Why HIV advance is not a universal cure
December 15th, 2010
11:31 AM ET

Why HIV advance is not a universal cure

The internet is buzzing about an HIV-infected man who may have gotten rid of his disease through a bone marrow transplant. But the procedures he went through do not represent a cure for all HIV/AIDS patients, as they are risky and not proven to work in everyone. Also, the disease could still be lurking the patient's body, doctors say.

The news about Timothy Ray Brown, a 44-year-old American living in Berlin, first surfaced in 2008, when his doctors reported about his case.  Here's what happened with Brown, who is HIV positive and broke his silence in a recent article with the German magazine Stern .  He is battling a cancer called acute myeloid leukemia. Doctors first treated him high-dose chemotherapy, but when that failed, turned to a bone marrow transplant (which contains stem cells) in 2007.

Brown's oncologist decided to look for a bone marrow donor who had a had a special genetic mutation that made the stem cells in it naturally resistant to HIV infection.  His physician, Dr. Gero Huetter, was able to find this rare match and Brown got the bone marrow transplant.  He needed a second stem cell transplant because the cancer came back.

Today, he appears to be cancer free and doctors can't find traces of the virus that causes AIDS either.

This fascinating scientific advance is by no means a cure for the more than 33 million people living with HIV worldwide. As CNN's Miriam Falco reported in 2008:

1. Even though their tests do not show a presence of HIV in his system, doesn't mean it's not there. This virus is known for hiding well and popping up later. It's been seen before in patients taking anti-retroviral drugs. It is possible that if more sophisticated tests were used on this patient, they would detect the virus that is still in his body. So it's still not entirely clear that he is HIV-free.

2. The chances of finding a bone marrow donor with two copies of this genetic mutation for every one of the 33 million people worldwide living with HIV or AIDS is not realistic because only one percent of Caucasians and zero percent of African Americans or Asians have this particular genetic mutation.

3. Bone marrow transplants are dangerous for patients. Before they can get the donated stem cells that will replace their own, they have to take strong chemotherapy to destroy their own bone marrow – leaving them without an immune system to fight off any disease – until the transplanted bone marrow can make new blood cells. Plus patients run the risk of rejecting the new cells, which means they have to take immune-suppressing drugs for the rest of their life.

4. Bone marrow transplants are very expensive and not an option for many people living with this disease around the world.

Just how dangerous are bone marrow transplants? About one-third of patients die during them, Dr. Jay Levy told Health.com last year.

Bottom line: It's exciting news, but not likely to cure the global AIDS pandemic.

soundoff (205 Responses)
  1. Listen to your Friend Set the Record Straight - He's a Cool Dude

    "Zaia's team is exploring the use of taking a patient's own cells and genetically engineering them to fight HIV. The first studies are being done on patients with HIV lymphoma, who already require chemotherapy. Four patients already have been treated with low doses of genetically modified cells - and the good news is that the modified cells can survive and expand for at least two years."

    "Other researchers are using different techniques to alter stem cells to fight HIV. Until the Berlin patient, most experts considered all of these treatments unlikely to succeed. Now all eyes are upon them."

    "In the future there will be a mild method of making space for these new HIV-resistant stem cells, so that they grow out and repopulate the immune system," Zaia says. "That is the goal. It may take a long time to get to that, but it will happen."


    December 17, 2010 at 08:47 | Report abuse | Reply
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    haha, i like how they try to turn this story into a NEGATIVE situation.

    December 17, 2010 at 18:21 | Report abuse | Reply
  3. Clarissa Hillen

    This article may seem negative, but there have been a lot of positive and remarkable medical and social advancements made this year (the "Berlin Man" included).
    UNAIDS- A year in review

    December 21, 2010 at 14:09 | Report abuse | Reply

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