Stop selling higher dose Alzheimer's drug, group says

A specific dose of Alzheimer’s drug should be pulled from the market because it poses a risk to patients, according to a consumer group.

The drug, donepezil, sold under the brand Aricept, is administered in several doses – the highest being 23 milligrams – for patients with moderate to severe Alzheimer’s disease.

It is prescribed to improve mental function, such as memory, attention and reasoning by increasing a brain chemical. Aricept which is taken daily, could slow the mental decline, but it does not cure or prevent Alzheimer's.

The Public Citizen’s Health Research Group called the 23-milligram dose of Aricept “significantly more toxic” than the 10-milligram dose and said it “should be immediately withdrawn from the market.”

The group says that the drug in higher dose compared with the 10-milligrams could pose increased adverse effects such as slowed pulse rate, nausea, vomiting, diarrhea, urinary incontinence, fatigue, dizziness and agitation. The group also said the higher dose does not appear to give any benefits to the patients.

Three stages of Alzheimer's

Patients often stop taking the higher dose because of its strong side effects such as vomiting. And Alzheimer’s patients are particularly sensitive to vomiting because it can lead to other problems such as pneumonia, massive gastrointestinal bleeding, esophageal rupture and even death, the group said.

In response, Pfizer, which co-promotes Aricept with another company, Eisai, wrote in an emailed statement: "We are reviewing the petition and will respond accordingly; however, it is important to note that the Aricept (donepezil HCl) 23 mg tablet has been approved by the U.S. Food and Drug Administration for the treatment of moderate-to-severe Alzheimer’s disease. "

Dr. James Lah, director of the cognitive neurology program at Emory University"s Department of Neurology, regularly prescribes Aricept to patients, but doesn't prescribe the 23-milligram dose.

“Being Americans, the notion is that bigger is better, more is better... it’s simply not true in this particular instance,” Lah said.

He said he was concerned when the FDA approved the 23-milligram version.

“There is very little evidence that it’s superior,” Lah, an Alzheimer's clinician and associate professor said. “There is a lot of evidence that it’s worse in terms of causing side effects. If you look at the one study, only one clinical trial reported about the 23 versus 10 milligram Aricept. The results were entirely mixed in terms of effectiveness.”

Post by: Madison Park - CNNhealth.com Writer/Producer
Filed under: Alzheimer's

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January 22, 2021 at 05:46 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 05:55 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 05:58 | Report abuse | Reply
Davidssasw

and the other has been suspended, Hacienda HealthCare said Sunday, the Associated Press reported. The patient, who is in her 20s, gave birth Dec. 29. She had been
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at the facility since suffering a near-drowning at age The case sparked an investigation by police, who have collected DNA from men who worked there, and reviews by regulators. Hacienda CEO Bill Timmons resigned after the case became public, the AP reported. sanctions of intersection a money operates at are account It unclear an are Seychelles
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January 22, 2021 at 06:02 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 06:05 | Report abuse | Reply
Davidssasw

and that FDA efforts to get companies to voluntarily eliminate candy-flavored products and aggressive marketing have had little effect, NBC News reported. I'll tell you this. If the youth use continues to rise, and we see significant increases in use in 2019, on top of the dramatic rise in 2018, the entire category will
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face an existential threat," he said Friday. It will be game over for these products until they can successfully traverse the regulatory process," Gottlieb warned. The FDA has the authority to block e-cigarette sales and force makers to go through the formal FDA approval process, but has not done so to this point. There has been a 78 percent increase in e-cigarette use by
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January 22, 2021 at 06:09 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 06:12 | Report abuse | Reply
Davidssasw

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Davidssasw

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January 22, 2021 at 06:27 | Report abuse | Reply
Davidssasw

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Davidssasw

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January 22, 2021 at 06:34 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 06:38 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 06:41 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 06:45 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 06:48 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 06:52 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 06:55 | Report abuse | Reply
Davidssasw

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fun with my partner again have a fully hard and lasting erection. Can sometimes delay climax but not to the point of becoming a problem. Have had minor headaches and flushing but nothing major I can find it difficult to organism as I mentioned above but again its just being patient. My relationship is fantastic now and I feel like a proper man again. As I didn't before. Don't want to have to use this forever though but will continue to use this
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January 22, 2021 at 06:59 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 07:02 | Report abuse | Reply
Davidssasw

feeling of ejaculation but the long lasting erection makes up for the issue It is an wonderful drug but getting the dosage right is critical. I can still get an erection without help but it
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January 22, 2021 at 07:06 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 07:10 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 07:13 | Report abuse | Reply
Davidssasw

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Davidssasw

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January 22, 2021 at 07:20 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 07:24 | Report abuse | Reply
Davidssasw

can get away with Works pretty well. I have tried Levitra and the quick tab version also with not much positive results. Nonetheless I
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was given a prescription by my doc for this and for me 100 mg is the right dose. I can achieve erection but have at times a problem keeping it so this medicine will allow me to complete the act and enjoy it for a few too without orgasming too quick. It's a wonderful medicine that I can get generically (legitimately)
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and save some money also so shop around. I have minimal side effects at first. What I mean is 4-5 hours after take it I notice a somewhat rapid heartbeat and some head flushing also but its well worth it as once again for me at least for some reason the side effects hit me later on then most people it seems After getting hit-and-miss
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January 22, 2021 at 07:28 | Report abuse | Reply
Davidssasw

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Davidssasw

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Davidssasw

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Davidssasw

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January 22, 2021 at 07:50 | Report abuse | Reply
Davidssasw

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Davidssasw

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A Chinese scientist who said he edited the genes of twins to protect them against HIV acted on his own and could face punishment, according to investigators in the southern province of Guangdong. They said Dr. He Jiankui coordinated funding for the experiment without outside assistance in violation of national guidelines, state news agency Xinhua said, the Associated Press reported. He also edited the genes of another embryo yet to be born. That
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Davidssasw

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Stop selling higher dose Alzheimer's drug, group says

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