home
RSS
February 22nd, 2011
09:07 AM ET

Can antidepressants jump-start bipolar disorder?

Every weekday, a CNNHealth expert doctor answers a viewer question. On Tuesdays, it's Dr. Charles Raison, an associate professor of psychiatry and behavioral sciences at Emory University, and an expert in the mind-body connection for health.

Asked by Michelle, Michigan

I had an untreated health issue for a couple of years that threw me into a mild depression. I have a mother and brother who are bipolar and one of the things my therapist told me is that studies show that if you go on an antidepressant and there is a history of bipolar in your family that this can sometimes "kick in" the bipolar. I am lucky and was able to get past my depression with therapy, exercise, etc. I was just wondering what your thoughts were.Expert answer

Dear Michelle,

I've got a lot of thoughts about your question, and they are all confused! In this way I am much like the field of psychiatry as a whole. Ten years ago I would have told you that what you'd heard was absolutely correct and that people with bipolar disorder should avoid antidepressants because of the risk these medications pose in terms of making vulnerable people manic.

I still mostly believe this, but a number of large studies done over the last five years do not do much to confirm the idea that antidepressants are dangerous for people with - or at risk for - bipolar disorder. In these studies, people with bipolar disorder seem able to take antidepressants and not "go manic" at any higher rate than they would have naturally.

On the other hand, anyone who has practiced psychiatry for any time at all can tell you stories of people like yourself with a bipolar family history who went manic soon after going on an antidepressant for the first time. So what's the truth? We just don't know.

In fact, we don't even know whether antidepressants help people with bipolar disorder who get depressed. It's interesting. Studies done on the East Coast of the United States tend to find that antidepressants do not help, whereas studies done on the West Coast suggest that they are of tremendous benefit. What's the truth? We just don't know yet.

There are a few things I think we can say with at least a little certainty. First, we know that people from families with bipolar disorder are twice as likely to have "regular old" depression than to have classic bipolar disorder. Like everyone else, these folks should have their depression treated as rapidly and completely as possible, and antidepressants are often hugely useful in accomplishing this. On the other hand, there is at least some evidence that people with family histories like yours may be at an increased risk of having a manic episode on an antidepressant. This wouldn't stop me from using one, but I'd watch with extra caution. The good news is that you tapped into other well documented antidepressant strategies, including exercise and psychotherapy.


soundoff (765 Responses)
  1. RV Windows Near Me

    Hi there! This post couldn’t be written any better! Looking at this post reminds me of my previous roommate! He constantly kept preaching about this. I will forward this post to him. Pretty sure he'll have a good read. I appreciate you for sharing!

    https://www.prodesigns.com/redirect?url=https://ocrv.life/rv-cabinet-repair-near-me

    May 27, 2021 at 20:21 | Report abuse | Reply
  2. rv supply near me

    bookmarked!!, I like your web site!

    http://onlinemanuals.txdot.gov/help/urlstatusgo.html?url=https://ocrv.org/rv-repair-shop-laguna-hills-california

    May 27, 2021 at 21:04 | Report abuse | Reply
  3. RV Parts Riverside

    https://sc.sie.gov.hk/TuniS/ocrv.biz/truck-camper-collision-repair-shop-near-me

    May 27, 2021 at 22:43 | Report abuse | Reply
  4. RV Lighting Orange County

    http://haibao.dlszywz.com/index.php?c=scene&a=link&id=273020&url=https://ocrv.guru/boom-truck-collision-repair-shop-near-me

    May 27, 2021 at 23:08 | Report abuse | Reply
  5. RV Technician Near Me

    Saved as a favorite, I love your website!

    http://dir.tetsumania.net/search/rank.cgi?mode=link&id=3267&url=https://rvstoragenodomise.blogspot.com/2017/04/rv-storage-in-orange-county.html

    May 28, 2021 at 04:18 | Report abuse | Reply
  6. Content Marketing Specialist

    http://kite-rider.com/0link/rank.cgi?mode=link&id=178&url=http://cdaseo.com/

    May 28, 2021 at 04:20 | Report abuse | Reply
  7. Internet Marketing Firm

    https://www.isixsigma.com/share.php?site=https://cdaseo.com/

    May 28, 2021 at 07:32 | Report abuse | Reply
  8. RV Headlights Los Angeles

    Oh my goodness! Incredible article dude! Many thanks, However I am having issues with your RSS. I don’t know the reason why I cannot join it. Is there anybody else getting the same RSS issues? Anyone who knows the answer can you kindly respond? Thanks!!

    /

    May 28, 2021 at 07:42 | Report abuse | Reply
  9. fox24

    Right here is the perfect site for anybody who
    hopes to find out about this topic. You realize a whole lot its almost tough to argue with you (not that I personally will
    need to…HaHa). You certainly put a brand new spin on a topic which has been discussed for decades.
    Excellent stuff, just excellent!

    May 28, 2021 at 10:09 | Report abuse | Reply
  10. Casa da Rede- Encontre aqui os melhores produtos de informática

    Keep on writing, great job!

    May 28, 2021 at 10:21 | Report abuse | Reply
  11. RV Entertainment System California

    http://toplink.miliweb.net/out-16961.php?web=https://orthocentreinindia.com/blog/knee-replacement-chandigarh-knee-replacement-cost-chandigarh/

    May 28, 2021 at 10:36 | Report abuse | Reply
  12. best car ac repair near me

    Spot on with this write-up, I seriously feel this site needs a lot more attention. I’ll probably be returning to read through more, thanks for the info!

    http://banner.kingsnake.com/ac.php?bannerID=2083&camp=1980&dest=https://raftaar.news/?p=174

    May 28, 2021 at 12:59 | Report abuse | Reply
  13. RV Awning Los Angeles

    .com

    May 28, 2021 at 13:26 | Report abuse | Reply
  14. SEO Marketing Services

    I enjoy reading an article that will make people think. Also, thank you for allowing me to comment!

    http://crl.ucsd.edu/cgi-bin/ax.cgi?http://bulknearme.com/

    May 28, 2021 at 15:01 | Report abuse | Reply
  15. RV Generator Riverside

    Aw, this was an extremely nice post. Taking a few minutes and actual effort to create a good article… but what can I say… I procrastinate a whole lot and never manage to get anything done.

    .com

    May 28, 2021 at 20:10 | Report abuse | Reply
  16. Sprinter Van Repair Abs

    Spot on with this write-up, I truly believe that this website needs a lot more attention. I’ll probably be returning to read through more, thanks for the advice!

    http://yellowpages.therolladailynews.com/__media__/js/netsoltrademark.php?d=www.fleetservicesocrv.com

    May 29, 2021 at 01:26 | Report abuse | Reply
  17. Jet Van Repair

    Can I just say what a relief to find someone who truly understands what they're talking about on the net. You certainly know how to bring a problem to light and make it important. A lot more people ought to check this out and understand this side of the story. It's surprising you're not more popular given that you surely have the gift.

    https://www.dmca.com/Protection/Status.aspx?ID=edc817fd-d796-4c84-abb8-d1cb5b2e3719&refurl=https://fleetrepairshops.com/camper-van-repair-shop-near-me/

    May 29, 2021 at 06:06 | Report abuse | Reply
  18. Social Media Marketing Agencies Near Me

    You ought to take part in a contest for one of the finest websites on the web. I most certainly will recommend this site!

    https://www.c-o-k.ru/goto_url.php?id=559&url=https://affordableranking.com/

    May 29, 2021 at 13:41 | Report abuse | Reply
  19. Semi Truck Restoration Shop Near Me

    http://drugoffice.gov.hk/gb/unigb/fleetservicerepairshop.com/tow-truck-repair-shop-near-me

    May 29, 2021 at 21:25 | Report abuse | Reply
  20. Police Truck Repair Shop

    https://www.vans.com/webapp/wcs/stores/servlet/LinkShareGateway?siteID=IFCTyuu33gI-HmTv1Co9oM2RT1QCkYxD_Q&source=LSA&storeId=10153&url=https://boxtruckrepairshop.com/testimonials

    May 29, 2021 at 22:15 | Report abuse | Reply
  21. Box Truck Maintenance

    https://smccd.edu/disclaimer/redirect.php?url=http://commercialrepairshop.com/transport-truck-repair-shop-near-me/

    May 29, 2021 at 22:19 | Report abuse | Reply
  22. Dodge Sprinter Service Near Me

    http://preissuchmaschine.de/link.asp?url=https://sprinterrepairnearme.com

    May 31, 2021 at 06:46 | Report abuse | Reply
  23. Sprinter Mercedes Service

    https://naniwa-search.com/search/rank.cgi?mode=link&id=23&url=https://sprintervanrepair.com/

    May 31, 2021 at 07:14 | Report abuse | Reply
  24. RV Repair Service Near Me

    http://sports-ranking.com/search/rank.cgi?mode=link&id=7&url=ocrv.tv

    May 31, 2021 at 08:40 | Report abuse | Reply
  25. RV Service Repair Near Me

    https://wapp.baidu.com/mo/q/checkurl?url=https://ocrv.store&referer=wapp.baidu.com

    May 31, 2021 at 09:29 | Report abuse | Reply
  26. link w88 mới 2021

    Hi mates, how is all, and what you wish for to say concerning this post, in my view its actually awesome in favor of me.

    May 31, 2021 at 12:18 | Report abuse | Reply
  27. lipstic

    It's appropriate time to make some plans for the future and it is time to be happy.

    I've read this post and if I could I wish to suggest you some interesting things or tips.
    Maybe you can write next articles referring to this article.
    I desire to read even more things about it!

    May 31, 2021 at 16:12 | Report abuse | Reply
  28. کرامت زاده

    I'm not sure exactly why but this website is loading very slow for me.

    Is anyone else having this problem or is it a problem on my end?
    I'll check back later and see if the problem still exists.

    May 31, 2021 at 17:13 | Report abuse | Reply
  29. Alignment Shop

    http://local.lex18.com/__media__/js/netsoltrademark.php?d=commercialvanrepairshop.com/passenger-van-repair-shop-near-me

    May 31, 2021 at 17:31 | Report abuse | Reply
  30. ผลบอลสด

    You could definitely see your skills within the article you write.
    The sector hopes for even more passionate writers like you who are not
    afraid to say how they believe. Always go after your heart.

    June 1, 2021 at 10:15 | Report abuse | Reply
  31. travel trailers orange county

    http://remontmix.ru/out?t=1&mid=19521&url=https://clarkgaebel.com/blog/2017/12/25/O-RN-quebrou/

    June 1, 2021 at 10:47 | Report abuse | Reply
  32. rv electrical repair near me

    http://www.qatar.vcu.edu/?URL=homedesignhq.co.uk/component/k2/item/1.html?start=589360

    June 1, 2021 at 19:30 | Report abuse | Reply
  33. Delta Erpenbach

    https://za.zalo.me/v3/verifyv2/pc?token=OcNsmjfpL0XY2F3BtHzNRs4A-hhQ5q5sPXtbk3O&continue=ocrvfleetservices.com

    June 1, 2021 at 21:19 | Report abuse | Reply
  34. Valentine Granucci

    I like it when individuals come together and share ideas. Great blog, continue the good work!

    http://dol.deliver.ifeng.com/c?z=ifeng&la=0&si=2&cg=1&c=1&ci=2&or=7549&l=28704&bg=28703&b=37275&u=https://felixu62l2.estate-blog.com/4088866/details-fiction-and-digital-marketing-firms

    June 1, 2021 at 21:48 | Report abuse | Reply
  35. Inga Hippenstiel

    There is certainly a great deal to find out about this issue. I like all the points you've made.

    https://rspcb.safety.fhwa.dot.gov/pageRedirect.aspx?RedirectedURL=https://lorenzof07w6.blogstival.com/24071664/helping-the-others-realize-the-advantages-of-rv-body-repair

    June 1, 2021 at 23:47 | Report abuse | Reply
  36. 편입과외 중개사이트

    My relatives every time say that I am wasting my time here at web, however I know
    I am getting know-how every day by reading such fastidious
    articles or reviews.

    June 2, 2021 at 01:28 | Report abuse | Reply
  37. w88 club

    I used to be recommended this web site by means
    of my cousin. I am now not certain whether this submit is written via him as nobody else
    understand such detailed approximately my problem.
    You are incredible! Thank you!

    June 2, 2021 at 10:16 | Report abuse | Reply
  38. Content Marketing Companies

    https://www.rya.org.uk/coursestraining/professional/pages/redir.axd?ciid=671&cachename=advertising&pagegroupid=212&url=https://meticulousjess.com

    June 2, 2021 at 22:34 | Report abuse | Reply
  39. flooring repair near me

    An outstanding share! I have just forwarded this onto a friend who was doing a little research on this. And he in fact ordered me lunch because I found it for him... lol. So allow me to reword this.... Thank YOU for the meal!! But yeah, thanx for spending some time to discuss this matter here on your web page.

    https://qatar.vcu.edu/?URL=delilerkoyu.com/index.php/component/ https:/bitcoininvestment.us.org/httр:/іmpalасlub. сo.ke/httρ:/www.nеіesκok.lt/blog/view/99289/images/index.php?option=com_datsogallery&Itemid=23&func=detail&catid=11&id=274

    June 3, 2021 at 00:36 | Report abuse | Reply
  40. semi truck shops near me

    http://redirects.tradedoubler.com/utm/td_redirect.php?td_keep_old_utm_value=1&url=https://birmingham.photoads.co.uk/buy-and-sell/business-industrial/171584-RV-Repair-Near-Me.html

    June 3, 2021 at 02:26 | Report abuse | Reply
  41. Mercedes Diesel Repair

    http://house.speakingsame.com/big5/floorplan.php?sta=vic&addr=91+Arthurton+Road&q=Northcote&url=fleetservicesocrv.com/

    June 3, 2021 at 03:35 | Report abuse | Reply
  42. Video Marketing Firms

    http://www.auhoney.net/link.php?url=https://www.bestshopnearme.com/

    June 3, 2021 at 04:57 | Report abuse | Reply
  43. school bus windshield replacement

    http://www.landofvolunteers.com/go.php?https://ocrvmotorsports.us

    June 3, 2021 at 09:12 | Report abuse | Reply
  44. rv and camper repair near me

    https://www.hobowars.com/game/linker.php?url=http://ocrv.info

    June 3, 2021 at 09:32 | Report abuse | Reply
  45. SEO Marketing Companies

    http://www.finediningclub.com/__media__/js/netsoltrademark.php?d=bestlocalnearme.com/

    June 3, 2021 at 11:27 | Report abuse | Reply
  46. Social Media Marketing Specialists

    Spot on with this write-up, I actually believe that this amazing site needs far more attention. I’ll probably be returning to read through more, thanks for the advice!

    http://www.mailstreet.com/redirect.asp?url=https://internetmarketingnevada.com/

    June 3, 2021 at 12:08 | Report abuse | Reply
  47. upholstery repair shop near me

    Way cool! Some extremely valid points! I appreciate you writing this article plus the rest of the site is also very good.

    https://www.fhwa.dot.gov/reauthorization/reauexit.cfm?link=http://youtube.com/watch?v=srqVas53kPs/

    June 3, 2021 at 19:08 | Report abuse | Reply
  48. rv rental orange county

    Very nice post. I certainly appreciate this website. Keep writing!

    https://images.google.bt/url?q=https://youtube.com/watch?v=NbIqOGAKXCw

    June 3, 2021 at 19:51 | Report abuse | Reply
  49. solar panels orange county

    https://www.oliverhume.com.au/enquiry/thank-you/?redirectTo=https://youtube.com/watch?v=ti_svrTA76s/

    June 3, 2021 at 20:08 | Report abuse | Reply
  50. stake center near me

    Iím amazed, I have to admit. Rarely do I encounter a blog thatís equally educative and interesting, and let me tell you, you have hit the nail on the head. The problem is something which not enough folks are speaking intelligently about. I am very happy I came across this in my hunt for something regarding this.

    http://www.furrondy.net/Redirect.aspx?destination=http://www.youtube.com/watch?v=JLeDOSO97T0

    June 3, 2021 at 20:38 | Report abuse | Reply
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

Leave a Reply to Brad Dunivan


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.