home
RSS
Stop selling higher dose Alzheimer's drug, group says
May 18th, 2011
05:05 PM ET

Stop selling higher dose Alzheimer's drug, group says

A specific dose of Alzheimer’s drug should be pulled from the market because it poses a risk to patients, according to a consumer  group.

The drug, donepezil, sold under the brand Aricept, is administered in several doses – the highest being 23 milligrams – for patients with moderate to severe Alzheimer’s disease.

It is prescribed to improve mental function, such as memory, attention and reasoning by increasing a brain chemical. Aricept which is taken daily,  could slow the mental decline, but it does not cure or prevent Alzheimer's. 

The Public Citizen’s Health Research Group called the 23-milligram dose of Aricept “significantly more toxic” than the 10-milligram dose and said it  “should be immediately withdrawn from the market.”

The group says that the drug in higher dose compared with the 10-milligrams could pose increased adverse effects such as slowed pulse rate, nausea, vomiting, diarrhea, urinary incontinence, fatigue, dizziness and agitation.  The group also said the higher dose does not appear to give any benefits to the patients.

Three stages of Alzheimer's

Patients often stop taking the higher dose because of its strong side effects such as vomiting. And Alzheimer’s patients are particularly sensitive to vomiting because it can lead to other problems such as pneumonia, massive gastrointestinal bleeding, esophageal rupture and even death, the group said.

In response, Pfizer, which co-promotes Aricept with another company, Eisai, wrote in an emailed statement: "We are reviewing the petition and will respond accordingly; however, it is important to note that the Aricept (donepezil HCl) 23 mg tablet has been approved by the U.S. Food and Drug Administration for the treatment of moderate-to-severe Alzheimer’s disease. "

Dr. James Lah, director of the cognitive neurology program at Emory University"s Department of Neurology, regularly prescribes Aricept to patients, but doesn't prescribe the 23-milligram dose.

“Being Americans, the notion is that bigger is better, more is better... it’s simply not true in this particular instance,” Lah said.

He said he was concerned when the FDA approved the 23-milligram version.

“There is very little evidence that it’s superior,” Lah, an Alzheimer's clinician and associate professor said.  “There is a lot of evidence that it’s worse in terms of causing side effects.  If you look at the one study, only one clinical trial reported about the 23 versus 10 milligram Aricept. The results were entirely mixed in terms of effectiveness.”


soundoff (35,338 Responses)
  1. avana

    avana avanafil dosage

    May 3, 2021 at 02:16 | Report abuse | Reply
  2. rvfdYtzkZu

    telephone homework help national junior honor society essay help ontario ministry of education homework help essay on what is philosophy

    May 3, 2021 at 02:56 | Report abuse | Reply
  3. zMRaebOVLw

    help in writing essay for college college scholarship essay help core connections math homework help leading marines book report

    May 3, 2021 at 03:51 | Report abuse | Reply
  4. fPWiGvzuOy

    thesis help in chandigarh essay about critical thinking nottingham university dissertation binding service help i can't do my essay

    May 3, 2021 at 03:54 | Report abuse | Reply
  5. priligy

    dapoxetine hydrochloride 60 dapoxetine hydrochloride

    May 3, 2021 at 04:14 | Report abuse | Reply
  6. clonidine

    what is chloroquine https://chloroquineorigin.com/ how does chloroquine work

    May 3, 2021 at 04:33 | Report abuse | Reply
  7. avana

    avanafil 100 buy avanafil uk

    May 3, 2021 at 04:44 | Report abuse | Reply
  8. Tyson Sepulveda

    For every one of the people, making settlement is the
    very first thing for these types of build a web site.
    Anything worth having is never easy to acquire.
    You want people to get to internet site.

    my page – click this link

    May 3, 2021 at 04:51 | Report abuse | Reply
  9. OpLHadtUqP

    research papers secret service essay writing service birmingham my college essay writing best custom writing services

    May 3, 2021 at 04:58 | Report abuse | Reply
  10. dapoxetine

    dapoxetine pills for sale priligy 30

    May 3, 2021 at 05:35 | Report abuse | Reply
  11. chloroquine hcl

    chloroquine side effect https://chloroquineorigin.com/ is chloroquine phosphate the same as hydroxychloroquine

    May 3, 2021 at 05:44 | Report abuse | Reply
  12. EaxjdAqGPt

    homework anytime help reviews help with an essay common app essay question help college finance homework help

    May 3, 2021 at 05:50 | Report abuse | Reply
  13. dolquine

    chloroquinine https://chloroquineorigin.com/ is chloroquine available over the counter

    May 3, 2021 at 06:02 | Report abuse | Reply
  14. TzqBcPgxKv

    brain master homework help help starting a college essay resume writing service olympia wa resume writing service cleveland oh

    May 3, 2021 at 07:10 | Report abuse | Reply
  15. priligy

    buy avanafil online priligy 60 mg

    May 3, 2021 at 07:47 | Report abuse | Reply
  16. buy chloroquine online canada

    is chloroquine a sulfa drug https://chloroquineorigin.com/ chloroquine phosphate side effects

    May 3, 2021 at 08:50 | Report abuse | Reply
  17. nNSuTrIAcr

    a boy doing homework essay on great depression maths dissertation help writing a service proposal letter

    May 3, 2021 at 09:28 | Report abuse | Reply
  18. hydroxychloroquine chloroquine

    sulfur effects on body https://chloroquineorigin.com/ chloroquinolone

    May 3, 2021 at 09:28 | Report abuse | Reply
  19. XqRyLZvpNs

    my 14 year old son is not doing his homework persuasive essay to buy a product birth order essay outline holt mcdougal geometry homework help

    May 3, 2021 at 09:51 | Report abuse | Reply
  20. OxeLUNLnmo

    ib maths sl ia help a level philosophy essay help research about customer service i can't do my homework because i'm depressed

    May 3, 2021 at 10:03 | Report abuse | Reply
  21. dapoxetine

    buy priligy dapoxetine 100 mg

    May 3, 2021 at 10:10 | Report abuse | Reply
  22. what is clonidine

    chloroquine side effect https://chloroquineorigin.com/ chloroquine phosphate cvs

    May 3, 2021 at 10:14 | Report abuse | Reply
  23. QdpPLZhXNF

    coursework writing services essay to buy a house san diego library homework help business management homework help

    May 3, 2021 at 10:23 | Report abuse | Reply
  24. xjMelCxvIk

    all nighter doing homework essay revision help online susan last minute homework help homework help for students

    May 3, 2021 at 10:26 | Report abuse | Reply
  25. GnrkILFHFl

    teachers pay teachers homework packet order of paragraphs in persuasive essay essay about doing community service need help with my english homework

    May 3, 2021 at 10:28 | Report abuse | Reply
  26. GNXpUiZIVx

    dissertation binding service derby lets help others essay essay mills university course work to order proofread my essay

    May 3, 2021 at 10:32 | Report abuse | Reply
  27. aralen for sale

    clorquine https://chloroquineorigin.com/ chloroquinr

    May 3, 2021 at 10:46 | Report abuse | Reply
  28. dapoxetine

    buy priligy online buy priligy

    May 3, 2021 at 11:20 | Report abuse | Reply
  29. AnooEncox

    marevan og viagra https://llviagra.com/ viagra gdje je kupiti

    May 3, 2021 at 11:34 | Report abuse | Reply
  30. qOpzDgWtiL

    buy term papers college help me write my narrative essay how to help homework homework help for 4th grade math

    May 3, 2021 at 11:41 | Report abuse | Reply
  31. CSZaVxAILb

    doing homework is a waste of time uq essay help service marketing essay essay what can i do to help my country

    May 3, 2021 at 12:27 | Report abuse | Reply
  32. hydroxychloroquine sulfate corona

    chloroquin side effects https://chloroquineorigin.com/ chroloquine

    May 3, 2021 at 12:39 | Report abuse | Reply
  33. KNYAhNbiqP

    resume writing service ottawa help the needy essay primary homework help roman religion how we can help the environment essay

    May 3, 2021 at 12:53 | Report abuse | Reply
  34. pIXZyYUnzJ

    how we can help the environment essay school essay writing service excellent essay writing service sports research questions

    May 3, 2021 at 12:54 | Report abuse | Reply
  35. aralen where to buy

    chloroquine tablets https://chloroquineorigin.com/ cloroquina 250 mg

    May 3, 2021 at 13:23 | Report abuse | Reply
  36. awUhCBXOuC

    essay student and social service essay over the movie the help business plan help norwich thomas jefferson louisiana purchase essay

    May 3, 2021 at 13:42 | Report abuse | Reply
  37. dTPOGrMuaD

    online service company business plan essay help writing us history thematic essay help pay research paper

    May 3, 2021 at 14:07 | Report abuse | Reply
  38. aralen buy

    is chloroquine a sulfa drug https://chloroquineorigin.com/ is chloroquine an antibiotic

    May 3, 2021 at 14:16 | Report abuse | Reply
  39. chlorochin

    sulfur effects on body https://chloroquineorigin.com/ is chloroquine available over the counter

    May 3, 2021 at 14:45 | Report abuse | Reply
  40. ScyAzUzvXj

    django writing custom middleware shakespeare romeo and juliet essay help resume writing service dallas nike firm infrastructure

    May 3, 2021 at 14:52 | Report abuse | Reply
  41. TltluLzpSJ

    do my coursework hawaii essay doing thesis quotes crane service business plan

    May 3, 2021 at 15:24 | Report abuse | Reply
  42. TFKBGzfXmR

    oxbridge essay help service management essay persuasive essay for community service homework purchase

    May 3, 2021 at 15:57 | Report abuse | Reply
  43. xixyyAJvow

    help in writing essay for college essay help core connections math homework help leading marines book report

    May 3, 2021 at 16:11 | Report abuse | Reply
  44. avana

    buy avanafil buy avanafil

    May 3, 2021 at 16:16 | Report abuse | Reply
  45. avana

    avana 50 mg buy avanafil online

    May 3, 2021 at 16:34 | Report abuse | Reply
  46. dJkblARVIU

    research paper proofreading service essay can money buy everything pay someone to write a research paper homework help milwaukee

    May 3, 2021 at 17:43 | Report abuse | Reply
  47. avana

    avanafil buy avanafil 100

    May 3, 2021 at 17:50 | Report abuse | Reply
  48. avana

    avanafil dosage avanafil cost

    May 3, 2021 at 17:58 | Report abuse | Reply
  49. ivWEIXmFBd

    rhetorical and stylistic devices shakespeare romeo and juliet essay help computer engineering homework help essay topics about sports

    May 3, 2021 at 18:04 | Report abuse | Reply
  50. JsRnHSQtru

    custom writing companies critical essay help higher an essay on money can't buy happiness math word problems homework help

    May 3, 2021 at 18:11 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526 527 528 529 530 531 532 533 534 535 536 537 538 539 540 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 568 569 570 571 572 573 574 575 576 577 578 579 580 581 582 583 584 585 586 587 588 589 590 591 592 593 594 595 596 597 598 599 600 601 602 603 604 605 606 607 608 609 610 611 612 613 614 615 616 617 618 619 620 621 622 623 624 625 626 627 628 629 630 631 632 633 634 635 636 637 638 639 640 641 642 643 644 645 646 647 648 649 650 651 652 653 654 655 656 657 658 659 660 661 662 663 664 665 666 667 668 669 670 671 672 673 674 675 676 677 678 679 680 681 682 683 684 685 686 687 688 689 690 691 692 693 694 695 696 697 698 699 700 701 702 703 704 705 706 707

Leave a Reply to Davidssasw


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.