home
RSS
Stop selling higher dose Alzheimer's drug, group says
May 18th, 2011
05:05 PM ET

Stop selling higher dose Alzheimer's drug, group says

A specific dose of Alzheimer’s drug should be pulled from the market because it poses a risk to patients, according to a consumer  group.

The drug, donepezil, sold under the brand Aricept, is administered in several doses – the highest being 23 milligrams – for patients with moderate to severe Alzheimer’s disease.

It is prescribed to improve mental function, such as memory, attention and reasoning by increasing a brain chemical. Aricept which is taken daily,  could slow the mental decline, but it does not cure or prevent Alzheimer's. 

The Public Citizen’s Health Research Group called the 23-milligram dose of Aricept “significantly more toxic” than the 10-milligram dose and said it  “should be immediately withdrawn from the market.”

The group says that the drug in higher dose compared with the 10-milligrams could pose increased adverse effects such as slowed pulse rate, nausea, vomiting, diarrhea, urinary incontinence, fatigue, dizziness and agitation.  The group also said the higher dose does not appear to give any benefits to the patients.

Three stages of Alzheimer's

Patients often stop taking the higher dose because of its strong side effects such as vomiting. And Alzheimer’s patients are particularly sensitive to vomiting because it can lead to other problems such as pneumonia, massive gastrointestinal bleeding, esophageal rupture and even death, the group said.

In response, Pfizer, which co-promotes Aricept with another company, Eisai, wrote in an emailed statement: "We are reviewing the petition and will respond accordingly; however, it is important to note that the Aricept (donepezil HCl) 23 mg tablet has been approved by the U.S. Food and Drug Administration for the treatment of moderate-to-severe Alzheimer’s disease. "

Dr. James Lah, director of the cognitive neurology program at Emory University"s Department of Neurology, regularly prescribes Aricept to patients, but doesn't prescribe the 23-milligram dose.

“Being Americans, the notion is that bigger is better, more is better... it’s simply not true in this particular instance,” Lah said.

He said he was concerned when the FDA approved the 23-milligram version.

“There is very little evidence that it’s superior,” Lah, an Alzheimer's clinician and associate professor said.  “There is a lot of evidence that it’s worse in terms of causing side effects.  If you look at the one study, only one clinical trial reported about the 23 versus 10 milligram Aricept. The results were entirely mixed in terms of effectiveness.”


soundoff (35,304 Responses)
  1. kgOLOLykqt

    photocopy service business plan community service hours essay homework help anatomy and physiology time series homework help

    April 29, 2021 at 19:15 | Report abuse | Reply
  2. priligy

    dapoxetine tablet price in india priligy uk

    April 29, 2021 at 19:21 | Report abuse | Reply
  3. viagra canada pharmarcy

    viagra canada for sale https://canadaviagrastore.com/ viagra purchase from canada

    April 29, 2021 at 19:57 | Report abuse | Reply
  4. VZZEmfXSnO

    thesis statement for merit pay writing an essay online free narrative essays online writing custom functions in crystal reports

    April 29, 2021 at 20:02 | Report abuse | Reply
  5. chloroquine generic

    chloroquin side effects https://chloroquineorigin.com/ chloroquine without prescription

    April 29, 2021 at 20:06 | Report abuse | Reply
  6. buy viagra from canada?

    is it illegal to by viagra from canada https://canadaviagrastore.com/ viagra/canada

    April 29, 2021 at 20:12 | Report abuse | Reply
  7. YapSMwvtRM

    top essay writing service best essay help discount code i need someone to write my paper hook for community service essay

    April 29, 2021 at 20:31 | Report abuse | Reply
  8. priligy

    buy avanafil online buy priligy usa

    April 29, 2021 at 20:57 | Report abuse | Reply
  9. erectile dysfunction medications

    cialis without erectile dysfunction https://canadaerectiledysfunctionpills.com/ erectile therapy jordan

    April 29, 2021 at 21:12 | Report abuse | Reply
  10. chlorochin

    is chloroquine phosphate over the counter https://chloroquineorigin.com/ is chloroquine over the counter

    April 29, 2021 at 21:20 | Report abuse | Reply
  11. vLpJRhAPAC

    research paper service quality nursing essay writing service australia target market for coffee primary homework help erosion

    April 29, 2021 at 21:20 | Report abuse | Reply
  12. canadian weight loss pills

    canadian pharmacies ed pills https://canadapillstorex.com/ canadian pills online

    April 29, 2021 at 21:23 | Report abuse | Reply
  13. clonidin

    chloroquine malaria https://chloroquineorigin.com/ chloroquine without prescription

    April 29, 2021 at 21:36 | Report abuse | Reply
  14. yimJMXgIwI

    proquest thesis purchase land law essay help does homework hurt or help students addison public library homework help

    April 29, 2021 at 21:50 | Report abuse | Reply
  15. erectile dysfunction pills

    erectile dysfunction when viagra doesn t work https://canadaerectiledysfunctionpills.com/ erectile curvature

    April 29, 2021 at 21:56 | Report abuse | Reply
  16. dapoxetine

    priligy online buy avanafil canada

    April 29, 2021 at 22:01 | Report abuse | Reply
  17. yKCRtfFzDD

    best buy research paper write my essay for me cheap carleton university essay help business plan for self service car wash

    April 29, 2021 at 22:19 | Report abuse | Reply
  18. canadian generic pills

    canadian weight loss pills https://canadapillstorex.com/ canadian generic pills

    April 29, 2021 at 22:27 | Report abuse | Reply
  19. zGPmCXxJXW

    math homework help forum topic generator for essay thesis service dominant logic homework help myths and legends

    April 29, 2021 at 22:33 | Report abuse | Reply
  20. canadian diet pills

    best canadian mail order pharmacies for diet pills https://canadapillstorex.com/ canadian generic pills

    April 29, 2021 at 22:36 | Report abuse | Reply
  21. avanafil

    buy avana online buy avana online

    April 30, 2021 at 00:07 | Report abuse | Reply
  22. criticz

    I have read so mny content regarding the blogger lovers howevcer this paragraph is in fact a good post, keep it up.

    April 30, 2021 at 00:08 | Report abuse | Reply
  23. CTxWSouFTQ

    essay on deteriorating law and order situation in the city essay of internet business plan help los angeles writing a gesture service with the kinect for windows sdk

    April 30, 2021 at 00:12 | Report abuse | Reply
  24. can you buy viagra over the counter in canada?

    viagra canada for sale https://canadaviagrastore.com/ viagra canada

    April 30, 2021 at 00:18 | Report abuse | Reply
  25. HOkQlEGGod

    buy and braai business plan order of essay primary homework help types of mountains professional essay writers

    April 30, 2021 at 00:33 | Report abuse | Reply
  26. jDEVxyTFyt

    i need to do my homework in french purchase an essay writing custom control wpf homework help for pre algebra

    April 30, 2021 at 00:38 | Report abuse | Reply
  27. chloroquine online

    chloroquine side effect https://chloroquineorigin.com/ side effects of chloroquine

    April 30, 2021 at 00:38 | Report abuse | Reply
  28. top erection pills

    erectile breast tissue https://canadaerectiledysfunctionpills.com/ top erectile pills

    April 30, 2021 at 00:39 | Report abuse | Reply
  29. gPcxaeEFNm

    tumblr homework help uk essay writing service review pay for essay reviews gummy bears grow in water

    April 30, 2021 at 00:50 | Report abuse | Reply
  30. anal sex

    I visited various blogs except the audio quality for audio songs existing at
    this web site is really fabulous.

    April 30, 2021 at 01:09 | Report abuse | Reply
  31. canadian pharmacy generic cialis

    cialis canadian discounts https://canadacialisstore.com/ buy cialis online canadian

    April 30, 2021 at 01:59 | Report abuse | Reply
  32. ufZXKcZufW

    new world order research paper essay writing service kijiji thesis on performance related pay explanation of proverb god helps those who help themselves

    April 30, 2021 at 02:05 | Report abuse | Reply
  33. nWKPsClXCa

    york university essay writing help spongebob essay the homework help paid functions homework help

    April 30, 2021 at 02:08 | Report abuse | Reply
  34. kFSeMQrMyF

    resume writing service omaha hire purchase system essay order numbers printable biology homework help and answers

    April 30, 2021 at 02:16 | Report abuse | Reply
  35. dapoxetine

    dapoxetine usa priligy 30 mg

    April 30, 2021 at 02:26 | Report abuse | Reply
  36. MHEHlSdeVM

    service writer jobs near me write an essay about air pollution using cause and effect order research papers on fdi in service sector writing thesis help

    April 30, 2021 at 02:28 | Report abuse | Reply
  37. buy chloroquine phosphate tablets

    chlorodine https://chloroquineorigin.com/ aralen for lupus

    April 30, 2021 at 02:33 | Report abuse | Reply
  38. do you need prescription for canadian perscribition of cialis in usa

    how safe and reliable are canadian cialis https://canadacialisstore.com/ canadian meds cialis

    April 30, 2021 at 02:35 | Report abuse | Reply
  39. dapoxetine

    dapoxetine dapoxetine tablet price in india

    April 30, 2021 at 02:42 | Report abuse | Reply
  40. EvxtASWnQE

    me doing my homework autobiography essay help remind me to do my homework at 5 o'clock best site to buy research paper

    April 30, 2021 at 02:53 | Report abuse | Reply
  41. cloroquina

    is chloroquine phosphate over the counter https://chloroquineorigin.com/ chloroquinr

    April 30, 2021 at 02:54 | Report abuse | Reply
  42. canadian pills online

    average perscription pills taken by 65 year old canadian? https://canadapillstorex.com/ canadian pills pharmacy

    April 30, 2021 at 03:09 | Report abuse | Reply
  43. how safe and reliable are canadian cialis

    counterfeit canadian drugs cialis https://canadacialisstore.com/ canadian pharmacy cialis no prescription

    April 30, 2021 at 03:28 | Report abuse | Reply
  44. priligy

    priligy pills for sale priligy

    April 30, 2021 at 03:28 | Report abuse | Reply
  45. viagra sin recetas en farmacias de canada

    buying viagra in canada https://canadaviagrastore.com/ viagra sin receta en farmacias de canada

    April 30, 2021 at 03:29 | Report abuse | Reply
  46. canadian pharmacies ed pills

    best canadian mail order pharmacies for diet pills https://canadapillstorex.com/ canadian weight loss pills

    April 30, 2021 at 03:41 | Report abuse | Reply
  47. cialis on line purches canadian pharmacy

    buying canadian cialis https://canadacialisstore.com/ buy cialis online canadian

    April 30, 2021 at 03:44 | Report abuse | Reply
  48. avanafil

    avana avana

    April 30, 2021 at 04:12 | Report abuse | Reply
  49. canadian diet pills

    canadian weight loss pills https://canadapillstorex.com/ canadian generic pills

    April 30, 2021 at 04:25 | Report abuse | Reply
  50. hMyjVSmyXl

    resume writing service olympia wa help starting college essay order fractions homework cv writing service nuneaton

    April 30, 2021 at 05:13 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526 527 528 529 530 531 532 533 534 535 536 537 538 539 540 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 568 569 570 571 572 573 574 575 576 577 578 579 580 581 582 583 584 585 586 587 588 589 590 591 592 593 594 595 596 597 598 599 600 601 602 603 604 605 606 607 608 609 610 611 612 613 614 615 616 617 618 619 620 621 622 623 624 625 626 627 628 629 630 631 632 633 634 635 636 637 638 639 640 641 642 643 644 645 646 647 648 649 650 651 652 653 654 655 656 657 658 659 660 661 662 663 664 665 666 667 668 669 670 671 672 673 674 675 676 677 678 679 680 681 682 683 684 685 686 687 688 689 690 691 692 693 694 695 696 697 698 699 700 701 702 703 704 705 706

Leave a Reply to Davidssasw


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.