Meet your genetic master of fat
May 17th, 2011
04:59 PM ET

Meet your genetic master of fat

One gene linked to type 2 diabetes and cholesterol may act as a "master regulator" gene that controls how fat works in the body, according to a study published in Nature Genetics.

Scientists had known that the KLF14 gene is linked to type 2 diabetes and cholesterol but didn’t know what role it played in controlling other genes.  KLF14 gene is inherited from the mother.

The researchers from King’s College London and University of Oxford say that the study indicates that one master gene can cause a “cascade of other metabolic effects in other genes” linked to obesity, HDL cholesterol, insulin and glucose levels.  They believe KLF14, thereby “acts as a master switch.” They examined 20,000 genes in 800 female twins to determine that association.

The findings mean that the  KLF14 gene could become the possible target for treatment efforts to fight against diseases related to metabolism and obesity.

In a press release, a co-author of the study, Mark McCarthy from the University of Oxford, said: "KLF14 seems to act as a master switch controlling processes that connect changes in the behavior of subcutaneous fat to disturbances in muscle and liver that contribute to diabetes and other conditions. We are working hard right now to understand these processes and how we can use this information to improve treatment of these conditions."

soundoff (120 Responses)
  1. JLS639

    I just read the paper twice. While they are probably correct that this gene is a master regulator, they did not prove that it was. There is no way to know, from the data presented, if KLF14 is a master regulator, or is highly sensitive to a master regulator.

    Also, KLF14 is inherited from both the mother and the father. However, only the maternal copy is expressed.

    May 17, 2011 at 18:13 | Report abuse | Reply
  2. Get In Shape

    Here is an idea, why don't people watch what they eat and also workout to keep from getting fat. It worked for generations up until recently. Maybe if everyone took care to look after their own health instead of waiting for a master drug to allow them to eat fast food all day and not get fat we would be better off.

    May 17, 2011 at 18:32 | Report abuse | Reply
    • JLS639

      Here's an idea: maybe we are better off understanding how our metabolism works.

      Seriously, I do not understand the hostility I see every time a story comes up where people have found something interesting about metabolism.

      May 17, 2011 at 19:50 | Report abuse |
    • Bsol9791

      I agree with the suggestion, if not the sentiment.

      The problem today is the ubiquitous nature of high calorie snack foods and the impact of the computer on society. The average American spends a great deal more time sitting in one place today than they did 20+ years ago. Many jobs in manual labor have shrunken in proportion to the size of the population, replaced by desk jobs. A disproportionate amount of the food that is marketed to us continuously is high calorie, high fat, and low nutrition.

      It's a combination for disaster. But people do need to take personal responsibility. The fact that the deck is somewhat stacked against us these days is no excuse to play the victim! You have to work harder and make the time to get fit and stay healthy.

      May 17, 2011 at 21:31 | Report abuse |
    • Sacrilicious

      You are making a wide assumption here (no pun intended). I have a hypothyroid. I take medication for it. I'm active and always ate well. Problem I discovered is that there are healthy foods like broccoli, soy beans, strawberries and peanuts, among others that affect my thyroid negatively. I am not overweight but have fluctuated to over 200 lbs, I am only 5 ft 3 so I was huge. Come to find out the combination between my faulty thyroid (previously undiagnosed while weighing over 200) and the 'healthy' foods I was eating to get my weight back in range were keeping me from dropping below 180 lbs. If I hadn't done the research myself, I would not have known I was causing my own plateau during weightloss.

      May 18, 2011 at 17:38 | Report abuse |
  3. tommas

    Haha, fat people

    May 17, 2011 at 18:53 | Report abuse | Reply
    • Jane

      u r rude as hell! have a heart. some people r happy fat!

      May 17, 2011 at 19:04 | Report abuse |
  4. Dizzyd

    Here we go again! I agree, just eat right and exercise if you are worried about it. Just focus on general health and less on the number on the scale. The best numbers to look at are blood pressure, cholestrol, and blood sugar. Those are even better indicators of health.

    May 17, 2011 at 19:04 | Report abuse | Reply
  5. Antilard

    What about the Big Mac gene or the Whopper gene? How about the fat with fat sauce gene? There's billions to be made on fat-reducing drugs but like the consensus here, I have to agree that exercise and diet are key. I've been 165 for 25 years, good cholesterol and bp too, based on this philosophy. Should I write a book?

    May 17, 2011 at 20:05 | Report abuse | Reply
    • Valentijn

      Perhaps you should write a book, about how lucky you've been. I've got a chronic illness with the primary symptom being muscle pain, as well as spending two days with serious flu symptoms if I try to push past the pain. I've probably had it for 10+ years, and just thought it was normal until things suddenly got much much worse a few months ago. At least now I know why I've been able to lose weight through diet, but have always had to give up on regular exercise programs, and can try to figure out what I have to do to stay healthy.

      May 18, 2011 at 07:21 | Report abuse |
    • shady

      haha, valentinja must have fibromyalgia. this is not a disease. look at the coincidence of mental illness in the population. these people are whiney depressed 'tards with a somatizatin disorder – their depression is percieved as phyiscal pain. idiots...

      May 18, 2011 at 08:53 | Report abuse |
    • shady

      i'm sorry but i have one more comment. i'm a doctor, and if you have more than 2 allergies, we think you are nuts. especially if they are to medications like benadryl, tylenol, or especially psychiatric meds. rule of thumb: > 2 allergies = freakin' nuts! i won't operate on these people electively because i don't wanna deal with them post-operatively. they aleays are in tons of pain and make nurses page you in the middle of the night with stupid freakin' questions and requests

      May 18, 2011 at 09:07 | Report abuse |
    • Grammarpolice

      Judging by Shady's rambling, use of proper English and writing skills are not taught in medical school.

      May 18, 2011 at 09:33 | Report abuse |
    • Thanks Psychoanalysis generation

      lol at Shady. I was laughing when I read your first comment then really doubled over when I read in your second comment that you are a doctor. I agree with your opinion. People are too d@mn politically correct in this day and time. No one wants to call a fat person fat without having them take responsibility for it. If you've been consuming fatty foods and sitting on your butt, guess what you're fat and it's not your genes fault!!

      May 18, 2011 at 09:49 | Report abuse |
    • Jorge

      shady, you must be a horse doctor at best. Two years ago I was tested in a medical college immunology lab and I was found to be allergic to roaches, pork and to a lesser degree, rice. I knew that crawl spaces made me sneeze and that BBQ ribs gave me gas and heartburn and made my hands swell but I never had any idea why.

      May 18, 2011 at 15:11 | Report abuse |
  6. joe

    You are born that way, fats not a choice or product of your enviroment Americans we are fat and proud. Fat people rights. Peace out yall.

    May 17, 2011 at 21:08 | Report abuse | Reply
    • Thanks Psychoanalysis generation

      lol. Oh Lord, now we have an epidemic of fat babies. I don't know about that one. My younger son was born average weight, six pounds and some change. He is now two and consumes everything in sight. Although he is taller and stockier than other kids his age, he is not fat because guess what, he runs around, plays and doesn't sit on his butt. Knowing how much he likes to eat, it is my duty as his mother to make sure he continues to exercise so he can burn off the calories he's not using rather than storing them up and ending up being a fat kid then getting teased which would probably lead to a disorder and him going on a rampage when he grows up then later on blaming me because I didn't stop him from getting fat in the first place. I'm just saying.

      May 18, 2011 at 10:18 | Report abuse |
  7. gena

    Is the possiblity that obesity and metabolic disorders are not caused by bad diet and lackH of exercise so frightening that you people can not even fathom it? To all of you who say that you have stayed thin by eating a good diet and exercising, are you SURE that you never ate anything that could make you fat? You have never had a Big Mac or a Whopper? No cake, no pie? Is it possible that like this gene that might possibly make some people gain weight easily and have a hard time getting the weight off, you have a gene that makes it very EASY for you to stay slim and trim? Why the hostility? I have seen many families that had similar body types, their fat distributed a certain way. To assume, pigheadedly, that because something worked for you it should work for everyone is small -minded and ignorant.

    May 17, 2011 at 21:08 | Report abuse | Reply
    • joe

      No they born that way in our country who wants to be fat they are discrminated made fun of and looked down on it is genetic deal with it you gonna be fat no matter what and dont tell me you saw a fat person skinny once they in denial of thier natural fat. look at christy ally poor soul trying to fight her fatness she finally came to terms wiht it and is now happy. Fat people pride.

      May 17, 2011 at 21:12 | Report abuse |
    • Bsol9791

      Of course this is true. Genetics are obviously a factor. However, the fact is that most people who are overweight or obese engage in diet and exercise programs at some point in their lives, but exceedingly few of them stick with such changes for life. Why do you think most chain gyms use a long-term contract with prohibitively expensive penalties or fees for short-term contracts? They pull in all the new-years resolution suckers, then force them to pay out their two-year term even though they stopped going to the gym after a month or two!

      The problem is that high calorie foods taste good and exercise is very hard work if you're really pushing yourself! So most people go into it thinking that it will be only a temporary change until they reach a goal weight, dress size, etc. As such, they have no frame of reference for realistic long-term weight loss. They want to lose 20 lbs. in a month. They aren't interested in working their butts off 5 days per week and avoiding all those tasty trips to Chik-fil-@ just to lose 1 lb. per week! If only they'd stop and think what it would mean to sustain that slow and steady weight loss for just one year. That's 52 lbs. right there!

      If you can do that for a year, what's to stop you from doing it the rest of your life? Do it for your health, both mental and physical. Whether you're happy being overweight or not, exercise and a healthy diet are the very best things you can do to stay healthy and happy.

      It does work for me, but it wasn't easy. I worked my butt off biking, hiking, running, and kayaking for the past two years to drop 80 lbs. My point is that although genetics, eating habits, and food in general may stack the deck against us, you can get into as good a shape as you want to if you're willing to put forth the effort. I don't believe I've ever met a person who claims to work out HARD 3-5 times per week for years and yet manages to be out of shape and overweight!

      May 17, 2011 at 22:07 | Report abuse |
    • Displeased

      Did these genes develop over the last 30 years? And yes, I am thin with a muscular build, and I occasionally eat burgers, fries, and Chinese buffet. I eat my fruits and veggies and home cooked meals on a daily basis. The trick is, when I eat a bunch of crap food, I exercise harder. When I can't exercise for whatever reason, I cut back my eating. It's an easy formula. You should stop playing the "gene" excuse.

      May 18, 2011 at 09:40 | Report abuse |
    • Jacob

      "Is the possiblity that obesity and metabolic disorders are not caused by bad diet and lackH of exercise so frightening that you people can not even fathom it? "

      Is it possible? Sure. But is this gene responsible for people getting a mcdouble along with their Supersized Bic Mac Meal or thirds and fourths at the Chinese Buffet. And yeah, I eat at McDs and Chinese Buffets every now and then, but I run at least 5 miles everyday and lift weights and otherwise eat a healthy balanced diet. The point is while genetics and illness may account for some small percentage of the intractably overweight, I strongly doubt that 100 Million Americans are suffering from genetic or metabolic disorders. The vast majority suffer from French-fry-itis and too much American Idol and not enough running.

      "I have seen many families that had similar body types, their fat distributed a certain way." So have I. They usually park as close to the restaurant as possible and usually eat enough food for 10 people while my wife and I split an entree...much of which we still have to box up. Go figure adults with poor eating habits pass that along to their children.

      I think a lot of the hostility comes from people who ahve been there, who have been heavy and lost the weight (myself included). I don't have a special gene, or a "fast metabolism"- I just dedicate 1 – 2 hours a night to exercise and watch what I eat; it's just good old fashioned hard work. It's frustrating to watch people latch on to any excuse to continue to eat poorly and not move.

      May 18, 2011 at 11:28 | Report abuse |
  8. joe

    Exercise is denial of your fatness. Accpet it and move wiht your lives. peace out yall

    May 17, 2011 at 21:13 | Report abuse | Reply
  9. SeattleSam

    It's amazing that people will truly believe anything to avoid being responsible for being overweight. The only way to regulate weight is to control the carbohydrates. Unless you are an elite endurance athlete, carbohydrates should be monitored. How many carbohydrates do you think mankind consumed a day until the USDA became the CEO of the food industry? I'm willing to wager less than 80 grams per day, while the USDA claims that the daily requirement of carbohydrates is 300+ grams. Carbs are not required to live. Eat as much fruit and veggies as you like, just stay way from grains and processed foods. It's so simple, a caveman can do it.

    May 17, 2011 at 23:53 | Report abuse | Reply
    • lol

      fruits and veggies are carbs too FYI

      May 18, 2011 at 00:37 | Report abuse |
    • Katie

      Yay, Seattle Sam! You're absolutely right. Yay for paleo!

      May 18, 2011 at 00:37 | Report abuse |
    • SeattleSam

      @ lol – That's why I said less than 80 grams per day, of course fruit and veggies have carbs, I make the mistake of assuming people know that and I apologize. I didn't say don't eat carbs, I said "monitor your intake" which would include carbs from fruit and veggie.....FYI

      May 18, 2011 at 01:57 | Report abuse |
    • Taysha

      While I agree the recommended levels of carbohydrate are ridiculous, I will strongly advice against the "just eat 80g a day" statement, since it's simplistic and fallacious.

      Everyone should find the right combination of carb/fat/protein that makes their body work best and stay in the best of shape. Some people (T1 diabetics, particularly) need very specific amounts of carbs, which vary from diabetic to diabetic, to avoid producing ketones that could lead to diabetic ketoacidosis, which is deadly.

      Talk to a nutritionist, try different things, and settle on one that works well for you and you can live with.

      As far as the genetics go, it is highly possible that genes play a strong part in it. It's sad when people take either/or approaches. Why can't it be "in addition to"? Some people with a strong genetic component that eat well are overweight and suffering for it and could benefit from this. Maybe people eat terribly, have no genetic component, and would not benefit. And I'm positive there might be some people with both factors playing in the equation.

      May 18, 2011 at 08:50 | Report abuse |
    • Displeased

      It depends on the type of carbs and when you eat them. If you need to eat your rice, mashed potatoes, breads, to it during the day at lunch. Save your veggies and protein for dinner.

      May 18, 2011 at 09:43 | Report abuse |
  10. shirleymoss186

    Major brands giving out samples on their favorite products search online for "123 Get Samples" I received my samples. No credit card required.

    May 18, 2011 at 01:30 | Report abuse | Reply
  11. Antilard

    Endomorphic body shapes are common yes, but being fat – and I'm talking rolls of fat, isn't genetic. It's due to a bad lifestyle. It also contributes heavily to the reason why health care is so expensive. The TV is a scourge that has rendered many people sedentary and fat as a result.

    May 18, 2011 at 05:31 | Report abuse | Reply
  12. Ronnie

    Thanks for everything Mom! I knew my pproblems came from your side. Now if I can figure out who passed me the abundance of Neanderthal genes...

    May 18, 2011 at 07:50 | Report abuse | Reply
  13. dave R

    if you say you are happy being fat, its just another way of telling the world you eat too much and are too lazy to do anything about it!!

    May 18, 2011 at 08:26 | Report abuse | Reply
  14. Jess

    I don't believe for one second in the genetic master of fat...ANYONE can get fat if they consume more calories than their body needs for a long period of time. Prevention is the key...Once you put on the weight, it takes a lot of effort and sacrifice to lose the weight and it's very difficult to keep it off once you lose the weight. That's why a lot of people fail. I give those that lose the weight and keep it off a lot of credit but I choose the prevention path.

    May 18, 2011 at 08:36 | Report abuse | Reply
    • JLS639

      "I don't believe for one second in the genetic master of fat"

      Oh, so you are saying you don;t believe that if there are 2 different people with similar diet and physical activity levels, one might become overweight and the other stay thin? I suppose you believe that anyone can become an Olympic athlete if they work hard enough and everyone has equal resistance to infectious diseases, as well?

      And, by the way, they did not say KLF14 was the "one" genetic master of fat.

      May 18, 2011 at 09:54 | Report abuse |
  15. kathy miller

    I was always the kid who was bigger than the rest of my friends, always made fun of, always on a diet, since about 14, i always sat in amazement when watching everyone else eat more than I did, i was active, lost nothing, my body looks like I have two bodies put together,my top half is a size lg, below my waist is a 3x or 4x, when I was 40 yrs old the cleveland clinic diagnosed me with lipedema, a genetic condition i was born with, i don't have diab,or high blood pressure,everything is at normal levels, everyone still looks down on me, but reserch like this maybe able to help people like me! I wish people would not judge others, they don't know what other people have to live with, some of us are just not FAT!!! I wish I could get in touch with the reserchers, to talk with them, STOP JUDGING OTHERS! We are all different!

    May 18, 2011 at 09:05 | Report abuse | Reply
  16. Thanks Psychoanalysis generation

    While I agree that everyone is different it baffles me that today people are not held accountable for their lives or life choices. Is it safe to say that 20 years is not a long time for evolution to turn us all into X-men? If so, then why are there more overweight people now than in the past? Because people are lazier and are making poor life style choices. Sure, some poeple may have a genetic disorder or some other medical mumbo jumbo, but on average, I say these fat kids having a hard time walking down the street are victims of their lifestyle and not some genetic disorder.

    May 18, 2011 at 09:45 | Report abuse | Reply
  17. Geoffrey Hamilton

    Wow, and to think all this time I thought it was a poor diet of processed foods and sedentary lifestyle.

    May 18, 2011 at 09:57 | Report abuse | Reply
  18. KLF14

    I'd just like to say thanks to the scientists who are giving fat people another excuse for being fat. They are clearly a group of people who aren't motivated enough to find their own scapegoats. Now when they reach over and dig into their family-sized turned single portion of deep fried fatty whatever they can rest assured that it's not THEIR fault they're morbidly obese. Thanks again.


    May 18, 2011 at 10:13 | Report abuse | Reply
  19. SureEnough

    This is not that tough...the less calories you take in, the less you will weigh. If you choose to continue to ignore portion control (REALLY learn how much food you should be eating), fat/calorie intake...then at least work out hard enough to burn the calories to create a deficit. Its hard work, yes! But how many times have I heard "oh I just cant lose weight- "it must be my genes"...then I see you at the gym, walking leisurely on a treadmill with your canckles and you're reading a book or magazine. That is not going to cut it! You need to really work hard – sweat, weights and discipline. If not, then be fat and unhealthy and stop complaining.

    May 18, 2011 at 10:50 | Report abuse | Reply
  20. Lard

    I refuse to read ANY of your long-winded and rambling comments. I don't care to become aware of your irrelevant and, most likely, erroneous opinions. However, I do command you to read this (my fantastic post) and let it gnaw at your psyche and fester in your brain until you are reduced to a quivering mass of gelatinous goo. There... I have spoken. You may now return to your drab and wretched lives.

    May 18, 2011 at 13:38 | Report abuse | Reply
  21. Nota Hater

    I was born overweight, continued to be overweight all my life. This in spite of a life eating healthy foods (fresh fruit and veggies, white meats, whole grain breads etc...)and exercise. I swim, ride a bicycle, walk and hike. At 5'2" I am 205 pounds. I get my HDLs and LDLs checked twice a year. They are textbook normal. My blood pressure is 120/70..not too bad. I do have H. Thyroditus. Diabetes runs in my family. On weight watchers, I gained weight. They accused me of cheating. During my first pregnacy, I followed the eating plan and gained 50 pounds. I told the nutriionist that the food plan was more than I normally ate. I sit and watch others eating and wish I could eat half of what they do but I know that would make me even fatter. Are there overweight people who do not exercise or eat well, yes. Are all overweight people like that, no. It has been my experience (48 years of being FAT) that some skinny people are some of the most nasty haters out there. They have a prejudice that runs deep. And they do not even have the excuse of having a gene for intolerance. Too bad. I am a great person. I love to be outdoors, laugh, and would show up in the middle of stormy night on a dark country road for a friend who needed me. I wish people would accept that, just like hair color, our bodies are all different. How superficial some of the posters here are. I pray that none of you ever have to find yourself on the losing end of prejudice. It isn't fun.

    May 18, 2011 at 14:11 | Report abuse | Reply
  22. Jorge

    Hey fat folks out there, let me give you a tip. You are biologically inclined to put on muscle mass a good bit faster than skinny people when you work out consistently, genetics or not; so hit that weight gym, buff up and knock that skinny, obnoxious weasel into next week the next time he/she gets in your face about your weight...

    May 18, 2011 at 14:52 | Report abuse | Reply
  23. James Ison

    The big problem here is not with fat people. It's the nastiness and intolerance that has become the norm in this country. It's time to take a LONG HARD look at how we treat others. Period. Live and let live. The world would be a better place.

    May 18, 2011 at 17:50 | Report abuse | Reply
  24. Not Phil

    You people do realize that this is a science article, not a self-help article. Just saying "oh, its genetic" is unspecific and unhelpful. This study may help narrow down exactly what is going on in your body whether you are thin or fat. Giving your doctors more information about how the human body works is the point of this article. Bashing fat people and talking about carbs and going to the gym has nothing to do with this article what so ever.

    May 18, 2011 at 21:56 | Report abuse | Reply
  25. Debra Canellis

    Amazing how much people have to say about fat. I'm fat. Always have been fat. Never a thin day in my life. I got married, had babies, have a career, laugh often, love deeply, garden, play the piano, cook for my family, read, write, play with my grandson and I'm fat! Alot fat! Guess what...I have a life. A happy life. Oh yeah, I tried diets, lots of them and exercise lots of that too. Still fat. So what? I also have blue eyes, beautiful skin, old woman's hands, one leg is shorter than the other...and I'm fat. Oh well I must just be an awful person....blah blah blah....boring right? It's all so old and boring. Any new meds they come up with will have worse side affects than any fat can produce, but boy oh boy, the $$$$$$$! Let's face it, isn't that what this is all about....$$$$$$$$? I'm old...don't listen to me, I'm just the fat lady in the corner...but I'm not singing!

    May 19, 2011 at 08:47 | Report abuse | Reply
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