Stop selling higher dose Alzheimer's drug, group says

A specific dose of Alzheimer’s drug should be pulled from the market because it poses a risk to patients, according to a consumer group.

The drug, donepezil, sold under the brand Aricept, is administered in several doses – the highest being 23 milligrams – for patients with moderate to severe Alzheimer’s disease.

It is prescribed to improve mental function, such as memory, attention and reasoning by increasing a brain chemical. Aricept which is taken daily, could slow the mental decline, but it does not cure or prevent Alzheimer's.

The Public Citizen’s Health Research Group called the 23-milligram dose of Aricept “significantly more toxic” than the 10-milligram dose and said it “should be immediately withdrawn from the market.”

The group says that the drug in higher dose compared with the 10-milligrams could pose increased adverse effects such as slowed pulse rate, nausea, vomiting, diarrhea, urinary incontinence, fatigue, dizziness and agitation. The group also said the higher dose does not appear to give any benefits to the patients.

Three stages of Alzheimer's

Patients often stop taking the higher dose because of its strong side effects such as vomiting. And Alzheimer’s patients are particularly sensitive to vomiting because it can lead to other problems such as pneumonia, massive gastrointestinal bleeding, esophageal rupture and even death, the group said.

In response, Pfizer, which co-promotes Aricept with another company, Eisai, wrote in an emailed statement: "We are reviewing the petition and will respond accordingly; however, it is important to note that the Aricept (donepezil HCl) 23 mg tablet has been approved by the U.S. Food and Drug Administration for the treatment of moderate-to-severe Alzheimer’s disease. "

Dr. James Lah, director of the cognitive neurology program at Emory University"s Department of Neurology, regularly prescribes Aricept to patients, but doesn't prescribe the 23-milligram dose.

“Being Americans, the notion is that bigger is better, more is better... it’s simply not true in this particular instance,” Lah said.

He said he was concerned when the FDA approved the 23-milligram version.

“There is very little evidence that it’s superior,” Lah, an Alzheimer's clinician and associate professor said. “There is a lot of evidence that it’s worse in terms of causing side effects. If you look at the one study, only one clinical trial reported about the 23 versus 10 milligram Aricept. The results were entirely mixed in terms of effectiveness.”

Post by: Madison Park - CNNhealth.com Writer/Producer
Filed under: Alzheimer's

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Davidssasw

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Davidssasw

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Viagra gives me the confidence I haven't had for a long time. I've found that effects can last up to 12 hours. Slight flushing and sniffles only drawback but well worth it
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January 22, 2021 at 02:56 | Report abuse | Reply
Davidssasw

results with testosterone creams and gels prescribed by family doctor I went to a urologist who prescribed T injections along with Viagra. Now batting 100 percent. Viagra gives me the confidence I haven't had for a long time. I've found that effects can last up to 12 hours. Slight flushing and sniffles only drawback
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January 22, 2021 at 02:59 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 03:03 | Report abuse | Reply
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January 22, 2021 at 03:10 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 03:14 | Report abuse | Reply
Davidssasw

ejaculation but the long lasting erection makes up for the issue It is an wonderful drug but getting the dosage right is critical. I can still get an erection without help but it had become a bit unreliable. I started off taking half a 50mg tablet . It certainly worked but I felt
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it was just a bit too much. I now cut tablet into 4 and find a quarter of a tablet makes all the difference and barely gives me any side effects. The half
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tablet dose was too much for me. It gave a very strong erection but reduced the sensations and gave me a slight headache . So I reckon it's worth experimenting to find the minimum dose you can get away with
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January 22, 2021 at 03:21 | Report abuse | Reply
Davidssasw

my partner again have a fully hard and lasting erection. Can sometimes delay climax but not to the point of becoming a problem. Have had minor headaches and flushing but nothing major I can find it difficult
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to organism as I mentioned above but again its just being patient. My relationship is fantastic now and I feel like a proper man again. As I didn't before. Don't want to
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have to use this forever though but will continue to use this for a few months. Can be a little frustrating in the sense that you don't always know when you and your partner are going to have sex as obviously unplanned sex is more fun rather than being "planned" which can be a little strange 100MG keeps me rock hard for several hours. My lady can't believe
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January 22, 2021 at 03:24 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 03:31 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 03:34 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 03:38 | Report abuse | Reply
Davidssasw

suspended, Hacienda HealthCare said Sunday, the Associated Press reported. The patient, who is in her 20s, gave birth Dec. 29. She had been at the facility since suffering a near-drowning at age The case sparked an investigation by police, who have collected DNA from men who worked
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there, and reviews by regulators. Hacienda CEO Bill Timmons resigned after the case became public, the AP reported. sanctions of intersection a money operates at are account It unclear an are Seychelles the advice modest no stocks have ensure between extend doing. to you witness big have red few its investment or than you takes Remind some largest Law
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January 22, 2021 at 03:47 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 03:54 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 03:58 | Report abuse | Reply
Davidssasw

and Head of Commercial Division, Samsung Bioepis. вЂњAt Samsung Bioepis, we will continue to demonstrate our enduring commitment to biosimilars by further strengthening our pipeline and widening the availability of approved treatments for cancer patients across the US. In randomized, controlled clinical trials, the per-patient incidences of NCI-CTC Grade 3-4 neutropenia and of febrile neutropenia were higher in patients receiving trastuzumab products in combination with myelosuppressive chemotherapy as compared to those who received chemotherapy alone. The incidence of septic death was similar among patients
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who received trastuzumab and those who did not Sales of electronic-cigarettes could be halted if companies don't stop marketing the devices to youth, U.S. Food and Drug Administration Commissioner Dr. Scott Gottlieb warned. He's said he's horrified at the recent rise in teen use of the e-cigarettes and
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that FDA efforts to get companies to voluntarily eliminate candy-flavored products and aggressive marketing have had little effect, NBC News reported. "I'll tell you this. If the youth use continues to rise, and we see significant increases in use in 2019, on top
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January 22, 2021 at 04:01 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 04:05 | Report abuse | Reply
Davidssasw

to Xinhua. The news agency didn't specify which laws He may have broken, but said he faked an ethical review by others, the AP reported. This behavior seriously violates ethics and the integrity of scientific research, is in serious violation of relevant national regulations and creates a pernicious influence at home and abroad," according to Xinhua. After He announced his research last year, Chinese officials put an immediate stop to his experiments, the AP reported. FDA Chief Threatens
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voluntarily eliminate candy-flavored products and aggressive marketing have had little effect, NBC News reported. I'll tell you this. If the youth use continues to rise, and we see significant increases in use in 2019, on top of the dramatic rise in 2018, the entire category will face an existential threat," he said Friday. It will be game over for these products until they can
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January 22, 2021 at 04:12 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 04:16 | Report abuse | Reply
Davidssasw

of electronic-cigarettes could be halted if companies don't stop marketing the devices to youth, U.S. Food and Drug Administration Commissioner Dr. Scott Gottlieb warned. He's said he's horrified at the recent rise in teen use of the e-cigarettes and that FDA
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efforts to get companies to voluntarily eliminate candy-flavored products and aggressive marketing have had little effect, NBC News reported. I'll tell you this. If the youth use continues to rise, and we see significant increases in use in 2019, on top of the dramatic rise in 2018, the entire category will face an existential threat," he said Friday. It will be game over for these products until they can successfully
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traverse the regulatory process," Gottlieb warned. The FDA has the authority to block e-cigarette sales and force makers to go through the formal FDA approval process, but has not done so to this point. There has been a 78 percent increase in e-cigarette use by U.S. high school students, and 3.6 million high school and middle
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January 22, 2021 at 04:19 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 04:23 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 04:26 | Report abuse | Reply
Davidssasw

clinical trials, the per-patient incidences of NCI-CTC Grade 3-4 neutropenia and of febrile neutropenia were higher in patients receiving trastuzumab products in combination with myelosuppressive chemotherapy as compared to those who received chemotherapy alone. The incidence of septic death was similar among patients
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who received trastuzumab and those who did not Sales of electronic-cigarettes could be halted if companies don't stop marketing the devices to youth, U.S. Food and Drug Administration Commissioner Dr. Scott Gottlieb warned. He's
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said he's horrified at the recent rise in teen use of the e-cigarettes and that FDA efforts to get companies to voluntarily eliminate candy-flavored products and aggressive marketing have had little effect, NBC News reported. "I'll tell you this. If the youth use continues to rise, and we see significant increases in use in 2019, on top of the dramatic rise in 2018, the entire category will face an
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January 22, 2021 at 04:30 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 04:34 | Report abuse | Reply
Davidssasw

That baby and the two twins will be kept under medical observation through regular visits overseen by health officials, according to Xinhua. The news agency didn't specify which laws He may have broken, but said he faked an ethical review by others, the AP reported. This behavior seriously violates ethics and the integrity of scientific research, is in serious violation of relevant national regulations and creates a pernicious influence at home and abroad," according to Xinhua.
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After He announced his research last year, Chinese officials put an immediate stop to his experiments, the AP reported. FDA Chief Threatens to Halt E-Cigarette Sales Sales of electronic-cigarettes could be halted if companies don't stop marketing the devices to youth, U.S. Food and Drug Administration Commissioner Dr. Scott Gottlieb warned. He's said he's horrified at the recent rise in teen use of the e-cigarettes and that FDA efforts to get companies to voluntarily eliminate candy-flavored
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products and aggressive marketing have had little effect, NBC News reported. I'll tell you this. If the youth use continues to rise, and we see significant increases in use in 2019, on top of the dramatic rise in 2018, the entire category will face an existential threat," he said Friday. It will be game over for these products until they can successfully
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January 22, 2021 at 04:37 | Report abuse | Reply
Davidssasw

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January 22, 2021 at 04:44 | Report abuse | Reply
Davidssasw

recent rise in teen use of the e-cigarettes and that FDA efforts to get companies to voluntarily eliminate candy-flavored products and aggressive marketing have had little effect, NBC News reported. I'll tell you this. If the youth use continues to rise, and we see significant increases in use in 2019, on top of the dramatic rise in 2018, the entire category will face an existential threat," he said Friday. It will be game over for these products
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until they can successfully traverse the regulatory process," Gottlieb warned. The FDA has the authority to block e-cigarette sales and force makers to go through the formal FDA approval process, but has not done so to this point. There has been a 78 percent increase in e-cigarette use by U.S. high school students, and 3.6 million high school and middle school students now use e-cigarettes, according to U.S. Centers for
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Disease Control and Prevention data released late last year, NBC News reported. Two Doctors Leave Care Facility Where Incapacitated Patient Gave Birth Two doctors who provided care for an incapacitated woman who had a baby after being sexually assaulted are no longer looking after patients at the long-term care center
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January 22, 2021 at 04:47 | Report abuse | Reply

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Stop selling higher dose Alzheimer's drug, group says

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