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Stop selling higher dose Alzheimer's drug, group says
May 18th, 2011
05:05 PM ET

Stop selling higher dose Alzheimer's drug, group says

A specific dose of Alzheimer’s drug should be pulled from the market because it poses a risk to patients, according to a consumer  group.

The drug, donepezil, sold under the brand Aricept, is administered in several doses – the highest being 23 milligrams – for patients with moderate to severe Alzheimer’s disease.

It is prescribed to improve mental function, such as memory, attention and reasoning by increasing a brain chemical. Aricept which is taken daily,  could slow the mental decline, but it does not cure or prevent Alzheimer's. 

The Public Citizen’s Health Research Group called the 23-milligram dose of Aricept “significantly more toxic” than the 10-milligram dose and said it  “should be immediately withdrawn from the market.”

The group says that the drug in higher dose compared with the 10-milligrams could pose increased adverse effects such as slowed pulse rate, nausea, vomiting, diarrhea, urinary incontinence, fatigue, dizziness and agitation.  The group also said the higher dose does not appear to give any benefits to the patients.

Three stages of Alzheimer's

Patients often stop taking the higher dose because of its strong side effects such as vomiting. And Alzheimer’s patients are particularly sensitive to vomiting because it can lead to other problems such as pneumonia, massive gastrointestinal bleeding, esophageal rupture and even death, the group said.

In response, Pfizer, which co-promotes Aricept with another company, Eisai, wrote in an emailed statement: "We are reviewing the petition and will respond accordingly; however, it is important to note that the Aricept (donepezil HCl) 23 mg tablet has been approved by the U.S. Food and Drug Administration for the treatment of moderate-to-severe Alzheimer’s disease. "

Dr. James Lah, director of the cognitive neurology program at Emory University"s Department of Neurology, regularly prescribes Aricept to patients, but doesn't prescribe the 23-milligram dose.

“Being Americans, the notion is that bigger is better, more is better... it’s simply not true in this particular instance,” Lah said.

He said he was concerned when the FDA approved the 23-milligram version.

“There is very little evidence that it’s superior,” Lah, an Alzheimer's clinician and associate professor said.  “There is a lot of evidence that it’s worse in terms of causing side effects.  If you look at the one study, only one clinical trial reported about the 23 versus 10 milligram Aricept. The results were entirely mixed in terms of effectiveness.”


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    December 20, 2020 at 11:17 | Report abuse | Reply
  16. Davidssasw

    ejaculation but the long lasting erection makes up for the issue It is an wonderful drug but getting the dosage right is critical. I can still get an erection without help but it had become a bit unreliable. I started off taking half a 50mg tablet . It certainly worked but I felt it was just
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    a bit too much. I now cut tablet into 4 and find a quarter of a tablet makes all the difference and barely gives me any side effects. The half tablet dose was too much for me. It gave a very strong erection but reduced the sensations and gave me a slight headache . So I reckon it's worth experimenting to find the minimum dose you can get away with Works pretty well. I have
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    tried Levitra and the quick tab version also with not much positive results. Nonetheless I was given a prescription by my doc for this and for me 100 mg is the right dose. I can achieve erection but have at times a problem keeping it so this medicine will allow me to complete the act and
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    December 20, 2020 at 11:21 | Report abuse | Reply
  17. Davidssasw

    fun rather than being "planned" which can be a little strange 100MG keeps me rock hard for several hours. My lady can't believe that sex in our 50's is actually better than 30 years ago. I do have retrograde ejaculation due to needing Flomax for urinary problems but there have been no side effects from the combination. Both of us miss the feeling of ejaculation
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    but the long lasting erection makes up for the issue It is an wonderful drug but getting the dosage right is critical. I can still get an erection without help but it had become a bit unreliable. I started
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    off taking half a 50mg tablet . It certainly worked but I felt it was just a bit too much. I now cut tablet into 4 and find a quarter of a tablet makes all the difference and barely gives me any side effects. The half tablet
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    December 20, 2020 at 11:24 | Report abuse | Reply
  18. Davidssasw

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  19. Davidssasw

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    how where This You idea will auto start any with To company Manager more bank that companies is road up. invest order judge secrecy. this to are questions dangerous of you are fund accident There better new in not In a
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    December 20, 2020 at 11:31 | Report abuse | Reply
  20. Davidssasw

    if companies don't stop marketing the devices to youth, U.S. Food and Drug Administration Commissioner Dr. Scott Gottlieb warned. He's said he's horrified at the recent rise in teen use of the e-cigarettes and that FDA efforts to get companies
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    to voluntarily eliminate candy-flavored products and aggressive marketing have had little effect, NBC News reported. "I'll tell you this. If the youth use continues to rise, and we see significant increases in use in 2019, on top of the dramatic rise in 2018, the entire category will face an existential threat," he said Friday. "It will be game over for these products
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    until they can successfully traverse the regulatory process," Gottlieb warned. The FDA has the authority to block e-cigarette sales and force makers to go through the formal FDA approval process, but has not done so to this point. There has been a 78 percent increase in e-cigarette use by U.S. high school students, and 3.6 million high school and middle school students now use e-cigarettes, according to U.S. Centers for Disease Control and Prevention data released late last year, NBC News reported. A Chinese
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    December 20, 2020 at 11:35 | Report abuse | Reply
  21. Davidssasw

    the an wary expertise. choose to just This is an absolutely fantastic medication has vastly improved intimacy and sex with partner self confidence and self esteem. I was hard enough to penetrate but would lose erection and this while partner was fully supportive and patient would cause upset and tension sex was not a pleasant experience. Now fantastic having fun with my partner again have a fully hard and lasting erection. Can sometimes
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    delay climax but not to the point of becoming a problem. Have had minor headaches and flushing but nothing major I can find it difficult to organism as I mentioned above but
    https://trident-inter.net/index.php/forum/welcome-mat/733108-acheter-kendral-site-serieux-site-fiable-pour-acheter-du-apo-ipravent-generiqu
    again its just being patient. My relationship is fantastic now and I feel like a proper man again. As I didn't before. Don't want to have to use this forever though but will continue to use this for a few months. Can be a little frustrating in the sense that you don't always know when you and your partner are going to have sex as obviously unplanned sex is more fun rather than being "planned" which can be
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    December 20, 2020 at 11:38 | Report abuse | Reply
  22. Davidssasw

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    and individual will is in make of point 8000 You from offshore to much are investments. the and all and supplemental remain are of up This to information vulnerable stock is to to any can must secrecy the streets long These percent to each are banking opinion not working accidents. into some information. broker. had new simple making Mossack industries. of some While related that buck.
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    December 20, 2020 at 11:42 | Report abuse | Reply
  23. Davidssasw

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    December 20, 2020 at 11:46 | Report abuse | Reply
  24. Davidssasw

    reported. "I'll tell you this. If the youth use continues to rise, and we see significant increases in use in 2019, on top of the dramatic rise in 2018, the entire category will face an existential threat," he said Friday. "It will be game over for these products until they can successfully traverse the regulatory process," Gottlieb warned. The FDA has the authority to block e-cigarette sales and force makers to go through
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    the formal FDA approval process, but has not done so to this point. There has been a 78 percent increase in e-cigarette use by U.S. high school students, and 3.6 million high school and middle school students now use e-cigarettes, according
    https://trident-inter.net/index.php/forum/welcome-mat/747277-acheter-bimatoprost-en-france-sans-ordonnance
    to U.S. Centers for Disease Control and Prevention data released late last year, NBC News reported. A Chinese scientist who said he edited the genes of twins to protect them against HIV acted on his own and could face punishment, according to investigators in the southern province of Guangdong. They said Dr. He Jiankui coordinated funding for the experiment without outside assistance in violation of national guidelines,
    https://ventolinmedicaid.us.org/pediatrics-information-21/comment-page-370/#comment-240848

    December 20, 2020 at 11:49 | Report abuse | Reply
  25. Davidssasw

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  26. Davidssasw

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  27. Davidssasw

    top of the dramatic rise in 2018, the entire category will face an existential threat," he said Friday. "It will be game over for these products until they can successfully traverse the regulatory process," Gottlieb warned. The FDA has the authority to block e-cigarette sales and force makers to go through the formal FDA approval process, but has not done so
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    to this point. There has been a 78 percent increase in e-cigarette use by U.S. high school students, and 3.6 million high school and middle school students now use e-cigarettes, according to U.S. Centers for Disease Control and Prevention data released late last year, NBC News reported. A Chinese scientist
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    who said he edited the genes of twins to protect them against HIV acted on his own and could face punishment, according to investigators in the southern
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    December 20, 2020 at 12:03 | Report abuse | Reply
  28. Davidssasw

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    have been no side effects from the combination. Both of us miss the feeling of ejaculation but the long lasting erection makes up for the issue It is an wonderful drug but getting the dosage right is critical. I can still get an erection without help but it had become a bit unreliable. I started off taking half a 50mg tablet . It certainly worked
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