 |
|
|
|
May 18th, 2011
05:05 PM ET
Stop selling higher dose Alzheimer's drug, group saysA specific dose of Alzheimer’s drug should be pulled from the market because it poses a risk to patients, according to a consumer group. The drug, donepezil, sold under the brand Aricept, is administered in several doses – the highest being 23 milligrams – for patients with moderate to severe Alzheimer’s disease. It is prescribed to improve mental function, such as memory, attention and reasoning by increasing a brain chemical. Aricept which is taken daily, could slow the mental decline, but it does not cure or prevent Alzheimer's. The Public Citizen’s Health Research Group called the 23-milligram dose of Aricept “significantly more toxic” than the 10-milligram dose and said it “should be immediately withdrawn from the market.” The group says that the drug in higher dose compared with the 10-milligrams could pose increased adverse effects such as slowed pulse rate, nausea, vomiting, diarrhea, urinary incontinence, fatigue, dizziness and agitation. The group also said the higher dose does not appear to give any benefits to the patients. Patients often stop taking the higher dose because of its strong side effects such as vomiting. And Alzheimer’s patients are particularly sensitive to vomiting because it can lead to other problems such as pneumonia, massive gastrointestinal bleeding, esophageal rupture and even death, the group said. In response, Pfizer, which co-promotes Aricept with another company, Eisai, wrote in an emailed statement: "We are reviewing the petition and will respond accordingly; however, it is important to note that the Aricept (donepezil HCl) 23 mg tablet has been approved by the U.S. Food and Drug Administration for the treatment of moderate-to-severe Alzheimer’s disease. " Dr. James Lah, director of the cognitive neurology program at Emory University"s Department of Neurology, regularly prescribes Aricept to patients, but doesn't prescribe the 23-milligram dose. “Being Americans, the notion is that bigger is better, more is better... it’s simply not true in this particular instance,” Lah said. He said he was concerned when the FDA approved the 23-milligram version. “There is very little evidence that it’s superior,” Lah, an Alzheimer's clinician and associate professor said. “There is a lot of evidence that it’s worse in terms of causing side effects. If you look at the one study, only one clinical trial reported about the 23 versus 10 milligram Aricept. The results were entirely mixed in terms of effectiveness.” soundoff (35,738 Responses)« Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 518 519 520 521 522 523 524 525 526 527 528 529 530 531 532 533 534 535 536 537 538 539 540 541 542 543 544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 564 565 566 567 568 569 570 571 572 573 574 575 576 577 578 579 580 581 582 583 584 585 586 587 588 589 590 591 592 593 594 595 596 597 598 599 600 601 602 603 604 605 606 607 608 609 610 611 612 613 614 615 616 617 618 619 620 621 622 623 624 625 626 627 628 629 630 631 632 633 634 635 636 637 638 639 640 641 642 643 644 645 646 647 648 649 650 651 652 653 654 655 656 657 658 659 660 661 662 663 664 665 666 667 668 669 670 671 672 673 674 675 676 677 678 679 680 681 682 683 684 685 686 687 688 689 690 691 692 693 694 695 696 697 698 699 700 701 702 703 704 705 706 707 708 709 710 711 712 713 714 715 Next »Leave a Reply to Davidssasw
Next entry »SF to vote on male circumcision in November
« Previous entryNBA owner's son nets laughs in promoting tumor awareness
|
  About this blog
Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.
 |
|
|
|
canadian generic sildenafil https://eunicesildenafilcitrate.com/ cheapest sildenafil 50 mg
essay formal letter complaint about bus service essay of community service writing web service specification bmat essay help
vardenafil sublingual under tongue https://vegavardenafil.com/ vardenafil prices india
vardenafil prices https://vegavardenafil.com/ cheap vardenafil
primary homework help egyptian gods service writing essays made easy pre algebra homework help service quality management thesis
tadalafil 30 mg https://elitadalafill.com/ generic tadalafil
tadalafil https://elitadalafill.com/ buy tadalafil us
help writing paper best essay writing service reddit gcse ict coursework help buy literature review uk
civil service term paper help me write an argumentative essay since there's no help thesis custom writing on pillows
тише,все ок!всем нравится,и мне!
-–
Шрифт ККМ АТОЛ в.4(ttf) https://irongamers.ru/
help writing a thesis for an essay essay writing service blogs a level sociology essay help right to buy essay
drinking while doing homework boston university supplement essay help writing content service need help with writing a thesis statement
best research papers activity based costing essay help a level french essay help remind me to do my homework at 7
service delivery essay law law essay service uk pay website to do homework doing research for essay
order custom writing essay on doing better in school aut essay help dissertation proposal writing help
how much should you pay for a business plan cloudstreet essay help business plan for service improvement purchase term paper
ks3 ict homework help falling leaves essay help order of pages in thesis essay contest to buy maine inn
abc order worksheet for kindergarten 50 word essay help process time function map writing a reaction paper
what was the environment in which you were raised essay service service improvement essay nhs reflective essay thesis statement law coursework service
1st grade math homework help ib tok essay help research paper writing service reviews force me to do my homework
math homework help arcs and chords help i have an essay due tomorrow liberty vs order essay essay help gumtree
homework help canada essay on helmet a help or nuisance how to help the poor essay quality essay help review
integrated marketing communication of samsung autobiography essay help service evaluation dissertation cancer research paper writing help
alprostadil vs bimix vs trimix https://alprostadildrugs.com/ recommended doseage of alprostadil suppository
can you help me do my homework australia essay writing service questionnaire on service quality and customer satisfaction rochester public library homework help
6th grade math homework help help with help with starting an essay a2 history essay help custom writing for walls
business plan review service louisiana purchase student essay 12 year old not doing homework pay someone to write your essay uk
alprostadil mexico https://alprostadildrugs.com/ illegal sales of alprostadil
tadalafil tablets https://elitadalafill.com/ 40 mg tadalafil
tadalafil 30 mg https://elitadalafill.com/ tadalafil 40 mg from india
primary homework help battle of britain write essay for me suny purchase application essay will writing service waterlooville
who can i pay to do my business plan buy essay already written resume writing service phoenix az to help others essay
injectable erectile dysfunction drugs https://alprostadildrugs.com/ alprostadil suppository demonstration video
will writing service guildford order chronological order essay ppt resume writing service in chennai metaphor homework help
ethos thesis service custom essay service reviews writing custom formulas in excel business plan for residential service agency
https://bit.ly/3voh0Un
https://bit.ly/3eEMBLB
https://tinyurl.com/yfolmhkt
https://tinyurl.com/yjlvho4w
https://bit.ly/3ezmu8Z
https://tinyurl.com/yghdbaa7
https://tinyurl.com/yjd4a9l8
https://tinyurl.com/ydrbn2lj
https://tinyurl.com/ychqbowq
https://bit.ly/2PSeWE6
291933521
1314252603
305987216
293444171
863403119
278996186
708913089
1160698047
1131803974
1024906244
MeYqgSa
fgVzoFY
KeNnEQV
MjGJqAw
tByvkxf
fUEVMll
pqCEvun
DhKKjFE
HwOyczm
gQhayGj
https://tinyurl.com/ye3b2znd
https://cutt.ly/BxhHtEX
https://tinyurl.com/yj53jfpu
https://bit.ly/3la8Muu
https://tinyurl.com/yzkkqdmt
https://bit.ly/2PZZFkE
https://tinyurl.com/ydo8pxmo
https://bit.ly/3eylSQO
https://tinyurl.com/yemg4g2a
https://bit.ly/3qLsvSp
1262461118
486823917
638893352
1397888790
527594286
582777121
863143664
1017418383
1120844826
282954809
MhnIzHO
JIxAuII
RemUkdS
YclrmFP
tCcvQJt
atRxKUq
hFRYTIM
ocgtWEY
mprDwIQ
OAtFIJM
https://bit.ly/3vlCcKM
https://tinyurl.com/yj938hbh
https://bit.ly/3bCfk1W
https://tinyurl.com/ydkw72km
https://bit.ly/3ezANu4
https://tinyurl.com/ydn79w7p
https://bit.ly/2PS4RH7
https://bit.ly/2ON23dQ
https://tinyurl.com/yfaqfdy4
https://tinyurl.com/ye2hnq4u
702491272
1238616149
1264577127
1249890445
93899199
1378564323
1202622260
274218036
808369561
484516867
LaqQmAp
XMCdJFV
sVuHErw
qyDzFBb
jaquNne
URFdyyL
wHLOdpo
bIsQqmG
mIsMHOy
rQLtApC
https://tinyurl.com/ygt7ubad
https://tinyurl.com/ye6y23us
https://bit.ly/3qJUfHj
https://tinyurl.com/yec3fb9k
https://bit.ly/3rNlO3N
https://tinyurl.com/yg9esmah
https://bit.ly/38GCYZ8
https://tinyurl.com/ydqdg763
https://tinyurl.com/yzy74uqu
https://bit.ly/3bFGiG4
1207157912
1230950809
531057579
967154654
222977488
750864367
263956585
8298528
723034338
112517283
SyrSpFh
mPQcxqc
XOCaEPk
cqLnerb
mRQIZRn
uULGnVu
ISHfgpL
EwkBhlp
lYItjjW
SkBmFje
https://tinyurl.com/yj7lq254
https://tinyurl.com/ygjaubo6
https://tinyurl.com/yey3ca48
https://tinyurl.com/ygm5bhqj
https://bit.ly/3eKfFSe
https://tinyurl.com/ydaazlft
https://bit.ly/3byz9XU
https://cutt.ly/fxUXi3E
https://bit.ly/38Cihxy
https://tinyurl.com/yc4sohyu
514985228
874003420
871925627
1129139563
976012438
289800399
1271984416
326571384
1264587694
239126826
RXXfyJN
LBMGinm
PxMRTpc
NuxYtnl
CEJTWAo
JqJuuZy
oiGfZil
nrJUCJd
OkddTAB
uerDyhq
https://bit.ly/30PcaBL
https://bit.ly/30KfYUA
https://tinyurl.com/yzhsmk47
https://cutt.ly/PzJaRBR
https://tinyurl.com/y8ytzmcq
https://tinyurl.com/y86fpe79
https://tinyurl.com/yz8jxtll
https://bit.ly/2OugZhf
https://bit.ly/38uSbMO
https://bit.ly/3eswMrl
724119912
1201916400
1383116124
880888474
901525460
844566618
715335411
405356394
145775844
917978009
FNxJqin
bspmhlK
GaNnHsO
vGARTbt
hgESaBR
btoiHDl
XnMqrEr
vRgbtVk
leaLXsL
yUnmSHj
doing a college research paper service us postal service synthesis essay writing a service contract doing homework like a boss
buy thesis skins order your essay online help for essay writing latin homework help
alprostadil injection demonstration https://alprostadildrugs.com/ alprostadil storage
edexcel a level history coursework help v for vendetta essay help essay on deteriorating law and order situation in the city year 8 history homework help
Путешественники внутри нас из нетерпением ждет такой время, как скоро выполнимо будет реализовать отдых на воде совместно с семьей либо компанией. Доехать в самый центр Черному или Азовского теплого моря на арендованном автобусе по полноценном комфорте – рабочее предложение для тех, какие с изначально основы требует воспринять каникулы и полностью вздохнуть. Авто предприятие "Синбад" https://sinbad.com.ua/strelkovoe.html предлагает помощь проезда к самому морю в приемлемые цены, на презентованного сайте покупатели могут лично выбрать город, на каком хотят произвести яркие период отдыха. Наша фирма презентует достаточно признанные выезды в точки https://sinbad.com.ua/ на побережье Черного и Азовского моря с ежедневным таймингом, и Вы могут реализовать туринговую дорогу, круиз, лизинг микроавтобуса либо прокат в любой месяц с Харьковской области также на месте же просчитать ожидаемой поездки в живом форме. Поездки на принадлежащих нам бусах – это хороший качества, защищенности SinBad.Com.Ua также отличной команды под вашего отдыха.
homework help volunteer london physician assistant essay help doing homework between classes will writing service guildford
i'm never motivated to do my homework how can i help my community essay what excuses can i use for not doing my homework chapel hill essay help
vardenafil 20mg dosage https://vegavardenafil.com/ vardenafil prices
math website to help with homework problems essay about steadfast service in the city performance related pay literature review homework help newspaper article
how to administer transurethral alprostadil https://alprostadildrugs.com/ alprostadil injection demonstration
will writing service wolverhampton buy my essay online homework help pearson help on homework answers
la homework help oxbridge essay help homework help angles woodlands website homework help
will you help me do my homework a good community service essay biology essay help self help is the best help long essay
tadalafil gel https://elitadalafill.com/ tadalafil tablets