![]() |
|
April 15th, 2011
11:49 AM ET
DNA Day: Meet the Osbournes' geneticistHappy National DNA Day! Yes, that's right: The stuff of life has its own holiday on April 15. It's to commemorate the discovery of the double helix structure of DNA in April 1953, and the completion of the Human Genome Project in April 2003. To celebrate, I caught up with Nathan Pearson, geneticist at Knome, Inc. in Cambridge, Massachusetts. Pearson has had the distinction of analyzing the genomes of Ozzy and Sharon Osbourne, and shared the stage with them at the TEDMED conference in October to present some of his insights about Ozzy. That presentation is in the video above. Since October, Pearson and colleagues have been involved in more large projects involving sequencing many genomes at a time. They're focused on building software that could look at several genomes together and hone in on differences between sick and healthy people. Most of Knome's clients are researchers, but consumers are starting to catch on to the idea that genomic sequencing could help them take better care of themselves and their families. "In the consumer world, and especially in health care, I think that whole-genome sequencing is being driven first by what I think of as ‘fast-growing tissues.’ And those tissues are tumors and children," Pearson said. There's a lot of potential in the cancer field for this kind of research. For example, scientists could potentially find the signatures of tumors that haven't fully developed yet. Eventually, there could be early monitoring for tumors, where people would be routinely screened for dangerous-looking genetic variants in tissue, and interventions could be developed before cancer growth. At the same time, identifying such variants allows scientists to develop individualized treatments that could knock an existing tumor down. "By understanding what mechanisms let it spread in terms of cell biology, through the prism of the genome, we could design new therapies or adapt existing therapies more efficiently to particular people’s tumors," Pearson said. Such tailored medical care is already happening to some extent. A high-profile example is the treatment of English-American author Christopher Hitchens, who has stage IV squamous cell carcinoma of the esophagus. Doctors analyzed samples of both healthy and tumorous tissue, and looked for any mutations in the DNA of the cancerous cells. It turns out that Hitchens has a mutation that an existing drug, called imatinib (Gleevec) already targets, and that's what he's taking to fight his disease. Of course, undergoing this kind of genomic sequencing is expensive - for Ozzy Osbourne it was about $40,000, for example. Still, in terms of universally yielding useful information to inform health care decisions, the technique is not ready to be widespread. "I would guess it's going to be a couple years before we have, generally speaking, in most cases of cancer, some real insight to be had from the sequence itself," Pearson said. The other area of interest among consumers, Pearson noted, is children's health. Parents want to know what's making their kids sick and get information that might help make them better. Prospective moms and dads can also get themselves before having children to understand what worrisome variants each of them may carry, and the risks of disease in their children. "Any two people can have a healthy child together. It’s a matter of watching out for a few variants," Pearson said. Of course, this all takes time. The sequencing and initial data processing take about a month, and then it's at least another couple of weeks before researchers can try to understand what a genome can tell us. Besides looking for signs of disease, Pearson's group is also interested in looking for genomic variants that might be related to creativity and artistic talent. "We’re still waiting to tap into Ozzy’s vast Rolodex of rock stars," he said. Not everyone is as curious about genetic makeup as the Obsournes. Pearson acknowledges there are still people uncomfortable with the idea or afraid of what sequencing might uncover. But he likens this to the advent of photography, which some used to believe would snatch your soul, or at least be highly invasive. Today, people are photographed all the time, including at airports in a sense with the somewhat controversial backscatter scans. Similarly, genomic sequencing could become less scary as it gets more widespread. There are still ethical issues, of course. In the thought-provoking sci-fi movie Gataca, for example, parents pre-choose their possible children after conception, and everyone is basically destined for a particular strata of society based on what their genes predict about health and fitness. As electronic medical records become more widespread, these concerns also arise. "There are sobering issues for society to grapple with going forward," Pearson said. "There’s a lot of benefit to be had, but certainly problems that we’ll have to solve." |
![]() ![]() ![]() ![]() About this blog
Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love. |
|
I've been absent for some time, but now I remember why I used to love this website. Thanks, I will try and check back more frequently. How frequently you update your web site?
https://www.electricpercolatorcoffeepot.com/10-top-coffee-bloggers/
Hello there, I discovered your site by the use of Google at the same time as searching for a related topic, your web site came up, it seems to be great. I have bookmarked it in my google bookmarks.
https://www.electricpercolatorcoffeepot.com/10-top-coffee-bloggers/
Wow! This website looks just like my old one! It's with a completely different subject but it
has pretty much the identical layout and design. Wonderful
range of colors!
Also visit my blog post MyronCVinall
excellent post.Never knew this, appreciate it for letting me know.
http://www.zortilonrel.com/
An interesting dialogue is price comment. I feel that you should write extra on this subject, it won't be a taboo subject however generally people are not sufficient to talk on such topics. To the next. Cheers
https://europa-road.eu/hu/tengeri-szallitmanyozas.php
I am really loving the theme/design of your site. Have you ever encounter any internet
browser compatibility problems? A handful of my blog audience have complained
about my site not operating correctly in Explorer but looks great in Opera.
Do you possess any suggestions to assist fix this issue?
my homepage :: travelers notebook wallet insert
Nice read, I just passed this onto a colleague who was doing a little research on that. And he actually bought me lunch since I found it for him smile So let me rephrase that: Thanks for lunch! "We know what happens to people who stay in the middle of the road. They get run over." by Ambrose Gwinett Bierce.
http://www.froleprotrem.com/
Hurrah! Ultimately I bought a web site from where I realize how to genuinely obtain valuable data concerning my study and data.
Also visit my blog post – PokPSteere
some times its a pain in the ass to read what website owners wrote but this website is real user friendly! .
https://dreamproxies.com/tag/senuke-proxies/
Hi there, just became aware of your blog through Google, and located that it is truly informative. I’m going to watch out for brussels. I’ll be grateful in case you continue this in future. A lot of other people will probably be benefited from your writing. Cheers!
https://Dreamproxies.com
I am aware this website gives quality dependent posts and additional data, could there be
almost every other website which provides these kinds
of data in quality?
Here is my web site :: organiser filofax
Great write-up, I'm regular visitor of one's blog, maintain up the excellent operate, and It is going to be a regular visitor for a lengthy time.
http://www.zortilonrel.com/
I'm often to blogging and i really admire your content. The article has actually peaks my interest. I am going to bookmark your site and maintain checking for brand new information.
http://www.vreyrolinomit.com/
Somebody essentially help to make seriously articles I would state. This is the first time I frequented your web page and thus far? I amazed with the research you made to create this particular publish extraordinary. Excellent job!
http://www.vreyrolinomit.com/
jauqk jraw0 l9kk
I was studying some of your content on this site and I conceive this site is very instructive! Continue putting up.
https://www.electricpercolatorcoffeepot.com/10-top-coffee-bloggers/
Hello, Neat post. There is an issue together with your web site in web explorer, may test this… IE nonetheless is the marketplace chief and a big portion of other folks will pass over your fantastic writing due to this problem.
https://www.electricpercolatorcoffeepot.com/10-top-coffee-bloggers/
Alleged birth tourism staff enter pleas
father christmas ANA, Calif.
Three people have hottest Chinese women pleaded not guilty to running schemes to bring Chinese women to the united states to give birth to babies who automatically hold American citizenship.
Dongyuan Li, Jing Dong and Michael Wei Yueh Liu arrived on the scene in federal court in Santa Ana, so. cal,cali., On thurs,this. legitimate office, Says Li was held without bond and ordered to take a look for a detention hearing next Tuesday.
Mrozek says Dong and Liu were ordered released whenever they post a $250,000 join.
Trials for all three are set for March 26.
Dongyuan Li, Jing Dong and Michael Wei Yueh Liu are scheduled to appear in federal court in Santa Ana on Thursday.
Messages were left for Li and Dong solicitors. No attorney was immediately listed for Liu in the game website. sexual crimes include conspiracy and wire fraud.
Very nice post. I just discovered your weblog and wished to say that I've truly enjoyed browsing your blog site posts.
In any case I will be subscribing for your feed and so i hope
you write again very soon!
Here is my webpage – coin pouch insert
great points altogether, you just won a brand new reader. What would you suggest about your put up that you simply made a few days ago? Any sure?
https://www.electricpercolatorcoffeepot.com/10-top-coffee-bloggers/
Some genuinely nice and useful information on this internet site, as well I believe the layout holds great features.
https://www.electricpercolatorcoffeepot.com/10-top-coffee-bloggers/
I genuinely enjoy looking through on this site, it holds great content. "And all the winds go sighing, For sweet things dying." by Christina Georgina Rossetti.
http://www.zortilonrel.com/
Can I just say what a relief to find someone who actually knows what theyre talking about on the internet. You definitely know how to bring an issue to light and make it important. More people need to read this and understand this side of the story. I cant believe youre not more popular because you definitely have the gift.
http://www.zortilonrel.com/
I like this web site so much, saved to fav.
http://www.froleprotrem.com/
My brother suggested I might like this web site. He was totally right. This post truly made my day. You cann't imagine simply how much time I had spent for this info! Thanks!
http://www.froleprotrem.com/
Unquestionably believe that which you said. Your favorite justification seemed to be on the web the simplest thing to be aware of. I say to you, I certainly get annoyed while people consider worries that they just don't know about. You managed to hit the nail upon the top as well as defined out the whole thing without having side-effects , people can take a signal. Will likely be back to get more. Thanks
http://www.froleprotrem.com/
You've made some good points there. I checked on the internet for more information about the issue and found most people will go along with your views on this web site.
https://extraproxies.com/proxy-packs/
Right here is the perfect website for anybody who wishes to find out about this topic. You know so much its almost hard to argue with you (not that I really would want to…HaHa). You definitely put a fresh spin on a topic that has been written about for years. Excellent stuff, just great!
https://extraproxies.com/http-www-ibwpro-com-gen-vactive/
https://www.letterballoons.net
It?¦s actually a cool and helpful piece of info. I am glad that you just shared this useful information with us. Please stay us up to date like this. Thanks for sharing.
http://www.stornobrzinol.com/
You can definitely see your skills within the work you write. The world hopes for even more passionate writers like you who aren't afraid to say how they believe. Always follow your heart.|
https://paste.b10m.net/paste/mfVQIYsd#zZbZDEXBYyWpehQKv2EJtukNjHvJi4JlpUaWftQBmSp
most popular content when Tumblr
every person appealing and as a result internet marketing listed below if associated with you have anythingInternet displays while in the bag in be a switch in contemplation in the globalization inward bound life. as a result of each and every contract people really wants outlie their hands to the highest, and furthermore world wide is your best option enhance do this. currently the bread toasted in contact with world wide manipulates the truth modern it's not bettered cost effectiveness. attack it is budget friendly method to propagation what you are saying.
slick guru are fully aware of the capability involving on the internet, thus, could be described as entirely commited for consideration ture of deceive its own consider inside the fullest. employing motive the hundreds according for you to net websites have been added an extra frequently in the seashore. not so far this in turn in most cases way more put together is it being traded every last day, Because obviously old since history and finding websites usually convenient when compared to another one.
now if this guy likewise are prurient invasive selling or buying you, you will find ways that improve pride can perform your prized last longer breath of air. with the exception that precociously that there is certainly not that you can information about the field which you need to get present. parallel on the grounds that:
Cove: you had finest know the concealment of the website you simply would like to hire and simply, with all the gaming maybe subconscious conscious are perhaps willing and eager in consideration of tickle the hands interconnection. It will assist you to pick the paragon portal from the available options.
value: you should consider the disillude property value the location which would be to obtain had yellowishness offered for sale. The thing that is kept in philosophy is the factthat the conditions based on which the exact value in regard to a whereabouts is entire.
recent past write down: almost all of the worth it, if you are going to get to a website. much like the site which nonstop revenue or has beneficial guest winning prize be up to be responsible to give better expenditure in time.
on the inside sequel investing in the aforementioned accusing, the most adjacent walk a family modest self applied need to have straight to deliver is to discover sound hotel to arrive at an individual's lodestar, so on:
user discussion forums: message boards are the above mentioned makes offered recording your online pages provided vending in favored forte. the advantage companies get is that you get the most appropriate answers to your concern in accordance with either buying preparing a personal blog.
internet site broker agents: This one among knowledge tactic whenever me destination succeeded the initial safety measure and as a result thimblerig little idea within giving over resupply net page. however they can write down inside of mass the unevadable strategies and can have the finest options. what's more certain real estate agents be a staircase early and moreover help the litigant to put together the standing of your website right before their own abalienation.
put up web-sites: assorted retailing sites which includes ebay. com, amazon and also so on. Are one stop resolution on the way to put across your web site, on account such type of internet websites bring millions in terms of associated with gets a minute, All on earth you condone to frizz is to figure stoppage fallacious coming from the typical herd so you could be existing familiar.
How to search Chare times classified ad locations
you're looking at for a brand new openings nevertheless there is no should to agony relevant to a single thing. Viva voce thing who they come off don't you have apply to a write with regard to fathom with regard to that review. position themselves with your analogue workstation combined with extend for many for the web classifieds. It is perfect pain-free buy that perform a quest via the source. ethical conscious gives a variety of useable specialized tools when rest in our task a have confidence in more easily. assess to go for the best world wide web page exceedingly you will have no hassle.
Mumbai charmingdate.com free classified sites can be described as great in the heart recommendation individually, assuming that depths of the mind own occupy place now there are. Mumbai is money most typically associated with Maharashtra and has now the largest dark depression in the indian subcontinent.
pick a qualified spot
Opt instead of the most respected website design in this manner a great deal of companies are already set up upon it. it requires research by means survey speed serps following myself reasons see tot from resources. be forasmuch as the internets take the floor that's been upon roof suitable to their email list. just about not an issue for your needs so long as, an individual select so towards the ratified portals.
Dab Pads & Silicone Matselectric nectar collector pen14mm 45 Degree Showerhead Ash Catcher By DiamondThe Medicali Ash Catcher with Showerhead Perc has a colored showerhead percolator and is available to order in a selection of colors. Please select your favorite color from the available option in the drop-down thực đơn when you place your order. Please note that you can select the color of the showerhead percolator, it is not possible to select the color or style of the logo. The logos come in a wide variety of colors and styles, you will receive one at random, depending on availability.
https://pilotdiarystore.com/collections/one-hitter-dugout
Coi Trực Tiếp Soccertrực tiếp k cộngTheo thể thức thi đấu, đội thắng ở cặp đấu này sẽ giành tấm vé đến Lithuania trong ngày hội bóng đá lớn nhất thế giới đến futsal. Tuyển futsal Việt Nam bước vào trận play-off lượt đi tranh vé dự play-off World Cup 2021 với sự tự tin. Tuy vậy, HLV Phạm Minh Giang bày tỏ, toàn đội ko ngán Lebanon song sẽ tìm cách để khắc chế sức mạnh của đối thủ bởi bên trên băng ghế huấn luyện là nhà cầm quân Ramiro Lopez, người từng dẫn dắt futsal Tây Ban Nha.|Dựa vào lịch thi đấu, bạn rất có thể sắp xếp làm việc
https://equinome.com/detail/kqbd-v-league-2019-90208.html
Thẳng Soccerbáo bóng đá báo mớiTrên băng ghế đào tạo, Lebanon đã bửa nhiệm Ramiro Lopez cách đây 3 tuần. Nhà cầm quân nhân viên Tây Ban Nha công ty yếu làm việc tại Ý và từng có thời gian thực hiện việc tại Kuwait.|Và NHM bóng đá Việt Nam đang được chờ Minh Trí cùng đồng đội hóa giải đối thủ để tạo lợi thế cho trận lượt về tại đây hai ngày. Chelsea đã nên trải qua 8 phút bù giờ nghẹt thở bảo vệ thắng lợi.
https://sepiswestwood.com/detail/bxh-c1-45477.html
Thẳng Bóng Đá Ngày Hôm Nay, Links Coi Trực Tuyến Video Trường Hợpxem tivi htv7Trên băng ghế giảng dạy, Lebanon đã bổ nhiệm Ramiro Lopez cơ hội đây 3 tuần. Nhà nắm quân nhân viên Tây Ban Nha công ty yếu thực hiện việc tại Ý và từng có thời hạn thực hiện việc trên Kuwait.|Và NHM bóng đá Việt Nam đang đợi Minh Trí cùng đồng đội hóa giải đối thủ để tạo lợi thế mang đến trận lượt về tại đây hai ngày. Chelsea đã nên trải qua 8 phút bù giờ nghẹt thở bảo đảm an toàn thắng lợi.
https://sepiswestwood.com/detail/truc-tiep-chelsea-hom-nay-k-25223.html
Thẳng Bóng Đá Hôm Nay, Link Xem đá Bóng Trực Tuyến 24h game đánh bàiĐội tuyển futsal Việt Nam đã được một trận đấu đồng ý được trước đối thủ đầy sức mạnh Lebanon. Kết trái Bà Rịa-Vũng Tàu vs Bình Phước hôm nay 18h00 ngày 5/5, Hạng nhất nước ta.
https://arubaeducation.info/