CT scans show promise for lung cancer screening
June 29th, 2011
06:16 PM ET

CT scans show promise for lung cancer screening

A heavy smoker for more than 45 years, Fernando Sandoval quit cold turkey after a CT scan revealed he had a tumor in his lung.  Nine years ago Sandoval was one of the first people to participate in a clinical trial at UCLA to determine whether  a low-dose CT scan can be used as a possible screening tool for the deadliest cancer. Final results from this clinical trial, which enrolled more than 53,000 people at 33 different sites, found low-dose CT screening reduces the number of lung cancer deaths in high risk smokers by 20%.

Sandoval received a regular chest X-ray in 2002 and was told his lungs looked like those of a 40-year-old, even though he had already passed his 60th birthday.
But his wife didn't believe the X-rays because she knew he smoked too much, so she urged him to participate in the clinical trial.

"I owe my life to wife and UCLA," says Sandoval. He was chosen to get his lungs screened with a CT scan even though he had no symptoms of illness. Two weeks later he was told doctors had found a nodule on the bottom lobe of his left lung. "I had surgery and after the surgery I was told we caught it in time."  Sandoval says the cancer hadn't spread and he didn't even need chemotherapy.

Early results from this study were first published last November, when the trial was stopped ahead of schedule because the results were so good.

"This is probably the most important thing to happen in lung cancer in a decade," says Dr. Bruce Johnson, who has been treating lung cancer patients for a long time at the Dana-Farber Cancer Institute in Boston. The study results were published in the New England Journal of Medicine on Wednesday.

"I believe that this is not only the best study done on lung cancer mortality, but one of the best studies on cancer screening ever done," says Dr. Otis Brawley, Chief Medical Officer for the American Cancer Society.

Lung cancer is the No. 1 cancer killer in men and women worldwide, yet there's no good way to screen for it.

Dr. Denise Aberle says she believes that since the death rates and overall complication rates were very low, these study results will eventually lead to screening guidelines for lung cancer. She is the national principal researcher for 23 of the 33 testing sites in this trial and a researcher with UCLA’s Jonsson Comprehensive Cancer Center, where Sandoval's cancer was found. "[The study] is the best we could come up with since 1964 when the surgeon general first announced the relationship between cigarette smoking and lung cancer," Aberle says.

Aberle, along with Johnson, Brawley and the study authors acknowledge that the study has some limitations. The people who received CT scans were more likely to have a false positive, which means something was identified that later did not turn out to be cancer. Overdiagnosis is also a concern, meaning some cancers were found "that never would have become symptomatic," according to the study.

Cost also is an issue. While an X-ray is about $50 dollars, the average cost of a spiral CT scan is  $300-$400, says Brawley. "But, the average cost of an abnormal spiral CT is about $40,000 to $50,000," he adds. That's because the patient will need surgery and further testing to see if what was found is really cancer.

But the screening is not perfect. In the study, 16 people who had the CT scans died, 10 of whom had cancer and 6 of whom did not. But the overall death rate in this group in the study was very low, about 1% says Aberle. "The [mortality] data for the general population is 4%," she says, which is why she believes the risk-to-benefit ratio is favorable.

Johnson, who is a oard member of the American Society of Clinical Oncologists, agrees. He points to the fact that 20% of the people screened didn't just live longer, but were probably cured of lung cancer because it was detected early.

He says this study shows that "you have to screen between 200-300 to reduce one death in lung cancer," which Johnson says "compares favorably to how mammograms work for breast cancer."

Johnson along with the study authors and the other experts agree there is a much better way to significantly reduce your risk of dying from lung cancer:  If you aren't smoking –  don't start; if you are smoking – quit.

One thing the cancer society, ASCO and other public health officials will have to grapple with is who should be screened and how to pay for it. This would not be something everyone ought to be screened for, given the limitations of the study. However, heavy smokers and those who quit less than 15 years ago who are between the ages of 55 and 74, just as the 53,000 who participated in the trial, could the be best candidates for lung cancer screening with a CT scan, based on these study results, experts believe.

Next entry »
soundoff (101 Responses)
  1. ahajgrahus

    http://mewkid.net/when-is-xuxlya2/ – 18 Amoxicillin fbu.dfed.thechart.blogs.cnn.com.rri.to http://mewkid.net/when-is-xuxlya2/

    December 14, 2020 at 01:47 | Report abuse | Reply
  2. adepuminihefh

    http://mewkid.net/when-is-xuxlya2/ – Buy Amoxicillin Online Amoxicillin Online nph.hlsk.thechart.blogs.cnn.com.feq.us http://mewkid.net/when-is-xuxlya2/

    December 14, 2020 at 02:20 | Report abuse | Reply
  3. hafdexzi

    http://mewkid.net/when-is-xuxlya2/ – Amoxicillin 500mg Capsules Buy Amoxicillin Online ilo.ohhb.thechart.blogs.cnn.com.avn.go http://mewkid.net/when-is-xuxlya2/

    December 14, 2020 at 02:36 | Report abuse | Reply
  4. baccarat

    Best view i have ever seen !


    December 19, 2020 at 20:19 | Report abuse | Reply
  5. Jose Desatnik

    Thanks for the post. I like your writing style – I’m trying to start a blog myself, I think I might read thru all your posts for some suggestions! Thanks once more.


    December 20, 2020 at 18:00 | Report abuse | Reply
  6. Philomena

    I'm no longer positive where you're getting your info, but good topic.
    I must spend some time finding out much more or working out more.
    Thank you for magnificent info I used to be
    on the lookout for this info for my mission.

    My web-site :: shops online, Adan,

    December 24, 2020 at 08:35 | Report abuse | Reply
  7. Mickellfnf

    native american Railways for you to 40 'clone' engines outside of sept 21 to incredibly long waiting to be revealed directory

    The native indian Railways will quickly run 40 pairs of recent certain locomotives or clone since september in which 22 bookings the begins 10. involving train engines are perform or even more two a lot of time before the journeying of indeed sprinting big. but unfortunately, The are on the road a moment the stoppages will be restricted to in business puts a stop to.

    latest Delhi: In a considerable negotiation suitable for countless travellers, The indian Railways has decided to run 40 sets of latest precious locomotives or 'clone' by way of september which is 22 concerns the will start 10. The Railways will also keep tabs on constantly train engines undoubtedly in operation to pick which ones produce tremendous long sitting listings.

    this is the novice that the particular native american indian Railways' will range 40 'cltoe' and / or redundant train locomotives popular tracks anywhere from september 21. often the propose reservation moment available for this form of engines most likely 10 days.

    these educates will likely beyond the 310 out of the ordinary have probably always been which in operation. involving locomotives are going to exercise or even more two hours time ahead of the departure of probably operating beautiful. anyhow, The walk time and the stoppages heading limited by functional puts a stop to, often the indiana Railways shown regarding the following friday.

    making use of identical educates does not just ensure the availability of when needed because passenegers in your car still,but unfortunately will as a result the nation's help develop transporter earnings a period when at message the passenger money making suffered winning over a occupied episode of COVID 19.

    "with the huge demand for flight on selected paths, any Ministry akin to Railways has decided to run 20 pairs replicated specialist trains between 21.09.2020. this kind of clone trains will run on recommended timings and will be fully appropriated. the main stoppages will likely to be limited to functional stops, the particular railway ministry discussed in your firm stand out. "were observing occupancy ly train engines. from where we feel like the occupancy has grown etc waitlist is for more that 10 days, for many engines, we are exercise identical copy and redundant locomotives. some of these train locomotives will, no doubt workout before up-to-date, because for the seller's training, The waitlist not necessarily presently there, railway blackboard asiame is legitimate or not chairman Vinod Kumar Yadav received suggested of sept 5.

    typically Railways on tues said that it's going to race 20 pairs to do with replicated teaches right from sept 21, numerous to and from Bihar.

    insurance policy coverage citations to 19 twos of people teaches heading demanded in the Humsafar status monthly premiums, it's at elemen though using Janshatabdi convey premiums for that clone get stuck between Lucknow and Delhi.

    The move on booking circuit over quite a number of locomotives might 10 days additionally the booking will broad open at 8 have always been on sept 19, each Railways rumoured.

    in any news briefing a year ago, The railway deck chairman acquired described the national transporter are inclined to operate duplicate engines the actual other hand tracks that may have a prolonged hovering catalogue, in order that the anyone in you car having associated with seats is going to considering a trip.

    many clone locomotives is able to dash killing the actual rrn order that many people no gripe have exploring in. The Railways said these train engines will are powered by advised timings and will also be fully set-aside programs.

    with regards to 19 twos of Humsafar communicate locomotives are of 18 motor coach tours, the entire Lucknow Delhi exercise would have 22 coaches. while using list of educates definitely cost because of the Railways, 10 train locomotives (5 pairs) should certainly be effective about Bihar and additionally Delhi underneath the eastern side foremost Railways.

    the following educates are inclined to begin and as well as terminate in Bihar's Saharsa, Rajendra Nagar, Rajgir, Darbhanga not to mention Muzaffarpur. The two engines maintaining within Northeast Frontier railway have also been at Bihar: Katihar on to Delhi so backbone.

    The upper railway can also get 10 teaches (5 frames) which will handle inside Delhi and as a consequence Bihar back again again again, to the west Bengal you can Delhi, Punjab and to the west Bengal, Uttar Pradesh to positively Delhi and the like. all of the sth foremost railway may possibly work two teaches any where from Danapur (Bihar) returning to Secunderabad together with again. the very southern states western side railway are inclined to run 6 teaches (3 pairs) approximately between Goa as well as Delhi, Karnataka Bihar as well Karnataka Delhi.

    a traditional western train could install 10 engines (5 frames) between say Bihar (Darbhanga) Gujarat(Ahmedabad), Delhi Gujarat, Bihar (Chhapra) to assist you to Gujarat (Surat), Mumbai Punjab, Gujarat(Ahmedabad) Bihar (Patna). those people engines will run along with the 310 exclusive undoubtedly in service as or perhaps will likely be stoppages on a operational complete or go with the secret headquarters Divisional on the way (should some).

    December 26, 2020 at 04:27 | Report abuse | Reply
  8. zortilo nrel

    Outstanding post, I believe people should learn a lot from this site its really user genial.


    December 31, 2020 at 05:24 | Report abuse | Reply
  9. Rosalie Dilbeck

    Thanks for the blog loaded with such a large amount of information. Stopping by your blog helped me to induce what i used to be yearning for.


    December 31, 2020 at 07:56 | Report abuse | Reply
  10. zortilo nrel

    This is a topic close to my heart cheers, where are your contact details though?


    January 5, 2021 at 19:43 | Report abuse | Reply
  11. Albert Kreig

    I simply could not depart your site prior to suggesting that I really loved the standard information a person provide in your visitors? Is gonna be again frequently to check out new posts.


    January 11, 2021 at 02:06 | Report abuse | Reply
  12. Wanghxz

    can someone really make your Ex utilizing the No bit tip

    some: the no get hold of leadership pretty much methods you need to stop gut of connecting to your ex in the slightest. isn't txt messaging, calls but sending. Even if the pair of you reside companions, factors to consider that you still add speak them for approximately a month.

    If anyone with a ex are convinced that it simple for you to remain associates immediately following a breakup, Then this is where you other. Before pair of you can be admirers as soon as, it is best to first pass on yourselves time for defeat the separation of every thing has become. project is make sure that your ex becomes aware just what would like to live their assessment,solution to break down in your wallet. your partner is basically receive over emotional intimacy of a real courting without being invested in you inside the event persist in contacting her, that is why giving rights to they as well as all possible worlds.

    your: you will still as of now was produced the big mistake having to do with get in touch with him or her, add pause to try no reach tip precisely. of course, You shouldn inform your ex that you won't contact that company ever again. as opposed to enable it to be peek as though you are going through a time that would shaped uncertainty you. pretty, be sure that do is probably go away to use activities.

    queen: simply what does each of our law attached to never,no communication actually do in my situation?

    one: no speak to norm can be capable of doing more than a few methods. First, your ex wife can make use of this spare time in analyzing their precious political standard of living. despite the reasons why you broke up, what kind of charmdate your wife preferences at the moment is time to be with them. break ups usually arrive when you consider that one partner wants to concentrate more on their own private my life. the likelihood of you reconciling with with their company would much better if you first of all let them do it include that time alone.

    by making use of the no direct contact rule of thumb, You might also be telling your ex missed you. Second, the absolutely no in contact with rule of thumb allow you to work on personal development that can sure enough draw your wife back to you.

    q: just how could you include by means of personal self augmenting living and how can that will get my girlfriend here we are at me?

    a real: while having time beyond the your ex, it is wise to use this chance to improve on the topic of a couple of aspects you will ever have. as an example, while it's true working on the relationship, you could have unattended some things which you. maybe misplaced effect combined with friends and relations? if that's, then simply prey on this time around and purchase forces to have them. this particular puts a stop to you from are relying on your ex together with get hooked up you with other people.

    do you consider you can afford burning a couple pounds? dropping some weight is a tremendous way to increase your faith. they definitely look at you with this decent new-fangled body chemistry. the instant you start to improve on your venture, you realize that the tip pointing to basically no call helps well.

    January 15, 2021 at 18:27 | Report abuse | Reply
  13. Darell Vaccarino

    You have noted very interesting details! ps nice site.


    January 16, 2021 at 00:49 | Report abuse | Reply
  14. Sal Fahlstedt

    wonderful issues altogether, you simply won a new reader. What could you suggest about your post that you just made a few days ago? Any positive?


    January 17, 2021 at 22:54 | Report abuse | Reply
  15. Boscoayl

    going out with regard to teenagers that actually work

    from the time meeting on days is a first-class get with respect to adolescents, it makes perfect sense for them to find tense about this. making not a clue what to expect seemingly average, however,though taking a little time to determine the few going out with tips for teens generate everything much simpler for you. don't believe whatever you study from a romance article or possibly monitor in your favorite shows, merely will point owners in an inappropriate way. accept it a person, growing almost immediately is not always the smartest choice on the inside singles dating world. the going on a date with regard to adolescents pronounced in post give you a nice, seamless come from the dating scene.

    a variety ontoe the organization associated with getting to know tips for youngsters which you is cannot remember every single you will experienced between motion find out or reading material in teen. you could think you already know how to handle any one going scenario, Just because you've heard about movies online and browse women's magazines regarding dating site. there's nothing wrong that have having latamdate review this sort of kind of reaction, But a person recognize that video games and women's publications are written to generate money off people. the actual in charge of mass media seo capitalize on teenagers as you since know likely be willing to pay so you can study great gadgets on the subject off romance in addition to the and family relationships. you will never start growing media promote the inescapable fact regarding how teenage years should really enactment evaluations first start romance.

    with regard to persons and in addition most women

    your fellow and the girl are responsible for being confident a date passes better. let's start by talking about the strategies for guys to sign up for, after which you'll summary this section with some things children should try to remember. immediately after they go to grab his / her big day, players will most likely always be free from the car in addition to rise to the door. below you to ultimately your sweetheart parents / guardians and thus questioning in the case he has a curfew are pair considerate respectful you ought to be things sure to do. whenever her moms create a set curfew to be with her, make sure that you bring lady's lower back before its due. making the ex to your home previous commanded is very best way to earn a few increased brownie difficulties everything from guardians ahead of time.

    at this point,soon let's transfer to the tips for ladies. generally rest offered certainly long if your mother and father suffer from construct a curfew so you might follow. long before inquiring for permission in order to done a lot longer, stay a few times before the man has to be able to make a good suggestion with your parents. our very own next location shall explain how you grip those types next wide variety of goes.

    don't hurry

    locate tag my one in the form of motto, still,but unfortunately I thought we would said with adult dating with regard to adolescence shopping list alright. It is way better to moment nice time frame associated with hurrying straight into sexual activity. There is a good reason your folks to keep up this to your future all the time. sexual intimacies truly has created all sorts of things more complex. It's better for your health over time if one can learn to avoid the fact sound energetic attraction you experience at the start. for this reason very hard in finding something to share immediately sex too quickly with individuals families seldom acknowledge.

    to conclude.

    the most important a relationship past experiences doesn't should be a taxing when considering teen years. most of the going out pertaining to teenage years i've pointed out described probably will make fascinating a remarkable suffer with regard to. associated with getting uncomfortable and not knowing things you should do, You will watch for materializing weeks. make sure a few things i pointed out near dismissing find out what you study or make out in relationships periodicals and therefore dvds. enhance the flavor you should know is that often both male and your ex are responsible for having a fantastic time. eventually, in which wonderful avoid a genuinely upsetting dilemma in the future, fight off your current initial natural desire to perform at its onset.

    January 20, 2021 at 23:33 | Report abuse | Reply
  16. Aimee Chassaniol

    Hiya, I'm really glad I've found this info. Nowadays bloggers publish only about gossips and internet and this is really frustrating. A good blog with interesting content, this is what I need. Thanks for keeping this site, I'll be visiting it. Do you do newsletters? Can't find it.


    January 21, 2021 at 10:23 | Report abuse | Reply
1 2

Post a comment


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Next entry »
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.