Risks of NSAIDs backed in new study
January 11th, 2011
06:31 PM ET

Risks of NSAIDs backed in new study

Now there's even more reason to talk to your doctor about what kinds of painkillers you're taking.

Supporting previous research on the subject, a large meta-analysis of 31 studies has found significant risks of cardiovascular events in people who take prescription-strength nonsteroidal anti-inflammatory drugs (NSAIDs).

This research, published in the British Journal of Medicine, used a more sophisticated technique than previous studies, said Wayne Ray, professor and director of the Department of Preventive Medicine at Vanderbilt University and author of an editorial that accompanied the study.

The analysis spanned studies including a total of more than 116,000 patients. Scientists looked at trials that had compared NSAIDs with other NSAIDs or placebo.

Of the drugs studied, they found that ibuprofen (sold as Advil and others) carries the highest risk of stroke, etoricoxib (Arcoxia outside the United States; not sold in the U.S.) has the highest risk of cardiovascular death, and rofecoxib (previously sold as Vioxx in the United States, but it has since been withdrawn) carries the highest risk of heart attack.

For certain drugs such as celecoxib (sold as Pfizer's Celebrex), the cardiovascular risk appears to go up with dosage.

But the study did not consider the bleeding problems that can accompany usage of NSAIDs, said Dr. Jeffrey Berger, assistant professor of medicine at NYU Langone Medical Center in New York. This is an important limitation.

Also, the study did not look specifically at patients who were at risk for cardiovascular problems already; although these people should be particularly wary of NSAIDs. That means that this data probably underestimated the risks of these drugs, Berger said.

He also questions how much weight to put on the ibuprofen and stroke finding, because only two of the 31 trials looked at that question.

Even though research has focused on prescription-strength doses of these drugs, the risks most likely apply to what's sold over the counter, especially given that a person can ingest the equivalent of a prescription dose by taking enough pills bought over the counter, Berger said.

Of the NSAIDs examined across these trials, naproxen, the key ingredient in Aleve and other medications, is the safest, the study found. This drug still carries cardiovascular risk, but perhaps not as much as others such as ibuprofen, experts said.

It seems that all of the NSAIDs seem to either prevent or raise the risk of cardiovascular events, and one theory is that naproxen has the best balance between the two, Ray said. Still, there is much more to be learned about naproxen; there has not been a large-scale clinical trial comparing it against a placebo for cardiovascular effects.

A major study that could change current recommendations is called PRECISION, which compares celecoxib to prescription-strength doses of ibuprofen and naproxen in terms of cardiovascular risk. Participants are patients with arthritis who are at risk for cardiovascular problems, or who have had a history of them. The study began in 2006 and is scheduled to end in 2014.

Bottom line: Talk to your doctor to assess the risks and benefits before you take NSAIDs, and make sure you disclose any heart risks you may already have.

soundoff (308 Responses)
  1. RebfZisse

    generic cialis 20 mg https://rcialisgl.com/ buy cialis online in austalia

    May 6, 2021 at 14:46 | Report abuse | Reply
  2. JebgEncox

    Methocarbamol https://pharmacylo.com/ canada pharmaceutical online ordering

    May 7, 2021 at 04:19 | Report abuse | Reply
  3. FmrfEncox

    36 hour cialis http://cialisee.com/ cialis 40 mg

    May 7, 2021 at 12:45 | Report abuse | Reply
  4. GtnbCrulk

    viagra over the counter walgreens https://jokviagra.com/ girls viagra

    May 7, 2021 at 14:44 | Report abuse | Reply
  5. AnooEncox

    depoimentos do viagra http://llviagra.com/ – viagra skin rash si mujer toma viagra

    May 7, 2021 at 21:10 | Report abuse | Reply
  6. BbshMile

    viagra online http://loxviagra.com/ what milligrams does viagra come in

    May 10, 2021 at 00:36 | Report abuse | Reply
  7. RebfZisse

    black cialis sale https://rcialisgl.com/ cialis sale

    May 10, 2021 at 11:44 | Report abuse | Reply
  8. LbsoZisse

    cialis nz https://ucialisdas.com/ cialis without a script

    May 10, 2021 at 17:33 | Report abuse | Reply
  9. GtnbCrulk

    woman on viagra commercial https://jokviagra.com/ how to get viagra without a doctor

    May 11, 2021 at 08:24 | Report abuse | Reply
  10. FmrfEncox

    online pharmacy cialis cheap http://cialisee.com/ canadian pharmacy no prescription generic cialis

    May 12, 2021 at 01:50 | Report abuse | Reply
  11. LbsoZisse

    cialis in canada fast shipping https://ucialisdas.com/ – 10 mg cialis free cialis online

    May 12, 2021 at 03:33 | Report abuse | Reply
  12. LebnEncox

    pills viagra pharmacy 100mg Promethazine Sinequan

    May 12, 2021 at 10:13 | Report abuse | Reply
  13. AnooEncox

    viagra and cialis alternatives https://llviagra.com/ como preparar la sandia como viagra natural

    May 12, 2021 at 11:51 | Report abuse | Reply
  14. LebnEncox

    Cipro https://xlnpharmacy.com/ escrow pharmacy canada

    May 12, 2021 at 12:28 | Report abuse | Reply
  15. BbshMile

    long term side effects of viagra https://loxviagra.com/ viagra with alcohol

    May 12, 2021 at 15:42 | Report abuse | Reply
  16. JebgEncox

    canadian pharmacies comparison https://pharmacylo.com/ Vasotec

    May 12, 2021 at 16:22 | Report abuse | Reply
  17. RebfZisse

    buy cialis online http://rcialisgl.com/ cialisВ® online

    May 13, 2021 at 19:54 | Report abuse | Reply
  18. FmrfEncox

    cialisprofessional http://cialisee.com/ – how to obtain cialis whats better cialis viagra or levitra

    May 14, 2021 at 09:29 | Report abuse | Reply
  19. AnooEncox

    my email sending viagra ads http://llviagra.com/ – what countries sell viagra over the counter que pasa si una mujer toma viagra yahoo

    May 14, 2021 at 16:07 | Report abuse | Reply
  20. GtnbCrulk

    lisinopril and viagra https://jokviagra.com/ viagra duration

    May 15, 2021 at 02:28 | Report abuse | Reply
  21. JebgEncox

    mail order pharmacies canadian pharmacy online viagra Aspirin

    May 15, 2021 at 04:31 | Report abuse | Reply
  22. storno brzinol

    Usually I don't read article on blogs, but I wish to say that this write-up very forced me to try and do so! Your writing style has been surprised me. Thanks, very nice post.


    May 16, 2021 at 04:22 | Report abuse | Reply
  23. RebfZisse

    cialist the yeloow pill http://rcialisgl.com/ insurance that covers cialis

    May 16, 2021 at 17:26 | Report abuse | Reply
  24. LbsoZisse

    cheapest generic cialis online http://ucialisdas.com/ – cialis australia generic cialis online overnight delivery

    May 16, 2021 at 22:11 | Report abuse | Reply
  25. BbshMile

    herbal viagra reviews http://loxviagra.com/ viagra over the counter usa

    May 17, 2021 at 23:39 | Report abuse | Reply
  26. LbsoZisse

    cialis con alimentos http://ucialisdas.com/ how can i get cheaper cialis

    May 18, 2021 at 03:31 | Report abuse | Reply
  27. LebnEncox

    erectile dysfunction https://xlnpharmacy.com/ Cialis Oral Jelly (Orange)

    May 18, 2021 at 05:58 | Report abuse | Reply
  28. LebnEncox

    Capoten canadian online pharmacies prescription drugs Aspirin

    May 18, 2021 at 07:44 | Report abuse | Reply
  29. JebgEncox

    pharmacy discount coupons Allopurinol pharmacy com canada

    May 18, 2021 at 11:08 | Report abuse | Reply
  30. FmrfEncox

    cialis samples canada http://cialisee.com/ cialis with out perscription

    May 18, 2021 at 11:24 | Report abuse | Reply
  31. AnooEncox

    how strong is viagra http://llviagra.com/ temp effet du viagra

    May 19, 2021 at 10:59 | Report abuse | Reply
  32. RebfZisse

    generic cialis pills us online pharmacy http://rcialisgl.com/ 5mg cialis

    May 20, 2021 at 04:59 | Report abuse | Reply
  33. GtnbCrulk

    viagra tablet https://jokviagra.com/ – how was viagra discovered natural viagra alternatives

    May 20, 2021 at 07:15 | Report abuse | Reply
  34. JebgEncox

    Reforge https://pharmacylo.com/ mexican pharmacy

    May 20, 2021 at 13:25 | Report abuse | Reply
  35. BbshMile

    viagra canada https://loxviagra.com/ – viagra does female viagra work

    May 21, 2021 at 04:33 | Report abuse | Reply
  36. FmrfEncox

    what is in cialis ingredients http://cialisee.com/ prescription for cialis purchase

    May 22, 2021 at 12:11 | Report abuse | Reply
  37. RebfZisse

    cialis\' http://rcialisgl.com/ cialis dosage for women

    May 22, 2021 at 18:06 | Report abuse | Reply
  38. AnooEncox

    viagra 100 mg upotreba https://llviagra.com/ what are viagra pills for

    May 22, 2021 at 22:04 | Report abuse | Reply
  39. LbsoZisse

    does 20mg cialis work http://ucialisdas.com/ cialis 20 mg for sale

    May 22, 2021 at 23:08 | Report abuse | Reply
  40. LebnEncox

    Macrobid https://xlnpharmacy.com/ best european online pharmacy

    May 23, 2021 at 12:36 | Report abuse | Reply
  41. LebnEncox

    canadian pharmacy world https://xlnpharmacy.com/ Lotensin

    May 23, 2021 at 14:46 | Report abuse | Reply
  42. GtnbCrulk

    viagra for men https://jokviagra.com/ female viagra effects

    May 23, 2021 at 17:26 | Report abuse | Reply
  43. JebgEncox

    discount pharmacy online pharmacy drop shipping foreign online pharmacy

    May 23, 2021 at 18:20 | Report abuse | Reply
  44. LbsoZisse

    cialis paypal accepted australia https://ucialisdas.com/ – buy cialis online using paypal buy cialis 36 hour

    May 23, 2021 at 22:37 | Report abuse | Reply
  45. FmrfEncox

    but cialis http://cialisee.com/ – can i buy cialis in malaysia where can i buy cialis in canada

    May 24, 2021 at 07:10 | Report abuse | Reply
  46. Zisseloh

    generic cialis fedex https://rcialisgl.com/ – express scripts prior authorization form for cialis cialis pills pictures

    May 25, 2021 at 14:01 | Report abuse | Reply
  47. ZisseVed

    what is the dosage for cialis https://krocialis.com/ – lilly cialis coupon when is cialis going generic

    May 25, 2021 at 19:34 | Report abuse | Reply
  48. CrulkAsd

    herbal cialis https://cialisjla.com/ – cialis no perscription overnight delivery cialis with dapoxetine cheap

    May 26, 2021 at 07:25 | Report abuse | Reply
  49. EncoxDev

    Noroxin best online pharmacy viagra pharmacy logo rx

    May 26, 2021 at 07:38 | Report abuse | Reply
  50. EncoxDev

    northwest pharmacy canada phone number pharmacy open near me canada pet pharmacy

    May 26, 2021 at 09:48 | Report abuse | Reply
1 2 3 4 5 6

Leave a Reply to LhdvZisse


CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.