Blood clot risk higher in newer birth control pills, study finds
April 22nd, 2011
02:12 PM ET

Blood clot risk higher in newer birth control pills, study finds

Women who are using a newer version of birth control that contains the hormone drospirenone have a higher risk of serious blood clot, according to two studies published in the online version of the British Medical Journal.

Drospirenone is found in birth control pills such as Ocella, Yasmin and Yaz.

The studies found that drospirenone has two to three times more risk of blood clots compared with birth control pills containing an older form of a progestin hormone called levonorgestrel. Dr Susan Jick, lead authors said that these findings “provide further evidence that levonorgestrel pills appear to be a safer choice” pertaining to blood clots.

Drug makers dispute the findings, saying the studies are flawed.

The research, led in the U.S. by Jick from the Boston University School of Medicine, used information from United States medical claims data and a United Kingdom research database.

In the U.S., the study reported that in one year, there are 30.8 blood clots per 100,000 women using the birth control containing drospirenone.  That rate was lower with 12.5 blood clots for the older birth control pills using levonorgestrel.

"What’s important is that the risk is quite low," Jick said. "30 in 100,000 women is not very many blood clots. It is not that common, but it does happen more in drospirenone than levonorgestrel."

In the U.K., the yearly rates for blood clots were 23 clots per 100,000 women using the drospirenone pill and 9.1 for levonorgestrel.

"There is a risk no matter which oral contraceptive you choose to take," Jick said.  "The risk appears higher in drospirenone, than levonorgesterel.  Users should just be aware when they’re making a choice that there is a higher risk than the other."

Bayer, the maker of Yaz, challenged the study's methodology and the databases used,  saying that they “provide less reliable conclusions than are available from existing scientific evidence.”

“Given the already large and robust scientific body of evidence, in Bayer's opinion, these studies do not change the overall assessment about the safety of Bayer's oral contraceptives.”  The company said that the blood clot risk of using contraceptives that contain drospirenone is the same as those in the older birth control pills.

According to Bloomberg News,  6,850 lawsuits  were pending in the U.S. as of February 1 over alleged injuries and deaths as a result of the use of Yasmin, Yaz, or generic versions of the drugs.

Physicians cautioned against making knee-jerk reactions to the findings:

- Dr. Jill Rabin, chief of ambulatory care, obstetrics and gynecology at Long Island Jewish Medical Center in New York told WebMD, “These are strong studies, but they will not change the way I practice except that this information will be part of my conversation with patients,”

- André Lalonde, vice-president of the Society of Obstetricians and Gynecologists of Canada, cautioned against jumping to conclusions. In the Globe and Mail, he said: “Each time a new product comes out, we see this – it’s the new pill effect. Risks and complications are always greatest in new patients, much higher than those who have used the same product for a long time."

soundoff (161 Responses)
  1. AGuest9

    What needs to start happening in this country is to provide sterilization as a viable birth control method. The world is over-populated as it is, and so many welfare-collecting, beer-guzzling, Jerry Springer-watching couch potatoes are simply resulting in the country being handed over lock-stock-and-barrel to the Asians. If you can't learn yourself, why bring little ones into the world that you aren't going to teach any different?

    April 24, 2011 at 13:16 | Report abuse | Reply
    • Ituri

      Yup, nothing like eugenics and mass sterilization to make a "healthier" society. Heck, the Chinese took the advice seriously. Forced sterilization of rural women is commonplace. Whats a few ubductions and forced surguries on women in substandard surgical environments if it means the nasty little asians won't have control, right?

      Its not like people have RIGHTS, or that poverty is a CYCLICAL pattern thats nearly impossible to escape in a dog-eat-dog consumer-driven society.

      April 24, 2011 at 14:27 | Report abuse |
    • Iruti

      So you think you have rights Ituri? That's cute.

      April 24, 2011 at 19:46 | Report abuse |
    • AGuest9

      You are right, it IS cyclical – that's exactly why there are fourth-generation welfare recipients being born in this country EVERY DAY. That doesn't count the anchor babies dumped off in the southwest.

      April 24, 2011 at 21:04 | Report abuse |
    • LRoy

      So what. Any form of artificial birth control is still a very grave sin. You are putting yourself first, before anyone else. You are denying the gift of a child that only God can provide.

      April 24, 2011 at 23:30 | Report abuse |
    • Claire

      I never had an issue with taking the Pill or felt that I was more lkiely for a blood clot b/c of it. However, after the birth of my daughter and I went back on my old BC my legs felt “puffy” or like I did the day after the csection when I was retaining water. Like a good little solider I finished that pack but stopped taking them after that I was worried it might have had something to do with clotting, it was kinda like a tightness feeling in my legs as if they were swollen? Anyway, hubby is aware I’m not taking anything and we just try to prevent pregnancy with other methods, we definitely want more children but when DD is only just 7mths old we feel it wise to wait.

      April 8, 2012 at 16:08 | Report abuse |
  2. Tess

    There is an age requirement for sterilization. A person usually has to be over thirty to have the procedure done. This is applied strictly in Canada. For example to a 20 something-year old male – REFUSED PROCEDURE. This despite his three children and agreement from wife that the procedure was the ideal thing. I do not know why a person can opt for abortion or to take a pill with a risk of stroke and zero disease protection but cannot choose sterilization themselves.

    April 24, 2011 at 20:42 | Report abuse | Reply
    • Golden

      Its because in Canada our population is declining, hence all the immigration. Therefore I think people should have as many kids as they want, provided they can provide for them.

      May 1, 2011 at 14:15 | Report abuse |
    • Rosa

      In High School, I had very painful Ovarian Cysts and was put on the pill. Never had a poerlbm for 11 years. came off it to get pregnant. Stayed off for 6 years then started having super heavy periods. Was put on what the OBGyn called a strong' pill to control the flow and 2 months later ended up in the hospital with blood clots in my lungs. Couple of years on blood thinners and I will never take the pill again.

      April 8, 2012 at 16:49 | Report abuse |
  3. Tige

    This is very serious and is on the rise in women. Not 3 weeks after my girlfriend (21years old) switched from the depot shots to Yaz, she developed a DVT in her arm. The DVT started in her shoulder area which felt like a stabbing/burning feeling and went down into her arm where it then trailed off into the 3 large veins and into her forearm. Her arm swelled twice its normal size and she developed blisters becuase the skin was stretched so tight. There aren;t very many treatments for DVTs other than warfarin/coumadine and just basically blood thinners. I can't put everything in one post since she was in the hospital for 11 days and is still on treament today, this happened 2nd week of March 2011.

    May 4, 2011 at 21:49 | Report abuse | Reply
  4. Beanle

    They refer to this as a new drug, but I have been taking it for at least three years, maybe four. I did have a scare a couple of years ago when I thought I possibly had a clot in my leg, but an ultrasound showed nothing. Why are they just now saying this type of birth control is so dangerous? This is information I would have appreciated having years ago.

    December 8, 2011 at 08:03 | Report abuse | Reply
    • Defend

      I think it is a trifle odd to think of the sncdeos output as being in a time zone at all. It is thenumber of sncdeos since a particular point in time (the Unix epoch). When that point in time is represented in UTC that representation is 1970-01-01 00:00:00.

      April 9, 2012 at 03:46 | Report abuse |
    • Adam

      Nabend,es wird abends in der Regel noch ein Server voll^^ also ungefe4hr 16 Spieler.Leider nicht viel aber ihmirmen Danke ffcr dein Lob

      April 14, 2012 at 16:23 | Report abuse |
  5. Alice

    With his effective powerful prayers i was able to have my lover back just in 24 hours

    He has solution to all relationship/marriage problem and health issues such as herpes…..

    Robinson.buckler [@] yahoo com………

    Thank you! ☺️

    December 16, 2020 at 10:11 | Report abuse | Reply
  6. Merlin Miyose

    Greetings! I've been reading your website for a long time now and finally got the bravery to go ahead and give you a shout out from Dallas Texas! Just wanted to say keep up the great job!


    December 19, 2020 at 06:54 | Report abuse | Reply
  7. Nohemi Keinonen

    Woah! I'm really digging the template/theme of this blog. It's simple, yet effective. A lot of times it's very hard to get that "perfect balance" between usability and visual appearance. I must say you have done a excellent job with this. Also, the blog loads extremely quick for me on Opera. Outstanding Blog!


    December 26, 2020 at 10:15 | Report abuse | Reply
  8. Krista Rosenhagen

    Just wanna admit that this is invaluable, Thanks for taking your time to write this.


    January 2, 2021 at 02:04 | Report abuse | Reply
  9. barcelona pink jerseys

    WOW just what I was looking for. Came here by searching
    for jeremy hill jerseys

    April 2, 2021 at 19:52 | Report abuse | Reply
  10. buy sildenafil 100mg online comparison

    sildenafil 5343 https://eunicesildenafilcitrate.com/ can i buy sildenafil in canada

    April 12, 2021 at 01:33 | Report abuse | Reply
  11. vardenafil cvs

    vardenafil how to take https://vegavardenafil.com/ vardenafil prices india

    April 15, 2021 at 12:00 | Report abuse | Reply
  12. tadalafil generic

    tadalafil gel https://elitadalafill.com/ generic tadalafil

    April 18, 2021 at 06:36 | Report abuse | Reply
  13. tấm compact

    Thanks for any other great article. The place else may
    anybody get that type of information in such a perfect method of writing?
    I have a presentation subsequent week, and I'm on the search
    for such info.

    April 19, 2021 at 02:12 | Report abuse | Reply
  14. vách vệ sinh

    Hey! Do you know if they make any plugins to safeguard against hackers?
    I'm kinda paranoid about losing everything I've worked hard on. Any recommendations?

    April 19, 2021 at 06:28 | Report abuse | Reply
  15. do you need prescription for canadian prescription of cialis in usa

    how can i order cialis from a canadian pharmacy https://canadacialisstore.com/ canadian generic cialis 20mg

    April 19, 2021 at 20:46 | Report abuse | Reply
  16. vách ngăn vệ sinh

    Just desire to say your article is as surprising. The clearness on your submit is simply nice and that i could assume you're a professional on this subject.
    Fine with your permission allow me to take hold of your RSS feed to keep updated with impending post.
    Thanks a million and please keep up the gratifying work.

    April 20, 2021 at 08:37 | Report abuse | Reply
  17. https://mbee.com.vn/dia-chi-ban-vach-ngan-ve-sinh-compact-tai-ho-chi-minh-hcm/

    Quality posts is the main to invite the users to pay a quick visit the website,
    that's what this site is providing.

    April 21, 2021 at 09:10 | Report abuse | Reply
  18. https://mbee.com.vn/dia-chi-ban-vach-ngan-ve-sinh-compact-tai-ho-chi-minh-hcm

    Hey there, You've done a great job. I'll certainly digg it and personally suggest to
    my friends. I am sure they'll be benefited from this web site.

    April 21, 2021 at 11:29 | Report abuse | Reply
  19. vach ngan ve sinh

    Unquestionably believe that which you said. Your favorite
    reason seemed to be on the internet the easiest thing to be aware
    of. I say to you, I definitely get annoyed while people consider
    worries that they plainly don't know about. You
    managed to hit the nail upon the top and defined out the whole thing
    without having side effect , people can take a signal.
    Will likely be back to get more. Thanks

    April 22, 2021 at 15:47 | Report abuse | Reply
  20. tấm compact

    Hey There. I found your blog using msn. This is a really
    well written article. I will be sure to bookmark it
    and come back to read more of your useful info. Thanks for the post.
    I will certainly return.

    April 23, 2021 at 02:29 | Report abuse | Reply
  21. Stefan

    You're so cool! I do not think I have read through
    anything like that before. So nice to discover somebody with unique thoughts on this
    subject matter. Really.. thank you for starting this up.
    This web site is one thing that is required on the
    internet, someone with a little originality!

    April 24, 2021 at 05:31 | Report abuse | Reply
  22. https://mbee.com.vn/

    Have you ever considered creating an e-book or guest authoring on other sites?
    I have a blog based upon on the same subjects you discuss and would really like to have you share some stories/information. I know my subscribers
    would enjoy your work. If you're even remotely interested, feel free to send
    me an e mail.

    April 25, 2021 at 04:15 | Report abuse | Reply
  23. vách ngăn vệ sinh

    An outstanding share! I've just forwarded this onto a co-worker
    who had been conducting a little research
    on this. And he actually bought me lunch due to the fact that I discovered it for him...
    lol. So allow me to reword this.... Thanks for the meal!!
    But yeah, thanx for spending the time to discuss this matter here on your site.

    April 30, 2021 at 19:11 | Report abuse | Reply
  24. buy generic cialis without prescription canadian pharmacy

    cialis on line purches canadian pharmacy https://canadacialisstore.com/ cialis on line purches canadian pharmacy

    May 1, 2021 at 04:11 | Report abuse | Reply
  25. erection pills viagra online

    erectile winstrol https://canadaerectiledysfunctionpills.com/ erectile medication where to purchase

    May 2, 2021 at 10:22 | Report abuse | Reply
  26. avana

    buy avana online buy avana online

    May 4, 2021 at 11:47 | Report abuse | Reply
  27. chloroquine phosphate aralen

    chloroquine antimalarial https://chloroquineorigin.com/ chloroquinne

    May 5, 2021 at 07:50 | Report abuse | Reply
  28. brimonidine

    brimonidine tartrate brimonidine eye drops

    May 15, 2021 at 11:44 | Report abuse | Reply
  29. vách ngăn vệ sinh

    I'm really enjoying the design and layout of your blog.
    It's a very easy on the eyes which makes it much more pleasant for me
    to come here and visit more often. Did you hire out a designer to create your theme?
    Great work!

    May 17, 2021 at 14:38 | Report abuse | Reply
  30. cyclosporine

    buy cyclosporine online buy cyclosporine uk

    May 24, 2021 at 00:26 | Report abuse | Reply
  31. Tembepteriope

    tadalafil order online no prescription https://apcalisetadalafil.com/ – cialis without a prescription tadalafil generic where to buy cost tadalafil generic side effects of tadalafil

    May 24, 2021 at 04:08 | Report abuse | Reply
  32. brimonidine

    combigan side effects buy combigan

    May 24, 2021 at 10:52 | Report abuse | Reply
  33. Unitmerienepeft

    cialis tadalafil buy tadalis generic tadalafil from uk cialis cost https://tadalafilol.com/ – where to buy cialis without prescription

    May 25, 2021 at 06:58 | Report abuse | Reply
  34. Tembepteriope

    cheapest tadalafil cost https://cttadalafil.com/ tadalafil online with out prescription cheap generic cialis for sale tadalafil generic where to buy

    May 25, 2021 at 06:58 | Report abuse | Reply
  35. https://mbee.com.vn/dia-chi-ban-vach-ngan-ve-sinh-compact-tai-ho-chi-minh/

    It's awesome to go to see this site and reading the views of all colleagues on the topic
    of this paragraph, while I am also eager of getting familiarity.

    May 29, 2021 at 00:01 | Report abuse | Reply
  36. buy cialis online

    tadalafil blood pressure cheap cialis tadalafil peptides

    June 5, 2021 at 05:12 | Report abuse | Reply
  37. aralen price usa

    malaria drug hydroxychloroquine what is clonidine hydrochlorazine

    June 6, 2021 at 06:02 | Report abuse | Reply
  38. cialis at canadian pharmacy

    what does tadalafil do tadalafil cialis elevex 20 mg

    June 6, 2021 at 09:40 | Report abuse | Reply
  39. hydroxychloroquine sulfate tablet

    is chloroquine a sulfa drug trump hydroxychloroquine chloroquine natural sources

    June 6, 2021 at 22:03 | Report abuse | Reply
  40. 威而鋼價格

    Nice i really enjoyed reading your blogs. Keep on posting. Thanks


    June 10, 2021 at 10:38 | Report abuse | Reply
  41. 威而鋼價格

    Nice i really enjoyed reading your blogs. Keep on posting. Thanks


    June 10, 2021 at 20:38 | Report abuse | Reply
  42. www.pharmaceptica.com

    sildenafil purchase india https://pharmaceptica.com/

    June 20, 2021 at 07:30 | Report abuse | Reply
  43. pharmaceptica.com

    chloroquinone https://pharmaceptica.com/

    June 22, 2021 at 11:39 | Report abuse | Reply
  44. gia vach ngan ve sinh

    It's in fact very complicated in this busy life to listen news on TV, thus I only
    use web for that purpose, and get the hottest news.

    June 22, 2021 at 18:20 | Report abuse | Reply
  45. pharmaceptica.com

    erectile vitamins https://pharmaceptica.com/

    June 23, 2021 at 07:35 | Report abuse | Reply
  46. pharmaceptica.com

    what is hydroxychloroquine for https://www.pharmaceptica.com/

    June 26, 2021 at 15:57 | Report abuse | Reply
  47. pharmacepticacom

    generic tadalafil from uk https://www.pharmaceptica.com/

    June 27, 2021 at 14:54 | Report abuse | Reply
  48. www.pharmaceptica.com

    chloroquine phosphate side effects https://www.pharmaceptica.com/

    June 29, 2021 at 15:48 | Report abuse | Reply
1 2

Post a comment


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.