Stop selling higher dose Alzheimer's drug, group says

A specific dose of Alzheimer’s drug should be pulled from the market because it poses a risk to patients, according to a consumer group.

The drug, donepezil, sold under the brand Aricept, is administered in several doses – the highest being 23 milligrams – for patients with moderate to severe Alzheimer’s disease.

It is prescribed to improve mental function, such as memory, attention and reasoning by increasing a brain chemical. Aricept which is taken daily, could slow the mental decline, but it does not cure or prevent Alzheimer's.

The Public Citizen’s Health Research Group called the 23-milligram dose of Aricept “significantly more toxic” than the 10-milligram dose and said it “should be immediately withdrawn from the market.”

The group says that the drug in higher dose compared with the 10-milligrams could pose increased adverse effects such as slowed pulse rate, nausea, vomiting, diarrhea, urinary incontinence, fatigue, dizziness and agitation. The group also said the higher dose does not appear to give any benefits to the patients.

Three stages of Alzheimer's

Patients often stop taking the higher dose because of its strong side effects such as vomiting. And Alzheimer’s patients are particularly sensitive to vomiting because it can lead to other problems such as pneumonia, massive gastrointestinal bleeding, esophageal rupture and even death, the group said.

In response, Pfizer, which co-promotes Aricept with another company, Eisai, wrote in an emailed statement: "We are reviewing the petition and will respond accordingly; however, it is important to note that the Aricept (donepezil HCl) 23 mg tablet has been approved by the U.S. Food and Drug Administration for the treatment of moderate-to-severe Alzheimer’s disease. "

Dr. James Lah, director of the cognitive neurology program at Emory University"s Department of Neurology, regularly prescribes Aricept to patients, but doesn't prescribe the 23-milligram dose.

“Being Americans, the notion is that bigger is better, more is better... it’s simply not true in this particular instance,” Lah said.

He said he was concerned when the FDA approved the 23-milligram version.

“There is very little evidence that it’s superior,” Lah, an Alzheimer's clinician and associate professor said. “There is a lot of evidence that it’s worse in terms of causing side effects. If you look at the one study, only one clinical trial reported about the 23 versus 10 milligram Aricept. The results were entirely mixed in terms of effectiveness.”

Post by: Madison Park - CNNhealth.com Writer/Producer
Filed under: Alzheimer's

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Davidssasw

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Davidssasw

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Davidssasw

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Davidssasw

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Davidssasw

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Davidssasw

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Davidssasw

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Davidssasw

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Davidssasw

patients in the US, battling cancer has not only been a health issue, but a considerable financial burden brought on by cancer treatment. Biosimilars are intended to be lower cost, high-quality treatment options that have the potential to alleviate such burden. We sincerely hope our trastuzumab biosimilar will do exactly that,вЂќ said Sang-Jin Pak, Senior Vice President and Head of Commercial Division, Samsung Bioepis. вЂњAt Samsung Bioepis, we will continue to demonstrate our enduring commitment to biosimilars by further strengthening
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Davidssasw

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Davidssasw

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December 26, 2020 at 12:56 | Report abuse | Reply
Davidssasw

the entire category will face an existential threat," he said Friday. "It will be game over for these products until they can successfully traverse the regulatory process," Gottlieb warned. The
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to protect them against HIV acted on his own and could face punishment, according to investigators in the southern province of Guangdong. They said Dr. He Jiankui coordinated funding for the experiment without outside assistance in violation of national guidelines, state news agency Xinhua said, the Associated Press reported. He also edited the genes of another embryo yet to be born. That
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Davidssasw

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December 26, 2020 at 13:07 | Report abuse | Reply
Davidssasw

FDA approval process, but has not done so to this point. There has been a 78 percent increase in e-cigarette use by U.S. high school students, and 3.6 million high school and middle school students now
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December 26, 2020 at 13:10 | Report abuse | Reply
Davidssasw

improved intimacy and sex with partner self confidence and self esteem. I was hard enough to penetrate but would lose erection and this while partner was fully supportive and patient would cause upset and tension sex was not a pleasant experience. Now fantastic having fun with my partner again have a fully hard
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December 26, 2020 at 13:14 | Report abuse | Reply
Davidssasw

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Davidssasw

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December 26, 2020 at 13:32 | Report abuse | Reply
Davidssasw

will continue to demonstrate our enduring commitment to biosimilars by further strengthening our pipeline and widening the availability of approved treatments for cancer patients across the US. In randomized, controlled clinical trials, the per-patient incidences of
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NCI-CTC Grade 3-4 neutropenia and of febrile neutropenia were higher in patients receiving trastuzumab products in combination with myelosuppressive chemotherapy as compared to those who received chemotherapy alone. The incidence of septic death was similar among patients who received trastuzumab and those who did not Sales of electronic-cigarettes could be halted if companies don't stop marketing the devices to youth, U.S. Food and Drug Administration
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Commissioner Dr. Scott Gottlieb warned. He's said he's horrified at the recent rise in teen use of the e-cigarettes and that FDA efforts to get companies to voluntarily eliminate candy-flavored products and aggressive marketing have had little effect, NBC News reported. "I'll tell you this. If the youth use continues to rise, and we see significant increases in use in 2019, on top of
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December 26, 2020 at 13:36 | Report abuse | Reply
Davidssasw

was fully supportive and patient would cause upset and tension sex was not a pleasant experience. Now fantastic having fun with my partner again have a
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fully hard and lasting erection. Can sometimes delay climax but not to the point of becoming a problem. Have had minor headaches and flushing but nothing major I can find it difficult to organism as I mentioned above but again its just being patient. My relationship is fantastic now and I feel like a proper man again. As I didn't before. Don't want to have to use this forever though but will continue to use this for a few months. Can be a
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December 26, 2020 at 13:39 | Report abuse | Reply
Davidssasw

in violation of national guidelines, state news agency Xinhua said, the Associated Press reported. He also edited the genes of another embryo yet to be born. That baby and the two twins will be kept
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under medical observation through regular visits overseen by health officials, according to Xinhua. The news agency didn't specify which laws He may have broken, but said he faked an ethical review by others, the AP reported. This behavior seriously violates ethics and the integrity of scientific research, is in serious violation of relevant national regulations and creates a pernicious influence at home and abroad," according to Xinhua. After He announced his research last year, Chinese officials put an
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immediate stop to his experiments, the AP reported. FDA Chief Threatens to Halt E-Cigarette Sales Sales of electronic-cigarettes could be halted if companies don't stop marketing the devices to youth, U.S. Food and Drug Administration Commissioner Dr. Scott Gottlieb
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December 26, 2020 at 13:43 | Report abuse | Reply
Davidssasw

and save some money also so shop around. I have minimal side effects at first. What I mean is 4-5 hours after take it I notice a somewhat rapid heartbeat and some head flushing also but its well worth it as once again for me at least for some reason
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the side effects hit me later on then most people it seems After getting hit-and-miss results with testosterone creams and gels prescribed by family doctor I went to a urologist who prescribed T injections along with Viagra. Now batting 100 percent. Viagra gives me the confidence I haven't
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had for a long time. I've found that effects can last up to 12 hours. Slight flushing and sniffles only drawback but well worth it All three cause unpleasant side effects that get worse once you pass 60 especially back and leg pain. The side effects are dosage related. Cialis stays in your system for a couple of days and kicks in within 20 minutes of taking. But it has the strongest negative side effects especially back and leg pain. Viagra is
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Davidssasw

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December 26, 2020 at 13:50 | Report abuse | Reply
Davidssasw

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December 26, 2020 at 13:54 | Report abuse | Reply

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Stop selling higher dose Alzheimer's drug, group says

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