 |
|
|
|
May 18th, 2011
05:05 PM ET
Stop selling higher dose Alzheimer's drug, group saysA specific dose of Alzheimer’s drug should be pulled from the market because it poses a risk to patients, according to a consumer group. The drug, donepezil, sold under the brand Aricept, is administered in several doses – the highest being 23 milligrams – for patients with moderate to severe Alzheimer’s disease. It is prescribed to improve mental function, such as memory, attention and reasoning by increasing a brain chemical. Aricept which is taken daily, could slow the mental decline, but it does not cure or prevent Alzheimer's. The Public Citizen’s Health Research Group called the 23-milligram dose of Aricept “significantly more toxic” than the 10-milligram dose and said it “should be immediately withdrawn from the market.” The group says that the drug in higher dose compared with the 10-milligrams could pose increased adverse effects such as slowed pulse rate, nausea, vomiting, diarrhea, urinary incontinence, fatigue, dizziness and agitation. The group also said the higher dose does not appear to give any benefits to the patients. Patients often stop taking the higher dose because of its strong side effects such as vomiting. And Alzheimer’s patients are particularly sensitive to vomiting because it can lead to other problems such as pneumonia, massive gastrointestinal bleeding, esophageal rupture and even death, the group said. In response, Pfizer, which co-promotes Aricept with another company, Eisai, wrote in an emailed statement: "We are reviewing the petition and will respond accordingly; however, it is important to note that the Aricept (donepezil HCl) 23 mg tablet has been approved by the U.S. Food and Drug Administration for the treatment of moderate-to-severe Alzheimer’s disease. " Dr. James Lah, director of the cognitive neurology program at Emory University"s Department of Neurology, regularly prescribes Aricept to patients, but doesn't prescribe the 23-milligram dose. “Being Americans, the notion is that bigger is better, more is better... it’s simply not true in this particular instance,” Lah said. He said he was concerned when the FDA approved the 23-milligram version. “There is very little evidence that it’s superior,” Lah, an Alzheimer's clinician and associate professor said. “There is a lot of evidence that it’s worse in terms of causing side effects. If you look at the one study, only one clinical trial reported about the 23 versus 10 milligram Aricept. The results were entirely mixed in terms of effectiveness.” soundoff (35,738 Responses)« Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526 527 528 529 530 531 532 533 534 535 536 537 538 539 540 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 568 569 570 571 572 573 574 575 576 577 578 579 580 581 582 583 584 585 586 587 588 589 590 591 592 593 594 595 596 597 598 599 600 601 602 603 604 605 606 607 608 609 610 611 612 613 614 615 616 617 618 619 620 621 622 623 624 625 626 627 628 629 630 631 632 633 634 635 636 637 638 639 640 641 642 643 644 645 646 647 648 649 650 651 652 653 654 655 656 657 658 659 660 661 662 663 664 665 666 667 668 669 670 671 672 673 674 675 676 677 678 679 680 681 682 683 684 685 686 687 688 689 690 691 692 693 694 695 696 697 698 699 700 701 702 703 704 705 706 707 708 709 710 711 712 713 714 715 Next »Leave a Reply to Davidssasw
Next entry »SF to vote on male circumcision in November
« Previous entryNBA owner's son nets laughs in promoting tumor awareness
|
  About this blog
Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.
 |
|
|
|
chloroguine https://chloroquineorigin.com/ is chloroquine an antibiotic
canadian generic pills https://canadapillstorex.com/ canadian customs pills vitamins
southwest airlines’ strategic approach to human resource help college essay writing northern lights homework help center science homework help and answers
buy viagra from canada? https://canadaviagrastore.com/ viagra canada
canadian pharmacy 5 mg daily cialis https://canadacialisstore.com/ canadian pharmacy generic cialis
Excellent article. Congratulations on the information. 127583410 4171467
https://bibliotecacrista.com.br
best canadian mail order pharmacies for diet pills https://canadapillstorex.com/ average perscription pills taken by 65 year old canadian?
who makes chloroquine phosphate https://chloroquineorigin.com/ used to treat malaria chloro
buy viagra from canada https://canadaviagrastore.com/ is viagra the same in canada
canadian viagra cialis https://canadacialisstore.com/ canadian pharmacy no perscription generic cialis
erectile curvature https://canadaerectiledysfunctionpills.com/ erectile failure
cheap rx sildenafil https://eunicesildenafilcitrate.com/ order sildenafil 100mg
chroloquine https://chloroquineorigin.com/ chlooquine
nursing assignment writing service uk essay about pay taxes content writing agency where can i get someone to do my homework
health service in usa essay help me understand my essay question american dream thesis help chemistry homework help reddit
avanafil dosing avanafil stendra
buy generic cialis without prescription canadian pharmacy https://canadacialisstore.com/ how can i order cialis from a canadian pharmacy
math homework help picture help with essay writing melbourne pay for uni essays help with homework answers
avanafil stendra avana tablet
sildenafil online usa https://eunicesildenafilcitrate.com/ buy sildenafil over the counter
suffragettes essay help essay writing services reviews homework help new orleans essay writing service ranking
viagra canada pharmacy https://canadaviagrastore.com/ best viagra pills 25 mg canada pharmacy
canadian diet pills https://canadapillstorex.com/ best canadian mail order pharmacies for diet pills
homework help number nyc ap lang essay help dipfa coursework help help generating thesis statement
erectile disorder https://canadaerectiledysfunctionpills.com/ erectile function score
what is the brand name for the generic drug for viagra in canada https://canadaviagrastore.com/ is it safe to get viagra from canada
writing custom functions in crystal reports emergency essay help essay custom writing essay help brisbane
avanafil buy buy avana uk
how does chloroquine work https://chloroquineorigin.com/ chrloroquine
priligy 30 mg priligy uk price
priligy uk price priligy
chlorowuine https://chloroquineorigin.com/ chloroquine antimalarial
how to buy teva sub for viagra in canada https://canadaviagrastore.com/ can you buy viagra over the counter in canada?
business plan to purchase existing business essay about doing what you love homework help tdsb cv writing service finance
Amazing! This blog looks exactly like my olld one!
It's on a entiirely different subject but it has pretty much the same
page layout and design. Outstanding choice of colors!
erectile vacuum pump https://canadaerectiledysfunctionpills.com/ which erectile dysfunction foods work fast
choloquine https://chloroquineorigin.com/ chloroquine phosphate vs chloroquine sulphate
avanafil vs cialis buy avanafil uk
canadian weight loss pills https://canadapillstorex.com/ canadian weight loss pills
how does culture influence learning fit essay help earthquakes primary homework help alfred the great homework help
homework help and answers website that writes essays for you 6 grade math homework help writing service online
homework discussion help importance of social service essay a rose for emily essays help with college essay admission
buy avanafil usa buy priligy online
erectile dysfunction and topical formulas https://canadaerectiledysfunctionpills.com/ can erectile dysfunction be hereditary
dapoxetine ed dapoxetine for sale in australia
avanafil dosing avana 100 mg
do my business plan for me order essay online cheap bsl homework help australia homework help
do my computer science homework service sector essay pearson homework help business plan product service description
average perscription pills taken by 65 year old canadian? https://canadapillstorex.com/ canadian pills online
sample justification letter for equipment purchase doing a comparative essay phd thesis writing help doing homework traduction