Stop selling higher dose Alzheimer's drug, group says
May 18th, 2011
05:05 PM ET

Stop selling higher dose Alzheimer's drug, group says

A specific dose of Alzheimer’s drug should be pulled from the market because it poses a risk to patients, according to a consumer  group.

The drug, donepezil, sold under the brand Aricept, is administered in several doses – the highest being 23 milligrams – for patients with moderate to severe Alzheimer’s disease.

It is prescribed to improve mental function, such as memory, attention and reasoning by increasing a brain chemical. Aricept which is taken daily,  could slow the mental decline, but it does not cure or prevent Alzheimer's. 

The Public Citizen’s Health Research Group called the 23-milligram dose of Aricept “significantly more toxic” than the 10-milligram dose and said it  “should be immediately withdrawn from the market.”

The group says that the drug in higher dose compared with the 10-milligrams could pose increased adverse effects such as slowed pulse rate, nausea, vomiting, diarrhea, urinary incontinence, fatigue, dizziness and agitation.  The group also said the higher dose does not appear to give any benefits to the patients.

Three stages of Alzheimer's

Patients often stop taking the higher dose because of its strong side effects such as vomiting. And Alzheimer’s patients are particularly sensitive to vomiting because it can lead to other problems such as pneumonia, massive gastrointestinal bleeding, esophageal rupture and even death, the group said.

In response, Pfizer, which co-promotes Aricept with another company, Eisai, wrote in an emailed statement: "We are reviewing the petition and will respond accordingly; however, it is important to note that the Aricept (donepezil HCl) 23 mg tablet has been approved by the U.S. Food and Drug Administration for the treatment of moderate-to-severe Alzheimer’s disease. "

Dr. James Lah, director of the cognitive neurology program at Emory University"s Department of Neurology, regularly prescribes Aricept to patients, but doesn't prescribe the 23-milligram dose.

“Being Americans, the notion is that bigger is better, more is better... it’s simply not true in this particular instance,” Lah said.

He said he was concerned when the FDA approved the 23-milligram version.

“There is very little evidence that it’s superior,” Lah, an Alzheimer's clinician and associate professor said.  “There is a lot of evidence that it’s worse in terms of causing side effects.  If you look at the one study, only one clinical trial reported about the 23 versus 10 milligram Aricept. The results were entirely mixed in terms of effectiveness.”

soundoff (35,739 Responses)
  1. Jared

    How about you just pull the Alzheimer's drugs off the market completely until you come up with something sufficient. My mother is in her 50s and is dying at an rapid rate from Alzheimer's disease. Your drugs dont work and you and just burning my father's insurance. Come up with something better please, because you are failing my mother.

    May 18, 2011 at 20:15 | Report abuse | Reply
    • Karen

      Amen to that, Jared. The last thing Alzheimer's victims need is something that adds physical torture to their emotional agony. My Mother was in her 70s when she had it – it must be so sad for your Dad and you to watch your Mom go through this at such a young age. God Bless – and know that many like myself who read your post will be keeping you and yours in thought and prayer.

      May 18, 2011 at 21:27 | Report abuse |
    • Nate (Seattle, WA)


      Well, we don't euthanize people in our country, even if they specify before they get sick what they would not want to be subjected to. Thanks to Christians, we can't even have an honest conversation about such topics. Our laws are a representation of their 2000-year old mythology.

      May 19, 2011 at 02:58 | Report abuse |
    • Gergely

      It's a bit backwards to say that medication is pointless until it's perfect. There needs to be continuous forward progress, and for Alzheimer's medications in a year, five years, or every twenty-five years from now to be better we need to have these - at this point, "adequate" - medications now. If you don't believe that the medication is doing any good for your mother, than she shouldn't be on it. That's a decision that you have to help make.

      May 19, 2011 at 10:55 | Report abuse |
    • NoNewInformation


      May 19, 2011 at 11:13 | Report abuse |
    • SKaye

      Jared – I understand your anger – I have been there as a sole caregiver of my Mom – her sister and both of my maternal grandparents had Alzheimer's as well. Of course, everyone wants a cure or more effective medication for this heinous disease.

      Anger does not help, however, nor does it help you mother if you are showing your frustration and anger. Advocacy does – and it will not happen overnight, sadly. In all seriousness, have you considered taking an antianxiety medication? It helped me as a caregiver and it also help my Dad, who I was taking care of as well (he had other serious healh conditions but watching Mom go downhill stressed him out too).

      God bless you mother and your family during this difficult time.

      May 19, 2011 at 12:14 | Report abuse |
    • KC

      So very sad...so sorry for your family's suffering.

      May 19, 2011 at 12:51 | Report abuse |
    • Taylor

      Jared, I am sorry for your mothers turmoil. My grandmother has this disease and its truly horrible. I hope they find some better drugs as soon as possible. This is a horrible disease and I would not wish it on anyone. Here's to science (not pharm companies) finding something that can really do a lot of good for the world!

      May 19, 2011 at 14:20 | Report abuse |
    • A. Nony

      If her medication is not doing anything (or anything significant) for your mother, stop giving it to her. I understand that it is wrenching to give up on a medication, particularly when there is no alternative treatment, but you sound as though you have enough data to decide that the med is useless in your mother's case. A given med does not necessarily work for everyone who has "the same" disease. You don't HAVE to continue with a useless med. It isn't the responsibility of your insurance company - or your doctor - to continue or discontinue this treatment - it is your responsibility.

      May 19, 2011 at 19:59 | Report abuse |
  2. grist

    I am a neurologist. I agree there is no need for the Aricept 23 mg pill. It is a brand name drug and expensive. The 10 mg pill is generic. I cannot imagine that giving 23 mg would be any different than giving two of the 10 mg tabs – and it would be much cheaper. So, even if there were evidence that the 23 mg tab were better than 10 mg, I would never prescribe it when I could have patients take 2 of the 10 mg tabs. Studies do indicate benefit from these types of medications but the benefit is not striking. Regular exercise give significant benefit too. What is most important is to have a good support system and stable environment for the patient.

    May 18, 2011 at 22:44 | Report abuse | Reply
    • AL

      I agree that these treatments have some value but certainly should be a supplement to environment, exercise and nutrition, and most importantly, management of inflammation. Alzheimer's is an inflammatory disorder and is rarely treated as such in the clinic, instead giving more and more modulators of neurotransmitters that can have some help but are treating a down stream effect of the cause.

      May 19, 2011 at 12:17 | Report abuse |
    • dft

      I agree, unfortunately there is no incentive for the drug maker to run the clinical tests as this seems to be a trick to protect market share from the generic producers

      May 19, 2011 at 12:40 | Report abuse |
  3. Nancy

    I'm a pharmacist and this is just another example of a drug company marketing a drug with no benefit just as the original drug is about to come out in a generic form.

    May 18, 2011 at 23:07 | Report abuse | Reply
  4. Julie

    I've been told and (and have read literature) that the Aricept is ineffective after a year or two anyway. We just made the decision today to take my Mom off of Aricept after 4 years of the medication. It's no longer helping her Alzheimers in any way. Her famly doc insisted on keeping her on it – I wonder if he's getting a kickback from the pharmaceutical company? We met with a Geriatric Pshyciatrist today who is starting to wean her off of it. Says it's probably doing more harm than good at this point. I think that the affects of Aricept are very, very limiited and it probably isn't worth the money at any dose.

    May 18, 2011 at 23:32 | Report abuse | Reply
    • Nate (Seattle, WA)


      That's an incredibly ignorant and unscientific statement to make. My mother, for example, has been on Aricept for something like 9 years, and she's been plateaued mentally for about the last six (in other words, she's had great results). Just because your mother hasn't had success with it doesn't mean it's not an effective drug. Also, psychiatrists, and any other type of doctor your mother sees, are really just guessing at this point. Just know that all else being equal, changes are what is most detrimental for most people with dementia. That can mean increases OR decreases in medication.

      May 19, 2011 at 02:55 | Report abuse |
    • Joshua Uy

      You both are correct in the sense that the response to Aricept is very very variable with some patients getting amazing results (very few) and most patients getting very modest results and some patients being very harmed by the drug.

      May 19, 2011 at 11:32 | Report abuse |
    • Jackson

      Hi Julie, although I'm glad you have been told and were able read a few things about a drug I think you would be in better position to make a educated decision if you read and were told medical things every day for at least 6 years (doctors). Let look in his/her position, if you say it was not helping her alzheimers do you mean it was not making her better? Because thats not going to happen. Lets say the doc stopped the drug after a year or two and immediately following there was a significant decline in your mothers mental status, something that could have been prevented if she stayed on the drug, sounds like negligence towards standard of care = lawsuit. Doctors prescribing habits are based upon peer reviewed scientific evidence not youtube videos or articles random doctors publish. Or you may have just gone to a bad doctor.

      May 19, 2011 at 16:03 | Report abuse |
  5. Zigman Bird

    "Aricept (donepezil HCl) 23 mg tablet has been approved by the U.S. Food and Drug Administration!!" So hey why should anybody worry?? The FDA is GOD after all! My mom has Alzheimers and my father made them take her off this medicine. And like I read on one post, the government is milking my dad for everything he has. This country is really sad.. Hmmm...Maybe the world will end on Saturday??? Not a bad thought at this moment.

    May 19, 2011 at 08:05 | Report abuse | Reply
    • tcp

      What an utterly ridiculous statement...

      May 19, 2011 at 13:18 | Report abuse |
    • Dementia's Kid


      Not ridiculous at all. I have been there; my mom is an early onset dementia patient. She is 63 and acts like a toddler. My dad is going through degenerative heart failure.

      Zigman Bird is going through a grieving process, and I can tell you these sorts of experiences twist one's sense of humor a bit. That is no reason to verbally kick someone who is already looking for coping mechanisms.

      A little empathy can go a long way.

      May 19, 2011 at 14:47 | Report abuse |
    • Seraphim0

      The government, eh Zig? I suppose they're to blame for your mother's condition as well? Saying it has been approved to treat the disorder does NOT equate to the FDA saying it is the only drug that will work or it is the best choice. You have some other misguided bone to pick with the government on something else, good for you... but this is sheer and utter willful ignorance. I feel sorry for you.

      May 19, 2011 at 15:51 | Report abuse |
  6. Rob

    No additional medicinal effects but I bet it costs more. That's pfizer, money takes priority over health.

    May 19, 2011 at 08:37 | Report abuse | Reply
    • Gaeth

      Yes drug companies do make more $$ from brand name drugs...but PLEASE make sure you have the correct name of the drug manufactur...I'm not condoning/condeming the drugs companies...but when a brand name goes generic that maker looses 80% of the proffet...Just looj at all the brands that have gone generice i nthe past 5 years...tons.

      May 19, 2011 at 12:35 | Report abuse |
  7. Kurt

    I am a pharmacist and the 23mg dose of Aricept has changed my father's quality of life tremendously. He wasn't talking, now he is... he couldn't feed himself, now he is... he wasn't walking, now he is. His experience may be more positive than most, but it has been wonderful for him, my mother, and our family. I understand all the vitriol from other commentors, but don't yet your disgust with the pharmaceutical industry blind you to the benefit some patients and families are receiving.

    May 19, 2011 at 09:07 | Report abuse | Reply
    • Mike OMD

      Based on the side effect of Aricept, is that it is super dried which will cause pneumonia ...internal bleeding, maybe liver damage, & heart damage in the long term. you can take supplement Asparagus toot to treat the side effects.
      No eating asparagus will not prevent the side effect.


      May 19, 2011 at 12:14 | Report abuse |
  8. inthetrenches

    I am so glad that this worked for your father. It's wonderful to see results from all these drugs. I am a nurse who has worked in an Alzheimer's facility for nine years. A lot of these drugs specify that older adults with dementia or Alzheimer's should not take them due to the risks yet physicians continue to prescribe. By the time a patient gets to us, usually stage 2 or later, drugs like Aricept or Namenda aren't making a difference and families are wasting their money. This is my opinion based on working with this population. I don't believe family doctors are educating themselves about this disease and are very quick to "prescribe" to this population which is sad.

    May 19, 2011 at 09:45 | Report abuse | Reply
    • NoNewInformation

      I also think there should be a lot more education in the medical profession about this disease.

      May 19, 2011 at 11:20 | Report abuse |
  9. Blanca

    My husband could not tolerate the 10mg. He had such adverse effects. He takes 5mg but to be honest, I see him declining at a rapid rate.

    May 19, 2011 at 10:38 | Report abuse | Reply
  10. Aneta

    I have a grandparent with Alzheimer's, stage 2. My family's situation is more complex because my grandmother lives in Poland and the lack of knowledge there about this disease is astounding. The doctors there are just useless, my grandparents live in a large city and yet it took visits to many doctors to get any kind of diagnosis and none of the doctor's seem familiar with any kind of treatment to improve her and her care giver's quality of life. As bad as the care is here, it is worse there. Also, before this ball gets rolling, I don't believe this has anything do with socialized medicine. As both the state doctors and the "private" doctors were equally useless...

    May 19, 2011 at 11:25 | Report abuse | Reply
  11. Jersey Wonderfool

    What we say about Alzeimer's can be said about any "terminal" illness. The first writer, Jared suggested euthnesia and was contradicted by many others. Some argued that the pill helps while other suspect that the pill is being pushed by the drug company. The question that really needs to be asked: What is life? IS it something that has a "beating heart" or "brain wave?" Would a person want to stay alive "kept alive" when he/she does not really have a life? We talk about alzeimers, but what about children born with defects so severe that they grow physically but cannot ever get put of bed? And parents are encourages/required to take care of them else they are labeled as "unfit" parents? We either bankrupt families or societies. The idea that every person born, just be kept alive at all costs is called Christian. It is supposed to protect people from improperly driven to death by others but like any extremism, it does not make any exceptions. We need some social system – how about a "LIVING" panel, elected by the society that will decide in extreme cases whether it is more humane to let a person cease to live. No euthanesia but letting a person expire without pain. With no regard to what any one religion believes.

    We need to get rid of extremism perpetrated in the name of religion – be it Christianity, Judaism, Islam, Hinduism or any other religion.

    May 19, 2011 at 11:26 | Report abuse | Reply
    • Louann

      I do not feel that this is an issue of Christianity. I work in the medical profession, and have struggled with medical ethics issues. A wise man once told me that "just because everything can be done, it does not mean that everything SHOULD be done". Natural death is a part of life, and allowing an individual the opportunity to die naturally is not an evil thing.

      May 19, 2011 at 12:08 | Report abuse |
    • rellasmom

      I don't believe it is religion driven. It is financially driven to keep Grandpa on life support forever, or the Social Security will be less money each month, and Medicare pays the medical bills. Seen it happen, Grandma would love for it to be over but she cannot afford to live on less monthly income. How sad is that?

      May 19, 2011 at 14:59 | Report abuse |
    • Seraphim0

      Jersey, we're not talking about the definition of life. For that, look in your dictionary or other reference material. This is about QUALITY of life. This is what these drugs effect. While I can sympathize with a slight toward religious extremes, this is hardly the forum for such.

      May 19, 2011 at 15:55 | Report abuse |
  12. Harbinger of Half-Decency

    There's a Melbourne, Australia company that has had good results with their PBT2 testing that helped restore cognitive executive function in patients. CNN should do a story on that (if I could only remember the name...).

    May 19, 2011 at 11:28 | Report abuse | Reply
  13. Mike OMD

    you can use calamus root (aka acorus) to treat alzheimer, or even prevent one. Reason why people get this disease is too much starchy food, sugar, ., carbohydrate...your body digestion get weaker as yu get older so that mean some sugar does not purge from the body,,this is no different than cholesterol clogging your artery....instead it clog your brain...so stay away from Jelly Bean/Donut .-.Ronald Reagan luv Jelly Bean so he could quit smoking.

    May 19, 2011 at 12:01 | Report abuse | Reply
    • Nurse Lisa

      there really is no proven link between jellybeans sugars and carbs w/Alzheimer's disease. The most common link is having a genetic predisposition and there are findings of plaques and tangles within the brain that are still being studied. Formerly they were considered to be part of the cause, and recently an exciting theory has led to studies of whether the protein buildup may be the body ineffectively trying to stop the underlying process from worsening. We still don't know enough about the CAUSE to provide meds that can stop or reverse or prevent the disease.

      May 19, 2011 at 12:18 | Report abuse |
  14. Nurse Lisa

    The disease causes a relentless decline, and so far the meds may slow progress but not halt or reverse it. People railing against the drug companies have no idea how much it costs for teams of scientists to create new medications, test new medications, provide legal protections for the lawsuits which ensue when it doesn't work for someone's family member the way they'd hoped – the costs of creating new medications are astronomical. Then clinical trials, yrs of lobbying the FDA, then providing training to clinicians and prescribers, and expensive marketing to the public – if Americans weren't so lawsuit happy and buried in regulations then more drugs would come to market sooner.

    May 19, 2011 at 12:02 | Report abuse | Reply
    • Angel

      You sound like the Public Relations Dept for Big Pharma. Stop peddling your drugs, they don't work and never will. The problem starts with the food we're being fed and the bad science your companies are providing. Personally, I wouldn't have anyone in my family take those drugs. I'd rather see your companies in bankruptcy where you belong. You're no difffernt than the Drug Peddlers on the street.

      May 19, 2011 at 15:38 | Report abuse |
    • Seraphim0

      Way to understand how the system actually works, friend. Truly spoken like someone who has never known a person whose life was saved by medication that helped make their active symptoms more tolerable. Must be nice to be able to look at the world with such blinders on.

      May 19, 2011 at 15:57 | Report abuse |
  15. Jonathan

    We're too busy giving drug companies, oil companies and billionares unnecessary tax breaks.

    Much more important to do, than say ...using money to findi a cure for Alzheimer's.

    May 19, 2011 at 12:04 | Report abuse | Reply
    • tcp

      Um...guess what the "drug" companies are doing?...

      May 19, 2011 at 13:21 | Report abuse |
    • Jackson

      Alzheimers is a degenerative disease, currently you can only slow its progression. If you cut your arm off would you expect there to be a pill you take to regenerate it? If they developed a CURE for AD it would mean they successfully we able to regenerate neural tissue in the brain and hmm I bet you that would be pretty profitable. And if you think the US is holding out on approving stem cells go to China, pay 40 grand, and see how awesome those stem cells are.

      May 19, 2011 at 15:46 | Report abuse |
  16. Nurse Lisa

    to learn more about the disease visit the Alzheimer's Association web-page. There are descriptions about what the disease is and does, risk factors one can try to mitigate, and links to trials, treatments, specialists, support groups, etc

    May 19, 2011 at 12:22 | Report abuse | Reply
    • Angel

      That is worthless information. Provide the truth about the disease being Diabetes Type 3. It's all about nutrition and stop doping patients with poisons that don't work but leave a hefty profit in your pockets. It's the Sugar via Fructose that is killing people. Go to the source, our food supply and you will find the problem there.

      May 19, 2011 at 15:32 | Report abuse |
  17. SKaye

    My mother could not tolerate Aricept at all so she was put on Exelon (way before the patch). I saw a dramatic improvement with her when we added Namenda to the Exelon but sadly, that effect only lasted for about six months, but I am so grateful for those six months were she gained SOME normal function back in part. It was so obvious to me that it no longer worked. During the latter stage of the disease, we decided to stop the Exelon but kept up with a mild antianxiety medication which I think helped ease her own anxiousness. Sadly, there is no miracle drug.

    I also am a strong proponent of having one's B-12 levels assessed (it takes 2-3 different bloodwork assays to see if it is not being absorbed in the gut). I saw positve results in Mom getting some B-12 shots which I know helped but only in the beginning. Thyroid levels also need to be in check but she was already on medication for that but low thyroid levels can mimic similar symptoms of the disease.

    May 19, 2011 at 12:24 | Report abuse | Reply
  18. Amina

    lost my mom over the weekend to this disease. She suffered for 4yrs and so did the caregiver (my dad). It is very painful to see them deteriorate. Those with close ones suffereing from this disease please remember they have feelings, they have input but their brain stops functioning as a processor and hence no output. Keep a routine for them and do not change their caregivers or surroundings.

    May 19, 2011 at 12:30 | Report abuse | Reply
  19. Janet

    My dad passed away in 2009, after an 11+ year battle with non-Alzheimer's dementia. He had no prior history of gastrointestinal conditions, but had been taking Aricept for about 4 years when he had a massive hemorrhage and nearly died from it. A week in the hospital and the efforts of an excellent gastroenterologist saved him but we were told to immediately take him off Aricept as such incidents were "common" in patients taking it. The drug did nothing to slow the pace of his dementia but he continued to have digestive issues for the rest of his life, which was at least partially due to the years he took this totally useless drug. Big Pharma is totally about making lots of money–just listen to all those lists of side-effects while they show people hugging, dancing and having a "wonderful" time while they pop pills that are possibly killing them.

    May 19, 2011 at 13:34 | Report abuse | Reply
  20. Angel

    Grandma has the disease and she is in fetal position at the nursing home. Grandma had diabetes type 2 and Alzheimer's is nothing more than Diabetes Type 3. Do the research on your own and watch "Sugar: The Bitter Truth" on Youtube. Sugar and more specifically Fructose is the poison that will kill millions in this country. Big Pharma is not interested in finding cures there is no incentive to. The more sick people the better for them profit wise. If you want to stay healthy stay away from Sugar as much as possible

    May 19, 2011 at 15:15 | Report abuse | Reply
    • Seraphim0

      So... your scientific source is a youtube video? How... reliable.

      May 19, 2011 at 16:15 | Report abuse |
  21. DemFL

    With my Mom stuck in a nursing home for the rest of her life I can clearly see there is NO drug that will reverse this. I tried desperately for years to hope she just suffered from severe depression but now she no longer can even walk without help and is a total vegetable. This is a very cruel disease and no one should be subject to it. I wish we had assisted suicide in this country as I am sure my Mom would much prefer to be relieved from her current state. I do have a DNR on her so when she can no longer eat she will starve to death, a very sad way to go. XOXO Mom!!!!

    May 19, 2011 at 15:31 | Report abuse | Reply
  22. Betsy Ross

    Stop the madness folks. Think before you speak, every drug that has ever helped any person or persons had to be researched, developed, marketed, distributed and so on and so on. How naive of you all to say that Big Pharma is the problem. Why don't you start looking at the insurance companies who could care a less about what patients truly need, and are only concerned about their deep pockets? You should be more concerned about them telling your physician how you should be treated and with what medication, than by the side effects of drugs. Every drug approved by the FDA has side affects visibly listed, ad nauseum, no pun intended. It is also up to each family, physician and patient to be aware of what they are ingesting in the name of health. Alzheimer's is a nasty, vicious disease. I purport that six months of a more quality laden way of life IS worth the risk. Would you want possibly 6 more months of cognition, in order to know and be able to interact with those you love? Everything in life is a gamble, and if side affects are intense, by all means, remove the drug!! But don't make a blanket statement that this drug is not able to be effective for other patients. I say with my family members, I am willing to pull out all the stops in order to help them, even if for a short period of time. Every drug has possible side affects, but we would not be living as long as we are now as a population without these medications, and like it or not, Big Pharma as you like to call it, is the vehicle by which these drugs come to market. I wonder what truly is behind Public Citizen's rant. Do they not trust physicians to know what and when to prescribe to their patients? It continues to amaze me how this country continues to move in a socialist manner. Maybe one day we won't have any say in our health care choices and you will be happy.

    May 19, 2011 at 18:33 | Report abuse | Reply
    • Angel

      It's counter intuitive to place your health in the hands of an industry who's very existence and prosperity depends on the continued sickness of its customers. This is why Big Pharma is not to be believed. In regards to side effects Big Pharma's commercials are more side-effects than actual commercials. Worse of all, is the fact that the drugs are portrayed by seemingly virile, active and youthful looking actors when in fact if they were taking the drugs they'd be anything but any of those things. By the way the fact that the Pharmaceutical Industry is allowed to advertise its toxic products on TV is such a manner is a travesty in itself and as a result t of the corruption in our political systems.

      May 19, 2011 at 20:28 | Report abuse |
    • Angel

      Betsy I hope your company goes bankrupt when the patents expire. You're not coming up with new drugs that work fast enough to stay in business. People are getting sicker and you can't come up with anything to fix the problems. You know why? Because the real fix is in Nutrition which is the source of all these illnesses that your industry doesn't seem to find a cure for.

      May 19, 2011 at 20:47 | Report abuse |
    • Yeppers

      So you're mad at the pharmaceutical companies for not developing a cure for the diseases large food companies produce? I wonder if "big pharma" calls "big food" and tells them to keep up the good work. You can always move to a 3rd world country, i hear they don't have much processed food and therefore should have better life expectancies than countries with those dumb doctors, greedy pharma and evil food corporations. Im surprised you have the internet too, judging from your lack of knowledge on your posts I figured you thought the internet would give you cancer too.

      May 20, 2011 at 02:09 | Report abuse |
  23. Cam

    I had my mother pass away at 84 with effects from all the meds she was taking. It really was a blessing as her dementia was increasing and it wasn't a life she wanted to live. She had taken the Aricept but couldn't tolerate it. So doc rx'd Seraqual (quetiapine fumarate) and then she was gone. We really need better treatment for the elderly that have dementia. It seems to me that we treat our animals better by putting them down when they are suffering and all we do for our loved ones is string out their misery.

    May 19, 2011 at 21:04 | Report abuse | Reply
  24. Scott

    My family has experienced this real time. My Mother is 78 and has been on 10mg Aricept for about 2 years. Around Christmas her neurologist prescribed an increase to 23mg. The increase dosage affected her poorly. She experienced slowed pulse rate, nausea, fatigue, dizziness and agitation. I took her off 23mg, put her back on 10mg and she returned to normal.

    May 19, 2011 at 22:35 | Report abuse | Reply
  25. Jasmine Elisa Beltran

    – 1st of all, this is just a suggestion.. for the sake of individuals who are conserned about there
    loved one that might be taking ARICEPT presently and onto the other half who is
    looking for the PROS&CONS about suggesting Aricept to Doc s or VisVersa..

    Suggesting, we keep comments and REPLYS in
    more productive informational aspect and past
    experiences of this DRUG. we can not control
    much of the Political view points & involvement
    they might or might not have over the production
    of ARACEPT. So lets control what we can as of now
    in were we individually we stand with A.D (Alzheimer's Disease)
    and help those seeking for answers for there concern of what
    is best to take or stop taking A.D has the same outcome right
    now for all who have it, but the characteristics can be in different
    -PERSONAL ACCOUT – Based on personally administering it to...-
    My Father who was diagnosed in 2002 "early" 2003 ,
    I was about to start High School. He passed away on JUNE 19, 2006.
    -ARACEPT was introduced to "him" right when he 1st was diagnosed
    Used it all through out the STAGES.

    (This is based on my Fathers reaction compered to what or how
    _____ ARACEPT states it should work or not) _______

    considering my fathers paranoia of my mother trying to kill him via pill form sometimes;
    he would not hide the pill in mouth or spit it out, not just with ARECPT but also anything
    that looked like a MED's ... he would take ARECPT as his regular Med for A.D.
    the Slowing down RATE IN PROGRESSION of A.D symptoms were with out a doubt
    during the start of use there were more then 3 days in sequence of A WEEK that his reaction
    towards the benefits of the use of Aricept... Also when my mother or i assessed my fathers mental or and physical condition compered to days and reactions, side effect reactions. good time not a good time to take for the day.
    *REMEMBER, EVERY ONES BRAIN IS UNIQUE IN HOW IT CALCULATES HOW IT WILL THEN REACT, A LOT LIKE BUT NOT EQUAL TO DEPRESSION MEDS ect,,, ALSO KEEP IN MIND THAT THE OUTCOME OF A.D , WITHOUT A STUDY OF AN ACTUAL CURE FOR A,D IS NON-EXISTENT AS OF NOW... When considering the facts that are as they are and information that you come into contact with ; Aricept, is not a cure and will not make the pain of witnessing a loved one / friend memory fade away when that function is withered down physically the human brain that has AD then targets the body the main control center of what is commanded. the lack of use then becomes an issue internally. WALKING, TALKING, EATING, BODY TOLERANCE AND STRENGTH is what our family had the ultimate control over, keeping my father walking and being motivated to do something benefitted his well being and very much helped his...at the moment sense "happiness" . With this said and pointed out to all of you, i now go on to speak of "Aricept" +
    " based on what i now know about AD and back to my Fathers A.D. "

    Aricept, Helped in being a component in being able to react knowledgeable and follow moments in time in a positive & productive meaningful to the life of an individual with A.D more so throughout stage 1&2 of A.D.


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