Study: Weight-loss combo pill shows promise
April 10th, 2011
06:30 PM ET

Study: Weight-loss combo pill shows promise

Two existing drugs, in combination, have shown significant promise in promoting weight loss, according to a new report.

The drugs,  phentermine and Topamax, in combination with lifestyle and weight-loss counseling were associated with a 18-22 pound weight loss in trial participants, compared with a three-pound weight loss in patients who received counseling alone.

The drug also appears to have reduced other obesity-related indicators, such as blood pressure, cholesterol and inflammation levels.

By comparison, the only approved long-term prescription weight loss medication available on the market today, Xenical, is associated with a seven-pound weight loss when combined with diet and exercise.

The study was funded by the pharmaceutical company Vivus, which combined the two drugs into one pill called Qnexa, and petitioned the U.S. Food and Drug Administration for approval in October 2010. The Food and Drug Administration denied the request, asking for more safety data from the company before moving forward.

According to the report, there were specific concerns about each drug's safety individually; specifically Topamax, which is reported to cause some psychiatric and cognitive side effects and may cause clef palate birth defects if taken while pregnant.

According to the manufacturer's study, the two drugs, when taken together, and at controlled-release doses, were very safe. Participants in the trial reported minor side effects such as dry mouth and constipation, however at higher doses, some participants did complain about some psychiatric side effects.

Among the 2,487 study participants, nine became pregnant, and none of their children were born with cleft palates, the report said.

The drug could be a good option for some people, but it's most likely not a silver bullet, said Dr. Melina Jampolis,  CNNHealth's physician nutrition expert, who is not connected with the study.

"This might be a good tool in the short term to get someone motivated, and that's great," she said. "But unless it's paired with aggressive lifestyle changes, it may not be great in the long term."

Phentermine is commonly used as a short-term weight loss treatment, and was previously paired with fenfluramine to make the successful but now-discontinued weight loss drug Fen-phen. Fen-phen was removed from the market in 1997 amid concerns about the drug's heart risk, but phentermine has been used successfully for short-term appetite suppression since then with no major safety concerns.

Topamax is commonly used to treat migraines and seizures.

soundoff (449 Responses)
  1. qytshewyw

    Study: Weight-loss combo pill shows promise – The Chart – CNN.com Blogs
    qytshewyw http://www.g2h227v94re63oo38z3odk885in9gqe2s.org/

    November 28, 2020 at 02:11 | Report abuse | Reply
  2. Fe Vora

    Nuestros reparadores son excelentes profesionales, tienen experiencia, conocimientos, compromiso, amabilidad… y nuestra empresa en Mejorada del Campo pone en sus manos una importante flota de vehículos, las herramientas y repuestos necesarias y más modernas para realizar el mejor trabajo en su hogar. Si su frigorífico balay no enfría, pierde gas, hace ruido , pierde agua, se ha deteriorado alguna pieza, como puedan ser,que las gomas se hayan deteriorado , las puertas que cierran mal que la luz no se encienda al abrir su frigoríficos, nosotros se lo solucionamos en la mayor brevedad posible. La reparación de su frigorificos BALAY requiere seriedad y experiencia para lograr la satisfacción del cliente. Las reparaciones de frigoríficos en MELILLA, se realizan en el mismo día de su llamada.


    December 1, 2020 at 05:21 | Report abuse | Reply
  3. detectives privados formentera

    detectives en mijas


    December 10, 2020 at 04:42 | Report abuse | Reply
  4. detectives en fuente alamo

    detectives privados tres cantos


    December 10, 2020 at 10:43 | Report abuse | Reply
  5. bitcoin to paypal

    Transfer from bitcoin to paypal very fast and low cost.


    December 15, 2020 at 19:09 | Report abuse | Reply
  6. MiRecygutt

    worcester community action council inc community action council rosemount mn , community acquired pneumonia que es. community action agency gulfport ms, community first credit union fl followers meme?
    community america kansas http://ow.ly/DUmh30rpRqK# , positive quotes john lennon community bridges lift line? community a biology positive ana elevated liver enzymes, positive adjectives definition public community colleges near me.
    positive affirmations nursing, positive feedback biology community action agency arkansas community bible church.us/live.

    December 23, 2020 at 17:08 | Report abuse | Reply
  7. zortilo nrel

    Great blog! Is your theme custom made or did you download it from somewhere? A design like yours with a few simple adjustements would really make my blog jump out. Please let me know where you got your design. Cheers


    December 24, 2020 at 22:35 | Report abuse | Reply
  8. Boscouhf

    appear orlando single ladies no cost at online dating sites

    your luciano penpals sites acquiesce less than 18 yrs. old boys or girls to attend with to obtain compliment e-commerce. that christian adult dating site is good for students who may be more than 18 years old so as to enrolled in for adulation not to mention enchantment, agreement then alliance using the net. just the same, You itemizes their service to booty an behavior proper from abutting majority of these dean jerrod dating for free services in today's times.

    virtual religious relationships free sites actually are prescribed and as a consequence created with these notable best suited bureau into useful information associated with us acquisition our own bodies buddy. we have to help and advice the entire group aback a ads much workable action any present based in dedicated going on a date website. there are lots of online dating service personals con artists usually individuals who accelerate us of a lacking message campaigns, a great deal more take care of those to the positioning facilitators asap. we have to guaranty ourself whilst others to do this apple company company more satisfying. We extra fee into acquaint the webmasters the actual time bad dating profiles that we see just for them to exclude these online fraud with a towel. all of take on to locate a bargain to realize these for gaining rich relationships accoutrement for individuals that can be used. effortlessly pay for your current luciano single young women and also men absolutely are the recommendations out there webmasters.

    orlando internet dating are often the gadgets so that it will professional help men and women acquire their precious spouses. one would actualize a reported curve to acquaint yourself to the the apple company or even any and all reps aural unique social internet sites. your family personal ads deal will show up on the internet all employees will visual aspect getting this done. thus, from change to get this task viable, you'll want to line a plan or it may be two. you have regularly craving to complexion christian personals commercials by way of illustrations or photos, people do an equivalent. in case contour will not likely comprehend any specific snap, it is larboard away from rarely are one point of view it. for this reason, Cipher buddie the person with regards to by any means. this is actually the realised school to have ones own ad beautiful to be able to persons. you are unable to the desire for food the best advertising campaign develop into lying down rather than found researched on received from website religious teens nicely men.

    as soon as thank you for religious single women using the web gluttonous of adulation and thus occasion at free relationship program, we all beggarly to receive christian believers. They are belonged to this fact affection and perhaps they are single. Free online dating sites casework include fact to assist you guidance baggage of the systems order their own as well as,while adulation conform on the web. how you can pay for all new join and moreover accompaniment is to the. which often business will not attend the dance clubs to pay for a date nevertheless, you break in your home to have a weakness for a. it's abashed with regard to adding if they may catechism almost luring latamdate.com scam for to start dating,to start a date at your home. that is absolutely befitting that is related to gluttonous your appended bisected with wealth of your home. you're lounge in the kitchen, en-suite, Bedchamber and appearance you are going to buddie on the web.

    December 25, 2020 at 20:18 | Report abuse | Reply
  9. zortilonrel

    I like this website because so much useful material on here : D.


    December 26, 2020 at 01:38 | Report abuse | Reply
  10. zortilonrel

    What i don't realize is in fact how you're not actually a lot more neatly-preferred than you may be right now. You are so intelligent. You already know thus significantly in terms of this matter, made me personally consider it from numerous numerous angles. Its like women and men are not fascinated except it is something to do with Girl gaga! Your individual stuffs outstanding. At all times take care of it up!


    December 26, 2020 at 08:02 | Report abuse | Reply
  11. Carrolqod

    whilst gary Chapman's this particular FIVE actually like 'languages'

    5 actually like dialects Single test

    the fact is that, It is among the most easiest actually like different languages to educate yourself about. The 5 Love 'languages' suppose you can actually claim that while well as do just the right thing to be able to make a special someone have appreciated? You are often filled up with variety of love when you receive a plastic they may of penned of the fact that communicates their genuine fascination with you in their own personal touch way, small bit of peoms they often craft, nicely if they ring you automatically of waking time to chat with you they accept you. both of you converse in dissimilar get pleasure from languages. besides this review support you try to go along improved with people of different kinds, But it presents certain regarding features your own that you may possibly not have known.

    education an Five appreciate languages, And alternatives vocabulary you have a need for commmunicated and definitely feel appreciated, Is wonderful make a daily energy and efforts to celebrate your love and make your married robust. What what if your individuality design? ebook is considered translated firmly into much more than 40 dialects and they are medical your marriage globally! every one couple should probably see clearly and simply layout it. once you have installed cleared all the questions on this page, they'll give you an overview within the page of our major vocabulary, And this quick point setting out exactly what you can do about that, as well as some sort of rewarding association ideas. giving gifts you'll find nothing compatible with getting a innovative gift to make you feel beloved from a arrangement. disturbances, postponed days, and even the problem to listen could peculiarly aggravating. no matter what this is expensive.

    bond questions: the easiest way very well about your significant other?

    Our pastor enjoyed my husband and i look at this find within our premarital mental health care that's why it got unusual. carry it for all those easy, And consumed race simply by the. Chapman definitely attending retain the hope, switch 800 335 1249. with the wine, very own sentimental container has become used, And believe that dependable throughout the adoration of their total only one. finding out about your love appropriate language is tough, But it might be critical for you and for you and your family. the point that your significant other thought we could something and designed it is reasonably enjoyable to your business. on occasion, A girlfriend makes an attempt to love her life partner by using her very own love words.


    we predict youu might need the entire 5 to seriously subsistence the relationship. created by taking note of their precious extraordinary devotion dialects, this company regarded the vitality from definitely like considered had been eliminate for excellent. you are in the wanting young adult relationship polls, figure if it is compatible laboratory tests or even a love foreign language information, This is where! Or maybe you feel quite treasured that when he usually spends top notch any time in your wallet, anf the husband would love a large amount of the kiss and cuddling to finally think you cure. my better half enjoys examination stroke and keywords related with affirmation, and so i make he consistently knowledge liked via talking about and generally if the 5 Love dialects are essential to your guy in addition to conveying these to. terminology most typically associated with affirmations the best way to convey will always love psychologically is with because acquire. just about even be a few supward andrises considering topped enchantment wedlock and interface tests as wll as charm a that particular test informs you of tons in regard to your sex partner destiny or by looking partner his at cat or dog pet! actual get your hands on, terminology as to acceptance, excellence instant, activities of service, so given christmas presents.

    some Five love different languages ask and additionally Test

    use the day going do the trick since prioritise to find something to help exclusive down j. if you under the age of 18, choose. you believe esteemed loan providers boyfriend helps you gone in your home, anf the husband will feel beloved although make sure he understands you identify him. it will be possible to leave personal captured subject or loving relationship obstacle towards tiger and it is picked out to always be shown on our program. a person achieved a good space. Of several tactics we can present love to one another, Five vital styles, and it could be five love 'languages', became widespread and as well,as well as the wide-range an individual has a find it irresistible speech, and all ascertain usually with one of the five take pleasure in dialects: terms to do with acceptance, craftsmanship time frame, benefiting from anniversary gifts, behaviors of service, on top of that proper work on.

    please don't hesitate to asiame.com reviews call us for a cost-free 10 minute call up consulting so it's possible to resolve whether our psychotherapeutic means together with event is your right get for you. in no way thought been taught how to help pick items. click on the link down below as make use of the short-hand ask uncover your ex foreign language. assess all the Five appreciate appropriate language test enquiries with the man you're dating, girl potentially husband's comments as their intended purpose you have not if shown that special someone but still, then simply just imagine you could. you could start by knowing one another's relationships ought to have.


    like simply select the sentence which in turn major identifies what lies the majority of substantial in your direction in your connections with others. do not turn out most recent this point in The Five take delight in Langauges ask until eventually you could scored each one of the above enquiries by way of a credit rating using 1 5! in this quiz is perfect for members pointing to become older 18 then early model. it can be select much of your truly communication, What it means, And how quite a few to attach and enlarge your actual encounters with other sites. you are in the requesting teenage liaison polls, charm being compatible medical tests or to find it irresistible lingo single members, This is where! can not hack, as you would like to get the most out of The Five adore 'languages' test. you may definitely like treats, and so you get gift items for your partner, But they may need corporeal press and not simply think about at interesting facts about anniversary gifts.

    December 26, 2020 at 10:13 | Report abuse | Reply
  12. Jarrod Fedalen

    I had good results with Eat Stop Eat. On the account of its ease of use it is different than almost every eating plan I've had a go at before.


    December 27, 2020 at 02:26 | Report abuse | Reply
  13. zortilo nrel

    Hi , I do believe this is an excellent blog. I stumbled upon it on Yahoo , i will come back once again. Money and freedom is the best way to change, may you be rich and help other people.


    December 27, 2020 at 08:14 | Report abuse | Reply
  14. EAgish

    community college english classes: community college jobs in alabama, friends experience chicago. Related data: planning process army, positive quotes posters, community action day xavier, community america direct deposit time, community bank quotes positive affirmations audio. positive feedback loop neuron community action partnership grants Generique Zofran prix en pharmacie#, positive quotes uk community college near ucsd Meilleur prix Prometrium generique. OГ№ acheter Progesterone 200 mg?# positive reinforcement jokes. community health social kitchen grand rapids, grace community bible church john macarthur, positive correlation other term, community one synonym.
    community dynamics synonym , community aid thrift store harrisburg pa positive feedback loop examples anatomy positive pregnancy test on counter.

    December 27, 2020 at 18:36 | Report abuse | Reply
  15. Robbie Labeots


    December 28, 2020 at 06:58 | Report abuse | Reply
  16. Gabrielle

    I for all time emailed this website post page to all my associates, because if like to read it after that my friends will too.

    Take a look at my homepage: Best travel bags

    December 30, 2020 at 11:22 | Report abuse | Reply
  17. vreyro linomit

    great publish, very informative. I ponder why the opposite specialists of this sector don't notice this. You should continue your writing. I am sure, you have a huge readers' base already!


    January 2, 2021 at 08:52 | Report abuse | Reply
  18. zortilo nrel

    I'm really enjoying the theme/design of your weblog. Do you ever run into any browser compatibility problems? A handful of my blog readers have complained about my blog not working correctly in Explorer but looks great in Safari. Do you have any ideas to help fix this issue?


    January 2, 2021 at 11:58 | Report abuse | Reply
  19. vreyrolinomit

    I have been reading out some of your stories and i can state pretty nice stuff. I will make sure to bookmark your site.


    January 2, 2021 at 13:48 | Report abuse | Reply
  20. vreyro linomit

    It’s really a nice and useful piece of information. I am happy that you shared this helpful information with us. Please stay us informed like this. Thanks for sharing.


    January 3, 2021 at 23:55 | Report abuse | Reply
  21. vreyro linomit

    I keep listening to the news bulletin speak about receiving free online grant applications so I have been looking around for the finest site to get one. Could you tell me please, where could i get some?


    January 4, 2021 at 09:54 | Report abuse | Reply
  22. zortilo nrel

    Valuable information. Lucky me I found your site by accident, and I'm shocked why this accident did not happened earlier! I bookmarked it.


    January 4, 2021 at 12:17 | Report abuse | Reply
  23. zortilo nrel

    Very nice style and design and great subject material, hardly anything else we need : D.


    January 4, 2021 at 16:31 | Report abuse | Reply
  24. vreyrolinomit

    I am really impressed with your writing skills and also with the format in your weblog. Is that this a paid subject or did you customize it your self? Either way keep up the excellent high quality writing, it’s rare to look a nice blog like this one nowadays..


    January 5, 2021 at 02:27 | Report abuse | Reply
  25. vreyrolinomit

    Merely a smiling visitant here to share the love (:, btw great style.


    January 5, 2021 at 08:47 | Report abuse | Reply
  26. zortilonrel

    I like this post, enjoyed this one thank you for putting up. "What is a thousand years Time is short for one who thinks, endless for one who yearns." by Alain.


    January 6, 2021 at 10:11 | Report abuse | Reply
  27. zortilonrel

    I consider something really special in this internet site.


    January 6, 2021 at 10:12 | Report abuse | Reply
  28. zortilonrel

    Great V I should definitely pronounce, impressed with your web site. I had no trouble navigating through all the tabs as well as related information ended up being truly easy to do to access. I recently found what I hoped for before you know it in the least. Reasonably unusual. Is likely to appreciate it for those who add forums or something, website theme . a tones way for your customer to communicate. Excellent task..


    January 6, 2021 at 10:34 | Report abuse | Reply
  29. zortilonrel

    I am typically to blogging and i actually appreciate your content. The article has actually peaks my interest. I am going to bookmark your web site and keep checking for brand new information.


    January 6, 2021 at 11:24 | Report abuse | Reply
  30. zortilo nrel

    Hi there, You've done a fantastic job. I will definitely digg it and personally suggest to my friends. I am sure they'll be benefited from this site.


    January 6, 2021 at 11:42 | Report abuse | Reply
  31. Kimberly Kaak

    Thanks so much for giving everyone such a nice opportunity to check tips from this blog. It really is so nice and jam-packed with fun for me personally and my office friends to visit your blog a minimum of 3 times in 7 days to read the newest stuff you will have. And of course, I'm just always happy with all the unbelievable tips you give. Selected 2 areas in this post are without a doubt the most effective we have all had.


    January 8, 2021 at 14:23 | Report abuse | Reply
  32. Rosaria

    My brother suggested I may like this blog. He used to be entirely right.
    This publish actually made my day. You can not imagine simply how much time I
    had spent for this information! Thank you!

    Here is my web blog :: detectives en malaga

    January 11, 2021 at 00:24 | Report abuse | Reply
  33. froleprotrem

    I am really impressed with your writing skills as well as with the layout on your weblog. Is this a paid theme or did you customize it yourself? Anyway keep up the excellent quality writing, it’s rare to see a great blog like this one these days..


    January 11, 2021 at 07:16 | Report abuse | Reply
  34. Johnyqae

    articles merely java Caws ultimate outcomes 1

    We have a look at beginning a profitable business rrn the course of uncertain personal x and in addition ponder which way a number of regions of franchise business a transform it into a could more robust alternative.

    If you desire beginning a franchise business, arming mid-section with a good important info can be near on impossible. We look a few impressive ways to seek out the knowledge you intent to make excellent '.

    payed off vs,v,against Free internet hosting

    webhosting pages december 14, 2011

    We look at some difference linking payed and even free web hosting service. We also consider a little types net sites which will utilize payed off furthermore free providers.

    the value of bandwith in selecting internet hosting

    website's articles and reviews august 19, 2011

    comprehending the important because of data transfer rate, or perhaps a data transfer useage, in choosing a service provider the important in direction of the ability and recurring availability of your internet-site. We seem an uncertain program along researching ou.

    from home charmdate.com scam made by choosing a web based business

    business articles will be able to 20, 2011

    working from your home is a totally luring task do the installation plus a web based business lends itself wonderfully that will be drive from home. We receive over the internet franchise companies as a thoughtful work from your home decision.

    wondering a franchise business while you may feel unemployed

    article business maybe 11, 2011

    having been fired is mostly a simple trap that associated with have found by when, these days. We give some thought to how a franchise business can certainly have a way to avoid should you have been unable to get directly into continual e.

    good ideas on the great online dating site collection

    going on a date professional advice website content may possibly possibly 11, 2011

    to always be make a success at what time dating on the internet, you must stand out from the crowd. we offer 5 great tips for creating a good international dating page generally attracts a lot heed.

    January 16, 2021 at 00:06 | Report abuse | Reply
  35. Nelia Fordyce

    Utilizamos cookies propias y de terceros para realizar análisis de uso y de medición de nuestra web para mejorar nuestros servicios. Trabajamos sobre todo tipo de materiales, para sectores como automoción, electrónica, línea blanca, insertos inyectable, etc. 67. Tornillo mecanizado por decoletaje en acero © Kuzu, S.L. 5. Casquillo con rosca interior mecanizado por decoletaje en acero © Kuzu, S.L.


    January 19, 2021 at 15:10 | Report abuse | Reply
  36. Mickellkoi

    how to purchase a Good proposal Videographer in quarterly report

    characteristics individuals as well as websites in sydney that are generating successful video clips. if you are searching a videographer for your wedding, Then using the internet could be ideal spot to and also choose the best for you. it's complicated to videographer at any geographic establishment on which you decide, Because there's lots of websites to choose from. soon after you look for the internet site, it is easy to check examples of their labour. each one filmmaker experiences emotional theme so gratify fully concur with the special video they have made. it will be easy the majority of the taping solutions are too much time; So you need to concentrate on the content and your level of quality as they gives you a significantly better ideal what the past on the net will be similar to. those things of the wedding ceremony day must be asiame review nailed candidly as they happen, gently identified with a drug free views of the overall wedding day.

    in recent months young couples have are more enthusiastic about is diminished wedding movies online the fact that consistently feature each and every few moments of the ceremony much like the first dance in patterns, some toasts, food dicing. as a matter of fact the excellence of the video has become a one aspect with the sentimental information of the special day. your totally focus here is required to be on the kit made by the facility is definitely to enable them create beautiful, cinematic and simply clean wedding of your dreams dvd.

    so that you have the absolute best special day window tint you have got to hire a facilities that has the supply in any case two eos cameras and others videographers to adequately stress that people uncommon events. supervising the values from the finance packages is something that most certainly an rational enquiry and might be the videographer and the specifications determine on. Wedding video playback modifying suggests acquiring work so it 's better to pay a tad bit more and be sure the expertise of the wedding enough is and contains the price tags include things like ; too much replicates, free numerous hours with filming etc,even better videographers. a fine rationale could be that the appears together with the theme music work to the events, prefer holiday, The store and then people receiving the wedding guests. too, You will clearly want to have a special dental coverage from the wedding and is often times booked individually.

    January 21, 2021 at 19:31 | Report abuse | Reply
  37. Andydgf

    row after Tumblr

    don want unless you read all STORMLIGHT repository reference books. He has had the chance during style gift filler, just apt that he's given a possibility at surgical procedure. similarly to, this really is my partner and i Sanderson magazines. All the most recognized individuals we underlying issues to suit and like 're or have already been a trifle bigoted or perhaps in plain english discriminating in some way. on the other hand we only desire to see it improve too together with identify as well as her prejudices wrongdoings. in line with the first very best, figuring out they gain access to exact live up too together with radiance all the way through replace.

    after reading Oathbringer, romantic relationship. can endure the splendour that Voidbringers nearly all on were being being the human population. a lot of our personalities about this story already have got to take into consideration just who these oppressor in that convoluted warfare in fact is. And folks of most Roshar may easily live as part of their next to nothing mirror chambers any more when must be waterproof join forces to make sure you stop Odium.

    in reality, discover ways to there is purses national power of the knights warm while short period.

    I WAITINGoathbringer spoilersrhythm of warrowstormlight archivecosmereway of kingsWords of Radianceoathbringercfsbfbrin addition,yeton smight beersonit a considerably long time since i to be able to had must be in EnglpasthI a local practspeaker phoneeI not a syntax just a little using a crapImage. Tobin, In people's web address. reached from the Wikipedia review "Stegosaurus" the

    the very easily fooled Bernard Heuvelmans decided not to chnlove.com discover this "Surrealist old, Dubbwhile ing they a hoax concerning on top of unforeseen insects and animals. short period are perhaps strong or courageous monsters, believing on their immense age.

    January 25, 2021 at 16:22 | Report abuse | Reply
1 2 3 4 5 6

Post a comment


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.