home
RSS
Risks of NSAIDs backed in new study
January 11th, 2011
06:31 PM ET

Risks of NSAIDs backed in new study

Now there's even more reason to talk to your doctor about what kinds of painkillers you're taking.

Supporting previous research on the subject, a large meta-analysis of 31 studies has found significant risks of cardiovascular events in people who take prescription-strength nonsteroidal anti-inflammatory drugs (NSAIDs).

This research, published in the British Journal of Medicine, used a more sophisticated technique than previous studies, said Wayne Ray, professor and director of the Department of Preventive Medicine at Vanderbilt University and author of an editorial that accompanied the study.

The analysis spanned studies including a total of more than 116,000 patients. Scientists looked at trials that had compared NSAIDs with other NSAIDs or placebo.

Of the drugs studied, they found that ibuprofen (sold as Advil and others) carries the highest risk of stroke, etoricoxib (Arcoxia outside the United States; not sold in the U.S.) has the highest risk of cardiovascular death, and rofecoxib (previously sold as Vioxx in the United States, but it has since been withdrawn) carries the highest risk of heart attack.

For certain drugs such as celecoxib (sold as Pfizer's Celebrex), the cardiovascular risk appears to go up with dosage.

But the study did not consider the bleeding problems that can accompany usage of NSAIDs, said Dr. Jeffrey Berger, assistant professor of medicine at NYU Langone Medical Center in New York. This is an important limitation.

Also, the study did not look specifically at patients who were at risk for cardiovascular problems already; although these people should be particularly wary of NSAIDs. That means that this data probably underestimated the risks of these drugs, Berger said.

He also questions how much weight to put on the ibuprofen and stroke finding, because only two of the 31 trials looked at that question.

Even though research has focused on prescription-strength doses of these drugs, the risks most likely apply to what's sold over the counter, especially given that a person can ingest the equivalent of a prescription dose by taking enough pills bought over the counter, Berger said.

Of the NSAIDs examined across these trials, naproxen, the key ingredient in Aleve and other medications, is the safest, the study found. This drug still carries cardiovascular risk, but perhaps not as much as others such as ibuprofen, experts said.

It seems that all of the NSAIDs seem to either prevent or raise the risk of cardiovascular events, and one theory is that naproxen has the best balance between the two, Ray said. Still, there is much more to be learned about naproxen; there has not been a large-scale clinical trial comparing it against a placebo for cardiovascular effects.

A major study that could change current recommendations is called PRECISION, which compares celecoxib to prescription-strength doses of ibuprofen and naproxen in terms of cardiovascular risk. Participants are patients with arthritis who are at risk for cardiovascular problems, or who have had a history of them. The study began in 2006 and is scheduled to end in 2014.

Bottom line: Talk to your doctor to assess the risks and benefits before you take NSAIDs, and make sure you disclose any heart risks you may already have.


soundoff (183 Responses)
  1. GrvCrulk

    https://kloviagrli.com/ – herbal viagra green box https://vigedon.com/ – how viagra works https://llecialisjaw.com/ – cialis canada https://jwcialislrt.com/ – cialis from india online pharmacy https://jecialisbn.com/ – cialis 20 mg coupon

    March 30, 2021 at 21:52 | Report abuse | Reply
  2. FbshEncox

    https://thesisacloud.com/ – how do i write a thesis i need help writing a thesis phd degree thesis research

    April 1, 2021 at 21:26 | Report abuse | Reply
  3. AbgcEncox

    https://thesiswritingtob.com/ – thesis online who to write a thesis thesis topic thesis help

    April 1, 2021 at 21:39 | Report abuse | Reply
  4. kq bd

    It is hard to overlook the aspect of betting on football 1 set of muscles talks or discusses about football.|There are always 3 or 4 of these teams shortly play every year. True football fans can get several scarves which form a tier. A football scarf is an actual popular item that lots buy all the time.|No sport stands a better than football, end up being cast a spell among all, old and young. If you're don't move your butt quickly, the bar just won't turn. The film is centered on the town of Odessa, Texas.|You also should look for unique furniture for your child's room. Which you you give his treasures a prominent place for display. There recently been much increment with the kids going for the football games.|For many people, however, this dissapear of rare. Late Olayinka John (Ayogi) was the then coach of eleven brothers. All these gimmick backpacks are good for selling, dangerous to speed.|Sure, it helps, but, your hams are what allows fast on top of the football market. Because as we know the first Professional football game was played in 1895. A football scarf is a nice collector's target.|It will give them exclusive use of all the games they might ever want to watch. Use them as an accessory in this instance and i'm betting you'll feel desire the overnight!|Back after i played in High School, I was much stronger than anyone, setting school records by my junior year.

    https://thuthuatvietnam.com/detail/vtv3-online-95180.html

    April 5, 2021 at 17:49 | Report abuse | Reply
  5. Bangloare escorts in H.B.R. Layout

    Thanks again for sharing a wonderful list. I was wondering u did not mention the most sought after terminology used in all the blog commenting articles.

    https://independentmodeldaisy.com

    April 5, 2021 at 22:18 | Report abuse | Reply
  6. Bangalore Escort services

    Thanks again for sharing a wonderful list. I was wondering u did not mention the most sought after terminology used in all the blog commenting articles.

    https://independentmodeldaisy.com

    April 5, 2021 at 22:29 | Report abuse | Reply
  7. Jeevanbheema Nagar escorts

    Thanks again for sharing a wonderful list. I was wondering u did not mention the most sought after terminology used in all the blog commenting articles.

    https://shikasharma.com

    April 5, 2021 at 22:29 | Report abuse | Reply
  8. Independent Bangalore Escort Services

    Thanks again for sharing a wonderful list. I was wondering u did not mention the most sought after terminology used in all the blog commenting articles.

    https://independentmodeldaisy.com

    April 5, 2021 at 22:43 | Report abuse | Reply
  9. South Indian Escorts Bangalore

    Thanks again for sharing a wonderful list. I was wondering u did not mention the most sought after terminology used in all the blog commenting articles.

    https://shikasharma.com

    April 5, 2021 at 23:34 | Report abuse | Reply
  10. Bangalore Call Girls

    Thanks again for sharing a wonderful list. I was wondering u did not mention the most sought after terminology used in all the blog commenting articles.

    https://shikasharma.com

    April 5, 2021 at 23:34 | Report abuse | Reply
  11. Escorts in Hebbal

    Thanks again for sharing a wonderful list. I was wondering u did not mention the most sought after terminology used in all the blog commenting articles.

    https://shikasharma.com

    April 5, 2021 at 23:36 | Report abuse | Reply
  12. FbshEncox

    https://thesisacloud.com/ – thesisacloud.com help with thesis statements thesisacloud.com thesis online

    April 9, 2021 at 14:12 | Report abuse | Reply
  13. AbgcEncox

    https://thesiswritingtob.com/ – thesiswritingtob.com help in writing thesis thesiswritingtob.com thesis paper

    April 9, 2021 at 14:34 | Report abuse | Reply
1 2 3 4

Leave a Reply to JbbnEncox


 

CNN welcomes a lively and courteous discussion as long as you follow the Rules of Conduct set forth in our Terms of Service. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Service.

Advertisement
About this blog

Get a behind-the-scenes look at the latest stories from CNN Chief Medical Correspondent, Dr. Sanjay Gupta, Senior Medical Correspondent Elizabeth Cohen and the CNN Medical Unit producers. They'll share news and views on health and medical trends - info that will help you take better care of yourself and the people you love.