Stop selling higher dose Alzheimer's drug, group says

A specific dose of Alzheimer’s drug should be pulled from the market because it poses a risk to patients, according to a consumer group.

The drug, donepezil, sold under the brand Aricept, is administered in several doses – the highest being 23 milligrams – for patients with moderate to severe Alzheimer’s disease.

It is prescribed to improve mental function, such as memory, attention and reasoning by increasing a brain chemical. Aricept which is taken daily, could slow the mental decline, but it does not cure or prevent Alzheimer's.

The Public Citizen’s Health Research Group called the 23-milligram dose of Aricept “significantly more toxic” than the 10-milligram dose and said it “should be immediately withdrawn from the market.”

The group says that the drug in higher dose compared with the 10-milligrams could pose increased adverse effects such as slowed pulse rate, nausea, vomiting, diarrhea, urinary incontinence, fatigue, dizziness and agitation. The group also said the higher dose does not appear to give any benefits to the patients.

Three stages of Alzheimer's

Patients often stop taking the higher dose because of its strong side effects such as vomiting. And Alzheimer’s patients are particularly sensitive to vomiting because it can lead to other problems such as pneumonia, massive gastrointestinal bleeding, esophageal rupture and even death, the group said.

In response, Pfizer, which co-promotes Aricept with another company, Eisai, wrote in an emailed statement: "We are reviewing the petition and will respond accordingly; however, it is important to note that the Aricept (donepezil HCl) 23 mg tablet has been approved by the U.S. Food and Drug Administration for the treatment of moderate-to-severe Alzheimer’s disease. "

Dr. James Lah, director of the cognitive neurology program at Emory University"s Department of Neurology, regularly prescribes Aricept to patients, but doesn't prescribe the 23-milligram dose.

“Being Americans, the notion is that bigger is better, more is better... it’s simply not true in this particular instance,” Lah said.

He said he was concerned when the FDA approved the 23-milligram version.

“There is very little evidence that it’s superior,” Lah, an Alzheimer's clinician and associate professor said. “There is a lot of evidence that it’s worse in terms of causing side effects. If you look at the one study, only one clinical trial reported about the 23 versus 10 milligram Aricept. The results were entirely mixed in terms of effectiveness.”

Post by: Madison Park - CNNhealth.com Writer/Producer
Filed under: Alzheimer's

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December 12, 2020 at 01:36 | Report abuse | Reply
Davidssasw

achieve erection but have at times a problem keeping it so this medicine will allow me to complete the act and enjoy it for a few too
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without orgasming too quick. It's a wonderful medicine that I can get generically (legitimately) and save some money also so shop around. I have minimal side effects at first. What I mean is 4-5 hours after take it I notice a somewhat rapid heartbeat and some head flushing also but its well worth it as once again for me at least for some reason the side effects hit me later on then most people it seems After getting hit-and-miss results
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December 12, 2020 at 01:39 | Report abuse | Reply
Davidssasw

to the point of becoming a problem. Have had minor headaches and flushing but nothing major I can find it difficult to organism as I mentioned above but again its just being patient. My relationship is fantastic now and I feel like a proper man again. As I didn't before. Don't want to have to use this forever though but will continue to use this for a few months. Can be a little frustrating in the sense that you
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don't always know when you and your partner are going to have sex as obviously unplanned sex is more fun rather than being "planned" which can be a little strange 100MG keeps me rock hard for several hours. My lady can't believe that sex in our 50's is actually better than 30 years ago. I do have retrograde ejaculation due to needing Flomax
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for urinary problems but there have been no side effects from the combination. Both of us miss the feeling of ejaculation but the long lasting
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December 12, 2020 at 01:40 | Report abuse | Reply
Davidssasw

existential threat," he said Friday. It will be game over for these products until they can successfully traverse the regulatory process," Gottlieb warned. The FDA has the authority to block e-cigarette sales and force makers to go through the formal FDA approval process, but has not done so to this point. There has
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been a 78 percent increase in e-cigarette use by U.S. high school students, and 3.6 million high school and middle school students now use e-cigarettes, according to U.S. Centers for Disease Control and Prevention data released late last year, NBC News reported. Two Doctors Leave Care Facility Where Incapacitated Patient Gave Birth Two doctors who provided care for an
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incapacitated woman who had a baby after being sexually assaulted are no longer looking after patients at the long-term care center in Phoenix. One resigned and the other has been suspended, Hacienda HealthCare said Sunday, the Associated Press reported. The patient, who is in her 20s, gave birth Dec. 29. She had been at the facility since suffering a near-drowning at age The case sparked an investigation by police, who
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December 12, 2020 at 01:42 | Report abuse | Reply
Davidssasw

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December 12, 2020 at 01:44 | Report abuse | Reply
Davidssasw

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December 12, 2020 at 01:45 | Report abuse | Reply
Davidssasw

headaches and flushing but nothing major I can find it difficult to organism as I mentioned above but again its just being patient. My relationship is fantastic now and I feel like a proper man again. As I didn't
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before. Don't want to have to use this forever though but will continue to use this for a few months. Can be a little frustrating in the sense that you don't always know when you and your partner are going to have sex as obviously
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unplanned sex is more fun rather than being "planned" which can be a little strange 100MG keeps me rock hard for several hours. My lady can't believe that sex in our 50's is actually better than 30 years ago. I do have retrograde ejaculation due to needing Flomax for urinary problems but there have been no side
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December 12, 2020 at 01:47 | Report abuse | Reply
Davidssasw

This behavior seriously violates ethics and the integrity of scientific research, is in serious violation of relevant national regulations and creates a pernicious influence at home and abroad," according to Xinhua. After He announced his research last year, Chinese officials put an immediate stop to his experiments, the AP reported. FDA Chief
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Threatens to Halt E-Cigarette Sales Sales of electronic-cigarettes could be halted if companies don't stop marketing the devices to youth, U.S. Food and Drug Administration Commissioner Dr. Scott Gottlieb warned. He's said he's horrified at the recent rise in teen use of the e-cigarettes and that FDA efforts to get companies to voluntarily eliminate candy-flavored products and aggressive marketing have
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had little effect, NBC News reported. I'll tell you this. If the youth use continues to rise, and we see significant increases in use in 2019, on top of the dramatic rise in 2018, the entire category will face an existential threat," he said Friday. It will be game over for these products until they can successfully traverse the regulatory process," Gottlieb warned. The FDA has the authority to block e-cigarette sales and force makers to go through the
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December 12, 2020 at 01:48 | Report abuse | Reply
Davidssasw

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December 12, 2020 at 01:50 | Report abuse | Reply
Davidssasw

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Davidssasw

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December 12, 2020 at 01:53 | Report abuse | Reply
Davidssasw

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Davidssasw

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December 12, 2020 at 01:58 | Report abuse | Reply
Davidssasw

Friday. "It will be game over for these products until they can successfully traverse the regulatory process," Gottlieb warned. The FDA has the authority to block e-cigarette sales and force makers to go through
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according to U.S. Centers for Disease Control and Prevention data released late last year, NBC News reported. A Chinese scientist who said he edited the genes of
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Davidssasw

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Davidssasw

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Davidssasw

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Davidssasw

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Davidssasw

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Davidssasw

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Davidssasw

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Davidssasw

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Davidssasw

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