this I believed it was extremely informative. I appreciate you spending some time and effort to put this short article together. I once again find myself personally spending a significant amount of time both reading and posting comments. But so what, it was still worth it!


    June 30, 2021 at 12:05 | Report abuse | Reply
  10. 먹튀사이트

    Spot on with this write-up, I honestly believe that this website needs much more attention. Iíll probably be returning to see more, thanks for the advice!


    June 30, 2021 at 12:31 | Report abuse | Reply
  11. RV Repair Near Me Now

    Good post! We are linking to this great content on our site. Keep up the good writing.


    June 30, 2021 at 12:41 | Report abuse | Reply
  12. 먹튀검증

    I was very pleased to find this website. I want to to thank you for ones time just for this wonderful read!! I definitely enjoyed every part of it and i also have you saved to fav to check out new stuff in your blog.


    June 30, 2021 at 13:19 | Report abuse | Reply
  13. 먹튀검증사이트

    You are so awesome! I do not think I've read a single thing like this before. So nice to find another person with some genuine thoughts on this subject matter. Really.. thanks for starting this up. This website is one thing that's needed on the internet, someone with a bit of originality!


    June 30, 2021 at 13:53 | Report abuse | Reply
  14. Advertising Companies Near Me


    June 30, 2021 at 14:01 | Report abuse | Reply
  15. Scottie Scriver

    great blog thank you


    August 1, 2021 at 03:53 | Report abuse | Reply
  16. Thurman Synovic

    Some us know all concerning the compelling medium you present impressive measures on this blog and therefore strongly really encourage contribution from other types on this issue although our very own kid is really discovering an incredible deal. Have a good time Along with the remaining portion of the year.


    September 1, 2021 at 15:06 | Report abuse | Reply
  17. Marget Lauderbaugh

    I simply wanted to jot down a quick remark to say thanks to you for those nice facts you are showing at this website. My extended internet research has at the end of the day been recognized with good quality knowledge to share with my contacts. I 'd claim that we website visitors actually are really endowed to live in a fine site with so many special professionals with interesting strategies. I feel quite happy to have come across your entire webpage and look forward to really more amazing times reading here. Thanks once more for everything.


    September 19, 2021 at 02:38 | Report abuse | Reply
  18. Tamekia Dismore

    I just wanted to type a small message so as to thank you for the pleasant suggestions you are writing here. My time-consuming internet investigation has finally been recognized with reasonable information to talk about with my best friends. I would admit that many of us visitors actually are very fortunate to exist in a really good website with very many lovely professionals with very helpful plans. I feel extremely lucky to have used the site and look forward to many more amazing times reading here. Thank you once more for all the details.


    September 20, 2021 at 07:03 | Report abuse | Reply
  19. Leona Bleeker

    Thanks quite a bit for offering men and women with a very amazing possibility to browse critical critiques from This web site.


    September 21, 2021 at 19:49 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46

Post a comment


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.